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Chemistry

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Also known as: Berberine hydrochloride, 633-65-8, Natural yellow 18, Berberinium chloride, Benzodioxide, Berberine hcl
Molecular Formula
C20H18ClNO4
Molecular Weight
371.8  g/mol
InChI Key
VKJGBAJNNALVAV-UHFFFAOYSA-M
FDA UNII
UOT4O1BYV8

Berberine Hydrochloride
Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.
1 2D Structure

Berberine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
2.1.2 InChI
InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
2.1.3 InChI Key
VKJGBAJNNALVAV-UHFFFAOYSA-M
2.1.4 Canonical SMILES
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
2.2 Other Identifiers
2.2.1 UNII
UOT4O1BYV8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Barberry Root

2. Barberry Root Extract

3. Berberidis Radix

4. Berberidis Radix Extract

5. Berberis Wilsoniae Root

6. Berberis Wilsoniae Root Extract

7. Sankezhen

2.3.2 Depositor-Supplied Synonyms

1. Berberine Hydrochloride

2. 633-65-8

3. Natural Yellow 18

4. Berberinium Chloride

5. Benzodioxide

6. Berberine Hcl

7. Berberine (chloride)

8. Berberinum

9. Nsc-163088

10. Berberin Hydrochloride

11. 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium Chloride

12. Mfcd00011939

13. Uot4o1byv8

14. Nsc-646666

15. Mls002702530

16. Natural Yellow 18 (chloride)

17. Chebi:31271

18. Nsc163088

19. 633-65-8 (chloride)

20. Dsstox_cid_4602

21. Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, Chloride

22. 5,6-dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium Chloride

23. Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, Chloride

24. Dsstox_rid_77465

25. Dsstox_gsid_24602

26. Berberinium Chloride Hydrate

27. Chembl12089

28. Berberine Chloride [jan]

29. Gnf-pf-4545

30. 16,17-dimethoxy-5,7-dioxa-13$l^{5}-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-13-ylium Chloride

31. Smr001233240

32. Nsc646666

33. Berberine Chloride Form

34. Sr-01000711827

35. Ncgc00016526-02

36. Ncgc00016526-07

37. Cas-633-65-8

38. Einecs 211-195-9

39. Unii-uot4o1byv8

40. Nsc 163088

41. Berberine Chloride, Primary Pharmaceutical Reference Standard

42. Ai3-61834

43. Ccris 8656

44. 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium Chloride

45. Prestwick_91

46. Barberry Root Extract

47. Nsc 646666

48. Dimethoxy[?] Chloride

49. Berberine Chloride (tn)

50. Berberinum [hpus]

51. Berberine Hydrochloride,(s)

52. Mls002153890

53. Schembl153906

54. Spectrum1500811

55. Dtxsid8024602

56. Hms500n07

57. Chebi: 16118

58. Hms1569f14

59. Hms1921i18

60. Hms2096f14

61. Hms2210a06

62. Hms2235h16

63. Hms3336c05

64. Hms3373l14

65. Hms3655f20

66. Pharmakon1600-01500811

67. Berberine Chloride [usp-rs]

68. Tox21_110474

69. Tox21_200348

70. Ac-118

71. Ccg-39622

72. Nsc757795

73. S2271

74. Akos007930622

75. Tox21_110474_1

76. Cs-3214

77. Ks-5294

78. Nsc-757795

79. 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium Chloride Hydrate

80. Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, Chloride

81. Berberine Hydrochloride [who-dd]

82. Ncgc00091896-01

83. Ncgc00094858-01

84. Ncgc00094858-02

85. Ncgc00257902-01

86. 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride

87. Hy-18258

88. Sy076593

89. Cas: 638-65-8

90. B0450

91. Ft-0622874

92. N1699

93. Sw196403-2

94. A834344

95. Berberine Chloride Hydrate, Technical, >=90% (at)

96. Q-100261

97. Q-100731

98. Sr-01000711827-4

99. Sr-01000711827-6

100. Z2768724441

101. Berberine Chloride, British Pharmacopoeia (bp) Reference Standard

102. Berberine Chloride, European Pharmacopoeia (ep) Reference Standard

103. Benzo[g]-1,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, Chloride

104. Berberine Chloride, United States Pharmacopeia (usp) Reference Standard

105. 5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium Chloride (1:1)

106. Berberine Chloride, Pharmaceutical Secondary Standard; Certified Reference Material

107. Berbinium,8,13,13a-tetradehydro-9.10-dimethoxy-2,3-(methylene Dioxy)-, Chloride

108. 16,17-dimethoxy-5,7-dioxa-13lambda5-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15(20),16,18-octaen-13-ylium Chloride

109. 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-iumchloride

110. Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, Chloride (1:1)

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 371.8 g/mol
Molecular Formula C20H18ClNO4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass371.0924357 g/mol
Monoisotopic Mass371.0924357 g/mol
Topological Polar Surface Area40.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity488
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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Berberine Hydrochloride

About the Company : Chengdu Chen Green Biotechnology (Chen Green) is a company specializing in plant extracts, pharmaceutical raw materials, food additives and dietary supplements manufacturers and wh...

