Bupropion Hydrobromide

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

13 API Suppliers, 9 USDMF, 2 EU WC, 5 NDC API, 3 Listed Suppliers

DOSSIERs // Finished Dosage Formulations

5 Dossiers, 5 FDA Orange Book

DRUG PRODUCT COMPOSITION

TABLET, EXTENDED RELEASE;ORAL - 174MG, TABLET, EXTENDED RELEASE;ORAL - 348MG, TABLET, EXTENDED RELEASE;ORAL - 522MG

TABLET, EXTENDED RELEASE;ORAL - 174MG
TABLET, EXTENDED RELEASE;ORAL - 348MG
TABLET, EXTENDED RELEASE;ORAL - 522MG

RELATED EXCIPIENT COMPANIES

Suppliers, 23 BASF, 9 Corel Pharma Chem, 6 Gangwal Chemicals, 5 Boai NKY Pharmaceuticals Ltd, 5 Kerry, 3 Actylis, 2 Ulanqab Kema New Material, 2 Pharmatrans-Sanaq, 2 Ideal Cures Pvt Ltd, 2 Microlex e.U, 2 Nomisma Healthcare, 2 Seqens, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Gangwal Healthcare, 1 Finar, 1 The Dow Chemical Company, 1 Vertellus, 1 Kima Chemical, 1 Alcedo Pharmachem

EXCIPIENTS BY APPLICATIONS

19 Coating Systems & Additives, 16 Disintegrants & Superdisintegrants, 16 Controlled & Modified Release, 13 Fillers, Diluents & Binders, 13 Solubilizers, 12 Granulation, 10 Direct Compression, 8 Topical, 7 Thickeners and Stabilizers, 5 Parenteral, 4 Chewable & Orodispersible Aids, 4 Film Formers & Plasticizers, 3 Taste Masking, 2 Co-Processed Excipients, 1 API Stability Enhancers

GLOBAL SALES INFORMATION

3 Finished Drug Prices

3 Finished Drug Prices

PATENTS

24 US Patents

24 US Patents

ANALYTICAL SOLUTION(s)

1 USP Standards, 1 Other Ref. Standards

DIGITAL CONTENT

1 Data Compilations & Company Tracker #PharmaFlow, 2 News

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U.S. Medicaid

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54.00

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Also known as: 905818-69-1, Aplenzin, Bupropion hbr, Bupropion hydrobromide [usan], Bupropion (hydrobromide), 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one hydrobromide

Molecular Formula

C₁₃H₁₉BrClNO

Molecular Weight

320.65 g/mol

InChI Key

WSTCENNATOVXKQ-UHFFFAOYSA-N

FDA UNII

E70G3G5863

Bupropion Hydrobromide is the hydrobromide salt of an aminoketone with antidepressant activity. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine.

1 2D Structure

Bupropion Hydrobromide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrobromide

2.1.2 InChI

InChI=1S/C13H18ClNO.BrH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

2.1.3 InChI Key

WSTCENNATOVXKQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Br

2.2 Other Identifiers

2.2.1 UNII

E70G3G5863

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 905818-69-1

2. Aplenzin

3. Bupropion Hbr

4. Bupropion Hydrobromide [usan]

5. Bupropion (hydrobromide)

6. 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one Hydrobromide

7. Bvf-033

8. E70g3g5863

9. Bupropion Hydrobromide (usan)

10. Aplenzin Er

11. Unii-e70g3g5863

12. Aplenzin (tn)

13. Schembl636116

14. Chembl1201735

15. Dtxsid20920317

16. Bupropion Hydrobromide [mi]

17. 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one,hydrobromide

18. 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrobromide

19. Bupropion Hydrobromide [vandf]

20. Akos015917698

21. Bupropion Hydrobromide [mart.]

22. Bupropion Hydrobromide [usp-rs]

23. Bupropion Hydrobromide [who-dd]

24. Bupropion Hydrobromide [orange Book]

25. D07938

26. Q27276951

27. (2rs)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)propan-1-one Hbr

28. (2rs)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)propan-1-one Hydrobromide

