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ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 3 JDMF, 4 Listed Suppliers

6 API Suppliers
3 JDMF
4 Listed Suppliers

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 Listed Dossiers

1 FDF Dossiers
1 Listed Dossiers

DIGITAL CONTENT

2 NEWS #PharmaBuzz

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2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 Annual Reports

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1 Annual Reports

MARKET PLACE

3 APIs, 1 FDF Dossiers

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3 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM

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1 EDQM

Betahistine Dimesilate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

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Chemistry

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Also known as: Betahistine mesylate, 54856-23-4, Meginalisk, Merislon, Extovyl, Melopat

Molecular Formula

C₁₀H₂₀N₂O₆S₂

Molecular Weight

328.4 g/mol

InChI Key

ZBJJDYGJCNTNTH-UHFFFAOYSA-N

FDA UNII

X1L0E3R43Y

A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.

1 2D Structure

Betahistine Dimesilate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methanesulfonic acid;N-methyl-2-pyridin-2-ylethanamine

2.1.2 InChI

InChI=1S/C8H12N2.2CH4O3S/c1-9-7-5-8-4-2-3-6-10-8;2*1-5(2,3)4/h2-4,6,9H,5,7H2,1H3;2*1H3,(H,2,3,4)

2.1.3 InChI Key

ZBJJDYGJCNTNTH-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CNCCC1=CC=CC=N1.CS(=O)(=O)O.CS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

X1L0E3R43Y

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aequamen

2. Betahistin Al

3. Betahistin Ratiopharm

4. Betahistin Stada

5. Betahistin-ratiopharm

6. Betahistine

7. Betahistine Biphar

8. Betahistine Dihydrobromide

9. Betahistine Dihydrochloride

10. Betahistine Hydrochloride

11. Betahistine Mesylate

12. Betahistine Methanesulfonate

13. Betahistine Methanesulphonate

14. Betaserc

15. Betavert

16. By Vertin

17. By-vertin

18. Dihydrobromide, Betahistine

19. Dihydrochloride, Betahistine

20. Extovyl

21. Fidium

22. Hydrochloride, Betahistine

23. Lectil

24. Melopat

25. Mersilon

26. Mesylate, Betahistine

27. Methanesulfonate, Betahistine

28. Methanesulphonate, Betahistine

29. Pt 9

30. Pt-9

31. Pt9

32. Ribrain

33. Serc

34. Vasomotal

35. Vertigon

2.3.2 Depositor-Supplied Synonyms

1. Betahistine Mesylate

2. 54856-23-4

3. Meginalisk

4. Merislon

5. Extovyl

6. Melopat

7. 2-pyridineethanamine, N-methyl-, Dimethanesulfonate

8. Tenyl

9. Betahistine Methanesulfonate

10. Betahistine Dimesylate

11. Betahistine (mesylate)

12. Methanesulfonic Acid;n-methyl-2-pyridin-2-ylethanamine

13. X1l0e3r43y

14. 2-[2-(methylamino)ethyl]pyridine Methanesulfonate

15. Riptonin

16. Einecs 259-377-7

17. Unii-x1l0e3r43y

18. Tenoxican

19. Suzutolon (tn)

20. 2-(ethylammonio)-n-methylpyridinium Dimethanesulphonate

21. Betahistine Dimethanesulfonate

22. Betahistine Mesilate (jp17)

23. Betahistine Di Mesylate

24. Schembl194604

25. Chembl4303472

26. Chebi:31274

27. Hms2096n07

28. Hms3713n07

29. Hms3886k08

30. Bcp13129

31. Hy-d0237

32. Betahistine Mesilate [mart.]

33. Mfcd00211321

34. S5498

35. Betahistine Mesilate [who-dd]

36. Akos015898737

37. Ccg-220543

38. Ac-23916

39. Betahistine Mesilate [ep Impurity]

40. Betahistine Mesilate [ep Monograph]

41. Db-052657

42. Cs-0010146

43. Ft-0622912

44. D01592

45. D87714

46. N-methyl-2-pyridineethylamine Dimethanesulfonate

47. Bethahistinemethanesulfonate;betahistine Mesilate

48. N-methyl-2-(2-pyridinyl)ethanamine Methanesulfonate

49. Sr-01000722006-3

50. W-105601

51. Q27293318

52. N-methyl-2-(pyridin-2-yl)ethanamine Dimethanesulfonate

53. 2-pyridineethanamine, N-methyl-, Dimethanesulphonate

54. N-methyl-2-(pyridin-2-yl)ethan-1-amine Dimethanesulfonate

55. 2-pyridineethanamine, N-methyl-, Methanesulfonate (1:2)

56. 2-pyridineethanamine, N-methyl-, Methanesulphonate (1:2)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₂₀N₂O₆S₂
Molecular Weight	328.4 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	328.07627871 g/mol
Monoisotopic Mass	328.07627871 g/mol
Topological Polar Surface Area	150 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	176
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine Agonists

Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically. (See all compounds classified as Histamine Agonists.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

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