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    Chemistry

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    Also known as: 86541-75-5, Benazeprilum [latin], Benazeprilum, Lotrel, Benazepril sandoz, Cgs-14824a
    Molecular Formula
    C24H28N2O5
    Molecular Weight
    424.5  g/mol
    InChI Key
    XPCFTKFZXHTYIP-PMACEKPBSA-N
    FDA UNII
    UDM7Q7QWP8
    Benazepril
    Benazepril is a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
    Benazepril is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of benazepril is as an Angiotensin-converting Enzyme Inhibitor. The physiologic effect of benazepril is by means of Decreased Blood Pressure.
    1 2D Structure

    Benazepril

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
    2.1.2 InChI
    InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
    2.1.3 InChI Key
    XPCFTKFZXHTYIP-PMACEKPBSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O
    2.1.5 Isomeric SMILES
    CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    UDM7Q7QWP8
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Benazapril

    2. Benazepril Hydrochloride

    3. Benzazepril

    4. Briem

    5. Cgs-14824-a

    6. Cgs-14824a

    7. Cibacne

    8. Cibacen

    9. Labopal

    10. Lotensin

    2.3.2 Depositor-Supplied Synonyms

    1. 86541-75-5

    2. Benazeprilum [latin]

    3. Benazeprilum

    4. Lotrel

    5. Benazepril Sandoz

    6. Cgs-14824a

    7. Forteekor

    8. Cibacen Ws

    9. Benazepril (inn)

    10. 2-[(3s)-3-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3h-1-benzazepin-1-yl]acetic Acid

    11. C09aa07

    12. Udm7q7qwp8

    13. Chembl838

    14. Chebi:3011

    15. 1h-1-benzazepine-1-acetic Acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (s-(r*,r*))-

    16. [(3s)-3-{[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl]acetic Acid

    17. 109010-10-8

    18. Benazepril [inn]

    19. Benazepril [inn:ban]

    20. Cgs-14824-a

    21. Benazepril Free Base

    22. [(3s)-3-{[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl]acetic Acid

    23. 2-((s)-3-(((s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b]azepin-1-yl)acetic Acid

    24. 2-[(3s)-3-{[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl]acetic Acid

    25. Benazepril Sandoz (tn)

    26. Unii-udm7q7qwp8

    27. Forteekor [veterinary] (tn)

    28. ((3s)-3-(((1s)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl)acetic Acid

    29. 1h-1-benzazepine-1-acetic Acid, 3-(((1s)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (3s)-

    30. 1h-1-benzazepine-1-acetic Acid, 3-[[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3s)-

    31. Benazepril Impurity A

    32. Spectrum_001922

    33. Benazepril [mi]

    34. Spectrum2_000482

    35. Spectrum3_001674

    36. Spectrum4_000286

    37. Spectrum5_001546

    38. Benazepril [vandf]

    39. Benazepril [who-dd]

    40. Schembl16396

    41. Bspbio_003487

    42. Kbiogr_000812

    43. Kbioss_002464

    44. Mls006011854

    45. Bidd:gt0800

    46. Spbio_000343

    47. Gtpl6374

    48. Dtxsid5022645

    49. Hsdb 7081

    50. Kbio2_002457

    51. Kbio2_005025

    52. Kbio2_007593

    53. Kbio3_002707

    54. Bcp12672

    55. Hy-b0093

    56. Zinc3781943

    57. Bbl034011

    58. Bdbm50021153

    59. Mfcd00864466

    60. S5938

    61. Stk627447

    62. Akos005560204

    63. Cs-1795

    64. Db00542

    65. Benazepril [ema Epar Veterinary]

    66. Ncgc00165740-01

    67. Ncgc00165740-02

    68. Ncgc00165740-03

    69. Ncgc00165740-04

    70. [(3s)-3-({(1s)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}amino)-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl]acetic Acid

