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Chemistry

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Also known as: 38304-91-5, Rogaine, Loniten, Minoximen, Regaine, Theroxidil
Molecular Formula
C9H15N5O
Molecular Weight
209.25  g/mol
InChI Key
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
FDA UNII
5965120SH1

Minoxidil
A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
Minoxidil is an Arteriolar Vasodilator. The physiologic effect of minoxidil is by means of Arteriolar Vasodilation.
1 2D Structure

Minoxidil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
2.1.2 InChI
InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
2.1.3 InChI Key
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
2.2 Other Identifiers
2.2.1 UNII
5965120SH1
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Loniten

2. Regaine

3. Rogaine

4. U 10858

2.3.2 Depositor-Supplied Synonyms

1. 38304-91-5

2. Rogaine

3. Loniten

4. Minoximen

5. Regaine

6. Theroxidil

7. Alopexil

8. Alostil

9. Tricoxidil

10. Lonolox

11. Normoxidil

12. Prexidil

13. Minodyl

14. Pierminox

15. Riup

16. Mintop

17. 6-(1-piperidinyl)-2,4-pyrimidinediamine 3-oxide

18. 2,4-pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide

19. U-10858

20. C9h15n5o

21. 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine

22. Chebi:6942

23. 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide

24. U-10,858

25. 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine

26. Nsc-757106

27. Mls000028566

28. Minossidile [italian]

29. Minoxidilum [inn-latin]

30. Ncgc00015673-08

31. Minoxidilum

32. Smr000058963

33. 6-amino-2-imino-4-(piperidin-1-yl)-1,2-dihydropyrimidin-1-ol

34. Cas-38304-91-5

35. Apo-gain

36. U10858

37. Dsstox_cid_20685

38. Dsstox_rid_79541

39. 6-piperidin-1-ylpyrimidine-2,4-diamine 3-oxide

40. Dsstox_gsid_40685

41. 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide

42. 2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate

43. Neoxidil

44. Avacor And Mintop

45. Smr000326812

46. Loniten (tn)

47. Rogaine (tn)

48. Riup (tn)

49. 2,4-diamino-6-piperidinopyrimidine 3-oxide

50. Sr-01000075331

51. Sr-05000001479

52. Mfcd00063409

53. 3-oxido-6-piperidin-1-ylpyrimidin-3-ium-2,4-diamine

54. Kopdil

55. Regaine For Men

56. Minoxidil,(s)

57. Regaine For Women

58. Prestwick_521

59. 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine

60. Tm-160

61. Men''''s Rogaine

62. Women''''s Rogaine

63. 6-amino-2-imino-4-(piperidin-1-yl)pyrimidin-1(2h)-ol

64. Rogaine Extra Strength

65. Pyrimidin-1(2h)-ol

66. Spectrum_000969

67. Tocris-0583

68. Minoxidil [inn]

69. Minoxidil [jan]

70. Minoxidil [mi]

71. Minoxidil Extra Strength

72. Minoxidil [hsdb]

73. Minoxidil [inci]

74. Minoxidil [usan]

75. Regid855572

76. Opera_id_1150

77. Prestwick0_000020

78. Prestwick1_000020

79. Prestwick2_000020

80. Prestwick3_000020

81. Spectrum2_001053

82. Spectrum3_000509

83. Spectrum4_000063

84. Spectrum5_001299

85. Lopac-m-4145

86. Minoxidil [vandf]

87. M1389

88. Chembl802

89. Minoxidil [mart.]

90. M 4145

91. Minoxidil [usp-rs]

92. Minoxidil [who-dd]

93. Minoxidil (u-10858)

94. Minoxidil (jan/usp/inn)

95. Cbiol_001798

96. Lopac0_000786

97. Schembl29698

98. Bspbio_000059

99. Bspbio_001385

100. Bspbio_002037

101. Kbiogr_000105

102. Kbiogr_000585

103. Kbioss_000105

104. Kbioss_001449

105. 16317-69-4

106. Mls000859953

107. Mls001077294

108. Divk1c_000160

109. Schembl232565

110. Spectrum1500415

111. Spbio_001006

112. Spbio_001980

113. Bpbio1_000065

114. Chembl609587

115. Gtpl4254

116. Minoxidil, >=99% (tlc)

117. Sgcut00112

118. Zinc1735

119. Minoxidil [orange Book]

120. Chembl1372483

121. Dtxsid9040685

122. Minoxidil [ep Monograph]

123. Bcbcmap01_000193

124. Bdbm81463

125. Chebi:92128

126. Hms500h22

127. Kbio1_000160

128. Kbio2_000105

129. Kbio2_001449

130. Kbio2_002673

131. Kbio2_004017

132. Kbio2_005241

133. Kbio2_006585

