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Chemistry

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Also known as: 1198300-79-6, Cerdulatinib (prt062070), Prt062070, Cerdulatinib [inn], 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide, Prt-062070
Molecular Formula
C20H27N7O3S
Molecular Weight
445.5  g/mol
InChI Key
BGLPECHZZQDNCD-UHFFFAOYSA-N
FDA UNII
D1LXQ45S1O

Cerdulatinib
Cerdulatinib is an orally bioavailable dual inhibitor of spleen tyrosine kinase (Syk) and Janus-associated kinases (JAK), with potential anti-inflammatory and antineoplastic activity. Upon oral administration, cerdulatinib specifically binds to and inhibits the activity of Syk, JAK1, and JAK3 with preferential inhibition of JAK1 and JAK3-dependent cytokine-mediated signaling and functional responses. This negatively affects the downstream JAK-STAT (signal transducer and activator of transcription) pathway, and leads to both reduced inflammation in various animal models and enhanced antiproliferative activity towards non-Hodgkin's lymphoma (NHL) cell lines. Syk is a non-receptor cytoplasmic tyrosine kinase involved in signal transduction in cells of hematopoietic origin including B cells, macrophages, basophils and neutrophils. Abnormal function of Syk has been implicated in several hematopoietic malignancies including NHL and chronic lymphocytic leukemia (CLL). The JAK-STAT pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
1 2D Structure

Cerdulatinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide
2.1.2 InChI
InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25)
2.1.3 InChI Key
BGLPECHZZQDNCD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N
2.2 Other Identifiers
2.2.1 UNII
D1LXQ45S1O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

2. Prt062070

2.3.2 Depositor-Supplied Synonyms

1. 1198300-79-6

2. Cerdulatinib (prt062070)

3. Prt062070

4. Cerdulatinib [inn]

5. 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide

6. Prt-062070

7. D1lxq45s1o

8. Chembl4116008

9. Rvt-502

10. Prt-2070

11. Prt 062070

12. 4-(cyclopropylamino)-2-((4-(4-(ethanesulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

13. 5-pyrimidinecarboxamide, 4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)-1-piperazinyl)phenyl)amino)-

14. Prt2070

15. Unii-d1lxq45s1o

16. 4-(cyclopropylamino)-2-({4-[4-(ethanesulfonyl)piperazin-1-yl]phenyl}amino)pyrimidine-5-carboxamide

17. Cerdulatinib (prt2070)

18. Cerdulatinib [who-dd]

19. Schembl736734

20. Gtpl8957

21. Dtxsid001115521

22. Bcp10681

23. Ex-a2143

24. Yxb30079

25. Bdbm50468574

26. Nsc800071

27. Nsc825827

28. S3566

29. Akos026750510

30. Zinc114483165

31. Cs-3329

32. Db15499

33. Nsc-800071

34. Nsc-825827

35. Sb16931

36. Cerdulatinib; Prt062070; Prt2070

37. Ncgc00386415-04

38. 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide

39. Ac-30243

40. As-56368

41. Da-34986

42. Hy-15999

43. B8023

44. Ft-0741914

45. A14147

46. C71670

47. Q27075860

48. Prt2070; Prt-2070; Prt 2070; Prt-062070; Prt 062070; Prt062070

49. 4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

2.4 Create Date
2010-02-01
3 Chemical and Physical Properties
Molecular Weight 445.5 g/mol
Molecular Formula C20H27N7O3S
XLogP31.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass445.18960892 g/mol
Monoisotopic Mass445.18960892 g/mol
Topological Polar Surface Area142 Ų
Heavy Atom Count31
Formal Charge0
Complexity711
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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Looking for 1198300-79-6 / Cerdulatinib API manufacturers, exporters & distributors?

Cerdulatinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cerdulatinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cerdulatinib manufacturer or Cerdulatinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cerdulatinib manufacturer or Cerdulatinib supplier.

PharmaCompass also assists you with knowing the Cerdulatinib API Price utilized in the formulation of products. Cerdulatinib API Price is not always fixed or binding as the Cerdulatinib Price is obtained through a variety of data sources. The Cerdulatinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cerdulatinib

Synonyms

1198300-79-6, Cerdulatinib (prt062070), Prt062070, Cerdulatinib [inn], 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide, Prt-062070

Cas Number

1198300-79-6

Unique Ingredient Identifier (UNII)

D1LXQ45S1O

About Cerdulatinib

Cerdulatinib is an orally bioavailable dual inhibitor of spleen tyrosine kinase (Syk) and Janus-associated kinases (JAK), with potential anti-inflammatory and antineoplastic activity. Upon oral administration, cerdulatinib specifically binds to and inhibits the activity of Syk, JAK1, and JAK3 with preferential inhibition of JAK1 and JAK3-dependent cytokine-mediated signaling and functional responses. This negatively affects the downstream JAK-STAT (signal transducer and activator of transcription) pathway, and leads to both reduced inflammation in various animal models and enhanced antiproliferative activity towards non-Hodgkin's lymphoma (NHL) cell lines. Syk is a non-receptor cytoplasmic tyrosine kinase involved in signal transduction in cells of hematopoietic origin including B cells, macrophages, basophils and neutrophils. Abnormal function of Syk has been implicated in several hematopoietic malignancies including NHL and chronic lymphocytic leukemia (CLL). The JAK-STAT pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

Cerdulatinib Manufacturers

A Cerdulatinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cerdulatinib, including repackagers and relabelers. The FDA regulates Cerdulatinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cerdulatinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cerdulatinib Suppliers

A Cerdulatinib supplier is an individual or a company that provides Cerdulatinib active pharmaceutical ingredient (API) or Cerdulatinib finished formulations upon request. The Cerdulatinib suppliers may include Cerdulatinib API manufacturers, exporters, distributors and traders.

Cerdulatinib GMP

Cerdulatinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cerdulatinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cerdulatinib GMP manufacturer or Cerdulatinib GMP API supplier for your needs.

Cerdulatinib CoA

A Cerdulatinib CoA (Certificate of Analysis) is a formal document that attests to Cerdulatinib's compliance with Cerdulatinib specifications and serves as a tool for batch-level quality control.

Cerdulatinib CoA mostly includes findings from lab analyses of a specific batch. For each Cerdulatinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cerdulatinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Cerdulatinib EP), Cerdulatinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cerdulatinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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