Find Dexbrompheniramine Maleate manufacturers, exporters & distributors on PharmaCompass

(+)-Brompheniramine maleate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

9 API Suppliers, 5 USDMF, 1 EU WC, 1 NDC API, 4 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports

DOSSIERs // Finished Dosage Formulations

10 Dossiers, 10 FDA Orange Book

RELATED EXCIPIENT COMPANIES

Suppliers, 31 Kerry, 30 Roquette, 29 BASF, 19 Microlex e.U, 17 SPI Pharma, 15 Seppic, 13 Gangwal Healthcare, 12 Sigachi Industries, 11 Gangwal Chemicals, 11 Corel Pharma Chem, 10 Actylis, 9 Ideal Cures Pvt Ltd, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 7 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 7 Nanjing Well Pharmaceutical, 7 Rochem International Inc, 6 Lonza Capsugel, 6 DFE Pharma, 5 DKSH, 5 Ingredion Pharma Solutions, 4 Vasa Pharmachem, 4 ACG Worldwide, 4 Kima Chemical, 4 Prachin Chemical, 3 The Dow Chemical Company, 3 Pharmatrans-Sanaq, 3 Boai NKY Pharmaceuticals Ltd, 2 Pfanstiehl, 2 Seqens, 2 Finar, 2 Ulanqab Kema New Material, 2 Nomisma Healthcare, 2 Jai Radhe Sales, 2 Zhejiang Huakang Pharmaceutical, 2 Qualicaps, 2 Shijiazhuang Huaxu Pharmaceutical, 1 Vertellus, 1 Nanjing Bold Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Clariant, 1 Aeon Procare, 1 Pharm-RX Chemical, 1 Evonik, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Bioplus Life Sciences

EXCIPIENTS BY APPLICATIONS

88 Fillers, Diluents & Binders, 58 Coating Systems & Additives, 40 Direct Compression, 34 Controlled & Modified Release, 32 Disintegrants & Superdisintegrants, 32 Solubilizers, 30 Taste Masking, 29 Thickeners and Stabilizers, 26 Granulation, 23 Film Formers & Plasticizers, 22 Parenteral, 19 Lubricants & Glidants, 19 Topical, 18 Chewable & Orodispersible Aids, 16 Co-Processed Excipients, 9 Empty Capsules, 7 Rheology Modifiers, 7 API Stability Enhancers, 6 Emulsifying Agents, 5 Surfactant & Foaming Agents, 4 Vegetarian Capsules, 2 Coloring Agents, 1 Soft Gelatin

ANALYTICAL SOLUTION(s)

1 USP Standards, 1 Other Ref. Standards

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

1,294

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

311

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 2391-03-9, Disomer, (+)-brompheniramine maleate, (s)-brompheniramine maleate, Brompheniramine d-form maleate, Chebi:59273

Molecular Formula

C₂₀H₂₃BrN₂O₄

Molecular Weight

435.3 g/mol

InChI Key

SRGKFVAASLQVBO-DASCVMRKSA-N

FDA UNII

BPA9UT29BS

Dexbrompheniramine Maleate is the maleate salt form of dexbrompheniramine, an alkylamine derivative with anticholinergic and sedative properties. Dexbrompheniramine is a histamine H1-receptor antagonist that competes with histamine for the H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels and respiratory tract. The antagonistic action of this agent blocks the activities of endogenous histamine, which subsequently leads to temporary relief from the negative histamine-mediated symptoms of allergic reaction such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle.

1 2D Structure

(+)-Brompheniramine maleate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid

2.1.2 InChI

InChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

2.1.3 InChI Key

SRGKFVAASLQVBO-DASCVMRKSA-N

2.1.4 Canonical SMILES

CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

CN(C)CC[C@@H](C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

2.2 Other Identifiers

2.2.1 UNII

BPA9UT29BS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dexbrompheniramine

2. Disophrol

2.3.2 Depositor-Supplied Synonyms

1. 2391-03-9

2. Disomer

3. (+)-brompheniramine Maleate

4. (s)-brompheniramine Maleate

5. Brompheniramine D-form Maleate

6. Chebi:59273

7. Dexbrompheniramine Fumarate

8. Bpa9ut29bs

9. 2391-03-9 (maleate)