134. Kbio3_000209

135. Kbio3_000210

136. Kbio3_001537

137. Minoxidil [usp Monograph]

138. Ninds_000160

139. Bcpp000162

140. Bio1_000084

141. Bio1_000573

142. Bio1_001062

143. Bio2_000105

144. Bio2_000585

145. Hms1361f07

146. Hms1568c21

147. Hms1791f07

148. Hms1920p03

149. Hms1989f07

150. Hms2089l08

151. Hms2091f20

152. Hms2095c21

153. Hms2233e04

154. Hms2235n21

155. Hms3259p21

156. Hms3262m14

157. Hms3266o06

158. Hms3371e15

159. Hms3372m19

160. Hms3402f07

161. Hms3411g16

162. Hms3675g16

163. Hms3712c21

164. Pharmakon1600-01500415

165. Act04612

166. Bcp01409

167. Cas_4201

168. Hy-b0112

169. Nsc_4201

170. To_000070

171. Zinc6507066

172. Tox21_110193

173. Tox21_500786

174. Bdbm50237593

175. Ccg-40112

176. Nsc757106

177. S1383

178. Stl453211

179. Akos015920078

180. Akos016339636

181. Tox21_110193_1

182. 6-amino-2-imino-4-(piperidin-1-yl)

183. Ac-5271

184. Bcp9000929

185. Ccg-220020

186. Cs-1867

187. Db00350

188. Gs-3605

189. Ks-5164

190. Lp00786

191. Nc00686

192. Sdccgsbi-0050764.p005

193. Idi1_000160

194. Idi1_033855

195. Smp1_000192

196. Ncgc00015673-01

197. Ncgc00015673-02

198. Ncgc00015673-03

199. Ncgc00015673-04

200. Ncgc00015673-05

201. Ncgc00015673-06

202. Ncgc00015673-07

203. Ncgc00015673-09

204. Ncgc00015673-10

205. Ncgc00015673-11

206. Ncgc00015673-13

207. Ncgc00015673-20

208. Ncgc00018278-01

209. Ncgc00018278-02

210. Ncgc00018278-03

211. Ncgc00018278-04

212. Ncgc00024666-01

213. Ncgc00024666-02

214. Ncgc00024666-03

215. Ncgc00024666-04

216. Ncgc00024666-05

217. Ncgc00024666-06

218. Ncgc00024666-07

219. Ncgc00024666-08

220. Ncgc00179672-01

221. Ncgc00261471-01

222. Bd164673

223. Sbi-0050764.p004

224. 2,6-diamino-4-piperidinopyrimidine 1-oxide

225. 5965120sh1

226. Ab00513797

227. Eu-0100786

228. Ft-0620793

229. D00418

230. H10337

231. O10620

232. 6-(1-piperidinyl)-2,4-pyrimidinediamine3-oxide

233. Ab00052047-08

234. Ab00052047_09

235. Ab00052047_10

236. Ab00513797-02

237. 304m915

238. A824098

239. Q424165

240. Q-201408

241. Sr-01000075331-1

242. Sr-01000075331-3

243. Sr-01000075331-5

244. Sr-05000001479-1

245. Sr-05000001479-2

246. 2,4-diamino-6-piperidinopyrimidine 3-oxide.

247. 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine

248. Brd-k06902185-001-05-2

249. Brd-k06902185-001-10-2

250. Brd-k14888893-001-02-3

251. Minoxidil, British Pharmacopoeia (bp) Reference Standard

252. Z1541638524

253. Minoxidil, European Pharmacopoeia (ep) Reference Standard

254. 2-azanylidene-3-oxidanyl-6-piperidin-1-yl-pyrimidin-4-amine

255. 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidino-pyrimidine

256. Minoxidil, United States Pharmacopeia (usp) Reference Standard

257. Minoxidil For System Suitability, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 209.25 g/mol
Molecular Formula C9H15N5O
XLogP31.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass209.12766012 g/mol
Monoisotopic Mass209.12766012 g/mol
Topological Polar Surface Area88.9 Ų
Heavy Atom Count15
Formal Charge0
Complexity329
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 16  
Drug NameMen's rogaine
PubMed HealthMinoxidil
Drug ClassesAlopecia Agent, Antihypertensive, Peripheral Vasodilator
Drug LabelMinoxidil tablets contain minoxidil, an antihypertensive peripheral vasodilator. Minoxidil occurs as a white to off-white, odorless, crystalline solid that is soluble in water to the extent of approximately 2 mg/mL, is readily soluble in propylene gl...
Active IngredientMinoxidil
Dosage FormAerosol, foam
RouteTopical
Strength5%
Market StatusOver the Counter
CompanyJohnson And Johnson

2 of 16  
Drug NameMinoxidil
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength2%
Market StatusOver the Counter
CompanyHi Tech Pharma; Perrigo

3 of 16  
Drug NameMinoxidil
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength2%
Market StatusOver the Counter
CompanyWockhardt; Hi Tech Pharma; Actavis Mid Atlantic; Perrigo