    71. Smr000857173

    72. Sbi-0206744.p001

    73. C06843

    74. D07499

    75. Ab00698518-07

    76. Ab00698518_08

    77. Ab00698518_09

    78. 541b744

    79. A841713

    80. Q592802

    81. Brd-k49807096-003-02-3

    82. Tert Butyl-3-(3s) Amino-2,3,4,5-tetrahydro-1h(1) Benzazepin-2-one-1-acetate

    83. Tert Butyl-3-(3s)amino-2,3,4,5-tetrahydro-1h(1)benzazepin-2-one-1-acetate

    84. 2-((s)-3-((s)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b]azepin-1-yl)acetic Acid

    85. 2-[(3s)-3-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-2-oxo-4,5-dihydro-3h-1-benzazepin-1-yl]acetic Acid;benazepril

    86. 2-[(4s)-4-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-2-yl]acetic Acid

    2.3.3 Other Synonyms

    1. 86541-78-8

    2. Benazeprilate

    3. Benazeprilat

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 424.5 g/mol
    Molecular Formula C24H28N2O5
    XLogP31.3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count10
    Exact Mass424.19982200 g/mol
    Monoisotopic Mass424.19982200 g/mol
    Topological Polar Surface Area95.9 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity619
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Benazepril is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of August 30, 2017: https://clinicaltrials.gov/

    Lotensin is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. ... It may be used alone or in combination with thiazide diuretics. /Included in US product label/

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    ACE inhibitors have been used in the management of heart failure, usually in conjunction with other agents such as cardiac glycosides, diuretics, and beta-blockers. /Angiotensin-converting enzyme (ACE) inhibitors; NOT included in US product label/

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017, p. 2067

    Both angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists have been shown to slow the rate of progression of renal disease in patients with diabetes mellitus and persistent albuminuria, and use of a drug from either class is recommended in such patients with modestly elevated (30-300 mg/24 hours) or higher (exceeding 300 mg/24 hours) levels of urinary albumin excretion. The usual precautions of ACE inhibitor or angiotensin II receptor antagonist therapy in patients with substantial renal impairment should be observed. /Angiotensin-converting enzyme (ACE) inhibitors; NOT included in US product label/

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017, p. 2067

    For more Therapeutic Uses (Complete) data for Benazepril (7 total), please visit the HSDB record page.

    4.2 Drug Warning

    /BOXED WARNING/ When pregnancy is detected, discontinue Lotensin as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    Rare angiotensin-converting enzyme (ACE) inhibitor-associated clinical syndrome manifested initially by cholestatic jaundice; may progress to fulminant hepatic necrosis and is potentially fatal. Patients receiving an ACE inhibitor, including benazepril, who develop jaundice or marked elevations of hepatic enzymes should discontinue the drug and receive appropriate monitoring.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017, p. 2068

    Serum potassium should be monitored periodically in patients receiving Lotensin. Drugs that inhibit the renin-angiotensin system can cause hyperkalemia. Risk factors for the development of hyperkalemia include renal insufficiency, diabetes mellitus, and the concomitant use of potassium-sparing diuretics, potassium supplements and/or potassium-containing salt substitutes.

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    Adverse effects reported in greater than 1% of patients receiving benazepril include headache, dizziness, fatigue, somnolence, postural dizziness, nausea, and cough. Adverse effects reported in greater than 1% of patients receiving benazepril in fixed combination with hydrochlorothiazide include dizziness, fatigue, postural dizziness, headache, cough, hypertonia, vertigo, nausea, impotence, and somnolence. Adverse effects reported in greater than 1% of patients receiving benazepril in fixed combination with amlodipine include cough, headache, dizziness, and edema.

    American Society of Health-System Pharmacists 2017; Drug Information 2017. Bethesda, MD. 2017, p. 2069

    For more Drug Warnings (Complete) data for Benazepril (16 total), please visit the HSDB record page.

