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Chemistry

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Also known as: 23593-75-1, Lotrimin, Canesten, Mycelex, Clotrimazol, Mycosporin
Molecular Formula
C22H17ClN2
Molecular Weight
344.8  g/mol
InChI Key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
FDA UNII
G07GZ97H65

Clotrimazole
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Clotrimazole is an Azole Antifungal.
1 2D Structure

Clotrimazole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
2.1.2 InChI
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
2.1.3 InChI Key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
2.2 Other Identifiers
2.2.1 UNII
G07GZ97H65
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bay B 5097

2. Canesten

3. Fb B 5097

4. Kanesten

5. Klotrimazole

6. Lotrimin

7. Mycelex

2.3.2 Depositor-Supplied Synonyms

1. 23593-75-1

2. Lotrimin

3. Canesten

4. Mycelex

5. Clotrimazol

6. Mycosporin

7. Empecid

8. Mykosporin

9. Gyne Lotrimin

10. Chlotrimazole

11. Trimysten

12. Gyne-lotrimin

13. 1-(o-chlorotrityl)imidazole

14. Mycelex G

15. Rimazole

16. Mycelex 7

17. Tibatin

18. Gynix

19. Mono-baycuten

20. Lotrimin Af Cream

21. Mycelex Troches

22. Lotrimin Af Solution

23. Mycelex Otc

24. Canestine

25. Pedisafe

26. Veltrim

27. Lotrimin Af

28. Trivagizole 3

29. Desamix F

30. Mycelex-g

31. Bay B 5097

32. Fem Care

33. Gyne-lotrimin 3

34. Mycelex-7

35. Clotrimazolum

36. Monobaycuten

37. (chlorotrityl)imidazole

38. 1-((2-chlorophenyl)diphenylmethyl)-1h-imidazole

39. Canifug

40. Bay 5097

41. Lotrimax

42. Lotrimin Af Jock-itch Cream

43. Mycelax

44. Mycofug

45. Mycelex-7 Combination Pack

46. Gyne-lotrimin Combination Pack

47. 1-(o-chloro-alpha,alpha-diphenylbenzyl)imidazole

48. Gyne-lotrimin 3 Combination Pack

49. Bay-b 5097

50. 1-[(2-chlorophenyl)-diphenylmethyl]imidazole

51. 1h-imidazole, 1-[(2-chlorophenyl)diphenylmethyl]-

52. Fb 5097

53. Lotrimin (tn)

54. Mycelex (tn)

55. 1-(o-chlorophenyldiphenylmethyl)imidazole

56. (2-chlorophenyl)diphenyl-1-imidazolylmethane

57. Trivagizole

58. Diphenyl(2-chlorophenyl)(1-imidazolyl)methane

59. Diphenyl-(2-chlorophenyl)-1-imidazolylmethane

60. 1-(alpha-(2-chlorophenyl)benzhydryl)imidazole

61. Nsc 257473

62. 1-[(2-chlorophenyl)diphenylmethyl]-1h-imidazole

63. 1-[(2-chlorophenyl)(diphenyl)methyl]-1h-imidazole

64. Mycelex: Mycosporinrimazole

65. Bay B 9057

66. Prestwick_120

67. Bis-phenyl-(2-chlorophenyl)(1-imidazoyl)methane

68. Gnf-pf-3499

69. 1h-imidazole, 1-((2-chlorophenyl)diphenylmethyl)-

70. Methane, Bis-phenyl-(2-chlorophenyl)-1-imidazolyl-

71. Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan

72. Lopac-c-6019

73. Nsc257473

74. Chembl104

75. Nsc-257473

76. 1-(2-chlorotrityl)imidazole

77. Mls000028502

78. Chebi:3764

79. 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole

80. G07gz97h65

81. Bay-5097

82. Svt-15652

83. 1-(o-chloro-.alpha.,.alpha.-diphenylbenzyl)imidazole

84. Ncgc00015251-02

85. Clotrimaderm

86. Canestene

87. Clomatin

88. Cutistad

89. Esparol

90. Smr000058306

91. Stiemazol

92. Nalbix

93. Femcare

94. Lotrimin Lotion

95. Canesten Cream

96. Cas-23593-75-1

97. Clotrimazole 100 Microg/ml In Acetonitrile

98. Gino-lotremine

99. Lotrimin Cream

100. Mycelex Cream

101. Myclo Solution

102. Mycelex Solution

103. Myclo Cream

104. Dsstox_cid_9871

105. Myclo-gyne

106. Pan-fungex

107. Canesten Solution

108. Lotrimin Solution

109. Neo-zol Cream

110. Bis-phenyl-(2-chlorophenyl)-1-imidazoyl)methane

111. Dsstox_rid_78827

112. Mycelex Twin Pack

113. Dsstox_gsid_29871

114. Lotrimin Af Lotion

115. Clotrimazol [inn-spanish]

116. Clotrimazolum [inn-latin]

117. Myclo Spray Solution

118. Clotrimeizol

119. Jidesheng

120. Canesten 1-day Therapy

121. Canesten 3-day Therapy

122. Canesten 6-day Therapy

123. Drg-0072

124. B 5097

125. Ccris 6245

126. Canesten 1-day Cream Combi-pak

127. Hsdb 3266

128. Canesten Combi-pak 1-day Therapy

129. Canesten Combi-pak 3-day Therapy

130. Sr-01000075771

131. Einecs 245-764-8

132. Brn 0622318

133. Chlortrimazole

134. Clortrimazole

135. Otomax

136. Unii-g07gz97h65

137. 1-((o-chloro-phenyl)diphenylmethyl)imidazole

138. Gyne-lotrimin3

139. Bis-fenil-(2-clorofenil)-1-imidazolil-metano

140. Clotrimaderm Cream

141. Clotrimazole,(s)

142. Mfcd00057220

143. Bis-fenil-(2-clorofenil)-1-imidazolil-metano [italian]

144. Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan [german]

145. Clotrimazole Crystalline

146. Clotrimazole [usan:usp:inn:ban:jan]

147. Spectrum_001343

148. Cpd000058306

149. Clotrimazole (canesten)

150. Prestwick0_000267

151. Prestwick1_000267

152. Prestwick2_000267

153. Prestwick3_000267

154. Spectrum2_000128

155. Spectrum3_000359

156. Spectrum4_000295

157. Spectrum5_000781

158. Clotrimazole [mi]

159. Clotrimazole [inn]

160. Clotrimazole [jan]

161. C 6019

162. Clotrimazole [usan]

163. Ncimech_000609

164. Cid_2812

165. Schembl3850

166. Clotrimazole [vandf]

167. Bidd:pxr0036

168. Lopac0_000315

169. Bspbio_000114

170. Bspbio_002057

171. Clotrimazole [mart.]

172. Kbiogr_000850

173. Kbioss_001823

174. 5-23-04-00291 (beilstein Handbook Reference)