4 of 16  
Drug NameMinoxidil
Active IngredientMinoxidil
Dosage FormTablet; Aerosol, foam
RouteOral; Topical
Strength2.5mg; 5%; 10mg
Market StatusOver the Counter; Prescription
CompanyPar Pharm; Watson Labs; Mutual Pharm; Perrigo Israel

5 of 16  
Drug NameMinoxidil extra strength
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength5%
Market StatusOver the Counter
CompanyWockhardt; Avacor Prods; Actavis Mid Atlantic; Perrigo; Perrigo New York

6 of 16  
Drug NameRogaine
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength2%
Market StatusOver the Counter
CompanyJohnson And Johnson

7 of 16  
Drug NameRogaine extra strength
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength5%
Market StatusOver the Counter
CompanyJohnson And Johnson

8 of 16  
Drug NameTheroxidil
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength5%; 2%
Market StatusOver the Counter
CompanyEi

9 of 16  
Drug NameMinoxidil extra strength
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength5%
Market StatusOver the Counter
CompanyWockhardt; Avacor Prods; Actavis Mid Atlantic; Perrigo; Perrigo New York

10 of 16  
Drug NameRogaine
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength2%
Market StatusOver the Counter
CompanyJohnson And Johnson

11 of 16  
Drug NameRogaine extra strength
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength5%
Market StatusOver the Counter
CompanyJohnson And Johnson

12 of 16  
Drug NameTheroxidil
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength5%; 2%
Market StatusOver the Counter
CompanyEi

13 of 16  
Drug NameMen's rogaine
PubMed HealthMinoxidil
Drug ClassesAlopecia Agent, Antihypertensive, Peripheral Vasodilator
Drug LabelMinoxidil tablets contain minoxidil, an antihypertensive peripheral vasodilator. Minoxidil occurs as a white to off-white, odorless, crystalline solid that is soluble in water to the extent of approximately 2 mg/mL, is readily soluble in propylene gl...
Active IngredientMinoxidil
Dosage FormAerosol, foam
RouteTopical
Strength5%
Market StatusOver the Counter
CompanyJohnson And Johnson

14 of 16  
Drug NameMinoxidil
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength2%
Market StatusOver the Counter
CompanyHi Tech Pharma; Perrigo

15 of 16  
Drug NameMinoxidil
Active IngredientMinoxidil
Dosage FormSolution
RouteTopical
Strength2%
Market StatusOver the Counter
CompanyWockhardt; Hi Tech Pharma; Actavis Mid Atlantic; Perrigo

16 of 16  
Drug NameMinoxidil
Active IngredientMinoxidil
Dosage FormTablet; Aerosol, foam
RouteOral; Topical
Strength2.5mg; 5%; 10mg
Market StatusOver the Counter; Prescription
CompanyPar Pharm; Watson Labs; Mutual Pharm; Perrigo Israel

4.2 Therapeutic Uses

Antihypertensive Agents; Vasodilator Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Minoxidil is indicated for treatment of hypertension. Because of its serious side effects, minoxidil is not considered to be a primary agent in the treatment of essential hypertension. It is recommended for use only in patients with symptomatic or organ-damaging hypertension not responsive to other treatment. /Included in US product labeling/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 2077


Minoxidil is used topically to stimulate regrowth of hair in balding areas of individuals with androgenetic alopecia (male pattern alopecia, hereditary alopecia, common male baldness). The drug is effective in promoting hair regrowth on the vertex (crown) of the scalp but appears to have little or no effect on temporal recession; the efficacy of topical minoxidil therapy for frontal alopecia has not been evaluated objectively to date. There is evidence to suggest that individuals most likely to respond to topical minoxidil therapy are those younger than 40 years of age, those in whom treatment is initiated relatively early (less than 10 years' duration of hair loss), those with a small diameter of baldness (less than 10 cm), and those who have a large number of terminal or indeterminate (intermediate) hairs before initiation of treatment. At least 4 mo of continuous therapy with minoxidil topical solution usually is required for evidence of response; however, treatment for up to a year may be warranted before deciding that the alopecia is unresponsive. While the ultimate benefit of topical minoxidil therapy depends on the subjective perceptions of the treated individual, cosmetically acceptable hair regrowth as determined by study investigators has been reported in approximately one third of individuals after 6-12 mo of twice daily therapy in most clinical studies, and complete coverage of the balding areas of the scalp occurs rarely. Current evidence suggests that such therapy must be continued indefinitely for maintenance of hair growth.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3481-2


Topically applied minoxidil has been used as a 1, 3, or 5% solution, ointment, or cream to promote hair regrowth in males and females with alopecia areata, including those with the most severe forms, alopecia totalis (complete loss of scalp hair) or alopecia universalis (complete loss of body hair). Overnight petrolatum occlusion of the treated area, which has been reported to enhance efficacy, has been used in some studies. A cosmetically acceptable response to topical minoxidil therapy appears most likely to occur in patients with patchy alopecia areata; patients with total loss of scalp or body hair at baseline (eg; those with alopecia totalis or universalis) usually have the poorest and most delayed response. Efficacy of any therapy in patients with alopecia areata is difficult to evaluate because of the spontaneous hair regrowth and hair loss characteristic of the disease. As in androgenetic alopecia, some patients with alopecia areata receiving treatment with the vehicle alone in controlled studies have had regrowth of terminal hair, and hair loss has resumed in other patients during continued topical minoxidil therapy.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3482-3


For more Therapeutic Uses (Complete) data for MINOXIDIL (6 total), please visit the HSDB record page.


