Cefovecin

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

4 API Suppliers, 1 NDC API, 4 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Formulations

2 Dossiers, 1 Canada, 1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 1 Actylis

MARKET PLACE

6 APIs

6 APIs

PATENTS

2 Health Canada Patents

2 Health Canada Patents

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

276

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Cefovecin sodium, Uk-287074-02, Cefovecin sodium salt, Chembl2104475, Ex-a3268, A936300

Molecular Formula

C₁₇H₁₈N₅NaO₆S₂

Molecular Weight

475.5 g/mol

InChI Key

QRIBXVGHDLFNNE-BMCBYEKFSA-M

Cefovecin Sodium is the sodium salt form of cefovecin, a semisynthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. Cefovecin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

1 2D Structure

Cefovecin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2.1.2 InChI

InChI=1S/C17H19N5O6S2.Na/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9;/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26);/q;+1/p-1/b21-10+;/t9-,11+,15+;/m0./s1

2.1.3 InChI Key

QRIBXVGHDLFNNE-BMCBYEKFSA-M

2.1.4 Canonical SMILES

CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C4CCCO4)C(=O)[O-].[Na+]

2.1.5 Isomeric SMILES

CO/N=C(\C1=CSC(=N1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)[C@@H]4CCCO4)C(=O)[O-].[Na+]

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Cefovecin Sodium

2. Uk-287074-02

3. Cefovecin Sodium Salt

4. Chembl2104475

5. Ex-a3268

6. A936300

7. Q27114290

8. Sodium (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl] Amino]-8-oxo-3-[(2s)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene- 2-carboxylate

9. Sodium (6r,7r)-7-[2-(2-aminothiazol-4-yl)-2-(z)-methoxyiminoacetamido]-3-[(s) -tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate

10. Sodium (6r,7r)-7-[2-(2-aminothiazol-4-yl)-2-(z)-methoxyiminoacetamido]-3-[(s)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate

2.3 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₁₈N₅NaO₆S₂
Molecular Weight	475.5 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	6
Exact Mass	475.05961994 g/mol
Monoisotopic Mass	475.05961994 g/mol
Topological Polar Surface Area	213 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	827
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2