Bromazine Hydrochloride

Synopsis, Chemistry

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Also known as: 1808-12-4, Bromodiphenhydramine hydrochloride, Bromodiphenhydramine hcl, Bromdiphenhydramine hydrochloride, Ambodryl, Bromdiphenylhydramine hydrochloride

Molecular Formula

C₁₇H₂₁BrClNO

Molecular Weight

370.7 g/mol

InChI Key

ZQDJSWUEGOYDGT-UHFFFAOYSA-N

FDA UNII

202J683U97

Bromodiphenhydramine Hydrochloride is the hydrochloride salt form of bromodiphenhydramine, a synthetic ethanolamine with histamine H1 antagonistic and sedative properties. Bromodiphenhydramine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. This drug also prevents histamine-induced pain and itching of mucous membranes.

1 2D Structure

Bromazine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine;hydrochloride

2.1.2 InChI

InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H

2.1.3 InChI Key

ZQDJSWUEGOYDGT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C=C2)Br.Cl

2.2 Other Identifiers

2.2.1 UNII

202J683U97

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ambodryl

2. Bromazine

3. Bromodiphenhydramine

4. Bromodiphenhydramine Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 1808-12-4

2. Bromodiphenhydramine Hydrochloride

3. Bromodiphenhydramine Hcl

4. Bromdiphenhydramine Hydrochloride

5. Ambodryl

6. Bromdiphenylhydramine Hydrochloride

7. Nsc-36113

8. 2-((4-bromophenyl)(phenyl)methoxy)-n,n-dimethylethanamine Hydrochloride

9. Bromodiphenhydramine (hydrochloride)

10. Bromazin

11. 202j683u97

12. Bromodiphenhydramine Hydrochloride [usp]

13. Ambodryl Hydrochloride

14. 2-[(4-bromophenyl)-phenylmethoxy]-n,n-dimethylethanamine;hydrochloride

15. Ethanamine, 2-((4-bromophenyl)phenylmethoxy)-n,n-dimethyl-, Hydrochoride

16. Chebi:59178

17. Beta-(p-bromobenzhydryloxy)ethyldimethylamine Hydrochloride

18. 4-bromodiphenhydramine Hydrochloride

19. Diphenhydramine Impurity C Hydrochloride

20. Nsc 36113

21. Bromo-benzdryl

22. Unii-202j683u97

23. Einecs 217-310-9

24. 2-((4-bromophenyl)phenylmethoxy)ethyl(dimethyl)ammonium Chloride

25. Schembl141831

26. 4-bromo-alpha-phenylbenzyl 2-dimethylaminoethyl Ether

27. Bromodiphenhydramine Hydrochloride (200 Mg)

28. Chembl1200967

29. Hy-b1568a

30. 2-(4-bromobenzohydryloxy)-ethyl-dimethylamine Hydrochloride

31. Dtxsid70904541

32. Bcp27786

33. Ex-a3818

34. Nsc36113

35. 2-[(4-bromophenyl)phenylmethoxy]-n,n-dimethylethanamine Hydrochloride

36. Wln: Er Dyr&o2n1&1 &gh

37. 2-((p-bromo-alpha-phenylbenzyl)oxy)-n,n-dimethylethylamine Hydrochloride

38. Ethanamine, 2-((4-bromophenyl)phenylmethoxy)-n,n-dimethyl-, Hydrochloride

39. Bromazine Hydrochloride [mart.]

40. Bromazine Hydrochloride [who-dd]

41. 2-(4-bromodiphenylmethoxy)ethyldimethylamine

42. Cs-0013460

43. Ft-0663610

44. Bromodiphenhydramine Hydrochloride [mi]

45. Bromodiphenhydraminehydrochloride(200mg)

46. Bromodiphenhydramine Hydrochloride [vandf]

47. Bromodiphenhydramine Hydrochloride [usp-rs]

48. Q27126511

49. 4-bromo-.alpha.-phenylbenzyl 2-dimethylaminoethyl Ether

50. Bromodiphenhydramine Hydrochloride [orange Book]

51. Bromodiphenhydramine Hydrochloride [usp Monograph]

52. 2-[(4-bromobenzohydryl)oxy]ethyldimethylamine Hydrochloride

53. 4-bromo-.alpha.-phenylbenzyl 2-(dimethylamino)ethyl Ether

54. Ambenyl Component Bromodiphenhydramine Hydrochloride

55. Bromanyl Component Bromodiphenhydramine Hydrochloride

56. .beta.-(p-bromobenzhydryloxy)ethyldimethylamine Hydrochloride

57. .beta.-[(p-bromobenzhydryl)oxy]ethyldimethylamine Hydrochloride

58. 2-(p-bromobenzhydryloxy)-n,n-dimethylethylamine Hydrochloride

59. Bromazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

60. Bromodiphenhydramine Hydrochloride Component Of Ambenyl

61. Bromodiphenhydramine Hydrochloride Component Of Bromanyl

62. 2-(4-bromobenzhydryloxy)-n,n-dimethylethylamine Hydrochloride

63. 2-((4-bromophenyl)(phenyl)methoxy)-n,n-dimethylethan-1-amine Hydrochloride

64. 2-((4-bromophenyl)(phenyl)methoxy)-n,n-dimethylethanaminehydrochloride

65. 2-((p-bromo-.alpha.-phenylbenzyl)oxy)-n,n-dimethylethylamine Hydrochloride

66. Bromodiphenhydramine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

67. Ethylamine, 2-((p-bromo-alpha-phenylbenzyl)oxy)-n,n-dimethyl-, Hydrochloride

68. 2-[(rs)-(4-bromophenyl) Phenylmethoxy]-n,ndimethylethanamine Hydrochloride (bromodiphenhydramine Hydrochloride) (diphenhydramine Impurity C), Pharmaceutical Secondary Standard; Certified Reference Material

69. 2-[(rs)-(4-bromophenyl)phenylmethoxy]-n,n-dimethylethanamine Hydrochloride, Pharmaceutical Impurity Standard

70. Diphenhydramine Impurity C Hydrochloride;bromazine Hcl;diphenhydramine Impurity C Hcl;bromodiphenhydramine Hydrochloride

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₁BrClNO
Molecular Weight	370.7 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	369.04950 g/mol
Monoisotopic Mass	369.04950 g/mol
Topological Polar Surface Area	12.5 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	258
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2