175. Mls000758243

176. Mls001423972

177. Bidd:gt0450

178. Clotrimazole [usp-rs]

179. Clotrimazole [who-dd]

180. Divk1c_000665

181. Spectrum1500200

182. Bay B5097

183. Bayb 5097

184. Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-

185. Spbio_000176

186. Spbio_002333

187. Bpbio1_000126

188. Gtpl2330

189. Component Of Otomax (salt/mix)

190. Dtxsid7029871

191. Gyne-lotrimin3 Combination Pack

192. Bdbm31774

193. Clotrimazole (jp17/usp/inn)

194. Hms502b07

195. Kbio1_000665

196. Kbio2_001823

197. Kbio2_004391

198. Kbio2_006959

199. Kbio3_001277

200. Clotrimazole [green Book]

201. Imidazole, 1-(o-chloro-.alpha.,.alpha.-diphenylbenzyl)-

202. Component Of Lotrimax (salt/mix)

203. Ninds_000665

204. Clotrimazole [ep Impurity]

205. Clotrimazole [orange Book]

206. Hms1568f16

207. Hms1920o21

208. Hms2051e11

209. Hms2091g10

210. Hms2095f16

211. Hms2235e20

212. Hms3260p12

213. Hms3369i03

214. Hms3393e11

215. Hms3655i09

216. Hms3712f16

217. Pharmakon1600-01500200

218. Clotrimazole [ep Monograph]

219. Clotrimazole [usp Impurity]

220. Imidazole,.alpha.-diphenylbenzyl)-

221. Bcp02150

222. Clotrimazole For Peak Identification

223. Zinc3807804

224. Clotrimazole [usp Monograph]

225. Tox21_110111

226. Tox21_300415

227. Tox21_500315

228. Ccg-35563

229. Nsc756700

230. S1606

231. Stk700023

232. Akos005607024

233. Lotrisone Component Clotrimazole

234. Tox21_110111_1

235. Cs-1926

236. Db00257

237. Lp00315

238. Nc00035

239. Nsc-756700

240. Sb17418

241. Sdccgsbi-0050303.p005

242. Clotrimazole 100 Microg/ml In Methanol

243. Idi1_000665

244. Mrf-0000070

245. Qtl1_000024

246. Ncgc00015251-01

247. Ncgc00015251-03

248. Ncgc00015251-04

249. Ncgc00015251-05

250. Ncgc00015251-06

251. Ncgc00015251-07

252. Ncgc00015251-08

253. Ncgc00015251-09

254. Ncgc00015251-10

255. Ncgc00015251-11

256. Ncgc00015251-12

257. Ncgc00015251-13

258. Ncgc00015251-14

259. Ncgc00015251-27

260. Ncgc00093761-01

261. Ncgc00093761-02

262. Ncgc00093761-03

263. Ncgc00093761-04

264. Ncgc00093761-05

265. Ncgc00093761-06

266. Ncgc00254538-01

267. Ncgc00261000-01

268. 1-(o-chloro-a,a-diphenylbenzyl)imidazole

269. As-13816

270. Clotrimazole Component Of Lotrisone

271. Hy-10882

272. 1-(2-chloro-?,?-diphenylbenzyl)imidazole

273. Sbi-0050303.p004

274. Db-046195

275. 1-[(2-chlorophenyl)diphenylmethyl]imidazole

276. Ab00051951

277. Eu-0100315

278. Ft-0603193

279. Sw196431-5

280. C06922

281. D00282

282. 1-(.alpha.-(2-chlorophenyl)benzhydryl)imidazole

283. 1-[(2-chlorophenyl)-di(phenyl)methyl]imidazole

284. Ab00051951-14

285. Ab00051951_15

286. Ab00051951_16

287. Clotrimazole, Vetranal(tm), Analytical Standard

288. 593c751

289. A816789

290. Q413546

291. 1h-imidazole, 1-[(2-chlorophenyl)-diphenylmethyl]