4.3 Drug Warning

It is particularly important that the risks versus benefits of topical minoxidil therapy be assessed carefully in individuals older than 50 yr of age; those with cardiac, renal, or hepatic disease or scalp abnormalities; and those receiving potentially interacting drugs concomitantly (eg; hypotensive agents such as guanethidine); such individuals should be closely monitored if a decision is made to initiate therapy. In addition, individuals with underlying cardiac disease, including coronary artery disease or congestive heart failure, should be informed that adverse systemic effects of topical minoxidil therapy may be particularly serious should they occur.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3484


Individuals receiving topical minoxidil therapy and their clinician should be aware of the manifestations of common and otherwise potentially serious adverse effects associated with systemic minoxidil therapy, particularly sodium and water retention, weight gain, local or generalized edema, pericardial effusion, pericarditis, tamponade, tachycardia, and increased frequency or development of angina. ... While such effects generally appear to be unlikely during topical minoxidil therapy, certain individuals may be at increased risk of their development because of underlying disease, sensitivity to the drug, or achievement of higher than usual systemic concentrations (eg; secondary to misuse or enhanced percutaneous penetration of topical drug). Individuals receiving topical minoxidil therapy should be advised to watch for and report the occurrence of increased heart rate, weight gain, difficulty in breathing (especially when lying down), worsening or development of angina pectoris, edema (swelling) of the face, hands, ankles, or abdomen, or other systemic effects and should be monitored 1 mo after initiating therapy and at least every 6 mo thereafter for the possible development of such effects. If systemic effects occur, topical minoxidil therapy should be discontinued.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3484


As with other topically applied drugs, inflammation or disease processes associated with decreased integrity of the epidermal barrier (eg; excoriations of the scalp, severe sunburn, scalp psoriasis) may increase percutaneous absorption of minoxidil and potentially increase the likelihood of systemic adverse effects.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3484


In evaluating females in whom androgenetic alopecia is suspected, the possibility of an underlying endocrine abnormality such as Cushing's disease, polycystic ovary (Stein-Leventhal) syndrome, hypothyroidism, or an androgen secreting tumor should be considered.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3484


For more Drug Warnings (Complete) data for MINOXIDIL (14 total), please visit the HSDB record page.


4.4 Drug Indication

For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Minoxidil is also used topically to treat androgenetic alopecia. Microcirculatory blood flow in animals is enhanced or maintained in all systemic vascular beds. In man, forearm and renal vascular resistance decline; forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved. The predominant site of minoxidil action is arterial. Venodilation does not occur with minoxidil; thus, postural hypotension is unusual with its administration. The antihypertensive activity of minoxidil is due to its sulphate metabolite, minoxidil sulfate.


5.2 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
MINOXIDIL
5.3.2 FDA UNII
5965120SH1
5.3.3 Pharmacological Classes
Arteriolar Vasodilator [EPC]; Arteriolar Vasodilation [PE]
5.4 ATC Code

D11AX01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


C - Cardiovascular system

C02 - Antihypertensives

C02D - Arteriolar smooth muscle, agents acting on

C02DC - Pyrimidine derivatives

C02DC01 - Minoxidil


D - Dermatologicals

D11 - Other dermatological preparations

D11A - Other dermatological preparations

D11AX - Other dermatologicals

D11AX01 - Minoxidil


5.5 Absorption, Distribution and Excretion

Absorption

Minoxidil is at least 90% absorbed from the GI tract in experimental animals and man.


Minoxidil is almost completely absorbed (95%) from the GI tract. Peak plasma levels are reached in 1 hr. Protein binding does not occur. Minoxidil is widely distributed in the tissues, with an apparent volume of distribution of about 2.8-3.3 l/kg. Placental passage and distribution into breast milk have not been established. The elimination half-life of minoxidil is2.77-4.2 hr. About 90% of an oral dose of minoxidil is metabolized in the liver. The drug and its metabolites are largely excreted in the urine. Renal clearance is 73.9 ml/min.

Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 314


Percutaneous absorption of minoxidil appears to be minimal following topical application of minoxidil solution to intact scalp. However, systemic absorption of topically applied minoxidil is variable and depends on several factors, including the vehicle used in the formulation, the area of application, condition of the skin (eg; being increased with local abrasion or inflammation), and interindividual variation in the extent of percutaneous absorption. Percutaneous absorption of the drug does not appear to be altered by use of a hot-air hair dryer. Although limited in vitro evidence suggests comparable release of minoxidil from solutions with different proportions of propylene glycol, alcohol, and water, release of the drug from a cream base differs substantially from that from solution formulations, and water-in-oil creams appear to differ markedly from oil-in-water creams or ointments in terms of the rate and concentration dependency of drug permeation through human skin. Absorption of minoxidil from extemporaneously prepared solutions, ointments, creams, or other such topical formulations may not be comparable to that from the commercially available topical minoxidil solution.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3486


Percutaneous absorption of minoxidil following topical application of 2% hydroalcoholic, propylene glycol-containing solutions of the drug generally has been reported to average 0.3-4.5% of the applied dose. In a preliminary study in healthy balding men, the systemic bioavailability of minoxidil 2 or 3% topical solution (20 or 30 mg doses, respectively) at steady state relative to that of a 2.5 mg oral tablet averaged 1.4 or 1.2%, respectively. Based on urinary excretion of radiolabeled drug administered to healthy men in another study, percutaneous absorption of minoxidil after application of 1 or 5% minoxidil solutions to the scalp generally averaged 1.6-3.9% of the applied dose, based on urinary recovery of radiolabeled drug. In studies in animals, 5-36% of topically applied doses was absorbed systemically. Serum concentrations achieved after topical application of minoxidil solutions are variable, and clinical studies of topical minoxidil therapy have found no correlation between serum minoxidil concentrations and hair growth. In controlled studies in individuals with androgenetic alopecia or alopecia areata, serum concentrations of minoxidil after topical application of 1, 2, 3, or 5% solution formulations (with or without nightly petrolatum occlusion) generally averaged 2 ng/ml or less. However, about 1% of individuals receiving a 2% topical solution achieved peak serum concentrations of 5 ng/ml or greater, and a few patients achieved concentrations approaching 30 ng/ml. In part, increased percutaneous absorption of the drug in some individuals may have resulted from alterations in the stratum corneum (eg; secondary to irritation and inflammation from shaving of the scalp). In addition, some individuals may have a propensity for enhanced percutaneous absorption of the drug. Data from healthy balding men indicate that peak serum concentrations of unchanged minoxidil after oral doses of 5 mg daily generally are 20-30 times higher than mean serum concentrations achieved after twice daily topical application of approximately 20 mg (1 ml) of minoxidil as a 2% solution.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3486


The distribution of topically applied minoxidil has not been fully determined. Limited evidence suggests that intact stratum corneum serves as a barrier that inhibits substantial diffusion of topically applied minoxidil into systemic circulation, but additional study is needed. Skin biopsy specimens obtained after topical application of a radiolabeled minoxidil 1 or 5% solution to the scalp of healthy balding men indicate an average retention in the skin of 2.6% or less of the applied dose after 24 hr, with twice as much radioactivity in the dermis as in the epidermis. The remainder of the dose remained on the skin or presumably was lost to the environment.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3486


For more Absorption, Distribution and Excretion (Complete) data for MINOXIDIL (8 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Approximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products. Known metabolites exert much less pharmacologic effect than minoxidil itself.


Preliminary evidence suggests that the activity of minoxidil sulfotransferase (the enzyme that converts the drug to its sulfate) is higher in the hair follicle than in epidermis or dermis. Minoxidil sulfate, which may be formed preferentially in the hair follicle following topical application of the drug, exhibits more potent vasodilatory activity than the parent drug.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3485


About 90% of an oral dose of minoxidil is metabolized, primarily by conjugation with glucuronic acid and also by conversion to more polar metabolites. Minoxidil's metabolites are considerably less active than the parent drug.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1852


The biotransformation of minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was studied in the rat, dog, and monkey and compared to reported results in the human. Chromatographic profiles of urinary metabolites show that each species excreted substantially the same metabolites but in quite different relative amounts. The monkey and the human exhibited similar metabolite profiles, whereas the dog and rat were quantitatively different from each other and from the monkey and human. The major excretory product for the monkey and human was a glucuronide conjugate of minoxidil. Substantially smaller amounts of unchanged minoxidil, 2,4-diamino-6-(4'-hydroxypiperidino)pyrimidine 3-oxide, and more polar metabolites also were excreted by these two species. The major excretory product in the rat was unchanged minoxidil. Almost as much (combined) of the two acidic metabolites, 2,4-diamino-6-(4'-carboxy-n-butylamino)pyrimidine and its 3-oxide, also were produced. Smaller amounts of the glucuronide of minoxidil, 2,4-diamino-6-(4'-hydroxypiperidino)pyrimidine 3-oxide, its 3'-hydroxy isomer, and 2,4-diamino-6-piperidinopyrimidine also were excreted by the rat. The major metabolite of minoxidil excreted by the dog was the 4'-hydroxy metabolite. Smaller amounts of unchanged minoxidil and polar metabolites and much smaller amounts of the glucuronide of minoxidil, the 3'-hydroxy metabolite, and 2,4-diamino-6-piperidinopyrimidine also were excreted by the dog. Evidence was obtained for a glucuronide conjugate of the 4'-hydroxy metabolite in this species. The major circulatory material in dog plasma was the 4'-hydroxy metabolite, whereas it was the glucuronide of minoxidil in monkey plasma.

