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    Chemistry

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    Also known as: Calcitonin-salmon, Thyrocalcitonin (salmon), Cibacalcin, Calcitonina, Calcitar, Bionocalcin
    Molecular Formula
    C145H240N44O48S2
    Molecular Weight
    3431.9  g/mol
    InChI Key
    BBBFJLBPOGFECG-VJVYQDLKSA-N
    Calcitonin
    Synthetic peptide, 32 residues long formulated as a nasal spray.
    1 2D Structure

    Calcitonin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(4R,7S,10S,13S,16S,19S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-[(1R)-1-hydroxyethyl]-10,19-bis(hydroxymethyl)-13-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-[[2-[[(2S)-1-[[2-[[(2S,3R)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
    2.1.2 InChI
    InChI=1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+/m1/s1
    2.1.3 InChI Key
    BBBFJLBPOGFECG-VJVYQDLKSA-N
    2.1.4 Canonical SMILES
    CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CO)N)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(C)O)C(=O)N5CCCC5C(=O)N)C(C)O)CO
    2.1.5 Isomeric SMILES
    C[C@H]([C@H]1C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CO)CC(C)C)CC(=O)N)CO)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N5CCC[C@H]5C(=O)N)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Calcihexal

    2. Calcimar

    3. Calcitonin Salmon

    4. Forcaltonin

    5. Fortical

    6. Miacalcic

    7. Miacalcin

    8. Recombinant Salmon Calcitonin

    9. Salcatonin

    10. Salmon Calcitonin (1-32)

    11. Synthetic Salmon Calcitonin

    2.2.2 Depositor-Supplied Synonyms

    1. Calcitonin-salmon

    2. Thyrocalcitonin (salmon)

    3. Cibacalcin

    4. Calcitonina

    5. Calcitar

    6. Bionocalcin

    7. Calcimonta

    8. Calcitoran

    9. Cibacalcine

    10. Eptacalcin

    11. Miracalcic

    12. Osseocalcina

    13. Ostostabil

    14. Porostenina

    15. Prontocalcin

    16. Rulicalcin

    17. Salmocalcin

    18. Salmotonin

    19. Tonocalcin

    20. Astronin

    21. Biocalcin

    22. Calciben

    23. Calcinil

    24. Calcioton

    25. Calogen

    26. Calsynar

    27. Caltine

    28. Catonin

    29. Citonina

    30. Ipocalcin

    31. Kalsimin

    32. Oseototal

    33. Osteobion

    34. Osteovis

    35. Ostosalm

    36. Quosten

    37. Riostin

    38. Salcatyn

    39. Salmofar

    40. Stalcin

    41. Staporos

    42. Steocin

    43. Cadens

    44. Casalm

    45. Ostora

    46. Salcat

    47. Ucecal

    48. Calco

    49. Karil

    50. Sical

    51. Isi-calcin

    52. Calcitonin,salmon

    53. Calsynar Lyo L

    54. Calcitonin(salmon)

    55. Calcitonin, Salmar

    56. Salmon Calcitonin I

    57. Calcitonin Vom Lachs

    58. Calcitonine De Saumon

    59. Tz-ct

    60. Unii-7sfc6u2vi5

    61. Salmon Calcitonin-(i-32)

    62. 7sfc6u2vi5

    63. Salmon Calcitonin-(1-32)

    64. Chebi:3306

    65. Calcitonin, Salmon, For Bioassay

    66. Dtxsid601026667

    67. Calcitonin [usan:inn:ban:jan]

    68. Einecs 256-342-8

    69. Ncgc00167232-01

    70. Calcitonin Salmon, >=97% (hplc), Powder

    71. Calcitonin Salmon, European Pharmacopoeia (ep) Reference Standard

    72. Calcitonin Salmon, United States Pharmacopeia (usp) Reference Standard

    73. Cyclo-[cys-ser-asn-leu-ser-thr-cys]-val-leu-gly-lys-leu-ser-gln-glu-leu-his-lys-leu-gln-thr-tyr-pro-arg-thr-asn-thr-gly-ser-gly-thr-pro-nh2

