Benziodarone

Synopsis, Chemistry

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Also known as: 68-90-6, Amplivix, Dilafurane, Cardivix, Dila-vasal, Corofam

Molecular Formula

C₁₇H₁₂I₂O₃

Molecular Weight

518.08 g/mol

InChI Key

CZCHIEJNWPNBDE-UHFFFAOYSA-N

FDA UNII

75CL65GTYR

Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout. It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients.

1 2D Structure

Benziodarone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone

2.1.2 InChI

InChI=1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

2.1.3 InChI Key

CZCHIEJNWPNBDE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)O)I

2.2 Other Identifiers

2.2.1 UNII

75CL65GTYR

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-ethyl-3-benzofuranyl-4-hydroxy-3,5-diiodophenyl Ketone

2. Algocor

3. Amplivix

4. Cardivix

5. Dila-vasal

6. Dilafurane

2.3.2 Depositor-Supplied Synonyms

1. 68-90-6

2. Amplivix

3. Dilafurane

4. Cardivix

5. Dila-vasal

6. Corofam

7. Coronal-crinos

8. Retrangor

9. Benziodaron

10. Carofam

11. Dilacoron

12. L 2329

13. 2329 Labaz

14. Nsc 82133

15. 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl Ketone

16. Nsc-82133

17. 75cl65gtyr

18. 2-ethyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)-cumarone

19. Benzofuran, 3-(3,5-diiodo-4-hydroxybenzoyl)-2-ethyl-

20. 3,5-diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl Ketone

21. Chembl232201

22. Corofam;dilacoron;nsc 82133

23. (2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone

24. Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)-

25. Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 Cumaron

26. Ncgc00160408-01

27. Plexocardio

28. Flanicone

29. Ketone, 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl

30. Ketone, 3,5-diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl

31. Uricor

32. L-2329

33. Dsstox_cid_26134

34. Dsstox_rid_81367

35. Dsstox_gsid_46134

36. Benziodarona

37. Benziodaronum

38. Benzoiodarone

39. Benziodaronum [inn-latin]

40. Cas-68-90-6

41. Benziodarona [inn-spanish]

42. Einecs 200-695-2

43. Unii-75cl65gtyr

44. Brn 1257683

45. Amplivix (tn)

46. Benziodarone [inn:ban:dcf:jan]

47. Ketone,5-diiodophenyl

48. Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 Cumaron [german]

49. Benziodarone (jan/inn)

50. Benziodarone [mi]

51. Benziodarone [inn]

52. Benziodarone [jan]

53. Methanone,5-diiodophenyl)-

54. Benziodarone [mart.]

55. Benziodarone [who-dd]

56. Schembl308541

57. Dtxsid1046134

58. Chebi:135814

59. Nsc82133

60. Zinc3875456

61. Tox21_111793

62. (2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone

63. Bdbm50209206

64. Mfcd00868246

65. Akos015994715

66. Tox21_111793_1

67. Db13277

68. Ks-1133

69. Ncgc00160408-02

70. Ncgc00160408-03

71. Ncgc00160408-06

72. E1290

73. Ft-0662545

74. D01833

75. T72830

76. Q4890775

77. 2-ethylbenzofuranyl 4-hydroxy-3,5-diiodophenyl Ketone

78. (2-ethyl-1-benzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone #

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₁₂I₂O₃
Molecular Weight	518.08 g/mol
XLogP3	5.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	517.88759 g/mol
Monoisotopic Mass	517.88759 g/mol
Topological Polar Surface Area	50.4 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	405
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Uricosuric Agents

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)

4.2 ATC Code

C - Cardiovascular system

C01 - Cardiac therapy

C01D - Vasodilators used in cardiac diseases

C01DX - Other vasodilators used in cardiac diseases

C01DX04 - Benziodarone