292. Sr-01000075771-1

293. Sr-01000075771-6

294. Sr-01000075771-8

295. W-107394

296. 1-[(2-chloro-phenyl)-diphenyl-methyl]-1h-imidazole

297. Brd-k15916496-001-14-7

298. Sr-01000075771-10

299. 3acdfdf8-38e3-4368-85d0-bdf8ae1e6591

300. Clotrimazole, British Pharmacopoeia (bp) Reference Standard

301. Clotrimazole, European Pharmacopoeia (ep) Reference Standard

302. Clotrimazole, United States Pharmacopeia (usp) Reference Standard

303. 1-(o-chlorotrityl)imidazole;1-(o-chloro-alpha,alpha-diphenylbenzyl)imidazole

304. Clotrimazole For Peak Identification, European Pharmacopoeia (ep) Reference Standard

305. Clotrimazole, Pharmaceutical Secondary Standard; Certified Reference Material

306. 117829-71-7

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 344.8 g/mol
Molecular Formula C22H17ClN2
XLogP35
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Exact Mass344.1080262 g/mol
Monoisotopic Mass344.1080262 g/mol
Topological Polar Surface Area17.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 20  
Drug NameClotrimazole
PubMed HealthClotrimazole
Drug ClassesAntifungal, Imidazole
Drug LabelEach Clotrimazole Troche (clotrimazole lozenges) USP contains 10 mg clotrimazole [1-(o-chloro-,-diphenylbenzyl) imidazole], a synthetic antifungal agent, for topical use in the mouth.Structural Formula:The troche dosage form is a large, slowly di...
Active IngredientClotrimazole
Dosage FormCream; Solution; Troche/lozenge
RouteTopical; Vaginal; Oral
Strength1%; 10mg
Market StatusOver the Counter; Prescription
CompanyFougera Pharms; Glenmark Pharms; Paddock; Actavis Mid Atlantic; Teva; Taro; Roxane

2 of 20  
Drug NameGyne-lotrimin
PubMed HealthClotrimazole
Drug ClassesAntifungal, Imidazole
Active IngredientClotrimazole
Dosage FormTablet; Cream
RouteVaginal
Strength1%; 100mg
Market StatusOver the Counter
CompanySchering Plough

3 of 20  
Drug NameGyne-lotrimin 3
PubMed HealthClotrimazole (Topical route)
Drug ClassesAntifungal, Imidazole
Active IngredientClotrimazole
Dosage FormTablet; Cream
RouteVaginal
Strength200mg; 2%
Market StatusOver the Counter
CompanySchering Plough

4 of 20  
Drug NameGyne-lotrimin 3 combination pack
PubMed HealthClotrimazole
Drug ClassesAntifungal, Imidazole
Active IngredientClotrimazole
Dosage FormCream, tablet
RouteTopical, vaginal
Strength1%,200mg
Market StatusOver the Counter
CompanySchering Plough

5 of 20  
Drug NameGyne-lotrimin combination pack
PubMed HealthClotrimazole (Vaginal)
Drug ClassesAntifungal
Active IngredientClotrimazole
Dosage FormCream, tablet
RouteTopical, vaginal
Strength1%,100mg
Market StatusOver the Counter
CompanySchering Plough

6 of 20  
Drug NameLotrimin af
Active IngredientClotrimazole
Dosage FormCream; Lotion; Solution
Routetopical
Strength1%
Market StatusOver the Counter
CompanySchering Plough