    2.3 Create Date
    2007-07-16
    3 Chemical and Physical Properties
    Molecular Weight 3431.9 g/mol
    Molecular Formula C145H240N44O48S2
    XLogP3-16.6
    Hydrogen Bond Donor Count52
    Hydrogen Bond Acceptor Count55
    Rotatable Bond Count99
    Exact Mass3430.7166627 g/mol
    Monoisotopic Mass3429.7133079 g/mol
    Topological Polar Surface Area1560 Ų
    Heavy Atom Count239
    Formal Charge0
    Complexity7970
    Isotope Atom Count0
    Defined Atom Stereocenter Count34
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Used in the treatment of symptomatic Paget's disease for patients unresponsive to alternate treatments or intolerant to such treatments. In addition, it is used in emergency situations when serum calcium levels must be decreased quickly until the underlying condition is identified. It can also be added to existing therapeutic regimens for hypercalcemia such as intravenous fluids and furosemide, oral phosphate or corticosteroids, or other agents. Calcitonin can be used in patients with azotemia and cases where intravenous fluids would be contraindicated due to limited cardiac reserves. Also for the treatment of post-menopausal osteoporosis in women more than 5 years post-menopause.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Calcitonin inhibits bone resorption by osteoclasts (bone remodeling cells) and promotes bone formation by osteoblasts. This leads to a net increase in bone mass and a reduction in plasma calcium levels. It also promotes the renal excretion of ions such as calcium, phosphate, sodium, magnesium, and potassium by decreasing tubular reabsorption. In consequence, there is an increase in the jejunal secretion of water, sodium, potassium, and chloride.

    5.2 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

    Calcium-Regulating Hormones and Agents

    Hormones and molecules with calcium-regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis. (See all compounds classified as Calcium-Regulating Hormones and Agents.)

    5.3 Absorption, Distribution and Excretion

    Absorption

    Salmon calcitonin is rapidly absorbed with bioavailability of 71% following subcutaneous injection and 66% following intramuscular injection in humans. Via the nasal route, the bioavailability varies between 3 to 5% relative to IM.

    Route of Elimination

    Urine. Studies with injectable calcitonin show increases in the excretion of filtered phosphate, calcium, and sodium by decreasing their tubular reabsorption in the kidney.

    Volume of Distribution

    0.15 to 0.3 L/kg

    5.4 Metabolism/Metabolites

    Salmon calcitonin primarily undergoes degradation in the kidneys to form pharmacologically inactive metabolites. It is also metabolized in the blood and the peripheral tissue.

    5.5 Biological Half-Life

    Half-life elimination (terminal): I.M. 58 minutes; SubQ 59 to 64 minutes; Nasal: ~18 to 23 minutes

    5.6 Mechanism of Action

    Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.

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    CALCITONIN SALMON

    NDC Package Code : 52416-111

    Start Marketing Date : 2009-06-08

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    Dosage Form (Strength) : POWDER (1g/g)

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    CALCITONIN SALMON

    NDC Package Code : 59651-552

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    CALCITONIN SALMON ACETATE

    NDC Package Code : 35207-0003

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    CALCITONIN SALMON

    NDC Package Code : 66558-0196

    Start Marketing Date : 2024-01-02

    End Marketing Date : 2026-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT

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    05

    Piramal Pharma Limited

    U.S.A
    BIO Partnering at JPM
    Not Confirmed
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    Piramal Pharma Limited

    U.S.A
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    BIO Partnering at JPM
    Not Confirmed
    • fda
    • EDQM
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    CALCITONIN SALMON

    NDC Package Code : 41701-010

    Start Marketing Date : 2011-03-18

    End Marketing Date : 2026-12-31

    Dosage Form (Strength) : POWDER (10g/10g)

    Marketing Category : BULK INGREDIENT

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    06

    Polypeptide Laboratories (Sweden) A...

    Switzerland
    BIO Partnering at JPM
    Not Confirmed
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    Polypeptide Laboratories (Sweden) A...

    Switzerland
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    CALCITONIN SALMON

    NDC Package Code : 63586-0002

    Start Marketing Date : 2011-12-16

    End Marketing Date : 2026-12-31

    Dosage Form (Strength) : POWDER (20g/20g)

    Marketing Category : BULK INGREDIENT

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    07

    Shanghai Soho-Yiming Pharmaceutical...