PMID:807713 Thomas RC, Harpootlian H; J Pharm Sci 64 (8): 1366-71 (1975)


Minoxidil has known human metabolites that include 2-Pyrimidinamine, 1,6-dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.7 Biological Half-Life

4.2 hours


In one study in patients with various degrees of renal function (eg; normal to uremic), the mean plasma half-life of minoxidil and its metabolites was 4.2 hr.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1852


5.8 Mechanism of Action

Minoxidil is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. Minoxidil may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. Minoxidil, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells. This vasodilation may also improve the viability of hair cells or hair follicles.


The mechanism(s) by which topically applied minoxidil and/or a metabolite of the drug stimulate vertex hair regrowth in androgenetic (male-pattern) alopecia or other forms of alopecia has not been fully elucidated. However, because minoxidil has stimulated hair regrowth in several forms of alopecia, it appears that the drug acts at the level of the hair follicle, possibly involving direct stimulation of hair follicle epithelial growth. ... While increased scalp blood flow resulting from local vasodilation often has been proposed as a principal mechanism of minoxidil's effect on hair growth, this mechanism has not been substantiated consistently and not all vasodilators produce hypertrichosis.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3485


Studies in animal cell cultures indicate that minoxidil directly induces proliferation of hair epithelial cells near the base of the hair follicle and increases incorporation of cysteine and glycine into the follicle; cysteine residues crosslink to form cystine, which provides strength to the hair shaft. The drug also appears to induce hypertrophy of existing small follicles, prolong the anagen phase of the hair follicle, and accelerate the cyclic turnover of vellus hair follicles, enabling these follicles to produce thick, terminal hair; these effects result in a decrease in vellus hair follicles, an increase in terminal hair follicles, and an increase in the diameter of the hair shaft. Biopsy specimens obtained after topical treatment with minoxidil demonstrate enlargement of preexisting hair follicles but no evidence of new hair follicle formation.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3485


In vitro studies demonstrate different effects of minoxidil on epithelial cells and lymphocytes, which may lead to synergistic effects on hair growth in patients with alopecia areata. In cultures of murine epithelial cells, minoxidil increased cell proliferation, prolonged cell passage time (delayed senescence), and altered cell morphology; the latter 2 effects also have been observed in cultures of human keratinocytes. Human lymphocytes exposed to minoxidil in cell culture demonstrated a modest suppression of mitogen-induced blast formation.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 3486


Minoxidil reduces peripheral vascular resistance and blood pressure as a result of a direct vasodilating effect on vascular smooth muscle; like diazoxide and hydralazine, minoxidil's effect on arterioles is greater than on veins. Minoxidil delays the hydrolysis of cyclic 3',5'-adenosine monophosphate and cyclic guanosine monophosphate by inhibiting the enzyme phosphodiesterase, and relaxation of arterial smooth muscle by the drug may be, at least partly, mediated by cyclic 3',5'-adenosinemonophospate. Animal studies indicate that minoxidil does not have CNS or adrenergic neuronal blocking effects.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1851


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Zeal MediPharma

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Pharm-RX Chemical

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Zeon Pharma Industries India Pvt L...

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Sms Lifesciences

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Flamma Spa

Italy

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Flamma Spa

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GDUFA

DMF Review : Complete

Rev. Date : 2023-03-08

Pay. Date : 2023-03-06

DMF Number : 15918

Submission : 2002-03-29

Status : Active

Type : II

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Icrom Srl

Italy

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GDUFA

DMF Review : Complete

Rev. Date : 2021-08-04

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DMF Number : 22367

Submission : 2009-01-02

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Type : II

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Olon Spa

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Trifarma Spa

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Jicheng Pharmaceutical Factory

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Guangzhou Zhujiang Medicine Co Inc

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Certificate Number : CEP 2022-331 - Rev 00

Status : Valid

Issue Date : 2025-01-23

Type : Chemical

Substance Number : 937

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ZHEJIANG CDMO PHARMACEUTICAL CO., L...

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Minoxidil IP/USP

Date of Issue : 2022-06-17

Valid Till : 2025-07-07

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Address of the Firm : 125 & 126, Sipcot Industrial Complex, Hosur 635126, Tamil Nadu

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Minoxidil Ph. Eur

Date of Issue : 2022-06-17

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Minoxidil USP/Ph. Eur.

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Flamma SpA

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Minoxidil

Registrant Name : Daeshin Pharmaceutical Co., Ltd.

Registration Date : 2025-02-21

Registration Number : 20250211-211-J-1759(1)

Manufacturer Name : FLAMMA SPA

Manufacturer Address : Via Strada Statale Via Briantea 83 (loc. BULCIAGO (LC)) - 23892 BULCIAGO (LC)

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Registrant Name : Ace Biopharm Co., Ltd.