7 of 20  
Drug NameMycelex
Active IngredientClotrimazole
Dosage FormSolution
Routetopical
Strength1%
Market StatusOver the Counter
CompanyBayer Hlthcare

8 of 20  
Drug NameMycelex-7
Active IngredientClotrimazole
Dosage FormTablet; Cream
RouteVaginal
Strength1%; 100mg
Market StatusOver the Counter
CompanyBayer

9 of 20  
Drug NameMycelex-7 combination pack
Active IngredientClotrimazole
Dosage FormCream, tablet
RouteTopical, vaginal
Strength1%,100mg
Market StatusOver the Counter
CompanyBayer

10 of 20  
Drug NameTrivagizole 3
Active IngredientClotrimazole
Dosage FormCream
RouteVaginal
Strength2%
Market StatusOver the Counter
CompanyTaro

11 of 20  
Drug NameClotrimazole
PubMed HealthClotrimazole
Drug ClassesAntifungal, Imidazole
Drug LabelEach Clotrimazole Troche (clotrimazole lozenges) USP contains 10 mg clotrimazole [1-(o-chloro-,-diphenylbenzyl) imidazole], a synthetic antifungal agent, for topical use in the mouth.Structural Formula:The troche dosage form is a large, slowly di...
Active IngredientClotrimazole
Dosage FormCream; Solution; Troche/lozenge
RouteTopical; Vaginal; Oral
Strength1%; 10mg
Market StatusOver the Counter; Prescription
CompanyFougera Pharms; Glenmark Pharms; Paddock; Actavis Mid Atlantic; Teva; Taro; Roxane

12 of 20  
Drug NameGyne-lotrimin
PubMed HealthClotrimazole
Drug ClassesAntifungal, Imidazole
Active IngredientClotrimazole
Dosage FormTablet; Cream
RouteVaginal
Strength1%; 100mg
Market StatusOver the Counter
CompanySchering Plough

13 of 20  
Drug NameGyne-lotrimin 3
PubMed HealthClotrimazole (Topical route)
Drug ClassesAntifungal, Imidazole
Active IngredientClotrimazole
Dosage FormTablet; Cream
RouteVaginal
Strength200mg; 2%
Market StatusOver the Counter
CompanySchering Plough

14 of 20  
Drug NameGyne-lotrimin 3 combination pack
PubMed HealthClotrimazole
Drug ClassesAntifungal, Imidazole
Active IngredientClotrimazole
Dosage FormCream, tablet
RouteTopical, vaginal
Strength1%,200mg
Market StatusOver the Counter
CompanySchering Plough

15 of 20  
Drug NameGyne-lotrimin combination pack
PubMed HealthClotrimazole (Vaginal)
Drug ClassesAntifungal
Active IngredientClotrimazole
Dosage FormCream, tablet
RouteTopical, vaginal
Strength1%,100mg
Market StatusOver the Counter
CompanySchering Plough

16 of 20  
Drug NameLotrimin af
Active IngredientClotrimazole
Dosage FormCream; Lotion; Solution
Routetopical
Strength1%
Market StatusOver the Counter
CompanySchering Plough

17 of 20  
Drug NameMycelex
Active IngredientClotrimazole
Dosage FormSolution
Routetopical
Strength1%
Market StatusOver the Counter
CompanyBayer Hlthcare

18 of 20  
Drug NameMycelex-7
Active IngredientClotrimazole
Dosage FormTablet; Cream
RouteVaginal
Strength1%; 100mg
Market StatusOver the Counter
CompanyBayer

19 of 20  
Drug NameMycelex-7 combination pack
Active IngredientClotrimazole
Dosage FormCream, tablet
RouteTopical, vaginal
Strength1%,100mg
Market StatusOver the Counter
CompanyBayer

20 of 20  
Drug NameTrivagizole 3
Active IngredientClotrimazole
Dosage FormCream
RouteVaginal
Strength2%
Market StatusOver the Counter
CompanyTaro

4.2 Therapeutic Uses

Anti-Infective Agents, Local; Antifungal Agents; Growth Inhibitors

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


CLOTRIMAZOLE IS A CHLORINATED IMIDAZOLE DERIVATIVE THAT IS USED TO TREAT TOPICAL FUNGAL, DERMATOPHYTE, & YEAST INFECTIONS. WHILE CLOTRIMAZOLE HAS MARKED IN VITRO ACTIVITY AGAINST MANY FUNGI, IT IS OF LITTLE VALUE IN TREATMENT OF SYSTEMIC MYCOSES.

Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 166


VAGINAL: 1 TABLET (100 MG) IS INSERTED DAILY FOR 1 WK FOR CANDIDAL VAGINITIS. TOPICAL: SUFFICIENT CREAM OR SOLN IS APPLIED TWICE DAILY TO SKIN INFECTED WITH CANDIDA ALBICANS, TRICOPHYTON, OR MICROSPORUM SPECIES. 2 WK OF THERAPY IS USUALLY SUFFICIENT.

Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 167


CLOTRIMAZOLE HAS BEEN USED INVESTIGATIONALLY FOR ORAL TREATMENT OF MUCOCUTANEOUS CANDIDIASIS.

Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 167


For more Therapeutic Uses (Complete) data for CLOTRIMAZOLE (12 total), please visit the HSDB record page.


4.3 Drug Warning

PREPN OF CLOTRIMAZOLE ARE NOT INTENDED FOR OPHTHALMIC USE & SHOULD BE USED WITH CAUTION AROUND EYES.

American Medical Association. AMA Drug Evaluations Annual 1991. Chicago, IL: American Medical Association, 1991., p. 1424


Clotrimazole lozenges should not be used for the treatment of systemic myotic infections.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1992 (Plus Supplements 1992)., p. 2102


Clotrimazole Vaginal tablets ... single-dose therapy is not recommended for the treatment of severe vulvovaginal candidiasis.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1992 (Plus Supplements 1992)., p. 2102


To achieve maximum theraputic effect of clotrimazole when the drug is administered orally as a lozenge, the lozenge must be dissolved slowly in the mouth. Therefore, patients receiving clotrimazole lozenges must be of such age and physical and/or mental condition that they can comprehend and follow administration instruction. Liver function tests should be conducted periodically during oral therapy with clotrimazole lozenges, especially in patients with preexisting hepatic impairment.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1992 (Plus Supplements 1992)., p. 2102


Clotrimazole topical cream, lotion, and solution should be used during the first trimester of pregnancy only when the drug is considered essential to the welfare of the patient. Since it is not known whether clotrimazole is distributed into milk, the drug should be used with caution in nursing women.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1992 (Plus Supplements 1992)., p. 2103


4.4 Drug Indication

**Topical preparations** Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections,: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid. **Oral preparations** The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation. Troche preparations are not indicated for the treatment of any systemic mycoses.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Clotrimazole is a broad-spectrum antifungal agent that inhibits the growth of pathogenic yeasts by changing the permeability of cell membranes. The action of clotrimazole is fungistatic at concentrations of drug up to 20 mcg/mL and may be fungicidal _in vitro_ against Candida albicans and other species of the genus Candida at higher concentrations. Unfortunately, resistance to clotrimazole, which was rare in the past, is now common in various patient populations. Clotrimazole is generally considered to be a fungistatic, and not a fungicidal drug, although this contrast is not absolute, as clotrimazole shows fungicidal properties at higher concentrations.


5.2 MeSH Pharmacological Classification

14-alpha Demethylase Inhibitors

Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism. (See all compounds classified as 14-alpha Demethylase Inhibitors.)


Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
CLOTRIMAZOLE
5.3.2 FDA UNII
G07GZ97H65
5.3.3 Pharmacological Classes
Azoles [CS]; Azole Antifungal [EPC]
5.4 ATC Code

G01AF02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


A - Alimentary tract and metabolism

A01 - Stomatological preparations

A01A - Stomatological preparations

A01AB - Antiinfectives and antiseptics for local oral treatment

A01AB18 - Clotrimazole


D - Dermatologicals

D01 - Antifungals for dermatological use

D01A - Antifungals for topical use

D01AC - Imidazole and triazole derivatives

D01AC01 - Clotrimazole


G - Genito urinary system and sex hormones

G01 - Gynecological antiinfectives and antiseptics

G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

G01AF - Imidazole derivatives

G01AF02 - Clotrimazole


5.5 Absorption, Distribution and Excretion

Absorption

Because clotrimazole is generally not significantly absorbed, drug interactions are not a major issue with its use.


Route of Elimination

Mainly hepatic.


Volume of Distribution

The topical form is minimally absorbed in the serum and tissues. Clotrimazole is a lipophilic drug, and has been shown to be secreted in breastmilk in animal studies. There are limited data available regarding the volume of distribution following oral troche administration.


GIVEN ORALLY OR IV WAS ABSORBED, DISTRIBUTED, ELIMINATED READILY. EXCRETED AS INACTIVE METABOLITE IN BILE, LITTLE IN URINE.

DUHM B ET AL; POSTGRAD MED J (SUPPL) 500 (1): 13-16 (1974)


Absorption of clotrimazol is less than 0.5% after application to the intact skin: from the vagina, it is 3 to 10%. Fungicidal concentrations remain in the vagina for as long as 3 days after application of the drug. The small amount absorbed is metabolized in the liver and excreted in bile. In adults, an oral dose of 200 mg per day will give rise to plasma concentrations of 0.2 to 0.35 ug/ml.