    China
    BIO Partnering at JPM
    Not Confirmed
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    Shanghai Soho-Yiming Pharmaceutical...

    China
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    Not Confirmed
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    CALCITONIN SALMON

    NDC Package Code : 46600-0002

    Start Marketing Date : 2021-11-03

    End Marketing Date : 2025-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

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    Listed Suppliers

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    01

    Transo-Pharm USA LLC

    U.S.A
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    Not Confirmed
    • fda
    • EDQM
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    Virtual BoothTransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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    Calcitonin

    About the Company : Transo-Pharm is a licensed distributor of pharmaceutical components for human and veterinary markets. The company supports the full API life cycle, from development to sales, and a...

    Transo-Pharm is a licensed distributor of pharmaceutical components for human and veterinary markets. The company supports the full API life cycle, from development to sales, and acts as a sourcing and regulatory marketing agent for API manufacturers. Transo-Pharm assists with DMF setup, GMP consulting, and regulatory activities, supported by a regulatory team, warehouse facilities, proprietary API process IPs, and laboratory partnerships, with offices in Shanghai, Hong Kong, Singapore, and the US. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    02

    HRV Pharma

    India
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    Not Confirmed
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    • EDQM
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    Virtual BoothHRV Pharma - Market Expansion Leader in Pharmaceuticals.

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    Calcitonin

    About the Company : HRV Pharma is a global manufacturer, seller, and exporter of APIs, intermediates, pellets, food-grade chemicals, food additives, and food ingredients. The company provides sourcing...

    HRV Pharma is a global manufacturer, seller, and exporter of APIs, intermediates, pellets, food-grade chemicals, food additives, and food ingredients. The company provides sourcing, manufacturing, and supply services to support partners entering new markets worldwide. HRV Pharma works closely with major pharma and food additive companies and represents over 30 Indian drugmakers, primarily serving Europe, the US, and the Middle East. Headquartered in India, it operates offices in the US, Switzerland, Dubai, Lithuania, and Turkey. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
    HRV Global Life Sciences

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    03

    Space Peptides Pharmaceutical

    Switzerland
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    Not Confirmed
    • fda
    • EDQM
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    Virtual BoothSpace Peptides Pharmaceutical delivers Peptide CRDMO Services at Premium Speed & Quality to transform healthcare worldwide.

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    Elcatonin

    About the Company : Space Peptides Pharmaceutical is a Swiss-Chinese company headquartered in Bern, Switzerland. We provides a full range of pharmaceutical peptide CDMO services and a portfolio of gen...

    Space Peptides Pharmaceutical is a Swiss-Chinese company headquartered in Bern, Switzerland. We provides a full range of pharmaceutical peptide CDMO services and a portfolio of generic peptide APIs. From discovery to clinical development and commercial supply, we work closely with our clients to overcome complex challenges and deliver fast, reliable, and high quality results. With advanced technologies, strict cGMP compliance, and immediately available manufacturing capacities. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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    04

    ANHUI ANKE BIOTECHNOLOGY (GROUP) CO...

    China
    BIO Partnering at JPM
    Not Confirmed
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    ANHUI ANKE BIOTECHNOLOGY (GROUP) CO...

    China
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    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Digital Content Digital Content

    Salmon Calcitonin

    About the Company : We, Anhui Anke Biotechnology (Group) Co., Ltd., professional and comprehensive in developing, producing and marketing pharmaceuticals concerning genetic engineering products,diagn...

