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    Also known as: Berberine hydrochloride, 633-65-8, Natural yellow 18, Berberinium chloride, Benzodioxide, Berberine hcl
    Molecular Formula
    C20H18ClNO4
    Molecular Weight
    371.8  g/mol
    InChI Key
    VKJGBAJNNALVAV-UHFFFAOYSA-M
    FDA UNII
    UOT4O1BYV8
    Berberine Hydrochloride
    Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.
    1 2D Structure

    Berberine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
    2.1.2 InChI
    InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
    2.1.3 InChI Key
    VKJGBAJNNALVAV-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
    2.2 Other Identifiers
    2.2.1 UNII
    UOT4O1BYV8
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Barberry Root

    2. Barberry Root Extract

    3. Berberidis Radix

    4. Berberidis Radix Extract

    5. Berberis Wilsoniae Root

    6. Berberis Wilsoniae Root Extract

    7. Sankezhen

    2.3.2 Depositor-Supplied Synonyms

    1. Berberine Hydrochloride

    2. 633-65-8

    3. Natural Yellow 18

    4. Berberinium Chloride

    5. Benzodioxide

    6. Berberine Hcl

    7. Berberine (chloride)

    8. Berberinum

    9. Nsc-163088

    10. Berberin Hydrochloride

    11. 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium Chloride

    12. Mfcd00011939

    13. Uot4o1byv8

    14. Nsc-646666

    15. Mls002702530

    16. Natural Yellow 18 (chloride)

    17. Chebi:31271

    18. Nsc163088

    19. 633-65-8 (chloride)

    20. Dsstox_cid_4602

    21. Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, Chloride

    22. 5,6-dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium Chloride

    23. Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, Chloride

    24. Dsstox_rid_77465

    25. Dsstox_gsid_24602

    26. Berberinium Chloride Hydrate

    27. Chembl12089

    28. Berberine Chloride [jan]

    29. Gnf-pf-4545

    30. 16,17-dimethoxy-5,7-dioxa-13$l^{5}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-13-ylium Chloride

    31. Smr001233240

    32. Nsc646666

    33. Berberine Chloride Form

    34. Sr-01000711827

    35. Ncgc00016526-02

    36. Ncgc00016526-07

    37. Cas-633-65-8

    38. Einecs 211-195-9

    39. Unii-uot4o1byv8

    40. Nsc 163088

    41. Berberine Chloride, Primary Pharmaceutical Reference Standard

    42. Ai3-61834

    43. Ccris 8656

    44. 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium Chloride

    45. Prestwick_91

    46. Barberry Root Extract

    47. Nsc 646666

    48. Dimethoxy[?] Chloride

    49. Berberine Chloride (tn)

    50. Berberinum [hpus]

    51. Berberine Hydrochloride,(s)

    52. Mls002153890

    53. Schembl153906

    54. Spectrum1500811

    55. Dtxsid8024602

    56. Hms500n07

    57. Chebi: 16118

    58. Hms1569f14

    59. Hms1921i18

    60. Hms2096f14

    61. Hms2210a06

    62. Hms2235h16

    63. Hms3336c05

    64. Hms3373l14

    65. Hms3655f20

    66. Pharmakon1600-01500811

    67. Berberine Chloride [usp-rs]

    68. Tox21_110474

    69. Tox21_200348

    70. Ac-118

    71. Ccg-39622

    72. Nsc757795

    73. S2271

    74. Akos007930622

    75. Tox21_110474_1

    76. Cs-3214

    77. Ks-5294

    78. Nsc-757795

    79. 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium Chloride Hydrate

    80. Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, Chloride

    81. Berberine Hydrochloride [who-dd]

    82. Ncgc00091896-01

    83. Ncgc00094858-01

    84. Ncgc00094858-02

    85. Ncgc00257902-01

    86. 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride

    87. Hy-18258

    88. Sy076593

    89. Cas: 638-65-8

    90. B0450

    91. Ft-0622874

    92. N1699

    93. Sw196403-2

    94. A834344

    95. Berberine Chloride Hydrate, Technical, >=90% (at)

    96. Q-100261

    97. Q-100731

    98. Sr-01000711827-4

    99. Sr-01000711827-6

    100. Z2768724441

    101. Berberine Chloride, British Pharmacopoeia (bp) Reference Standard

    102. Berberine Chloride, European Pharmacopoeia (ep) Reference Standard

    103. Benzo[g]-1,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, Chloride

    104. Berberine Chloride, United States Pharmacopeia (usp) Reference Standard

    105. 5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium Chloride (1:1)

    106. Berberine Chloride, Pharmaceutical Secondary Standard; Certified Reference Material

    107. Berbinium,8,13,13a-tetradehydro-9.10-dimethoxy-2,3-(methylene Dioxy)-, Chloride

    108. 16,17-dimethoxy-5,7-dioxa-13lambda5-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15(20),16,18-octaen-13-ylium Chloride

    109. 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-iumchloride

    110. Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, Chloride (1:1)

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 371.8 g/mol
    Molecular Formula C20H18ClNO4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass371.0924357 g/mol
    Monoisotopic Mass371.0924357 g/mol
    Topological Polar Surface Area40.8 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity488
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2

    API Reference Price

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    18-Feb-2022
    11-Jul-2025
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    Looking for 633-65-8 / Berberine Hydrochloride API manufacturers, exporters & distributors?

    Berberine Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Berberine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Berberine Hydrochloride manufacturer or Berberine Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Berberine Hydrochloride manufacturer or Berberine Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Berberine Hydrochloride API Price utilized in the formulation of products. Berberine Hydrochloride API Price is not always fixed or binding as the Berberine Hydrochloride Price is obtained through a variety of data sources. The Berberine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Berberine Hydrochloride

    Synonyms

    633-65-8, Natural yellow 18, Berberinium chloride, Benzodioxide, Berberine hcl, Berberine (chloride)

    Cas Number

    633-65-8

    Unique Ingredient Identifier (UNII)

    UOT4O1BYV8

    About Berberine Hydrochloride

    Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.

    Berberine Hydrochloride Manufacturers

    A Berberine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Berberine Hydrochloride, including repackagers and relabelers. The FDA regulates Berberine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Berberine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Berberine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Berberine Hydrochloride Suppliers

    A Berberine Hydrochloride supplier is an individual or a company that provides Berberine Hydrochloride active pharmaceutical ingredient (API) or Berberine Hydrochloride finished formulations upon request. The Berberine Hydrochloride suppliers may include Berberine Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Berberine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Berberine Hydrochloride USDMF

    A Berberine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Berberine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Berberine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Berberine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Berberine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Berberine Hydrochloride USDMF includes data on Berberine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Berberine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Berberine Hydrochloride suppliers with USDMF on PharmaCompass.

    Berberine Hydrochloride WC

    A Berberine Hydrochloride written confirmation (Berberine Hydrochloride WC) is an official document issued by a regulatory agency to a Berberine Hydrochloride manufacturer, verifying that the manufacturing facility of a Berberine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Berberine Hydrochloride APIs or Berberine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Berberine Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Berberine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Berberine Hydrochloride GMP

    Berberine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Berberine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Berberine Hydrochloride GMP manufacturer or Berberine Hydrochloride GMP API supplier for your needs.

    Berberine Hydrochloride CoA

    A Berberine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Berberine Hydrochloride's compliance with Berberine Hydrochloride specifications and serves as a tool for batch-level quality control.

    Berberine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Berberine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Berberine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Berberine Hydrochloride EP), Berberine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Berberine Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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