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1176


Only very small amounts of clotrimazole appear to be absorbed systemically following topical application to the skin. Following application to the skin, highest concentrations of clotrimazole are present in the stratum corneum; lower drug concentrations occur in the stratum spinosum and the papillary and reticular dermis. Small amounts of clotrimazole are absorbed systemically when the drug is administered intravaginally. Following intravaginal administration of radiolabeled clotrimazole in patients with normal or inflamed vaginal mucosa, peak serum concentrations of clotrimazole 24 hours after insertion of a single 100 mg tablet of the drug are 0.03 ug/ml and peak serum concentrations 24 hours after administration of a cream containing 50 mg of the drug are 0.01 ug/ml. About 3-10% of an intravaginal dose of the drug reaches systemic circulation, principally as metabolites.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1992 (Plus Supplements 1992)., p. 2101


Clotrimazole is absorbed from the gastrointestinal tract ... and excreted in the feces and urine. When applied topically clotrimazole penetrates the epidermis but there is little if any systemic absorption. Slight absorption has been reported following the administration of vaginal tablets.

Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982., p. 721


5.6 Metabolism/Metabolites

Hepatic (metabolized to inactive metabolites).


Clotrimazole ... is metabolized in the liver to inactive compounds ... .

Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982., p. 721


The effect of the antifungal imidazole compound, clotrimazole, on the metabolism of benzo[a]pyrene was studied in cultured keratinocytes prepared from BALB/c mouse epidermis. Varying concentrations of clotrimazole added to the cultured keratinocytes resulted in a dose dependent inhibition of the activities of the microsomal cytochrome p450 dependent monooxygenases aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-deethylase. The major organic solvent soluble metabolites of benzo(a)pyrene identified in the cultured cells were trans-7,8-dihydro-7,8-dihydroxybenzo(a)pyrene, 9-hydroxybenzo(a)pyrene, and 3-hydroxybenzo(a)pyrene, although small amounts of trans-4,5-dihydro-4,5-dihydroxybenzo(a)pyrene, benzo(a)pyrene-quinones, and trans-9,10-dihydroxybenzo(a)pyrene were also present. The major organic solvent extractable metabolites of benzo(a)pyrene found in the extracellular culture medium were primarily the diols with smaller quantities of phenols and quinones. The major water soluble metabolites of benzo(a)pyrene present both intracellularly and extracellularly were glucuronide conjugates of 3-hydroxybenzo(a)pyrene, 9-hydroxybenzo(a)pyrene, and benzo(a)pyrene-3,6-dione and to a lesser extent sulfate conjugates (primarily of the trans-7,8-dihydro-7,8- dihydroxybenzo(a)pyrene). Clotrimazole inhibited the generation of organic solvent soluble and water soluble conjugates in a dose dependent manner. The in vitro metabolism of benzo(a)pyrene by microsomes prepared from control and benz(a)anthracene induced cultured keratinocytes was also inhibited by clotrimazole with greater inhibitory effect on benz(a)anthracene induced keratinocytes especially with respect to the formation of diols and quinones. The enzyme mediated covalent binding of benzo(a)pyrene to mouse keratinocyte DNA and protein was also substantially diminished by clotrimazole in a dose dependent fashion. These results indicate that clotrimazole, a widely used drug for the management of a variety of superficial dermatophyte infections of the skin, is a potent inhibitor of cytochrome p450 dependent transformation of polycyclic aromatic hydrocarbons in cultured murine keratinocytes. This system offers a convenient approach for studies as inhibitors of carcinogen metabolism in the epidermis.

PMID:3755152 Das M et al; J Invest Dermatol 87 (1): 4-10 (1986)


5.7 Biological Half-Life

Clotrimazole was given by mouth in a dose of 1.5 g to 7 healthy subjects and 47 patients and peak blood concentrations of up to 1 ug/ml were detected microbiologically at 2 or 4 hours. The half-life was between 3.5 and 5.5 hours.

Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982., p. 721


Clotrimazole was absorbed from the gastrointestinal tract and had a biological half-life of about 4 hours. Liver and kidney dysfunction had little influence on serum concentrations or half-life.

Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982., p. 721


5.8 Mechanism of Action

Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane,. Because ergosterol directly promotes the growth of fungal cells in a hormonelike fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth. Though decreased ergosterol, due to the inhibition of lanosterol 14-demethylase (also known as _CYP51_) is accepted to be primarily responsible for the antimycotic properties of clotrimazole, this drug also shows other pharmacological effects. These include the inhibition of sarcoplasmic reticulum Ca2+ATPase, depletion of intracellular calcium, and blocking of calciumdependent potassium channels and voltagedependent calcium channels. The action of clotrimazole on these targets accounts for other effects of this drug that are separate from its antimycotic activities.