29. 1-propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, Hbr (1:1)

30. 1-propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, Hydrobromide (1:1)

31. 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one--hydrogen Bromide (1/1)

2.4 Create Date

2007-01-10

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₉BrClNO
Molecular Weight	320.65 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	319.03385 g/mol
Monoisotopic Mass	319.03385 g/mol
Topological Polar Surface Area	29.1 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	247
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Aplenzin
Active Ingredient	Bupropion hydrobromide
Dosage Form	Tablet, extended release
Route	Oral
Strength	348mg; 522mg; 174mg
Market Status	Prescription
Company	Valeant Bermuda

2 of 4
Drug Name	Bupropion hydrobromide
PubMed Health	Bupropion (By mouth)
Drug Classes	Antidepressant, Smoking Cessation Agent
Active Ingredient	Bupropion hydrobromide
Dosage Form	Tablet, extended release
Route	oral
Strength	522mg; 174mg
Market Status	Tentative Approval
Company	Watson Labs

3 of 4
Drug Name	Aplenzin
Active Ingredient	Bupropion hydrobromide
Dosage Form	Tablet, extended release
Route	Oral
Strength	348mg; 522mg; 174mg
Market Status	Prescription
Company	Valeant Bermuda

4 of 4
Drug Name	Bupropion hydrobromide
PubMed Health	Bupropion (By mouth)
Drug Classes	Antidepressant, Smoking Cessation Agent
Active Ingredient	Bupropion hydrobromide
Dosage Form	Tablet, extended release
Route	oral
Strength	522mg; 174mg
Market Status	Tentative Approval
Company	Watson Labs

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

Dopamine Uptake Inhibitors [MoA]; Increased Dopamine Activity [PE]; Increased Norepinephrine Activity [PE]; Norepinephrine Uptake Inhibitors [MoA]; Aminoketone [EPC]

Find Bupropion Hydrobromide manufacturers, exporters & distributors on PharmaCompass

Bupropion Hydrobromide

Bupropion Hydrobromide

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

13 API Suppliers

9 USDMF

2 EU WC

5 NDC API

3 Listed Suppliers

DOSSIERs // Finished Dosage Formulations

5 Dossiers

5 FDA Orange Book

DRUG PRODUCT COMPOSITION

TABLET, EXTENDED RELEASE;ORAL - 174MG

TABLET, EXTENDED RELEASE;ORAL - 348MG

TABLET, EXTENDED RELEASE;ORAL - 522MG

RELATED EXCIPIENT COMPANIES

Suppliers

23 BASF

9 Corel Pharma Chem

6 Gangwal Chemicals

5 Boai NKY Pharmaceuticals Ltd

5 Kerry

3 Actylis

2 Ulanqab Kema New Material

2 Pharmatrans-Sanaq

2 Ideal Cures Pvt Ltd

2 Microlex e.U

2 Nomisma Healthcare

2 Seqens

2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 Gangwal Healthcare

1 Finar

1 The Dow Chemical Company

1 Vertellus

1 Kima Chemical

1 Alcedo Pharmachem

EXCIPIENTS BY APPLICATIONS

19 Coating Systems & Additives

16 Disintegrants & Superdisintegrants

16 Controlled & Modified Release

13 Fillers, Diluents & Binders

13 Solubilizers

12 Granulation

10 Direct Compression

8 Topical

7 Thickeners and Stabilizers

5 Parenteral

4 Chewable & Orodispersible Aids

4 Film Formers & Plasticizers

3 Taste Masking

2 Co-Processed Excipients

1 API Stability Enhancers

GLOBAL SALES INFORMATION

3 Finished Drug Prices

PATENTS

24 US Patents

ANALYTICAL SOLUTION(s)

1 USP Standards

1 Other Ref. Standards

DIGITAL CONTENT

1 Data Compilations & Company Tracker #PharmaFlow

2 News

API SUPPLIERS

API REF. PRICE (USD / KG)

INTERMEDIATES

DOSSIERS // FDF

GLOBAL SALES (USD Million)

EXCIPIENTS

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

REF STANDARD

SERVICES

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