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Cadmium Sulfate

Cadmium sulfate

Synopsis, Chemistry

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Also known as: 10124-36-4, Cadmium sulphate, Sulfuric acid, cadmium salt (1:1), Cadmium monosulfate, Cadmium sulfate (1:1), Cadmium(2+) sulfate

Molecular Formula

CdO₄S

Molecular Weight

208.48 g/mol

InChI Key

QCUOBSQYDGUHHT-UHFFFAOYSA-L

FDA UNII

947UNF3Z6O

Cadmium Sulfate is a whitish, crystalline, inorganic compound that forms toxic fumes of cadmium oxides when heated. Calcium sulfate is used in electroplating, vacuum tubes, fluorescent screens, analytical chemistry, as a fungicide and as a chemical intermediate to produce cadmium containing pigments and stabilizers. Exposure to this substance irritates the eyes, skin and respiratory tract and causes damage to the lungs resulting in shortness of breath, chest pain and pulmonary edema, and can also damage the kidneys causing proteinuria and decreased renal function. Calcium sulfate is a known carcinogen and is associated with an elevated risk of developing lung cancer. (NCI05)

1 2D Structure

Cadmium sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

cadmium(2+);sulfate

2.1.2 InChI

InChI=1S/Cd.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2

2.1.3 InChI Key

QCUOBSQYDGUHHT-UHFFFAOYSA-L

2.1.4 Canonical SMILES

[O-]S(=O)(=O)[O-].[Cd+2]

2.2 Other Identifiers

2.2.1 UNII

947UNF3Z6O

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cadmium Sulfate, Hydrate (3:8)

2. Cadmium Sulfate, Tetrahydrate

2.3.2 Depositor-Supplied Synonyms

1. 10124-36-4

2. Cadmium Sulphate

3. Sulfuric Acid, Cadmium Salt (1:1)

4. Cadmium Monosulfate

5. Cadmium Sulfate (1:1)

6. Cadmium(2+) Sulfate

7. Cadmium Sulphate (1:1)

8. Cadmium(2+);sulfate

9. Cdso4

10. 947unf3z6o

11. 13477-20-8

12. Cadmium Sulfuricum

13. Sulfuric Acid, Cadmium Salt (1:1), Monohydrate

14. Cadmium Sulfate, Tetrahydrate

15. Caswell No. 136c

16. Sulfate De Cadmium

17. Ccris 116

18. Hsdb 274

19. Einecs 233-331-6

20. Cadmium Sulfate Monohydrate

21. Sulphuric Acid, Cadmium Salt (1:1)

22. Epa Pesticide Chemical Code 012905

23. Unii-947unf3z6o

24. Cadmiumsulfat

25. Kadmiumsulfat

26. Sulfuric Acid, Cadmium Salt, Tetrahydrate

27. Cadmium Mesosulfate (cdh2so5)

28. Cadmium Sulfate, Hydrate

29. Sulfato De Cadmio

30. Cadmium Sulphuricum

31. Cadmium Sulfate, Anhydrous

32. Ec 233-331-6

33. Cadmium Sulfate [cadmium And Cadmium Compounds]

34. Cadmium Sulfate [mi]

35. Cadmium Sulfate [hsdb]

36. Cadmium Sulfate [mart.]

37. Dtxsid1020229

38. Chebi:50292

39. Cadmium Sulfate [who-dd]

40. Cadmium Sulphuricum [hpus]

41. Mfcd00010923

42. Akos015915940

43. 13477-21-9

44. Cadmium Sulfate, Acs Reagent, >=99.0%

45. Db-023000

46. Cadmium Sulfate, >=99.99% Trace Metals Basis

47. Q414806

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	CdO₄S
Molecular Weight	208.48 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	209.855095 g/mol
Monoisotopic Mass	209.855095 g/mol
Topological Polar Surface Area	88.6 Å²
Heavy Atom Count	6
Formal Charge	0
Complexity	62.2
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 Absorption, Distribution and Excretion

IN RABBITS GIVEN 60 DAILY SC INJECTIONS OF CADMIUM SULFATE, ONLY ABOUT 1% OF DOSE WAS EXCRETED IN URINE EACH DAY.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V11 60 (1976)

ABOUT 20% OF IV DOSE IN RATS WAS EXCRETED VIA FECES IN 72 HR & LITTLE ... (115)CADMIUM WAS FOUND IN URINE; DISTRIBUTION IN LIVER ... AS SULFATE WAS UNIFORM, WHEREAS IN KIDNEY THE CORTEX SHOWED HIGH ACCUM & MEDULLA CONTENT WAS LOW. PANCREAS ACCUMULATED LARGE AMT IN UNIFORM DISTRIBUTION.

Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1014

NEARLY 70% OF (109)CD-LABELED CADMIUM SULFATE WAS FOUND IN LIVER 20 DAYS AFTER IP ADMIN TO RATS. WHEN ADMIN SMALL REPEATED DAILY DOSES, LIVER ACCUM, RATHER THAN RENEW, ITS CADMIUM SUPPLY. BILE WAS ACTUALLY INSTRUMENTAL IN REABSORPTION OF CADMIUM INTO INTESTINE.

CAUJOLLE F ET AL; J EUR TOXICOL 3 (4): 310 (1971)

WHETHER CADMIUM SULFATE WAS INJECTED SC, IP OR IM TO RATS, THE AMT OF CADMIUM EXCRETED INTO URINE WERE NEARLY SAME.

FURST A ET AL; PROC WEST PHARMACOL SOC 15: 55 (1972)

Copper and cadmium uptake and distribution in 2-week-old seedlings of stone pine (Pinus pinea L.), maritime pine (Pinus pinaster Ait.) and ash (Fraxinus angustifolia Vahl.) were investigated. Seedlings were grown in culture solution at increasing concentrations of CuSO4, (0.012-5 muM) and CdSO4 (0.0-5 muM). All species accumulated copper in a larger amount than cadmium. Translocation to the shoot was strongly restricted for both metals, though higher cadmium mobility within the plant could be evidenced. A strong relationship between root content and growth inhibition was detected in the roots in response to copper but not to cadmium treatments. Among species P. pinea seemed to be more tolerant to cadmium, whereas F. angustifolia was highly sensitive to both cadmium and copper. X-ray microanalysis of root tip sections showed that copper and cadmium only accumulated in the root tips of F. angustifolia, copper mostly in the cell walls of the cortex layer, cadmium in the inner compartments of the cortex cells. It is suggested that in the two Pinus species the well developed root cap plays a protecting role against metal uptake at the root-tip zone.

Arduini I et al; Physiologia Plantarum 97 (1): 111-7 (1996)