    We, Anhui Anke Biotechnology (Group) Co., Ltd., professional and comprehensive in developing, producing and marketing pharmaceuticals concerning genetic engineering products,diagnostic products,precision medicine, polypeptide APIs, biochemistry and traditional Chinese medicines,staffed with abount qualified and creative R&D team and equipped with first-class facilities, certified by GMP and ISO9001. Our parent company is located in China Hefei New and High Technology Development Area. As based on high-efficient Research & Development Center, we, AnkeBio always keep up with international development and have been undertaken with 10 subjects such as "National 863 Projects", National scientific and technological project, National key Torch Program and Scientific and Technological Projects, key scientific and technological specialties of Anhui province and Natural Fund Project and etc. and have developed nearly 10 National Novel Drugs in recent years. Our dominant products, Recombinant Human Growth Hormone (Ansomone®), Series of Recombinant Human Interferon alpha 2b (Anterferon®), MAR Kit for Anti-sperm Antibody and etc., are all developed independently. These products have more and more significant therapeutically effect on clinical testing and application of many kinds of intractable disease such as chronic hepatitis B, tumor, leukemia, nutritional support burned wound and immunopurification sterility and etc. Our subsidiary companies like Anhui Anke Yuliangqing Pharmaceutical Co., Ltd., Anhui Anke Hengyi Pharmaceutical Co., Ltd. and Anhui Anke Yuliangqing Pharmaceutical Co., Ltd have been established from recombination of Anqing Yuliangqing Pharmaceutical Co., Ltd.,Tongling NO.1 Pharmaceutical Company dominated by Anke biotechnology Co.,Ltd. since year 2000.The products are extended from biomedical products into modern Chinese herb medicines and synthetic medicines.
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    05

    Aurobindo Pharma Limited

    India
    BIO Partnering at JPM
    Not Confirmed
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    Aurobindo Pharma Limited

    India
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    Not Confirmed
    • fda
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    • WHO-GMP
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    Calcitonin

    About the Company : Founded in 1986 by Mr. P.V. Ramaprasad Reddy, Mr. K. Nityananda Reddy and a small group of highly committed professionals, Aurobindo Pharma was born off a vision. The company comme...

    Founded in 1986 by Mr. P.V. Ramaprasad Reddy, Mr. K. Nityananda Reddy and a small group of highly committed professionals, Aurobindo Pharma was born off a vision. The company commenced operations in 1988-89 with a single unit manufacturing Semi-Synthetic Penicillin (SSP) at Pondicherry. Aurobindo Pharma became a public company in 1992 and listed its shares in the Indian stock exchanges in 1995. In addition to being the market leader in Semi-Synthetic Penicillins, it has a presence in key therapeutic segments such as neurosciences, cardiovascular, anti-retrovirals, anti-diabetics, gastroenterology and cephalosporins, among others.
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    06

    BCN Peptides

    Spain
    BIO Partnering at JPM
    Not Confirmed
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    BCN Peptides

    Spain
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    Salmon Calcitonin

    About the Company : BCN Peptides is a privately own company completely focused on the cGMP manufacture of Bioactive Peptides for Pharmaceutical and Veterinary applications. We are a customer oriented...

    BCN Peptides is a privately own company completely focused on the cGMP manufacture of Bioactive Peptides for Pharmaceutical and Veterinary applications. We are a customer oriented organization focused on fulfilling the client’s needs at each stage of the their peptide drug development and lifecycle management. It also includes a team of dedicated and passionate scientists which help us to provide to our customer a scientific excellence in terms of synthetic peptide chemistry and analytical expertise. BCN Peptides has an excellent track record of successful inspections by Global Health Agencies (US FDA, EDQM, KFDA,…)
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    07

    Jin Dun Medical

    China
    BIO Partnering at JPM
    Not Confirmed
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    Jin Dun Medical

    China
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    BIO Partnering at JPM
    Not Confirmed
    • fda
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    Calcitonin

    About the Company : JIN DUN Medical Research Institute is affiliated to Shanghai JIN DUN Industrial Co., Ltd., headquartered in Shanghai, adjacent to Hongqiao High-speed Railway Station and Hongqiao I...

    JIN DUN Medical Research Institute is affiliated to Shanghai JIN DUN Industrial Co., Ltd., headquartered in Shanghai, adjacent to Hongqiao High-speed Railway Station and Hongqiao International airport. JIN DUN Medical Research Institute is committed to providing pharmaceutical intermediates and raw materials with the purpose of innovative drug research. Customized R&D and customized production services.
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    08

    PolyPeptide Group

    Switzerland
    BIO Partnering at JPM
    Not Confirmed
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    PolyPeptide Group

    Switzerland
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    BIO Partnering at JPM
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    Calcitonin

    About the Company : PolyPeptide is a Contract Development & Manufacturing Organization (CDMO) focusing on proprietary and generic GMP-grade peptides used by pharmaceutical and biotech companies in app...

