Find Canlitinib manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 2222730-78-9, Kanitinib, Canlitinib [inn], Pfr26a3awm, Orb2278797, Chembl5314510
Molecular Formula
C33H31F2N3O7
Molecular Weight
619.6  g/mol
InChI Key
PCKYITPVOLEZKL-UHFFFAOYSA-N
FDA UNII
PFR26A3AWM

Canlitinib
Kanitinib is a tyrosine kinase inhibitor targeting the oncoprotein c-Met (hepatocyte growth factor receptor; HGFR; MET) and vascular endothelial growth factor receptor 2 (VEGFR2), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, kanitinib targets and binds to c-Met and VEGFR2, thereby disrupting c-Met- and VEGFR2-dependent signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met and/or VEGFR2 protein. c-Met and VEGFR2 are both overexpressed in many tumor cell types and play key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.
1 2D Structure

Canlitinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[4-[2-fluoro-4-[[1-[(4-fluorophenyl)carbamoyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxyquinolin-7-yl]oxyhexanoic acid
2.1.2 InChI
InChI=1S/C33H31F2N3O7/c1-43-28-18-23-25(19-29(28)44-16-4-2-3-5-30(39)40)36-15-12-26(23)45-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
2.1.3 InChI Key
PCKYITPVOLEZKL-UHFFFAOYSA-N
2.2 Other Identifiers
2.2.1 UNII
PFR26A3AWM
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 2222730-78-9

2. Kanitinib

3. Canlitinib [inn]

4. Pfr26a3awm

5. Orb2278797

6. Chembl5314510

7. Schembl21273458

8. Schembl29429223

9. Gtpl12865

10. Cx1003

11. Cx-1003

12. Da-62026

13. Hy-156603

14. Cs-0885946

15. 6-[[4-[2-fluoro-4-[[[1-[[(4-fluorophenyl)amino]carbonyl]cyclopropyl]carbonyl]amino]phenoxy]-6-methoxy-7-quinolinyl]oxy]hexanoic Acid

16. 6-[4-[2-fluoro-4-[[1-[(4-fluorophenyl)carbamoyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxyquinolin-7-yl]oxyhexanoic Acid

17. Hexanoic Acid, 6-[[4-[2-fluoro-4-[[[1-[[(4-fluorophenyl)amino]carbonyl]cyclopropyl]carbonyl]amino]phenoxy]-6-methoxy-7-quinolinyl]oxy]-

2.4 Create Date
2019-11-02
3 Chemical and Physical Properties
Molecular Weight 619.6 g/mol
Molecular Formula C33H31F2N3O7
XLogP36.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count14
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area136
Heavy Atom Count45
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2222730-78-9 / Canlitinib API manufacturers, exporters & distributors?

Canlitinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Canlitinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Canlitinib manufacturer or Canlitinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Canlitinib manufacturer or Canlitinib supplier.

API | Excipient name

Canlitinib

Synonyms

2222730-78-9, Kanitinib, Canlitinib [inn], Pfr26a3awm, Orb2278797, Chembl5314510

Cas Number

2222730-78-9

Unique Ingredient Identifier (UNII)

PFR26A3AWM

About Canlitinib

Kanitinib is a tyrosine kinase inhibitor targeting the oncoprotein c-Met (hepatocyte growth factor receptor; HGFR; MET) and vascular endothelial growth factor receptor 2 (VEGFR2), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, kanitinib targets and binds to c-Met and VEGFR2, thereby disrupting c-Met- and VEGFR2-dependent signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met and/or VEGFR2 protein. c-Met and VEGFR2 are both overexpressed in many tumor cell types and play key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

Canlitinib Manufacturers

A Canlitinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Canlitinib, including repackagers and relabelers. The FDA regulates Canlitinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Canlitinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Canlitinib Suppliers

A Canlitinib supplier is an individual or a company that provides Canlitinib active pharmaceutical ingredient (API) or Canlitinib finished formulations upon request. The Canlitinib suppliers may include Canlitinib API manufacturers, exporters, distributors and traders.

Canlitinib GMP

Canlitinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Canlitinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Canlitinib GMP manufacturer or Canlitinib GMP API supplier for your needs.

Canlitinib CoA

A Canlitinib CoA (Certificate of Analysis) is a formal document that attests to Canlitinib's compliance with Canlitinib specifications and serves as a tool for batch-level quality control.

Canlitinib CoA mostly includes findings from lab analyses of a specific batch. For each Canlitinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Canlitinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Canlitinib EP), Canlitinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Canlitinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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