Clotrimazole exerts its antifungal activity by altering cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane. In contrast to polyene antibiotics (eg, amphotericin B), the action of clotrimazole is less dependent on the sterol content of the cell membrane. As a result of alteration of permeability, the cell membrane is unable to function as a selective barrier, and potassium and other cellular constituents are lost.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1992 (Plus Supplements 1992)., p. 2101


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MALPENSA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"40.00","actualQuantity":"40","unit":"KGS","unitRateFc":"152","totalValueFC":"6141.4","currency":"USD","unitRateINR":"13239.2","date":"27-Jan-2025","totalValueINR":"529568","totalValueInUsd":"6141.4","indian_port":"Bombay Air","hs_no":"29419011","bill_no":"8031617","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY SDNF","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737916200,"product":"CLOTRIMAZOLE USP MICRONIZED CLOTRIMAZOLE USP MICRONIZED","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"FLAVINE NORTH AMERICA INC","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"45.90","actualQuantity":"45.9","unit":"KGS","unitRateFc":"152","totalValueFC":"7047.3","currency":"USD","unitRateINR":"13239.2","date":"27-Jan-2025","totalValueINR":"607679.28","totalValueInUsd":"7047.3","indian_port":"Bombay Air","hs_no":"29419011","bill_no":"8031617","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY SDNF","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741285800,"product":"CLOTRIMAZOLE RELATED COMPOUND A (QTY: 1 X 25 MG, VALUE: USD903)(FOC)SAMPLES FOR IN HOUSE R&D\/TESTING PURPOSE","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL CONVENTION","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIAINDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.000025","unit":"KGS","unitRateFc":"36652800","totalValueFC":"928.8","currency":"USD","unitRateINR":"3218116400","date":"07-Mar-2025","totalValueINR":"80452.91","totalValueInUsd":"928.8","indian_port":"Hyderabad Air","hs_no":"29062990","bill_no":"8760298","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK, MD, US 21704, SDNF United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1743186600,"product":"CLOTRIMAZOLE PH.EUR CLOTRIMAZOLE PH.EUR","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"BAYER CONSUMER CARE AG","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"107.00","actualQuantity":"107","unit":"KGS","unitRateFc":"189.1","totalValueFC":"20397.8","currency":"EURO","unitRateINR":"16512.2","date":"29-Mar-2025","totalValueINR":"1766804.93","totalValueInUsd":"20397.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"9178584","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"PETER-MERIAN-STRASSE 84 CH-4052,BASEL SDNF CH","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1743186600,"product":"CLOTRIMAZOLE PH.EUR CLOTRIMAZOLE PH.EUR","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"BAYER CONSUMER CARE AG","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"115.00","actualQuantity":"115","unit":"KGS","unitRateFc":"189.1","totalValueFC":"21922.8","currency":"EURO","unitRateINR":"16512.2","date":"29-Mar-2025","totalValueINR":"1898902.5","totalValueInUsd":"21922.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"9178584","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"PETER-MERIAN-STRASSE 84 CH-4052,BASEL SDNF CH","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1745951400,"product":"CLOTRIMAZOLE USP MICRONIZED CLOTRIMAZOLE USP MICRONIZED","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"FLAVINE NORTH AMERICA INC","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"7.59","actualQuantity":"7.59","unit":"KGS","unitRateFc":"152","totalValueFC":"1164.4","currency":"USD","unitRateINR":"13132.8","date":"30-Apr-2025","totalValueINR":"99677.95","totalValueInUsd":"1164.4","indian_port":"Bombay Air","hs_no":"29419011","bill_no":"9786529","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY SDNF US","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1745951400,"product":"CLOTRIMAZOLE USP MICRONIZED CLOTRIMAZOLE USP MICRONIZED","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"FLAVINE NORTH AMERICA INC","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"7.80","actualQuantity":"7.8","unit":"KGS","unitRateFc":"152","totalValueFC":"1196.7","currency":"USD","unitRateINR":"13132.8","date":"30-Apr-2025","totalValueINR":"102435.84","totalValueInUsd":"1196.7","indian_port":"Bombay Air","hs_no":"29419011","bill_no":"9786529","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY SDNF US","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1745951400,"product":"CLOTRIMAZOLE USP MICRONIZED CLOTRIMAZOLE USP MICRONIZED","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"FLAVINE NORTH AMERICA INC","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.89","actualQuantity":"20.89","unit":"KGS","unitRateFc":"152","totalValueFC":"3204.9","currency":"USD","unitRateINR":"13132.8","date":"30-Apr-2025","totalValueINR":"274344.19","totalValueInUsd":"3204.9","indian_port":"Bombay Air","hs_no":"29419011","bill_no":"9786529","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY SDNF US","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1745951400,"product":"CLOTRIMAZOLE USP MICRONIZED CLOTRIMAZOLE USP MICRONIZED","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"FLAVINE NORTH AMERICA INC","supplierCountry":"ITALY","foreign_port":"MILAN - 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MALPENSA","supplierAddress":"61 SOUTH PARAMUS ROAD, SUITE 565 PARAMUS, NEW JERSEY SDNF US","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"}]
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30-Apr-2025
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ABOUT THIS PAGE

Looking for 23593-75-1 / Clotrimazole API manufacturers, exporters & distributors?