    PolyPeptide is a Contract Development & Manufacturing Organization (CDMO) focusing on proprietary and generic GMP-grade peptides used by pharmaceutical and biotech companies in approved pharmaceutical products, drugs in clinical development as well as in generic products. Dating back to 1952, PolyPeptide today manufactures around one half of all currently approved peptide drug substances with a global footprint of six GMP-certified facilities in Europe, the U.S. and India. As a multinational company with more than 1000 employees, its diversity brings breadth, depth of knowledge and experience to the group.
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    09

    Sajjala Bio Labs

    India
    BIO Partnering at JPM
    Not Confirmed
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    Sajjala Bio Labs

    India
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    Not Confirmed
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    Calcitonin

    About the Company : Sajjala Bio Labs is a two year old bio pharmaceutical API production company headquartered in Hyderabad. At the moment, we commercially produce and sell Enoxaparin Sodium and L-asp...

    Sajjala Bio Labs is a two year old bio pharmaceutical API production company headquartered in Hyderabad. At the moment, we commercially produce and sell Enoxaparin Sodium and L-asparaginase in the Indian market. Our pipeline of products to be launched in the calendar year 2018 include Liraglutide, Pegylated L-asparaginase, Teriparatide and Hyaluronic Acid. In addition to the production of APIs we also offer a range of R&D services including end-to-end technology transfers and contract product development services. Our infrastructure includes a WHO GMP certifies production facility with 2000 litres fermentation capacity, a DSIR recognised R&D lab, in-house Quality Control facilities and a microbiology lab and all the necessary supporting infrastructure.
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    10

    Shenzhen JYMed Technology

    China
    BIO Partnering at JPM
    Not Confirmed
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    Shenzhen JYMed Technology

    China
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    Not Confirmed
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    Calcitonin

    About the Company : Shenzhen JYMed Technology Co.,Ltd is a high-tech enterprise engaged in research and development, manufacturing and commercialization of peptides based products, including active ph...

