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Also known as: Azd7986, 1802148-05-5, Ins1007, (s)-n-((s)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide, Brensocatib [usan], Azd 7986

Molecular Formula

C₂₃H₂₄N₄O₄

Molecular Weight

420.5 g/mol

InChI Key

AEXFXNFMSAAELR-RXVVDRJESA-N

FDA UNII

25CG88L0BB

Brensocatib is an orally bioavailable, small molecule, reversible inhibitor of dipeptidyl peptidase 1 (DPP1), with potential anti-inflammatory activity. Upon oral administration, brensocatib reversibly binds to and inhibits the activity of DPP1, thereby inhibiting the activation of neutrophil serine proteases (NSPs), including neutrophil elastase (NE), during neutrophil maturation. This inhibits the activity of NSPs, and may prevent lung inflammation and injury and improve lung function associated with NSPs-induced respiratory diseases. NSPs, serine proteases released by neutrophils during inflammation, is upregulated in a number of respiratory diseases.

1 2D Structure

Brensocatib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide

2.1.2 InChI

InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1

2.1.3 InChI Key

AEXFXNFMSAAELR-RXVVDRJESA-N

2.1.4 Canonical SMILES

CN1C2=C(C=CC(=C2)C3=CC=C(C=C3)CC(C#N)NC(=O)C4CNCCCO4)OC1=O

2.1.5 Isomeric SMILES

CN1C2=C(C=CC(=C2)C3=CC=C(C=C3)C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)OC1=O

2.2 Other Identifiers

2.2.1 UNII

25CG88L0BB

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Azd7986

2. Ins-1007

3. Ins1007

4. N-(1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo(d)oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

2.3.2 Depositor-Supplied Synonyms

1. Azd7986

2. 1802148-05-5

3. Ins1007

4. (s)-n-((s)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

5. Brensocatib [usan]

6. Azd 7986

7. Azd-7986

8. Ins-1007

9. 25cg88l0bb

10. Chembl3900409

11. (2s)-n-[(1s)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide

12. (s)-n-((s)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo-(d)oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

13. 1,4-oxazepine-2-carboxamide, N-((1s)-1-cyano-2-(4-(2,3-dihydro-3-methyl-2-oxo-5-benzoxazolyl)phenyl)ethyl)hexahydro-, (2s)-

14. Ins 1007

15. Brensocatib [inn]

16. Unii-25cg88l0bb

17. Brensocatib [who-dd]

18. Gtpl9412

19. Schembl16932317

20. Ex-a1866

21. Bdbm50195235

22. Pz1130

23. Who 11097

24. Ac-36222

25. As-84225

26. Bb177302

27. Hy-101056

28. Cs-0020766

29. J3.556.230c

30. A17095

31. D84088

32. A937370

33. (2s)-n-{(1s)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide

34. (s)-3-[4-(2-oxo-3-methyl-2,3-dihydrobenzoxazole-5-yl)phenyl]-2-[(hexahydro-1,4-oxazepine-2alpha-yl)carbonylamino]propanenitrile

2.4 Create Date

2016-02-23

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₂₄N₄O₄
Molecular Weight	420.5 g/mol
XLogP3	2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	420.17975526 g/mol
Monoisotopic Mass	420.17975526 g/mol
Topological Polar Surface Area	104 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	699
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1