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Benztropine Mesylate

Benztropine Mesylate

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Also known as: Benztropine mesylate, 132-17-2, Cogentin mesylate, Benztropine (mesylate), Mls000737056, Nsc42199

Molecular Formula

C₂₂H₂₉NO₄S

Molecular Weight

403.5 g/mol

InChI Key

CPFJLLXFNPCTDW-UHFFFAOYSA-N

A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.

1 2D Structure

Benztropine Mesylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonic acid

2.1.2 InChI

InChI=1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)

2.1.3 InChI Key

CPFJLLXFNPCTDW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Apo Benztropine

2. Apo-benztropine

3. Bensylate

4. Benzatropine

5. Benzatropine Mesylate

6. Benzatropine Methanesulfonate

7. Benzatropine Methanesulfonate, Hydrobromide

8. Benzatropine Methanesulfonate, Hydrobromide, (endo)-isomer

9. Benzatropine Methanesulfonate, Hydrochloride, (endo)-isomer

10. Benztropine

11. Benztropine Mesylate

12. Cogentin

13. Cogentinol

14. Hydrobromide Benzatropine Methanesulfonate

15. Mesylate, Benzatropine

16. Mesylate, Benztropine

17. Methanesulfonate, Benzatropine

18. Methanesulfonate, Hydrobromide Benzatropine

19. N Methylbenztropine

20. N-methylbenztropine

21. Pms Benztropine

22. Pms-benztropine

2.2.2 Depositor-Supplied Synonyms

1. Benztropine Mesylate

2. 132-17-2

3. Cogentin Mesylate

4. Benztropine (mesylate)

5. Mls000737056

6. Nsc42199

7. Benzotropine Mesylate

8. 3-(benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octane Methanesulfonate

9. Smr000394012

10. Cobrentin Methanesulfonate

11. 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonic Acid

12. Mk 02

13. Benzatropine Mesylate;benzotropine Mesylate;benztropine Methanesulfonate

14. Tropine Benzohydryl Ether Methanesulfonate

15. 102701-02-0

16. Cogentin Methanesulfonate

17. Sr-01000075303

18. Benzotropine Methanesulfonate

19. Nsc-42199

20. Benzotropinemesylate

21. Opera_id_1229

22. Schembl41809

23. Chembl85236

24. Hy-b0520a

25. Hms2747a15

26. Hms3259p11

27. Hms3260h09

28. Hms3652k07

29. Tox21_500194

30. Nsc169913

31. 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane, Methanesulfonic Acid

32. Akos008105137

33. Ccg-221498

34. Lp00194

35. Nc00646

36. Sb19689

37. Ncgc00016118-02

38. Ncgc00093670-01

39. Ncgc00260879-01

40. As-17846

41. B5592

42. Cs-0300867

43. Eu-0100194

44. En300-51031

45. B 8262

46. Wln: T56 A Antj A1 Goyr & R & Osw1

47. Benzophenone-3,3'-4,4'-tetracarboxylic Dianhydrie

48. Q-200693

49. Sr-01000075303-1

50. Sr-01000075303-5

51. 8-azabicyclo[3.2.1]octane, Endo-, Methanesulfonate

52. 1.alpha.h, 3.alpha.-(diphenylmethoxy)-, Methanesulfonate

53. 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane,methanesulfonicacid

54. Benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl Ether Methanesulfonate

2.3 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₉NO₄S
Molecular Weight	403.5 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	403.18172958 g/mol
Monoisotopic Mass	403.18172958 g/mol
Topological Polar Surface Area	75.2 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	433
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Benztropine mesylate
PubMed Health	Benztropine Mesylate (By mouth)
Drug Classes	Antiparkinsonian
Drug Label	Benztropine Mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine.It is a crystalline white powder, very soluble in water, designated as 3-(Diphenylmethoxy)-1H, 5H-tropane methanesulfonate, with t...
Active Ingredient	Benztropine mesylate
Dosage Form	Injectable; Tablet
Route	Injection; Oral
Strength	1mg/ml; 0.5mg; 2mg; 1mg
Market Status	Prescription
Company	Corepharma; Navinta; Fresenius Kabi Usa; Excellium; Vintage; Usl Pharma; Luitpold; Hikma Farmaceutica; Pliva; Invagen Pharms

2 of 2
Drug Name	Benztropine mesylate
PubMed Health	Benztropine Mesylate (By mouth)
Drug Classes	Antiparkinsonian
Drug Label	Benztropine Mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine.It is a crystalline white powder, very soluble in water, designated as 3-(Diphenylmethoxy)-1H, 5H-tropane methanesulfonate, with t...
Active Ingredient	Benztropine mesylate
Dosage Form	Injectable; Tablet
Route	Injection; Oral
Strength	1mg/ml; 0.5mg; 2mg; 1mg
Market Status	Prescription
Company	Corepharma; Navinta; Fresenius Kabi Usa; Excellium; Vintage; Usl Pharma; Luitpold; Hikma Farmaceutica; Pliva; Invagen Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Dopamine Uptake Inhibitors

Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake. (See all compounds classified as Dopamine Uptake Inhibitors.)

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Antihistamine [EPC]; Cholinergic Antagonists [MoA]; Histamine Receptor Antagonists [MoA]; Anticholinergic [EPC]