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Also known as: 99592-39-9, Dermofix, Ertaczo, Zalain, Sertaconazole mononitrate, Ginedermofix
Molecular Formula
C20H16Cl3N3O4S
Molecular Weight
500.8  g/mol
InChI Key
HAAITRDZHUANGT-UHFFFAOYSA-N
FDA UNII
1DV05410M5

Sertaconazole Nitrate
Sertaconazole Nitrate is the nitrate salt form of sertaconazole, a synthetic imidazole derivative with antifungal property. Sertaconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and the inhibition of ergosterol synthesis, an essential component of the cell membrane of fungi. This leads to a disruption of cell membrane permeability and leakage of adenine triphosphate (ATP) and other constituents from fugal cells.
1 2D Structure

Sertaconazole Nitrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
2.1.2 InChI
InChI=1S/C20H15Cl3N2OS.HNO3/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22;2-1(3)4/h1-8,11-12,19H,9-10H2;(H,2,3,4)
2.1.3 InChI Key
HAAITRDZHUANGT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl.[N+](=O)(O)[O-]
2.2 Other Identifiers
2.2.1 UNII
1DV05410M5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dermofix

2. Dermoseptic

3. Ginedermofix

4. Mykosert

5. Sertaconazole

6. Sertaconazole Mononitrate

7. Zalain

2.3.2 Depositor-Supplied Synonyms

1. 99592-39-9

2. Dermofix

3. Ertaczo

4. Zalain

5. Sertaconazole Mononitrate

6. Ginedermofix

7. Dermovit

8. Fi 7056

9. Sertaconazole (nitrate)

10. Fi-7045

11. 99592-39-9 (nitrate)

12. 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric Acid

13. 1dv05410m5

14. Fi-7056

15. 1-[2-[(7-chloro-1-benzothien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole Nitrate

16. 1h-imidazole, 1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate

17. Dermoseptic

18. 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1h-imidazole; Nitric Acid

19. Fisderm

20. Extens

21. Onabet

22. Sr-05000001439

23. Unii-1dv05410m5

24. Sertaconazolenitrate

25. Ertaczo (tn)

26. Zalain (tn)

27. 1-(2-((7-chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole Nitrate

28. 1h-imidazole, 1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, Nitrate (1:1)

29. Ncgc00016966-01

30. Cas-99592-39-9

31. Dsstox_cid_25529

32. Dsstox_rid_80932

33. Dsstox_gsid_45529

34. Mls002154122

35. Schembl261807

36. Chembl1200725

37. Dtxsid2045529

38. Hy-b0736a

39. Hms1571a12

40. Hms2098a12

41. Hms2231n14

42. Hms3372h01

43. Hms3715a12

44. Sertaconazole Nitrate [mi]

45. Amy32537

46. Bcp09311

47. Tox21_110718

48. Ac-739

49. Fi7056

50. Mfcd00918063

51. S3161

52. Sertaconazole Nitrate [mart.]

53. Akos015888158

54. Akos015964610

55. Sertaconazole Nitrate [who-dd]

56. Ccg-221045

57. 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; Nitric Acid

58. As-14332

59. Smr001233429

60. Sertaconazole Nitrate [orange Book]

61. Sertaconazole Nitrate [ep Monograph]

62. Ft-0674558

63. D08510

64. F20635

65. A846049

66. A851341

67. Sr-05000001439-3

68. Q27252298

69. 1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole Mononitrate

70. 1-[2-[(7-chloranyl-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; Nitric Acid

71. 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole,nitric Acid

2.3.3 Other Synonyms

1. Sertaconazole

2. Sertaconazol

3. Demofix

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 500.8 g/mol
Molecular Formula C20H16Cl3N3O4S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass498.992710 g/mol
Monoisotopic Mass498.992710 g/mol
Topological Polar Surface Area121 Ų
Heavy Atom Count31
Formal Charge0
Complexity513
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameErtaczo
PubMed HealthSertaconazole (On the skin)
Drug ClassesAntifungal
Drug LabelERTACZO (sertaconazole nitrate) Cream, 2%, contains the imidazole antifungal, sertaconazole nitrate. Sertaconazole nitrate contains one asymmetric carbon atom and exists as a racemic mixture of equal amounts of R and S enantiomers.Sertaconazole nit...
Active IngredientSertaconazole nitrate
Dosage FormCream
RouteTopical
Strength2%
Market StatusPrescription
CompanyValeant Luxembourg

2 of 2  
Drug NameErtaczo
PubMed HealthSertaconazole (On the skin)
Drug ClassesAntifungal
Drug LabelERTACZO (sertaconazole nitrate) Cream, 2%, contains the imidazole antifungal, sertaconazole nitrate. Sertaconazole nitrate contains one asymmetric carbon atom and exists as a racemic mixture of equal amounts of R and S enantiomers.Sertaconazole nit...
Active IngredientSertaconazole nitrate
Dosage FormCream
RouteTopical
Strength2%
Market StatusPrescription
CompanyValeant Luxembourg

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Azoles [CS]; Azole Antifungal [EPC]

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15-May-2025
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ABOUT THIS PAGE

Looking for 99592-39-9 / Sertaconazole Nitrate API manufacturers, exporters & distributors?