Clotrimazole manufacturers, exporters & distributors 1

19

PharmaCompass offers a list of Clotrimazole API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Clotrimazole manufacturer or Clotrimazole supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Clotrimazole manufacturer or Clotrimazole supplier.

PharmaCompass also assists you with knowing the Clotrimazole API Price utilized in the formulation of products. Clotrimazole API Price is not always fixed or binding as the Clotrimazole Price is obtained through a variety of data sources. The Clotrimazole Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Clotrimazole

Synonyms

23593-75-1, Lotrimin, Canesten, Mycelex, Clotrimazol, Mycosporin

Cas Number

23593-75-1

Unique Ingredient Identifier (UNII)

G07GZ97H65

About Clotrimazole

An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.

Canesten Cream Manufacturers

A Canesten Cream manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Canesten Cream, including repackagers and relabelers. The FDA regulates Canesten Cream manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Canesten Cream API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Canesten Cream manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Canesten Cream Suppliers

A Canesten Cream supplier is an individual or a company that provides Canesten Cream active pharmaceutical ingredient (API) or Canesten Cream finished formulations upon request. The Canesten Cream suppliers may include Canesten Cream API manufacturers, exporters, distributors and traders.

click here to find a list of Canesten Cream suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Canesten Cream USDMF

A Canesten Cream DMF (Drug Master File) is a document detailing the whole manufacturing process of Canesten Cream active pharmaceutical ingredient (API) in detail. Different forms of Canesten Cream DMFs exist exist since differing nations have different regulations, such as Canesten Cream USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Canesten Cream DMF submitted to regulatory agencies in the US is known as a USDMF. Canesten Cream USDMF includes data on Canesten Cream's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Canesten Cream USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Canesten Cream suppliers with USDMF on PharmaCompass.

Canesten Cream JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Canesten Cream Drug Master File in Japan (Canesten Cream JDMF) empowers Canesten Cream API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Canesten Cream JDMF during the approval evaluation for pharmaceutical products. At the time of Canesten Cream JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Canesten Cream suppliers with JDMF on PharmaCompass.

Canesten Cream KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Canesten Cream Drug Master File in Korea (Canesten Cream KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Canesten Cream. The MFDS reviews the Canesten Cream KDMF as part of the drug registration process and uses the information provided in the Canesten Cream KDMF to evaluate the safety and efficacy of the drug.

After submitting a Canesten Cream KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Canesten Cream API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Canesten Cream suppliers with KDMF on PharmaCompass.

Canesten Cream CEP

A Canesten Cream CEP of the European Pharmacopoeia monograph is often referred to as a Canesten Cream Certificate of Suitability (COS). The purpose of a Canesten Cream CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Canesten Cream EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Canesten Cream to their clients by showing that a Canesten Cream CEP has been issued for it. The manufacturer submits a Canesten Cream CEP (COS) as part of the market authorization procedure, and it takes on the role of a Canesten Cream CEP holder for the record. Additionally, the data presented in the Canesten Cream CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Canesten Cream DMF.

A Canesten Cream CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Canesten Cream CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Canesten Cream suppliers with CEP (COS) on PharmaCompass.

Canesten Cream WC

A Canesten Cream written confirmation (Canesten Cream WC) is an official document issued by a regulatory agency to a Canesten Cream manufacturer, verifying that the manufacturing facility of a Canesten Cream active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Canesten Cream APIs or Canesten Cream finished pharmaceutical products to another nation, regulatory agencies frequently require a Canesten Cream WC (written confirmation) as part of the regulatory process.

click here to find a list of Canesten Cream suppliers with Written Confirmation (WC) on PharmaCompass.

Canesten Cream NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Canesten Cream as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Canesten Cream API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Canesten Cream as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Canesten Cream and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Canesten Cream NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Canesten Cream suppliers with NDC on PharmaCompass.

Canesten Cream GMP

Canesten Cream Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Canesten Cream GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Canesten Cream GMP manufacturer or Canesten Cream GMP API supplier for your needs.

Canesten Cream CoA

A Canesten Cream CoA (Certificate of Analysis) is a formal document that attests to Canesten Cream's compliance with Canesten Cream specifications and serves as a tool for batch-level quality control.

Canesten Cream CoA mostly includes findings from lab analyses of a specific batch. For each Canesten Cream CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Canesten Cream may be tested according to a variety of international standards, such as European Pharmacopoeia (Canesten Cream EP), Canesten Cream JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Canesten Cream USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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