    4.3 Drug Indication

    Benazepril is indicated for the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Benazeprilat, is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex.

    5.2 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Angiotensin-Converting Enzyme Inhibitors

    A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    BENAZEPRIL
    5.3.2 FDA UNII
    UDM7Q7QWP8
    5.3.3 Pharmacological Classes
    Angiotensin-converting Enzyme Inhibitors [MoA]; Decreased Blood Pressure [PE]; Angiotensin Converting Enzyme Inhibitor [EPC]
    5.4 ATC Code

    C09AA07

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    C - Cardiovascular system

    C09 - Agents acting on the renin-angiotensin system

    C09A - Ace inhibitors, plain

    C09AA - Ace inhibitors, plain

    C09AA07 - Benazepril

    5.5 Absorption, Distribution and Excretion

    Absorption

    Bioavailability of oral dosing is 3% to 4% in horses. In humans at least 37% of oral benazepril is absorbed and reaches peak plasma concentration in 0.5 hours to 1 hour. Other studies have shown a peak plasma concentration at a median of 1.5 hours.

    Route of Elimination

    Benazepril and benazeprilat are cleared predominantly by renal excretion in healthy subjects with normal renal function. Nonrenal (i.e., biliary) excretion accounts for approximately 11%-12% of benazeprilat excretion in healthy subjects.

    Volume of Distribution

    The final population pharmacokinetic model in one study estimated the volume of distribution to be 20369.9L.

    Clearance

    The final population pharmacokinetic model of one study estimates the clearance to be 12930.0L.

    /MILK/ Minimal amounts of unchanged benazepril and of benazeprilat are excreted into the breast milk of lactating women treated with benazepril. A newborn child ingesting entirely breast milk would receive less than 0.1% of the mg/kg maternal dose of benazepril and benazeprilat.

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    Benazepril and benazeprilat are cleared predominantly by renal excretion. About 37% of an orally administered dose was recovered in urine as benazeprilat (20%), benazeprilat glucuronide (8%), benazepril glucuronide (4%) and as trace amounts of benazepril. Nonrenal (i.e., biliary) excretion accounts for approximately 11% - 12% of benazeprilat excretion. The effective half-life of benazeprilat following once daily repeat oral administration of benazepril hydrochloride is 10 to 11 hours. Thus, steady-state concentrations of benazeprilat should be reached after 2 or 3 doses of benazepril hydrochloride given once daily. Accumulation ratio based on AUC of benazeprilat was 1.19 following once daily administration.

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    5.6 Metabolism/Metabolites

    Cleavage of the ester group (primarily in the liver) converts benazepril to its active metabolite, benazeprilat. Benazepril and benazeprilat are conjugated to glucuronic acid prior to urinary excretion.

    Benazepril and benazeprilat are cleared predominantly by renal excretion. About 37% of an orally administered dose was recovered in urine as benazeprilat (20%), benazeprilat glucuronide (8%), benazepril glucuronide (4%) and as trace amounts of benazepril. Nonrenal (i.e., biliary) excretion accounts for approximately 11% - 12% of benazeprilat excretion. The effective half-life of benazeprilat following once daily repeat oral administration of benazepril hydrochloride is 10 to 11 hours. Thus, steady-state concentrations of benazeprilat should be reached after 2 or 3 doses of benazepril hydrochloride given once daily. Accumulation ratio based on AUC of benazeprilat was 1.19 following once daily administration.

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    After oral dosing in healthy dogs, benazepril is rapidly absorbed and converted into the active metabolite benazeprilat with peak levels of benazeprilat occurring approximately 75 minutes after dosing.

    Plumb D.C. Veterinary Drug Handbook. 8th ed. (pocket). Ames, IA: Wiley-Blackwell, 2015., p. 146

    Benazepril is almost completely metabolized to benazeprilat by cleavage of the ester group (primarily in liver). Both benazepril and benazeprilat undergo glucuronidation.