Sertaconazole Nitrate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sertaconazole Nitrate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sertaconazole Nitrate manufacturer or Sertaconazole Nitrate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sertaconazole Nitrate manufacturer or Sertaconazole Nitrate supplier.

PharmaCompass also assists you with knowing the Sertaconazole Nitrate API Price utilized in the formulation of products. Sertaconazole Nitrate API Price is not always fixed or binding as the Sertaconazole Nitrate Price is obtained through a variety of data sources. The Sertaconazole Nitrate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sertaconazole Nitrate

Synonyms

99592-39-9, Dermofix, Ertaczo, Zalain, Sertaconazole mononitrate, Ginedermofix

Cas Number

99592-39-9

Unique Ingredient Identifier (UNII)

1DV05410M5

About Sertaconazole Nitrate

Sertaconazole Nitrate is the nitrate salt form of sertaconazole, a synthetic imidazole derivative with antifungal property. Sertaconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and the inhibition of ergosterol synthesis, an essential component of the cell membrane of fungi. This leads to a disruption of cell membrane permeability and leakage of adenine triphosphate (ATP) and other constituents from fugal cells.

CAS-99592-39-9 Manufacturers

A CAS-99592-39-9 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CAS-99592-39-9, including repackagers and relabelers. The FDA regulates CAS-99592-39-9 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CAS-99592-39-9 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of CAS-99592-39-9 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

CAS-99592-39-9 Suppliers

A CAS-99592-39-9 supplier is an individual or a company that provides CAS-99592-39-9 active pharmaceutical ingredient (API) or CAS-99592-39-9 finished formulations upon request. The CAS-99592-39-9 suppliers may include CAS-99592-39-9 API manufacturers, exporters, distributors and traders.

click here to find a list of CAS-99592-39-9 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

CAS-99592-39-9 CEP

A CAS-99592-39-9 CEP of the European Pharmacopoeia monograph is often referred to as a CAS-99592-39-9 Certificate of Suitability (COS). The purpose of a CAS-99592-39-9 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of CAS-99592-39-9 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of CAS-99592-39-9 to their clients by showing that a CAS-99592-39-9 CEP has been issued for it. The manufacturer submits a CAS-99592-39-9 CEP (COS) as part of the market authorization procedure, and it takes on the role of a CAS-99592-39-9 CEP holder for the record. Additionally, the data presented in the CAS-99592-39-9 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the CAS-99592-39-9 DMF.

A CAS-99592-39-9 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. CAS-99592-39-9 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of CAS-99592-39-9 suppliers with CEP (COS) on PharmaCompass.

CAS-99592-39-9 WC

A CAS-99592-39-9 written confirmation (CAS-99592-39-9 WC) is an official document issued by a regulatory agency to a CAS-99592-39-9 manufacturer, verifying that the manufacturing facility of a CAS-99592-39-9 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting CAS-99592-39-9 APIs or CAS-99592-39-9 finished pharmaceutical products to another nation, regulatory agencies frequently require a CAS-99592-39-9 WC (written confirmation) as part of the regulatory process.

click here to find a list of CAS-99592-39-9 suppliers with Written Confirmation (WC) on PharmaCompass.

CAS-99592-39-9 GMP

CAS-99592-39-9 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CAS-99592-39-9 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CAS-99592-39-9 GMP manufacturer or CAS-99592-39-9 GMP API supplier for your needs.

CAS-99592-39-9 CoA

A CAS-99592-39-9 CoA (Certificate of Analysis) is a formal document that attests to CAS-99592-39-9's compliance with CAS-99592-39-9 specifications and serves as a tool for batch-level quality control.

CAS-99592-39-9 CoA mostly includes findings from lab analyses of a specific batch. For each CAS-99592-39-9 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CAS-99592-39-9 may be tested according to a variety of international standards, such as European Pharmacopoeia (CAS-99592-39-9 EP), CAS-99592-39-9 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CAS-99592-39-9 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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