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    Chemistry

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    Also known as: 28860-95-9, Lodosyn, Carbidopa anhydrous, (s)-(-)-carbidopa, (s)-carbidopa, S-(-)-carbidopa
    Molecular Formula
    C10H14N2O4
    Molecular Weight
    226.23  g/mol
    InChI Key
    TZFNLOMSOLWIDK-JTQLQIEISA-N
    FDA UNII
    KR87B45RGH
    Carbidopa
    An inhibitor of DOPA DECARBOXYLASE that prevents conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no anti-parkinson activity by itself.
    1 2D Structure

    Carbidopa

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
    2.1.2 InChI
    InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
    2.1.3 InChI Key
    TZFNLOMSOLWIDK-JTQLQIEISA-N
    2.1.4 Canonical SMILES
    CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
    2.1.5 Isomeric SMILES
    C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
    2.2 Other Identifiers
    2.2.1 UNII
    KR87B45RGH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Carbidopa, (r)-isomer

    2. Carbidopa, (s)-isomer

    3. Lodosin

    4. Lodosyn

    5. Methyldopahydrazine

    6. Mk 485

    7. Mk 486

    8. Mk-485

    9. Mk-486

    10. Mk485

    11. Mk486

    2.3.2 Depositor-Supplied Synonyms

    1. 28860-95-9

    2. Lodosyn

    3. Carbidopa Anhydrous

    4. (s)-(-)-carbidopa

    5. (s)-carbidopa

    6. S-(-)-carbidopa

    7. Alpha-methyldopahydrazine

    8. L-alpha-methyldopahydrazine

    9. N-aminomethyldopa

    10. Carbidopum

    11. Carbidopum [inn-latin]

    12. Carbidopa (anhydrous)

    13. S(-)-carbidopa

    14. Mk 486

    15. (2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic Acid

    16. Carbidopa [inn]

    17. L-3-(3,4-dihydroxyphenyl)-2-methyl-2-hydrazinopropionic Acid

    18. (2s)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic Acid

    19. (-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic Acid

    20. (s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic Acid

    21. Kr87b45rgh

    22. (alphas)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic Acid

    23. Chebi:39585

    24. 28860-95-9 (anhydrous)

    25. Ncgc00024596-05

    26. Hadrazino-alpha-methyldopa

    27. C-dopa

    28. 3,3,3-trideuterio-2-[dideuterio-(3,4-dihydroxyphenyl)methyl]-2-hydrazinylpropanoic Acid

    29. Smr000058235

    30. Ccris 5093

    31. Sr-01000597655

    32. Einecs 249-271-9

    33. Unii-kr87b45rgh

    34. Benzenepropanoic Acid, .alpha.-hydrazino-3,4-dihydroxy-.alpha.-methyl-, (s)-

    35. Alpha-hydrazino-alpha-methyl-beta-(3,4-dihydroxyphenyl)propionic Acid

    36. L-alpha-methyl-alpha-hydrazino-beta-(3,4-dihydroxyphenylpropionic Acid

    37. L-alpha-methyl-beta-(3,4-dihydroxyphenyl)-alpha-hydrazinopropionic Acid

    38. Mfcd00069231

    39. Nd0611

    40. Tocris-0455

    41. C-126

    42. Dsstox_cid_2735

    43. Carbidopa [who-dd]

    44. Dsstox_rid_76707

    45. Dsstox_gsid_22735

    46. Lopac0_000382

    47. Schembl35084

    48. Mls000069628

    49. Mls002207014

    50. S-(-)-carbidopa Monohydrate

    51. Gtpl5159

    52. Carbidopa, L- Anhydrous

    53. Carbidopa Anhydrous [mi]

    54. Chembl1201236

    55. Dtxsid4022735

    56. Hms2089b12

    57. Hms3266a20

    58. Hms3411m13

    59. Hms3655g20

    60. Hms3675m13

    61. Hms3713l10

    62. Hms3884m14

    63. Hy-b0311

    64. Tox21_110910

    65. (2s)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methyl-propanoic Acid

    66. Bdbm50418773

    67. Nsc751137

    68. S1891

    69. Zinc19168887

    70. Akos015969657

    71. Benzenepropanoic Acid, Alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, (s)-

    72. Hydrocinnamic Acid, Alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, L-

    73. Ac-1676

    74. Ccg-204476

    75. Db00190

    76. Sdccgmls-0072919.p025

    77. Mls-0072919

    78. Smp1_000057

    79. Ncgc00024596-01

    80. Ncgc00024596-03

    81. Ncgc00024596-06

    82. Ncgc00024596-07

    83. Ncgc00024596-08

    84. As-16862

    85. Bc164279

    86. Mls-0072919.p013

    87. Cas-28860-95-9

    88. Eu-0100382

    89. Sw199080-2

    90. 60c959

    91. Ab00441332-05

    92. Ab00441332-06

    93. Ab00441332_07

    94. Ab00441332_08

    95. Sr-01000597655-1

    96. Sr-01000597655-3

    97. Sr-01000597655-5

    98. Sr-01000597655-9

    99. Brd-k78712176-001-07-5

    100. Benzenepropanoic Acid, A-hydrazino-3,4-dihydroxy-a-methyl-

    101. (-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinamic Acid

    102. (s)-?-hydrazino-?-methyl-?-(3,4-dihydroxyphenyl)propionic Acid

    103. (s)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid

    104. (s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoicacid

    105. (2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic Acid

    106. (2s)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid Monohydrate

    107. Benzenepropanoic Acid, .alpha.-hydrazinyl-3,4-dihydroxy-.alpha.-methyl-, (.alpha.s)-

    108. Kinson; 3-(3,4-dihydroxy-phenyl)-2-hydrazino-2-methyl-propionic Acid

    109. 1426847-87-1

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 226.23 g/mol
    Molecular Formula C10H14N2O4
    XLogP3-2.2
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass226.09535693 g/mol
    Monoisotopic Mass226.09535693 g/mol
    Topological Polar Surface Area116 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity261
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameCarbidopa
    PubMed HealthCarbidopa (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelCarbidopa and levodopa extended release tablets are extended release combination of carbidopa and levodopa for the treatment of Parkinsons disease and syndrome.Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline...
    Active IngredientCarbidopa
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyAmerigen Pharms

    2 of 4  
    Drug NameLodosyn
    PubMed HealthCarbidopa (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelCarbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as ()-L--hydrazino--methyl--(3,4-dihydroxybenzene) pro...
    Active IngredientCarbidopa
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyAton

    3 of 4  
    Drug NameCarbidopa
    PubMed HealthCarbidopa (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelCarbidopa and levodopa extended release tablets are extended release combination of carbidopa and levodopa for the treatment of Parkinsons disease and syndrome.Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline...
    Active IngredientCarbidopa
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyAmerigen Pharms

    4 of 4  
    Drug NameLodosyn
    PubMed HealthCarbidopa (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelCarbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as ()-L--hydrazino--methyl--(3,4-dihydroxybenzene) pro...
    Active IngredientCarbidopa
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyAton

    4.2 Drug Indication

    Carbidopa is indicated with [levodopa] for the treatment of symptoms of idiopathic Parkinson disease, postencephalitic parkinsonism and symptomatic parkinsonism followed by carbon monoxide or manganese intoxication. The combination therapy is administered for the reduction of [levodopa]-driven nausea and vomiting. The product of carbidopa should be used in patients where the combination therapy of carbidopa/[levodopa] provide less than the adequate daily dosage. As well carbidopa can be used in patients where the dosages of carbidopa and [levodopa] require individual titration.

    FDA Label