    Shenzhen JYMed Technology Co.,Ltd is a high-tech enterprise engaged in research and development, manufacturing and commercialization of peptides based products, including active pharmaceutical ingredient peptides, cosmetic peptides, and custom peptides as well other new drug development. We strive for continuing innovations in new peptide synthesis technology and process optimization, and our technical team have over decade of experience in peptide synthesis. Our peptide plant is located in Nanjing, Jiangsu province and it has set up a facility of 30,000 square meters in compliance with cGMP guideline.
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    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1672684200,"product":"CALCITONIN SALMON","address":"2ND FLOOR, PLOT NO.2, MAITHRIVIHAR, AMEERPET,","city":"HYDERABAD, AP.","supplier":"AURO PEPTIDES LTD","supplierCountry":"INDIA","foreign_port":"PARIS - CHARLES DE G","customer":"PROVEPHARM SAS","customerCountry":"FRANCE","quantity":"0.01","actualQuantity":"9","unit":"GMS","unitRateFc":"5000","totalValueFC":"45010.1","currency":"USD","unitRateINR":408888.88888888888,"date":"03-Jan-2023","totalValueINR":"3680000","totalValueInUsd":"45010.1","indian_port":"HYDERABAD AIR","hs_no":"29371900","bill_no":"6661748","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"2ND FLOOR, PLOT NO.2, MAITHRIVIHAR, AMEERPET,, HYDERABAD, AP.","customerAddress":""},{"dataSource":"API 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Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690223400,"product":"GLU 14-CALCITONIN (SALMON)","address":"2ND FLOOR, PLOT NO.2, MAITHRIVIHAR, AMEERPET,","city":"HYDERABAD, AP.","supplier":"AURO PEPTIDES LTD","supplierCountry":"INDIA","foreign_port":"BRUSSELS","customer":"PROVEPHARM SAS","customerCountry":"FRANCE","quantity":"0.00","actualQuantity":"0.11","unit":"GMS","unitRateFc":"80000","totalValueFC":"8626.4","currency":"USD","unitRateINR":6445455.5454545449,"date":"25-Jul-2023","totalValueINR":"709000.11","totalValueInUsd":"8626.4","indian_port":"HYDERABAD AIR","hs_no":"29371900","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"2ND FLOOR, PLOT NO.2, MAITHRIVIHAR, AMEERPET,, HYDERABAD, AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690223400,"product":"TRISULFIDE-CALCITONIN SALMON","address":"2ND FLOOR, PLOT NO.2, MAITHRIVIHAR, AMEERPET,","city":"HYDERABAD, AP.","supplier":"AURO PEPTIDES LTD","supplierCountry":"INDIA","foreign_port":"BRUSSELS","customer":"PROVEPHARM SAS","customerCountry":"FRANCE","quantity":"0.00","actualQuantity":"0.11","unit":"GMS","unitRateFc":"60000","totalValueFC":"6460.7","currency":"USD","unitRateINR":4827275.3454545448,"date":"25-Jul-2023","totalValueINR":"531000.288","totalValueInUsd":"6460.7","indian_port":"HYDERABAD AIR","hs_no":"29371900","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"2ND FLOOR, PLOT NO.2, MAITHRIVIHAR, AMEERPET,, HYDERABAD, AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"CALCITONIN SALMON","address":"MUMBAI CENTRAL,","city":"MUMBAI, MAHARASHTRA.","supplier":"CIPLA LTD","supplierCountry":"INDIA","foreign_port":"BARCELONA","customer":"BCN PEPTIDES S A","customerCountry":"SPAIN","quantity":"0.00","actualQuantity":"0.05","unit":"GMS","unitRateFc":"15000","totalValueFC":"808","currency":"EURO","unitRateINR":1354200,"date":"27-Sep-2024","totalValueINR":"67710","totalValueInUsd":"808","indian_port":"Bombay Air","hs_no":"29371900","bill_no":"4408676","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"MUMBAI CENTRAL,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"CALCITONIN SALMON","address":"MUMBAI CENTRAL,","city":"MUMBAI, MAHARASHTRA.","supplier":"CIPLA LTD","supplierCountry":"INDIA","foreign_port":"BARCELONA","customer":"BCN PEPTIDES S A","customerCountry":"SPAIN","quantity":"0.00","actualQuantity":"0.05","unit":"GMS","unitRateFc":"15000","totalValueFC":"808","currency":"EURO","unitRateINR":1354200,"date":"27-Sep-2024","totalValueINR":"67710","totalValueInUsd":"808","indian_port":"Bombay Air","hs_no":"29371900","bill_no":"4408789","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"MUMBAI CENTRAL,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727893800,"product":"CALCITONIN SALMON","address":"MUMBAI CENTRAL,","city":"MUMBAI, MAHARASHTRA.","supplier":"CIPLA LTD","supplierCountry":"INDIA","foreign_port":"ZURICH","customer":"SOLVIAS AG","customerCountry":"SWITZERLAND","quantity":"0.00","actualQuantity":"0.05","unit":"GMS","unitRateFc":"15000","totalValueFC":"522","currency":"EURO","unitRateINR":877220,"date":"03-Oct-2024","totalValueINR":"43861","totalValueInUsd":"522","indian_port":"Delhi Air","hs_no":"29371900","bill_no":"4542890","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"MUMBAI CENTRAL,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729535400,"product":"(D-LEU)9-CALCITONIN SALMON(PHARMA STANDARDS)(QTY:2 GMS)","address":"LABORATORY,NO.4A,PHASE III, ICICI","city":"N\/A","supplier":"DAICEL CHIRAL TECHNOLOGIES INDIA PRIVATE LTD","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"ATTNROSHIE BANISADR","customerCountry":"UNITED 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    21-Jan-2022
    17-Nov-2025
    KGS
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INJECTION - 100 IU/ML **F...DOSAGE - INJECTABLE;INJECTION - 100 IU/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 17808

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    DOSAGE - INJECTABLE;INJECTION - 200 IU/ML

    USFDA APPLICATION NUMBER - 17808

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    DOSAGE - SPRAY, METERED;NASAL - 200 IU/SPRAY ...DOSAGE - SPRAY, METERED;NASAL - 200 IU/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20313

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    Salmon Calcitonin (2 kg) API needed in India [ENA18669]
    A company that focuses on import and export of various finished formulations is looking for suppliers of Salmon Calcitonin (2 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    23 Nov 2023

