Find Burixafor Hydrobromide manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Burixafor hbr, 1191450-19-7, 2-[4-[6-amino-2-[[4-[[3-(cyclohexylamino)propylamino]methyl]cyclohexyl]methylamino]pyrimidin-4-yl]piperazin-1-yl]ethylphosphonic acid;hydrobromide, Burixafor hydrobromide (tg-0054 hydrobromide), Burixafor (hydrobromide), Da-71819
Molecular Formula
C27H52BrN8O3P
Molecular Weight
647.6  g/mol
InChI Key
ZXUVXYNBMUFEMK-UHFFFAOYSA-N

Burixafor Hydrobromide
Burixafor Hydrobromide is the hydrobromide salt form of burixafor, an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with hematopoietic stem cell (HSC)-mobilization and chemosensitizing activities. Upon administration, burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation. This may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into the peripheral circulation. Additionally, burixafor-mediated mobilization of disseminated tumor cells (DTCs) from the bone marrow into the blood may make these metastatic tumor cells more susceptible to the actions of chemotherapeutic agents. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. CXCL12/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow.
1 2D Structure

Burixafor Hydrobromide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[6-amino-2-[[4-[[3-(cyclohexylamino)propylamino]methyl]cyclohexyl]methylamino]pyrimidin-4-yl]piperazin-1-yl]ethylphosphonic acid;hydrobromide
2.1.2 InChI
InChI=1S/C27H51N8O3P.BrH/c28-25-19-26(35-15-13-34(14-16-35)17-18-39(36,37)38)33-27(32-25)31-21-23-9-7-22(8-10-23)20-29-11-4-12-30-24-5-2-1-3-6-24;/h19,22-24,29-30H,1-18,20-21H2,(H2,36,37,38)(H3,28,31,32,33);1H
2.1.3 InChI Key
ZXUVXYNBMUFEMK-UHFFFAOYSA-N
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Burixafor Hbr

2. 1191450-19-7

3. 2-[4-[6-amino-2-[[4-[[3-(cyclohexylamino)propylamino]methyl]cyclohexyl]methylamino]pyrimidin-4-yl]piperazin-1-yl]ethylphosphonic Acid;hydrobromide

4. Burixafor Hydrobromide (tg-0054 Hydrobromide)

5. Burixafor (hydrobromide)

6. Da-71819

7. G16612

2.2.2 Other Synonyms

1. Burixafor

2.3 Create Date
2020-09-04
3 Chemical and Physical Properties
Molecular Weight 647.6 g/mol
Molecular Formula C27H52BrN8O3P
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count11
Rotatable Bond Count14
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area152
Heavy Atom Count40
Formal Charge0
Complexity724
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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Looking for / Burixafor Hydrobromide API manufacturers, exporters & distributors?

Burixafor Hydrobromide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Burixafor Hydrobromide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Burixafor Hydrobromide manufacturer or Burixafor Hydrobromide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Burixafor Hydrobromide manufacturer or Burixafor Hydrobromide supplier.

PharmaCompass also assists you with knowing the Burixafor Hydrobromide API Price utilized in the formulation of products. Burixafor Hydrobromide API Price is not always fixed or binding as the Burixafor Hydrobromide Price is obtained through a variety of data sources. The Burixafor Hydrobromide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Burixafor Hydrobromide

Synonyms

Burixafor hbr, 1191450-19-7, 2-[4-[6-amino-2-[[4-[[3-(cyclohexylamino)propylamino]methyl]cyclohexyl]methylamino]pyrimidin-4-yl]piperazin-1-yl]ethylphosphonic acid;hydrobromide, Burixafor hydrobromide (tg-0054 hydrobromide), Burixafor (hydrobromide), Da-71819

About Burixafor Hydrobromide

Burixafor Hydrobromide is the hydrobromide salt form of burixafor, an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with hematopoietic stem cell (HSC)-mobilization and chemosensitizing activities. Upon administration, burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation. This may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into the peripheral circulation. Additionally, burixafor-mediated mobilization of disseminated tumor cells (DTCs) from the bone marrow into the blood may make these metastatic tumor cells more susceptible to the actions of chemotherapeutic agents. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. CXCL12/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow.

Burixafor Manufacturers

A Burixafor manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Burixafor, including repackagers and relabelers. The FDA regulates Burixafor manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Burixafor API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Burixafor Suppliers

A Burixafor supplier is an individual or a company that provides Burixafor active pharmaceutical ingredient (API) or Burixafor finished formulations upon request. The Burixafor suppliers may include Burixafor API manufacturers, exporters, distributors and traders.

Burixafor GMP

Burixafor Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Burixafor GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Burixafor GMP manufacturer or Burixafor GMP API supplier for your needs.

Burixafor CoA

A Burixafor CoA (Certificate of Analysis) is a formal document that attests to Burixafor's compliance with Burixafor specifications and serves as a tool for batch-level quality control.

Burixafor CoA mostly includes findings from lab analyses of a specific batch. For each Burixafor CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Burixafor may be tested according to a variety of international standards, such as European Pharmacopoeia (Burixafor EP), Burixafor JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Burixafor USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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