Registration Date : 2021-06-26

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Manufacturer Name : Flamma SPA

Manufacturer Address : Via Bedeschi, 22, 24040 Chignolo d'Isola (Bergamo), Italy

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Minoxidil

Registrant Name : Daeshin Pharmaceutical Co., Ltd.

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Manufacturer Name : Flamma SPA

Manufacturer Address : Via Bedeschi, 22, 24040 Chignolo d'Isola (Bergamo), Italy

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Minoxidil

Registrant Name : Sungjin Exim Co., Ltd.

Registration Date : 2025-02-11

Registration Number : 20250211-211-J-1759

Manufacturer Name : FLAMMA SPA

Manufacturer Address : Via Strada Statale Via Briantea 83 (loc. BULCIAGO (LC)) - 23892 BULCIAGO (LC)

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Italy
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Minoxidil

Registrant Name : Sungjin Exim Co., Ltd.

Registration Date : 2021-05-18

Registration Number : 20210518-211-J-997

Manufacturer Name : Flamma SPA

Manufacturer Address : Via Bedeschi, 22, 24040 Chignolo d'Isola (Bergamo), Italy

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Italy
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Minoxidil

Registrant Name : Hiple Co., Ltd.

Registration Date : 2023-07-06

Registration Number : 20230706-211-J-1492

Manufacturer Name : OLON SpA

Manufacturer Address : VIA DELLA VITTORIA, 89 - 26837 MULAZZANO (LO), Italy

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Minoxidil

Registrant Name : Masung LS Co., Ltd.

Registration Date : 2025-02-05

Registration Number : 20250205-211-J-1754

Manufacturer Name : Sonia Organics

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Trifarma

Italy
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Minoxidil

Registrant Name : Daeshin Pharmaceutical Co., Ltd.

Registration Date : 2022-11-10

Registration Number : 20210406-211-J-742(1)

Manufacturer Name : Trifarma SpA

Manufacturer Address : Via delle Industrie 6 - 20816 Ceriano Laghetto (MB) - ITALY

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Minoxidil

Registrant Name : Masung LS Co., Ltd.

Registration Date : 2021-04-06

Registration Number : 20210406-211-J-742

Manufacturer Name : Trifarma SpA

Manufacturer Address : Via delle Industrie 6 - 20816 Ceriano Laghetto (MB) - ITALY

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NDC API

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MINOXIDIL

NDC Package Code : 71859-006

Start Marketing Date : 2024-10-04

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (25kg/25kg)

Marketing Category : BULK INGREDIENT

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MINOXIDIL

NDC Package Code : 66219-0004

Start Marketing Date : 2014-01-23

End Marketing Date : 2025-12-31

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Marketing Category : BULK INGREDIENT

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Fagron Inc

Netherlands
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Fagron Inc

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MINOXIDIL

NDC Package Code : 51552-0536

Start Marketing Date : 2004-09-01

End Marketing Date : 2026-02-28

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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Galenova Inc

Canada
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Galenova Inc

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MINOXIDIL

NDC Package Code : 79572-022

Start Marketing Date : 2021-05-01

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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MINOXIDIL

NDC Package Code : 60592-009

Start Marketing Date : 2023-10-16

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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Olon SpA

Italy
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Olon SpA

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MINOXIDIL

NDC Package Code : 17337-0027

Start Marketing Date : 1988-05-02

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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MINOXIDIL

NDC Package Code : 73005-0008

Start Marketing Date : 2022-11-14

End Marketing Date : 2025-12-31

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MINOXIDIL

NDC Package Code : 51927-2885

Start Marketing Date : 2013-06-24

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Marketing Category : BULK INGREDIENT FOR HUMAN P...

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MINOXIDIL

NDC Package Code : 0009-5056

Start Marketing Date : 2020-01-01

End Marketing Date : 2025-12-31

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Marketing Category : BULK INGREDIENT

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MINOXIDIL

NDC Package Code : 46204-0159

Start Marketing Date : 2017-12-27

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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01

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Virtual BoothDelivering Quality APIs, Drug Intermediates, and Specialty Chemicals to Over 50 Countries Across the Globe.

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Minoxidil

About the Company : Zeal MediPharma is a globally recognized Star One Export House, serving customers in over 50 countries for more than two decades. We specialize in sourcing and exporting high-quali...

Zeal MediPharma is a globally recognized Star One Export House, serving customers in over 50 countries for more than two decades. We specialize in sourcing and exporting high-quality APIs for human and veterinary use, along with drug intermediates, excipients, and semi-finished formulations such as pellets and DC granules. Our diverse portfolio also includes herbal extracts, phytochemicals, nutraceuticals, food and feed ingredients, agrochemicals, preservatives, surfactants, and specialty chemicals. Committed to excellence, we deliver reliable, high-quality solutions to meet the evolving needs of global healthcare and industry.
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02

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Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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Minoxidil

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
Jai Radhe Sales

03

LGM Pharma

U.S.A
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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Minoxidil

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
LGM Pharma CB

04

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Virtual BoothEmay Pharmaceuticals is a GMP-certified API manufacturing company.