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    23 Nov 2023

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    23 Nov 2023

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    IP Grade Calcitonin API needed in India [ENA18202]
    A CDMO that focuses on topical semisolid formulations and cosmeceuticals is looking for suppliers of IP Grade Calcitonin API for development purposes. The suppliers must support this enquiry with CoA.
    02 Oct 2023

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    02 Oct 2023

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    02 Oct 2023

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    Calcitonin (1.5 kg/ annum) API needed in India [ENA16226]
    A company that focuses on the manufacturing of tablets, capsules, ointments, lotions, nasal sprays & cosmetics is looking for suppliers of Calcitonin (1.5 kg/ annum) API for commercial purposes. The suppliers must support this enquiry with CoA.
    27 Jan 2023

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    27 Jan 2023

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    Reply Comment (6)

    27 Jan 2023

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    Calcitonin API needed in India [ENA13811]
    A research-based company that deals in diabetes, oncology, immunology, and other non-communicable diseases segments is looking for suppliers of Calcitonin API for development purpose. The suppliers must support this enquiry with USDMF.
    30 May 2022

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    30 May 2022

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    30 May 2022

    China.png
    Salmon Calcitonin API needed in China [ENA13114]
    A company that specializes in R&D and manufacturing of aerosols & nasal sprays is looking for suppliers of rDNA origin Salmon Calcitonin API for development purpose. The required quantity is 20 g, 100 g & 500 g. The suppliers must support this enquiry with DMF.
    25 Mar 2022

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    25 Mar 2022

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    25 Mar 2022

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    Various APIs needed in India [ENA05893]
    An internationally reputed contract research and manufacturing organization, which supports R&D programs from lead generation to clinical supplies is looking for suppliers of APIs for the USA market. The supplier must support this enquiry with USDMF & USP/BP/EP/Injectable grade & the quantity required is 500 g-1 kg. 1. Fulvestrant 2. Decitabine 3. Cabazitaxel 4. Ixabepilone 5. Temsirolimus 6. Rolapitant 7. Carfilzomib 8. Calcitonin
    29 Nov 2019

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    29 Nov 2019

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    29 Nov 2019

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    Injectable grade Cysteine HCl and Calcitonin Salmon APIs needed in India [ENA04815]
    A fastest growing pharmaceutical company engaged in developing and manufacturing of a broad range of pharmaceutical products globally is looking for suppliers of Injectable grade Cysteine HCl and Calcitonin Salmon APIs. The supplier must support this enquiry with CoA, USDMF/EUDMF/CEP.
    03 Aug 2019

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    03 Aug 2019

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    03 Aug 2019

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    Calcitonin Salmon API needed in India [ENA03187]
    A speciality niche pharmaceutical company focused on the development and manufacturing of prescription products is looking for suppliers of Calcitonin Salmon API to develop a formulation for the USA market.
    20 Jan 2019

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    20 Jan 2019

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    20 Jan 2019

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    ABOUT THIS PAGE

    Looking for 47931-85-1 / Calcitonin API manufacturers, exporters & distributors?

    Calcitonin manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Calcitonin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Calcitonin manufacturer or Calcitonin supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Calcitonin manufacturer or Calcitonin supplier.

    PharmaCompass also assists you with knowing the Calcitonin API Price utilized in the formulation of products. Calcitonin API Price is not always fixed or binding as the Calcitonin Price is obtained through a variety of data sources. The Calcitonin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Calcitonin

    Synonyms

    Calcitonin-salmon, Thyrocalcitonin (salmon), Cibacalcin, Calcitonina, Calcitar, Bionocalcin

    Cas Number

    47931-85-1

    About Calcitonin

    Synthetic peptide, 32 residues long formulated as a nasal spray.

    Calcitonin Salmon Recombinant Manufacturers

    A Calcitonin Salmon Recombinant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Calcitonin Salmon Recombinant, including repackagers and relabelers. The FDA regulates Calcitonin Salmon Recombinant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Calcitonin Salmon Recombinant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Calcitonin Salmon Recombinant manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Calcitonin Salmon Recombinant Suppliers

    A Calcitonin Salmon Recombinant supplier is an individual or a company that provides Calcitonin Salmon Recombinant active pharmaceutical ingredient (API) or Calcitonin Salmon Recombinant finished formulations upon request. The Calcitonin Salmon Recombinant suppliers may include Calcitonin Salmon Recombinant API manufacturers, exporters, distributors and traders.

