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Calcium Sulfate

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Also known as: 7778-18-9, Drierite, Anhydrous gypsum, Karstenite, Calcium sulphate, Calcium sulfate, anhydrous

Molecular Formula

CaO₄S

Molecular Weight

136.14 g/mol

InChI Key

OSGAYBCDTDRGGQ-UHFFFAOYSA-L

FDA UNII

E934B3V59H

A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.

1 2D Structure

Calcium Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

calcium;sulfate

2.1.2 InChI

InChI=1S/Ca.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2

2.1.3 InChI Key

OSGAYBCDTDRGGQ-UHFFFAOYSA-L

2.1.4 Canonical SMILES

[O-]S(=O)(=O)[O-].[Ca+2]

2.2 Other Identifiers

2.2.1 UNII

E934B3V59H

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Alabaster

2. Anhydrous Sulfate Of Lime

3. Artificial Dental Stone

4. Calcium Sulfate (1:1), Dihydrate

5. Calcium Sulfate (1:1), Hemihydrate

6. Calcium Sulfate (2:1)

7. Calcium Sulfate Dihydrate

8. Calcium Sulfate, Anhydrous

9. Calcium Sulfate, Dihydrate

10. Calcium Sulfate, Hemihydrate

11. Calcium Sulphate

12. Dental Gypsum

13. Dental Stone, Artificial

14. Drierite

15. Gypsite

16. Gypsum

17. Gypsum, Dental

18. Karstenite

19. Plaster Of Paris

20. Stone, Artificial Dental

2.3.2 Depositor-Supplied Synonyms

1. 7778-18-9

2. Drierite

3. Anhydrous Gypsum

4. Karstenite

5. Calcium Sulphate

6. Calcium Sulfate, Anhydrous

7. Muriacite

8. Sulfuric Acid, Calcium Salt (1:1)

9. Anhydrite

10. Calcium Sulfate Anhydrous

11. Anhydrous Sulfate Of Lime

12. Basic Calcium Sulfate

13. Calcium;sulfate

14. Caso4

15. Calmatrix

16. Sulfuric Acid, Calcium Salt

17. Calcarea Sulphurica

18. Dead-burned Gypsum

19. Insoluble Anhydrite

20. Raddichem 27

21. Denka Sigma 1000

22. Calcium Sulfate [nf]

23. Sulfuric Acid Calcium Salt (1:1)

24. Calcium Sulphate Anhydrous

25. Drierite, Regular 8 Mesh

26. Mfcd00010912

27. Anhydrous Sulphate Of Lime

28. Calcium Sulphate, Anhydrous

29. Ci 77231

30. Ins No.516

31. Chebi:31346

32. Ins-516

33. E934b3v59h

34. Nsc-529649

35. Calcium Sulfate, Anhydrous, Puratronic (metals Basis)

36. Calcium Sulfate (nf)

37. Osteoset

38. E-516

39. Natural Anhydrite

40. Calcium Sulfuricum

41. Oparex 10

42. Caswell No. 152

43. Franklin Fiber H 45

44. Sss-a

45. Calcium Sulphate, Natural

46. Drierite, Regular (caso4), Lab Grade

47. Pigment White 25

48. Drierite?, Indicating (caso4), Lab Grade

49. Cas 20

50. Ccris 3666

51. Hsdb 902

52. Calcarea Sulphurica 30c

53. Einecs 231-900-3

54. Epa Pesticide Chemical Code 005602

55. Nsc 529649

56. Plaster Of Paris, Anhydrite

57. Kalziumsulfat

58. A 30

59. Calcium Sulfat

60. Calcii Sulfas

61. Unii-e934b3v59h

62. Ai3-02330

63. Calcium Sulfate Fcc

64. Calcium (as Sulfate)

65. Drierite, With Indicator

66. Regular Drierite 6 Mesh

67. Calcium Sulfate Submicron

68. Calcium Sulfate Nanopowder

69. Drierite, Regular 4 Mesh

70. Calcium Sulfate-325 Mesh

71. Indicating Drierite 8 Mesh

72. Ec 231-900-3

73. Drierite, Indicating 4 Mesh

74. Calcium Sulfate [mi]

75. Drierite, Indicatiing 6 Mesh

76. Calcium Sulfate [hsdb]

77. Chembl2106140

78. Drierite, Regular 10-20 Mesh

79. Drierite, Regular 20-40 Mesh

80. Dtxsid9029699

81. Indicating Drierite 10-20 Mesh

82. Calcium Sulfate (1:1) Dihydrate

83. Calcarea Sulphurica [hpus]

84. Ci 77231 [inci]

85. Akos015902936

86. Calcium Sulfate Anhydrous [ii]

87. Db15533

88. Calcium Sulfate, Anhydrous, Puratronic?

89. Calcium Sulphate Anhydrous (e516)

90. Ft-0623412

91. Calcium Sulfate With Cobalt Chloride Indicator

92. Drierite(r), Indicating (caso4), Lab Grade

93. D09201

94. Sulfuric Acid Calcium(2+) Salt (1:1)

95. Q407258

96. Calcium Sulfate, Anhydrous, Puratronic (metals Basis)

97. 99400-01-8

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	CaO₄S
Molecular Weight	136.14 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	135.9143205 g/mol
Monoisotopic Mass	135.9143205 g/mol
Topological Polar Surface Area	88.6 Å²
Heavy Atom Count	6
Formal Charge	0
Complexity	62.2
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Therapeutic Uses

EXPTL USE (VET): EXPERIMENTALLY, STERILE PELLETS HAVE BEEN USED SATISFACTORILY TO HELP REPAIR BONE DEFECTS & CAVITIES SUCH AS THOSE LEFT BY WOUNDS OR TUMORS.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 73

The use of calcium sulfate (plaster of Paris) has been advocated to repair bony defects because of its unique capability of stimulating osteoneogenesis. Plaster of Paris can be used as a bony alloplast and it can be analyzed histologically. Sinus roentgenograms and technetium Tc 99m medronate bone scanning further support the use of plaster of Paris as an alloplast and assess its osteoneogenic capacity when implanted in the frontal sinus of dogs; complete bone regeneration was demonstrated in six dogs within four to six months. The use of plaster of Paris for bone reconstruction in the head and neck can be applied in surgery. The experielce with plaster of Paris to date although limited shows it to be safe and highly encouraging as an effective bone allograft.

PMID:7295160 Beeson WH; Arch Otolaryngol 107 (11): 664-9 (1981)

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Dental Materials

Materials used in the production of dental bases, restorations, impressions, prostheses, etc. (See all compounds classified as Dental Materials.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Calcium [CS]; Cations, Divalent [CS]; Increased Coagulation Factor Activity [PE]; Blood Coagulation Factor [EPC]