10. Dsstox_cid_27795

11. Dsstox_rid_82567

12. Dsstox_gsid_47818

13. Dexbrompheniramine Maleate (usp)

14. Dexbrompheniramine Maleate [usp]

15. Disomer Maleate

16. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine Maleate

17. 2-pyridinepropanamine, G-(4-bromophenyl)-n,n-dimethyl-, (gs)-,(2z)-2-butenedioate (1:1)

18. Cas-2391-03-9

19. Ncgc00162100-02

20. Alahist Ir

21. Alahist Pe

22. Disomer (tn)

23. D-brompheniramine Maleate

24. Unii-bpa9ut29bs

25. Mls001401374

26. Schembl217770

27. 3-(2-hydroxyphenyl)benzoicacid

28. Chembl1200638

29. Dtxsid6047818

30. (+)-brompheniramine Maleate Salt

31. Hms2051f10

32. Hms2235o07

33. Hms3260p05

34. Einecs 219-236-2

35. Tox21_112000

36. Tox21_500232

37. Bdbm50247924

38. Akos015962824

39. Tox21_112000_1

40. Ac-1161

41. Ccg-101017

42. Lp00232

43. Nc00267

44. Ncgc00015146-11

45. Ncgc00093697-01

46. Ncgc00260917-01

47. Dexbrompheniramine Maleate [mart.]

48. Dexbrompheniramine Maleate [vandf]

49. Smr000471616

50. Dexbrompheniramine Maleate [usp-rs]

51. Dexbrompheniramine Maleate [who-dd]

52. Brompheniramine D-form Maleate [mi]

53. Eu-0100232

54. B 5275

55. D03704

56. Dexbrompheniramine Maleate [orange Book]

57. Dexbrompheniramine Maleate [usp Monograph]

58. Sr-01000075719

59. Disobrom Component Dexbrompheniramine Maleate

60. Disophrol Component Dexbrompheniramine Maleate

61. Drixoral Component Dexbrompheniramine Maleate

62. Resporal Component Dexbrompheniramine Maleate

63. Sr-01000075719-1

64. Brompheril Component Dexbrompheniramine Maleate

65. Dexbrompheniramine Maleate Component Of Disobrom

66. Dexbrompheniramine Maleate Component Of Drixoral

67. Dexbrompheniramine Maleate Component Of Resporal

68. Q27126583

69. Dexbrompheniramine Maleate Component Of Brompheril

70. Dexbrompheniramine Maleate Component Of Disophrol

71. Drixoral Plus Component Dexbrompheniramine Maleate

72. Dexbrompheniramine Maleate Component Of Drixoral Plus

73. (+)-2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine Maleate

74. (s)-1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane Maleate

75. (s)-2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine Maleate

76. (+)-2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate

77. (+)-3-(4-bromophenyl)-n,n-dimethyl-3-(2-pyridinyl)-1-propanamine Maleate

78. (+)-3-(p-bromophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine Maleate

79. (s)-3-(4-bromophenyl)-n,n-dimethyl-3-(2-pyridinyl)-1-propanamine Maleate

80. (s)-3-(p-bromophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine Maleate

81. (+)-2-(p-bromo-.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

82. (+)-2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

83. (+)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

84. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine (2z)-but-2-enedioate

85. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

86. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine;(z)-but-2-enedioic Acid

87. (s)-2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinium (z)-maleate (1:1)

88. (s)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

89. Dexbrompheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

90. Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1), (s)-

91. 2-pyridinepropanamine, G-(4-bromophenyl)-n,n-dimethyl-, (s)-, (z)-2-butenedioate (1:1)

92. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (s)-, (z)-2-butenedioate (1:1)

2.4 Create Date

2006-04-28

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₃BrN₂O₄
Molecular Weight	435.3 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	434.08412 g/mol
Monoisotopic Mass	434.08412 g/mol
Topological Polar Surface Area	90.7 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	368
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)