    click here to find a list of Calcitonin Salmon Recombinant suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Calcitonin Salmon Recombinant USDMF

    A Calcitonin Salmon Recombinant DMF (Drug Master File) is a document detailing the whole manufacturing process of Calcitonin Salmon Recombinant active pharmaceutical ingredient (API) in detail. Different forms of Calcitonin Salmon Recombinant DMFs exist exist since differing nations have different regulations, such as Calcitonin Salmon Recombinant USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Calcitonin Salmon Recombinant DMF submitted to regulatory agencies in the US is known as a USDMF. Calcitonin Salmon Recombinant USDMF includes data on Calcitonin Salmon Recombinant's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Calcitonin Salmon Recombinant USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Calcitonin Salmon Recombinant suppliers with USDMF on PharmaCompass.

    Calcitonin Salmon Recombinant JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Calcitonin Salmon Recombinant Drug Master File in Japan (Calcitonin Salmon Recombinant JDMF) empowers Calcitonin Salmon Recombinant API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Calcitonin Salmon Recombinant JDMF during the approval evaluation for pharmaceutical products. At the time of Calcitonin Salmon Recombinant JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Calcitonin Salmon Recombinant suppliers with JDMF on PharmaCompass.

    Calcitonin Salmon Recombinant CEP

    A Calcitonin Salmon Recombinant CEP of the European Pharmacopoeia monograph is often referred to as a Calcitonin Salmon Recombinant Certificate of Suitability (COS). The purpose of a Calcitonin Salmon Recombinant CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Calcitonin Salmon Recombinant EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Calcitonin Salmon Recombinant to their clients by showing that a Calcitonin Salmon Recombinant CEP has been issued for it. The manufacturer submits a Calcitonin Salmon Recombinant CEP (COS) as part of the market authorization procedure, and it takes on the role of a Calcitonin Salmon Recombinant CEP holder for the record. Additionally, the data presented in the Calcitonin Salmon Recombinant CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Calcitonin Salmon Recombinant DMF.

    A Calcitonin Salmon Recombinant CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Calcitonin Salmon Recombinant CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Calcitonin Salmon Recombinant suppliers with CEP (COS) on PharmaCompass.

    Calcitonin Salmon Recombinant WC

    A Calcitonin Salmon Recombinant written confirmation (Calcitonin Salmon Recombinant WC) is an official document issued by a regulatory agency to a Calcitonin Salmon Recombinant manufacturer, verifying that the manufacturing facility of a Calcitonin Salmon Recombinant active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Calcitonin Salmon Recombinant APIs or Calcitonin Salmon Recombinant finished pharmaceutical products to another nation, regulatory agencies frequently require a Calcitonin Salmon Recombinant WC (written confirmation) as part of the regulatory process.

    click here to find a list of Calcitonin Salmon Recombinant suppliers with Written Confirmation (WC) on PharmaCompass.

    Calcitonin Salmon Recombinant NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Calcitonin Salmon Recombinant as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Calcitonin Salmon Recombinant API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Calcitonin Salmon Recombinant as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Calcitonin Salmon Recombinant and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Calcitonin Salmon Recombinant NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Calcitonin Salmon Recombinant suppliers with NDC on PharmaCompass.

    Calcitonin Salmon Recombinant GMP

    Calcitonin Salmon Recombinant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Calcitonin Salmon Recombinant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Calcitonin Salmon Recombinant GMP manufacturer or Calcitonin Salmon Recombinant GMP API supplier for your needs.

    Calcitonin Salmon Recombinant CoA

    A Calcitonin Salmon Recombinant CoA (Certificate of Analysis) is a formal document that attests to Calcitonin Salmon Recombinant's compliance with Calcitonin Salmon Recombinant specifications and serves as a tool for batch-level quality control.

    Calcitonin Salmon Recombinant CoA mostly includes findings from lab analyses of a specific batch. For each Calcitonin Salmon Recombinant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Calcitonin Salmon Recombinant may be tested according to a variety of international standards, such as European Pharmacopoeia (Calcitonin Salmon Recombinant EP), Calcitonin Salmon Recombinant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Calcitonin Salmon Recombinant USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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