Cefteram Pivoxil

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

3 API Suppliers, 1 JDMF, 2 Listed Suppliers

INTERMEDIATES

1 Suppliers

1 Suppliers

MARKET PLACE

1 APIs

1 APIs

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

EU WC

Listed Suppliers

API REF. PRICE (USD / KG)

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Tomiron, 82547-81-7, Cefteram pivaloyloxymethyl ester, T 2588, T-2588, 0od86rt58c

Molecular Formula

C₂₂H₂₇N₉O₇S₂

Molecular Weight

593.6 g/mol

InChI Key

UIYAXIPXULMHAI-JLGRZTKVSA-N

FDA UNII

0OD86RT58C

Cefteram Pivoxil is the pivalate ester prodrug of cefteram, a semi-synthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. After oral administration of cefteram pivoxil, the ester bond is cleaved, releasing active cefteram.

1 2D Structure

Cefteram Pivoxil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.1.2 InChI

InChI=1S/C22H27N9O7S2/c1-10-26-29-30(27-10)6-11-7-39-18-14(25-16(32)13(28-36-5)12-8-40-21(23)24-12)17(33)31(18)15(11)19(34)37-9-38-20(35)22(2,3)4/h8,14,18H,6-7,9H2,1-5H3,(H2,23,24)(H,25,32)/b28-13-/t14-,18-/m1/s1

2.1.3 InChI Key

UIYAXIPXULMHAI-JLGRZTKVSA-N

2.1.4 Canonical SMILES

CC1=NN(N=N1)CC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C

2.1.5 Isomeric SMILES

CC1=NN(N=N1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)OCOC(=O)C(C)(C)C

2.2 Other Identifiers

2.2.1 UNII

0OD86RT58C

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ro 19-5248

2. Ro-19-5248

3. T 2588

4. T-2588

5. Tomiron

2.3.2 Depositor-Supplied Synonyms

1. Tomiron

2. 82547-81-7

3. Cefteram Pivaloyloxymethyl Ester

4. T 2588

5. T-2588

6. 0od86rt58c

7. 2,2-dimethylpropanoyloxymethyl (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

8. Ro-19-5248

9. Antibiotic T 2588

10. Tomiron (tn)

11. Unii-0od86rt58c

12. Brn 4223783

13. Cftm-pi

14. Starbld0016558

15. Cefteram Pivoxil (jp17)

16. Chembl3137676

17. Schembl22718900

18. Chebi:31381

19. Uiyaxipxulmhai-jlgrztkvsa-

20. Cefteram Pivoxil [mart.]

21. Cefteram Pivoxil [who-dd]

22. Dtxsid401316612

23. Act06271

24. Zinc3871962

25. S5354

26. Hy-106571

27. Cefteram Pivaloyloxymethyl Ester [mi]

28. Cs-0026074

29. D01686

30. 547c817

31. (7r)-7beta-[(2-aminothiazol-4-yl)(methoxyimino)acetylamino]-3-(5-methyl-2h-tetrazol-2-yl)methylcepham-3-ene-4-carboxylic Acid Pivaloyloxymethyl Ester

32. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((5-methyl-2h-tetrazol-2-yl)methyl)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r-(6-alpha,7-beta(z)))-

33. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl)amino)-3-((5-methyl-2h-tetrazol-2-yl)methyl)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (6r,7r)-

34. Pivaloyloxymethyl (z)-7-(2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)-3-(5-methyl-2h-tetrazol-2-ylmethyl)-3-cephem-4-carboxylate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₇N₉O₇S₂
Molecular Weight	593.6 g/mol
XLogP3	3.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	12
Exact Mass	593.14748658 g/mol
Monoisotopic Mass	593.14748658 g/mol
Topological Polar Surface Area	260 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	1100
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1