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    5.7 Biological Half-Life

    The half life of the prodrug benazepril is 2.78.5h. The half life of the active metabolite benazeprilat is 22.39.2h The accumulation half life of benazepril is 10 to 11 hours.

    The elimination half life of benazeprilat is approximately 3.5 hours in healthy dogs. /Benazeprilat/

    Plumb D.C. Veterinary Drug Handbook. 8th ed. (pocket). Ames, IA: Wiley-Blackwell, 2015., p. 146

    The effective half-life of benazeprilat following once daily repeat oral administration of benazepril hydrochloride is 10 to 11 hours. /Benazeprilat/

    NIH; DailyMed. Current Medication Information for Lotensin (Benazepril Hydrochloride Tablet) (Updated: August 2017). Available from, as of November 2, 2017: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e

    5.8 Mechanism of Action

    Benazeprilat, the active metabolite of Benazepril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion.

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    Unipex

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    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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    05

    Amino Chemicals

    Malta

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    World Health Expo
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    Amino Chemicals

    Malta

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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    Listed Suppliers

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    01

    Nuray Chemicals Private Limited

    India
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    Virtual BoothNuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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    Benazepril

    About the Company : Nuray Chemicals Pvt Ltd, established in 2012 near Chennai, is an API manufacturer for highly regulated markets. Its state-of-the-art R&D facility specializes in synthesizing NCEs, ...

    Nuray Chemicals Pvt Ltd, established in 2012 near Chennai, is an API manufacturer for highly regulated markets. Its state-of-the-art R&D facility specializes in synthesizing NCEs, impurities, metabolites, method development, advanced intermediates, and APIs for commercial launch. Focused on quality, reliability, and transparency, Nuray is a trusted partner in the global generic market. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
    Nuray Chemicals

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    02

    HRV Pharma

    India
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    Virtual BoothHRV Pharma - Market Expansion Leader in Pharmaceuticals.

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    Benazepril

    About the Company : HRV Pharma is a global manufacturer, seller, and exporter of APIs, intermediates, pellets, food-grade chemicals, food additives, and food ingredients. The company provides sourcing...

    HRV Pharma is a global manufacturer, seller, and exporter of APIs, intermediates, pellets, food-grade chemicals, food additives, and food ingredients. The company provides sourcing, manufacturing, and supply services to support partners entering new markets worldwide. HRV Pharma works closely with major pharma and food additive companies and represents over 30 Indian drugmakers, primarily serving Europe, the US, and the Middle East. Headquartered in India, it operates offices in the US, Switzerland, Dubai, Lithuania, and Turkey. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
    HRV Global Life Sciences

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    03

    Amino Chemicals

    Malta
    World Health Expo
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    Amino Chemicals

    Malta
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Benazepril

    About the Company : Amino Chemicals Ltd. manufactures high quality bulk active ingredients to support its customers for the earliest possible launch of generic pharmaceutical products into regulated m...

    Amino Chemicals Ltd. manufactures high quality bulk active ingredients to support its customers for the earliest possible launch of generic pharmaceutical products into regulated markets. Thanks to its US FDA-inspected multi-purpose plant in Malta, the company enjoys from the favourable local patent situation and Bolar provision which allow to fully exploit the potential of new generic APIs, using its own non-infringing processes while guaranteeing the full respect of third parties' rights in the destination countries. Production scale ranges from few KGs to tons per month.
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    04

    Symbio

    India
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    Symbio

    India
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Benazepril

    About the Company : Symbio Generrics India Private Limited is a specialized manufacturer and global supplier of Active Pharmaceutical Ingredients (APIs), intermediates, and R&D services. With faciliti...

