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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

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USDMF

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CEP/COS

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JDMF

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EU WC

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NDC API

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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Europe

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API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

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FDF

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Chemistry

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Also known as: 251111-30-5, Beloranib [inn], Zgn-433, Zgn-440, Ckd-732, Zgn 440
Molecular Formula
C29H41NO6
Molecular Weight
499.6  g/mol
InChI Key
ZEZFKUBILQRZCK-MJSCXXSSSA-N
FDA UNII
FI471K8BU6

Beloranib
Beloranib is a fumagillin analogue and inhibitor of methionine aminopeptidase 2 (METAP2), with potential antiangiogenic and anti-obesity activity. As an irreversible inhibitor, beloranib blocks METAP2's functions, which include both protecting eukaryotic initiation factor 2 from inhibitory phosphorylation during translation, and by removing the amino-terminal methionine residue from nascent protein permitting the conversion of an inactive or non-functional protein to an active one. As a result, this agent prevents endothelial cell growth and inhibits tumor angiogenesis. In addition, METAP2 inhibition also down-regulates ERK1/2 signaling pathway, which is usually overactive in the fat tissues of obese people. Therefore, at a much lower dose, beloranib can induce liver fat utilization and reduce cholesterol and fatty acid synthesis. METAP2, a member of the dimetallohydrolase family, plays an important role during angiogenesis and is over-expressed in various cancers.
1 2D Structure

Beloranib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate
2.1.2 InChI
InChI=1S/C29H41NO6/c1-20(2)7-13-24-28(3,36-24)27-26(32-6)23(15-16-29(27)19-34-29)35-25(31)14-10-21-8-11-22(12-9-21)33-18-17-30(4)5/h7-12,14,23-24,26-27H,13,15-19H2,1-6H3/b14-10+/t23-,24-,26-,27-,28+,29+/m1/s1
2.1.3 InChI Key
ZEZFKUBILQRZCK-MJSCXXSSSA-N
2.1.4 Canonical SMILES
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC4=CC=C(C=C4)OCCN(C)C)OC)C
2.1.5 Isomeric SMILES
CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C4=CC=C(C=C4)OCCN(C)C)OC)C
2.2 Other Identifiers
2.2.1 UNII
FI471K8BU6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl)-1-oxaspiro(2.5)oct-6-yl (2e)-3-(4-(2-(dimethylamino)ethoxy)phenyl)acrylate

2. Ckd-732

3. Ckd732

4. O-(4-dimethylaminoethoxycinnamoyl)fumagillol

2.3.2 Depositor-Supplied Synonyms

1. 251111-30-5

2. Beloranib [inn]

3. Zgn-433

4. Zgn-440

5. Ckd-732

6. Zgn 440

7. O-[4-(2-dimethylaminoethoxy)-trans-cinnamoyl]fumagillol

8. Fi471k8bu6

9. (3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-yl (2e)-3-(4-(2-(dimethylamino)ethoxy)phenyl)prop-2-enoate

10. O-(4-(2-dimethylaminoethoxy)-trans-cinnamoyl)fumagillol

11. 609845-93-4

12. Unii-fi471k8bu6

13. Zgn 433

14. [(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (e)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate

15. Zgn-440(beloranib)

16. O-(4-dimethylaminoethoxycinnamoyl)fumagillol

17. Beloranib [who-dd]

18. Gtpl8445

19. Us9682965, Compound A

20. Chembl4297504

21. Schembl14648763

22. Dtxsid40179800

23. Bdbm148430

24. Zgn-440;cdk-732

25. Zinc3982162

26. Db12671

27. (3r,4s,5s,6r)-5-methoxy-4-((2r,3r)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl)-1-oxaspiro(2.5)oct-6-yl (2e)-3-(4-(2-(dimethylamino)ethoxy)phenyl)acrylate

28. Hy-14811

29. Cs-0003572

30. A13870

31. Q4884554

32. [(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (e)-3-[4-(2-dimethylaminoethoxy)phenyl]prop-2-enoate

33. 3-[4-[2-(dimethylamino)ethoxy]phenyl]acrylic Acid (3r)-4beta-[(2r,3r)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5alpha-methoxy-1-oxaspiro[2.5]octane-6alpha-yl Ester

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 499.6 g/mol
Molecular Formula C29H41NO6
XLogP34.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count12
Exact Mass499.29338803 g/mol
Monoisotopic Mass499.29338803 g/mol
Topological Polar Surface Area73.1 Ų
Heavy Atom Count36
Formal Charge0
Complexity815
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Angiogenesis Inhibitors

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (See all compounds classified as Angiogenesis Inhibitors.)


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Looking for 609845-93-4 / Beloranib API manufacturers, exporters & distributors?

Beloranib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Beloranib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Beloranib manufacturer or Beloranib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Beloranib manufacturer or Beloranib supplier.

PharmaCompass also assists you with knowing the Beloranib API Price utilized in the formulation of products. Beloranib API Price is not always fixed or binding as the Beloranib Price is obtained through a variety of data sources. The Beloranib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Beloranib

Synonyms

251111-30-5, Beloranib [inn], Zgn-433, Zgn-440, Ckd-732, Zgn 440

Cas Number

609845-93-4

Unique Ingredient Identifier (UNII)

FI471K8BU6

About Beloranib

Beloranib is a fumagillin analogue and inhibitor of methionine aminopeptidase 2 (METAP2), with potential antiangiogenic and anti-obesity activity. As an irreversible inhibitor, beloranib blocks METAP2's functions, which include both protecting eukaryotic initiation factor 2 from inhibitory phosphorylation during translation, and by removing the amino-terminal methionine residue from nascent protein permitting the conversion of an inactive or non-functional protein to an active one. As a result, this agent prevents endothelial cell growth and inhibits tumor angiogenesis. In addition, METAP2 inhibition also down-regulates ERK1/2 signaling pathway, which is usually overactive in the fat tissues of obese people. Therefore, at a much lower dose, beloranib can induce liver fat utilization and reduce cholesterol and fatty acid synthesis. METAP2, a member of the dimetallohydrolase family, plays an important role during angiogenesis and is over-expressed in various cancers.

Beloranib Manufacturers

A Beloranib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Beloranib, including repackagers and relabelers. The FDA regulates Beloranib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Beloranib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Beloranib Suppliers

A Beloranib supplier is an individual or a company that provides Beloranib active pharmaceutical ingredient (API) or Beloranib finished formulations upon request. The Beloranib suppliers may include Beloranib API manufacturers, exporters, distributors and traders.

Beloranib GMP

Beloranib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Beloranib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Beloranib GMP manufacturer or Beloranib GMP API supplier for your needs.

Beloranib CoA

A Beloranib CoA (Certificate of Analysis) is a formal document that attests to Beloranib's compliance with Beloranib specifications and serves as a tool for batch-level quality control.

Beloranib CoA mostly includes findings from lab analyses of a specific batch. For each Beloranib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Beloranib may be tested according to a variety of international standards, such as European Pharmacopoeia (Beloranib EP), Beloranib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Beloranib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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