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About the Company : Inga Pharmaceuticals (Inga), established in 1980, is involved in the cultivation, isolation and extraction of actives from plant sources. The Corporate Office is located in Mumbai ...

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Berberine Chloride

About the Company : Inga Pharmaceuticals (Inga), established in 1980, is involved in the cultivation, isolation and extraction of actives from plant sources. The Corporate Office is located in Mumbai ...

Inga Pharmaceuticals (Inga), established in 1980, is involved in the cultivation, isolation and extraction of actives from plant sources. The Corporate Office is located in Mumbai & the manufacturing facility is located at Chennai. Plants required for the isolation of active principles are cultivated by the company at its own farms and those of its associates in India, Africa and the Americas. Inga has established excellent relations with it's customers in 60 countries through its dedicated service for the last 5 decades.
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Berberine chloride

About the Company : Northeast Pharmaceutical Group Co., Ltd ( NEPG ) is a large-scale comprehensive pharmaceutical enterprise in China.It is composed of three major business segments, i.e. 1. chemical...

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Berberine Hydrochloride

About the Company : Quad Lifesciences Pvt. Ltd is an esteemed manufacturer and supplier of phytochemical and standardized herbal extracts. has more than three decade experience in manufacturing and ma...

Quad Lifesciences Pvt. Ltd is an esteemed manufacturer and supplier of phytochemical and standardized herbal extracts. has more than three decade experience in manufacturing and marketing of its products in domestic as well as in international market. The products of the Group have wide acceptability in International market. The manufacturing Unit of Quad Lifesciences Pvt. Ltd. is situated near Chandigarh in the State of Punjab having head office in Connaught Place, New Delhi. Day to day operations of the Company are being looked after by qualified professionals, which are supervised by the Board of Directors.
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Berberine Hydrochloride

About the Company : Benepure is a global research, manufacture and supplier of ingredients and their derivatives for healthcare industry. It owns strong research and development team, cutting-edge equ...

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About the Company : Founded in 1980, Sichuan Xieli Pharmaceutical Co., Ltd. operates with the guiding principle of "collaborating to build a healthy enterprise." The company specializes in the cultiva...

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Berberine hydrochloride

About the Company : Since 2008, Sunriver Biotech has been a leader in the research and utilizing plant resources for people’s well-being and quality of life.Through 12 years development, Sunriver Bi...

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10-Jun-2025
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Looking for 633-65-8 / Berberine Hydrochloride API manufacturers, exporters & distributors?

Berberine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Berberine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Berberine Hydrochloride manufacturer or Berberine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Berberine Hydrochloride manufacturer or Berberine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Berberine Hydrochloride API Price utilized in the formulation of products. Berberine Hydrochloride API Price is not always fixed or binding as the Berberine Hydrochloride Price is obtained through a variety of data sources. The Berberine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Berberine Hydrochloride

Synonyms

633-65-8, Natural yellow 18, Berberinium chloride, Benzodioxide, Berberine hcl, Berberine (chloride)

Cas Number

633-65-8

Unique Ingredient Identifier (UNII)

UOT4O1BYV8

About Berberine Hydrochloride

Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.

Berberine Hydrochloride Manufacturers

A Berberine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Berberine Hydrochloride, including repackagers and relabelers. The FDA regulates Berberine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Berberine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Berberine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Berberine Hydrochloride Suppliers

A Berberine Hydrochloride supplier is an individual or a company that provides Berberine Hydrochloride active pharmaceutical ingredient (API) or Berberine Hydrochloride finished formulations upon request. The Berberine Hydrochloride suppliers may include Berberine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Berberine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Berberine Hydrochloride USDMF

A Berberine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Berberine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Berberine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Berberine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Berberine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Berberine Hydrochloride USDMF includes data on Berberine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Berberine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Berberine Hydrochloride suppliers with USDMF on PharmaCompass.

Berberine Hydrochloride WC

A Berberine Hydrochloride written confirmation (Berberine Hydrochloride WC) is an official document issued by a regulatory agency to a Berberine Hydrochloride manufacturer, verifying that the manufacturing facility of a Berberine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Berberine Hydrochloride APIs or Berberine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Berberine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Berberine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Berberine Hydrochloride GMP

Berberine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Berberine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Berberine Hydrochloride GMP manufacturer or Berberine Hydrochloride GMP API supplier for your needs.

Berberine Hydrochloride CoA

A Berberine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Berberine Hydrochloride's compliance with Berberine Hydrochloride specifications and serves as a tool for batch-level quality control.

Berberine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Berberine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Berberine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Berberine Hydrochloride EP), Berberine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Berberine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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