    Symbio Generrics India Private Limited is a specialized manufacturer and global supplier of Active Pharmaceutical Ingredients (APIs), intermediates, and R&D services. With facilities near Bengaluru and Visakhapatnam, we serve pharmaceutical, biotech, agrochemical, and specialty chemical industries. Backed by strong sales and distribution networks, we align with regional and global strategies of formulation partners, ensuring high-quality, regulatory-compliant APIs for both regulated and emerging markets.
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    05

    Unipex

    France
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    Unipex

    France
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Benazepril

    About the Company : Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build ar...

    Our work in the distribution sector starts and ends with the quality of human relations; first and foremost, it is trust that we want to build with you. The connections we build are made to last. They are built on professionalism, respect and transparency. This is how we work, and how we have been working for a long time now, with our client partners and constituents. Unipex has been operational for 50 years, and has always remained true to its core business: the distribution of specialities. This is also why we are independent and we intend to stay that way. Our structure is simple, our commitment is absolute: we work directly with you.
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    API Reference Price

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    18-Jan-2022
    04-Dec-2025
    KGS
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    INTERMEDIATE SUPPLIERS

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    01

    Vio Chemicals

    Switzerland
    World Health Expo
    Not Confirmed
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    Vio Chemicals

    Switzerland
    World Health Expo
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    Tert-butyl-(S)-(3-amino-2-oxo-2,3,4,5-tetrahydro-b...

    CAS Number : 109010-60-8

    End Use API : Benazepril

    About The Company : A Swiss chemical company specialized in custom design, development, production & sourcing of specialty chemicals, intermediates and Active Pharmaceutical Ingred...

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    02

    Zhejiang Huahai Pharmaceutical Co.,...

    China
    World Health Expo
    Not Confirmed
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    Zhejiang Huahai Pharmaceutical Co.,...

    China
    World Health Expo
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    (3s)-3-amino-1-t-butoxycarbonylmethyl-2,3,4,5-tetr...

    CAS Number : 109010-60-8

    End Use API : Benazepril

    About The Company : Zhejiang Huahai Pharmaceuticals Co., Ltd.was initially founded in 1989, and the company's stock was successfully listed in Shanghai Stock Exchange in March, 200...

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    ABOUT THIS PAGE

    Looking for 86541-75-5 / Benazepril API manufacturers, exporters & distributors?

    Benazepril manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Benazepril API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Benazepril manufacturer or Benazepril supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Benazepril manufacturer or Benazepril supplier.

    PharmaCompass also assists you with knowing the Benazepril API Price utilized in the formulation of products. Benazepril API Price is not always fixed or binding as the Benazepril Price is obtained through a variety of data sources. The Benazepril Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Benazepril

    Synonyms

    86541-75-5, Benazeprilum [latin], Benazeprilum, Lotrel, Benazepril sandoz, Cgs-14824a

    Cas Number

    86541-75-5

    Unique Ingredient Identifier (UNII)

    UDM7Q7QWP8

    About Benazepril

    Benazepril is a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

    Benazeprilat Manufacturers

    A Benazeprilat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Benazeprilat, including repackagers and relabelers. The FDA regulates Benazeprilat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Benazeprilat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Benazeprilat manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Benazeprilat Suppliers

    A Benazeprilat supplier is an individual or a company that provides Benazeprilat active pharmaceutical ingredient (API) or Benazeprilat finished formulations upon request. The Benazeprilat suppliers may include Benazeprilat API manufacturers, exporters, distributors and traders.

    click here to find a list of Benazeprilat suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Benazeprilat GMP

    Benazeprilat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Benazeprilat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Benazeprilat GMP manufacturer or Benazeprilat GMP API supplier for your needs.

    Benazeprilat CoA

    A Benazeprilat CoA (Certificate of Analysis) is a formal document that attests to Benazeprilat's compliance with Benazeprilat specifications and serves as a tool for batch-level quality control.

    Benazeprilat CoA mostly includes findings from lab analyses of a specific batch. For each Benazeprilat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Benazeprilat may be tested according to a variety of international standards, such as European Pharmacopoeia (Benazeprilat EP), Benazeprilat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Benazeprilat USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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