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Benzhexol Hydrochloride

Benzhexol hydrochloride

Synopsis, Chemistry

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Also known as: Benzhexol hydrochloride, 52-49-3, Artane, Trihexyphenidyl hcl, Cyclodol, Parcopane

Molecular Formula

C₂₀H₃₂ClNO

Molecular Weight

337.9 g/mol

InChI Key

QDWJJTJNXAKQKD-UHFFFAOYSA-N

FDA UNII

AO61G82577

One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.

1 2D Structure

Benzhexol hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride

2.1.2 InChI

InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

2.1.3 InChI Key

QDWJJTJNXAKQKD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O.Cl

2.2 Other Identifiers

2.2.1 UNII

AO61G82577

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Apo Trihex

2. Apo-trihex

3. Apotrihex

4. Artane

5. Benzhexol

6. Cyclodol

7. Hipokinon

8. Parkinane

9. Parkopan

10. Trihexane

11. Trihexidyl Hydrochloride

12. Trihexyphenidyl

13. Trihexyphenidyl Hydrochloride Elixir

2.3.2 Depositor-Supplied Synonyms

1. Benzhexol Hydrochloride

2. 52-49-3

3. Artane

4. Trihexyphenidyl Hcl

5. Cyclodol

6. Parcopane

7. Romparkin

8. Tremin

9. Benzhexol Hcl

10. Artane Hydrochloride

11. Triesifenidile

12. Cyclodolum

13. 58947-95-8

14. Trihexyphenidyl (hydrochloride)

15. Triphedinon

16. Aparkane

17. Sedrina

18. Benzhexol, Hcl

19. 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol Hydrochloride

20. Dl-trihexyphenidyl Hydrochloride

21. Nsc-757357

22. Mls000069670

23. Pacitane

24. Trihexyphenidyl-d,l Hydrochloride

25. Alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanol Hydrochloride

26. Ao61g82577

27. 52-49-3 (hcl)

28. Ncgc00094393-02

29. Triexifenidila

30. Paralest

31. Pargitan

32. Parkopan

33. Peragit

34. Pipanol

35. Smr000058515

36. Tsiklodol

37. 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol Hydrochloride

38. 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride

39. Dl-trihexyphenidylhydrochloride

40. Benzhexol Chloride

41. Dsstox_cid_25802

42. Dsstox_rid_81140

43. Dsstox_gsid_45802

44. (+-)-alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanol Hydrochloride

45. 1-piperidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride, (+-)-

46. Cas-52-49-3

47. Win 511

48. Sr-01000000226

49. Trihexyphenidyl Hydrochloride [jan]

50. Einecs 200-142-5

51. Unii-ao61g82577

52. D,l-trihexyphenidyl, Hydrochloride

53. Prestwick_133

54. Artane (tn)

55. Trihexyphenidyl Hydrochloride [usp:jan]

56. 1-phenyl-1-cyclohexyl-3-piperidyl-1-propanol Hydrochloride

57. 3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-propanol Hydrochloride

58. 1-piperidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride

59. Opera_id_1788

60. Chembl1092

61. Cyclodolum [who-ip]

62. Schembl42410

63. Mls001148658

64. Mls002548898

65. (+-)-benzhexol Hydrochloride

66. Spectrum1500592

67. Trihexyphenidyli Hydrochloridum

68. Regid_for_cid_66007

69. Chebi:9721

70. Dtxsid8045802

71. Niosh/tn2628000

72. Hms1570m03

73. Hms1921g17

74. Pharmakon1600-01500592

75. Bcp22935

76. Hy-b1277

77. Tox21_111274

78. Tox21_501125

79. Ccg-40279

80. Mfcd00058212

81. Nsc757357

82. S4542

83. Akos005267201

84. Tox21_111274_1

85. Ac-4520

86. Bcp9000392

87. Cs-4734

88. Dl-trihexyphenidyl Hydrochloride, Solid

89. Hs-0073

90. Lp01125

91. Nc00486

92. Nsc 757357

93. Benzhexol Hydrochloride [who-ip]

94. Ncgc00016003-10

95. Ncgc00094393-01

96. Ncgc00094393-03

97. Ncgc00094393-04

98. Ncgc00094393-05

99. Ncgc00261810-01

100. Trihexyphenidyl Hydrochloride (jp17/usp)

101. Trihexyphenidyl Hydrochloride [mi]

102. Bcp0726000149

103. Benzhexol Hcl;trihexyphenidyl Hydrochloride

104. Eu-0101125

105. Ft-0624385

106. Ft-0652998

107. T3303

108. Tn26280000

109. Trihexyphenidyl Hydrochloride [mart.]

110. Trihexyphenidyl Hydrochloride [vandf]

111. Trihexyphenidyl Hydrochloride [usp-rs]

112. Trihexyphenidyl Hydrochloride [who-dd]

113. Trihexyphenidyl Hydrochloride [who-ip]

114. D00787

115. D92689

116. T 1516

117. 052b493

118. 058b212

119. Trihexyphenidyl Hydrochloride [orange Book]

120. Q-200685

121. Sr-01000000226-2

122. Sr-01000000226-7

123. Trihexyphenidyl Hydrochloride [ep Monograph]

124. Trihexyphenidyl Hydrochloride [usp Monograph]

125. Q27274030

126. Trihexyphenidyli Hydrochloridum [who-ip Latin]

127. Z1551429739

128. 1-cyclohexyl-1-phenyl-3-(1-piperidyl)-1-propanol Hydrochloride

129. Trihexyphenidyl Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

130. Trihexyphenidyl Hydrochloride, British Pharmacopoeia (bp) Reference Standard

131. (+/-)-.alpha.-cyclohexyl-.alpha.-phenyl-1-piperidinepropanol Hydrochloride

132. 1-piperidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-, Hydrochloride, (+/-)-

133. Trihexyphenidyl Hydrochloride, European Pharmacopoeia (ep) Reference Standard

134. Trihexyphenidyl Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₃₂ClNO
Molecular Weight	337.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	337.2172423 g/mol
Monoisotopic Mass	337.2172423 g/mol
Topological Polar Surface Area	23.5 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	314
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Trihexyphenidyl hydrochloride
PubMed Health	Trihexyphenidyl Hydrochloride (By mouth)
Drug Classes	Antiparkinsonian
Drug Label	Trihexyphenidyl HCl is a synthetic antispasmodic drug. It is designated chemically as -Cyclohexyl-phenyl-1-piperidinepropanol hydrochloride and its structural formula is as follows: C20H31NO HCl...
Active Ingredient	Trihexyphenidyl hydrochloride
Dosage Form	Elixir; Tablet
Route	Oral
Strength	2mg/5ml; 5mg; 2mg
Market Status	Prescription
Company	Vintage Pharms; Pharm Assoc; Natco Pharma; Watson Labs; Mikart

2 of 2
Drug Name	Trihexyphenidyl hydrochloride
PubMed Health	Trihexyphenidyl Hydrochloride (By mouth)
Drug Classes	Antiparkinsonian
Drug Label	Trihexyphenidyl HCl is a synthetic antispasmodic drug. It is designated chemically as -Cyclohexyl-phenyl-1-piperidinepropanol hydrochloride and its structural formula is as follows: C20H31NO HCl...
Active Ingredient	Trihexyphenidyl hydrochloride
Dosage Form	Elixir; Tablet
Route	Oral
Strength	2mg/5ml; 5mg; 2mg
Market Status	Prescription
Company	Vintage Pharms; Pharm Assoc; Natco Pharma; Watson Labs; Mikart

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

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