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Cariprazine

Cariprazine

Synopsis, Chemistry

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Also known as: 1083076-69-0, Cariprazine hcl, Vraylar, Rgh188 hydrochloride, Rgh-188 hcl, Cariprazine (hydrochloride)

Molecular Formula

C₂₁H₃₃Cl₃N₄O

Molecular Weight

463.9 g/mol

InChI Key

GPPJWWMREQHLQT-UHFFFAOYSA-N

FDA UNII

KQD7C255YG

1 2D Structure

Cariprazine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride

2.1.2 InChI

InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H

2.1.3 InChI Key

GPPJWWMREQHLQT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

KQD7C255YG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea

2. Cariprazine

3. Cariprazine Hcl

4. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

5. Rgh-188

6. Trans-4-(2-(4-(2,3-dichlorophenyl)piperazine-1-yl)-ethyl)-n,n-dimethylcarbamoyl-cyclohexyl-amine Hydrochloride

7. Vraylar

2.3.2 Depositor-Supplied Synonyms

1. 1083076-69-0

2. Cariprazine Hcl

3. Vraylar

4. Rgh188 Hydrochloride

5. Rgh-188 Hcl

6. Cariprazine (hydrochloride)

7. Cariprazine Hydrochloride [usan]

8. Kqd7c255yg

9. Mfcd26142670

10. 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride

11. Unii-kqd7c255yg

12. Cariprazine.hcl

13. Vraylar (tn)

14. Cariprazine Hydrochloride (jan/usan)

15. Cariprazine Monohydrochloride

16. Schembl183803

17. Schembl183804

18. Chembl2024517

19. Chebi:90932

20. Dtxsid101026486

21. Bcp24194

22. Ex-a1644

23. Hy-14763a

24. S5849

25. Cariprazine Hydrochloride [mi]

26. Cariprazine Hydrochloride [jan]

27. Cs-1570

28. Sb16840

29. 3-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-1,1-dimethylurea Hydrochloride

30. Ac-33130

31. Cariprazine Hydrochloride [who-dd]

32. Sy039271

33. Ft-0701196

34. A15036

35. Cariprazine Hydrochloride [orange Book]

36. D09876

37. A857936

38. Q27162922

39. 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea Hydrochloride

40. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimethylurea Monohydrochloride

41. N'-(trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-n,n-dimthylurea Monohydrochloride

42. N'-(trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-n,n-dimethylurea Hydrochloride

43. N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-n,n-dimethylurea Hydrochloride

44. Urea, N'-(trans-4-(2-(4-(2,3-dichlorophenyl)-1-piperazinyl)ethyl)cyclohexyl)-n,n- Dimethyl-, Hydrochloride (1:1)

2.4 Create Date

2008-12-15

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₃₃Cl₃N₄O
Molecular Weight	463.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	462.171995 g/mol
Monoisotopic Mass	462.171995 g/mol
Topological Polar Surface Area	38.8 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	491
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Reagila is indicated for the treatment of schizophrenia in adult patients.

Treatment of schizophrenia

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

5.2 ATC Code

N05AX15