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Minoxidil

About the Company : Emay Pharmaceuticals Pvt Ltd functions as the merchant export division of M/s. Bhavna Laboratories Pvt Ltd. As a GMP-approved API manufacturing company, we boast over three decades...

Emay Pharmaceuticals Pvt Ltd functions as the merchant export division of M/s. Bhavna Laboratories Pvt Ltd. As a GMP-approved API manufacturing company, we boast over three decades of experience in exporting a wide array of Pharmaceutical and allied products, engaging in both manufacturing and export operations. Emay Pharmaceuticals Pvt Ltd comprises a team of seasoned professionals with extensive expertise in Human Health APIs and Veterinary Health APIs. Specializing in the trade of various raw materials for both Human and Veterinary medicine, Emay Pharmaceuticals Pvt Ltd is dedicated to providing quality products.
Emay Pharmaceuticals

05

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Virtual BoothIOL Chemicals is an innovation-driven bulk drug, Intermediate and Specialty Chemicals company.

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Minoxidil

About the Company : With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermediates and specialty ch...

With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermediates and specialty chemicals. As an API-based company, IOL Chemicals has substantial manufacturing capacities that provide economies of scale and cost advantages. It also has extensive expertise in specialty chemicals. IOL Chemicals’ API portfolio includes various therapeutic categories such as pain management, anti-diabetic, anti-hypertensive and anti-convulsant. IOL Chemicals is a backward-integrated company that produces all intermediates and key starting materials for ibuprofen.
IOL Chemicals

06

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Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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Minoxidil

About the Company : Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritio...

Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritional supplement, and food industries. The company maintains an exceptionally selective approach to its suppliers, personally visiting manufacturers overseas to ensure the highest standards. The sustained growth of Pharm-Rx can be attributed to its steadfast commitment to three core values: quality ingredients, competitive pricing, and unparalleled customer service.
Pharm RX

07

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Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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Minoxidil

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
HRV Global Life Sciences

08

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Virtual BoothTenatra connects Indian manufacturers with global buyers through active partners in Germany, Switzerland, Belgium, Spain & Turkey.

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Minoxidil

About the Company : Tenatra International was established as a proprietorship firm in 1999. It got off to a very good start, supporting clients in the United States, Mexico and Europe. As business opp...

Tenatra International was established as a proprietorship firm in 1999. It got off to a very good start, supporting clients in the United States, Mexico and Europe. As business opportunities grew, it was felt that the proprietorship firm had outlived its usefulness and that it needed a corporate structure. So, Tenatra Chemie Private Limited (TCPL) was incorporated in 2002. Since then, the company has come a long way, gaining valuable experience and knowledge in the fields of chemicals and pharmaceuticals in India.
Tenatra

09

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Virtual BoothZeon Pharma is a manufacturer and supplier of APIs & Intermediates.

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Minoxidil

About the Company : Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish form...

Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish formulations/Excipients, Phytochemicals/Enzymes & Intermediate and also has a GMP certified Manufacturing facility for Phytochemicals/Herbal extract and Enzymes through our associates.
Zeon Pharma Industries India Pvt Ltd

10

Remedy Labs

India
IOPC
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Remedy Labs

India
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Minoxidil

About the Company : Based in Ahmedabad, Gujarat, India, we are a reputed Manufacturer, Exporter and Supplier of bulk drugs, fine chemicals and intermediates. Some of our products include Triclosan, Di...

Based in Ahmedabad, Gujarat, India, we are a reputed Manufacturer, Exporter and Supplier of bulk drugs, fine chemicals and intermediates. Some of our products include Triclosan, Diclofenic Sodium, Benzocaine, Paracetamol, Sodium Monochloro Acetate, Monochloro Acetic Acid and Carbamazepine. Having rich experience and in-depth knowledge of the medical industry, we are able to hold the business with result bound solutions. We carry each assigned job work as per prevailing market trends, giving due emphasis on clients drawn specifications. All these have helped us to earn a reputed position in the marketplace.
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18-Jan-2022
26-Apr-2025
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

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Quantity (KGS) & Unit rate (USD/KGS) over time

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INTERMEDIATE SUPPLIERS

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothIOL Chemicals is an innovation-driven bulk drug, Intermediate and Specialty Chemicals company.

CAS Number : 156-83-2

End Use API : Minoxidil

About The Company : With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermedia...

IOL Chemicals

02

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothIOL Chemicals is an innovation-driven bulk drug, Intermediate and Specialty Chemicals company.

CAS Number : 35139-67-4

End Use API : Minoxidil

About The Company : With a history spanning over three decades, IOL Chemicals and Pharmaceuticals Limited is an innovation-driven company that specializes in bulk drugs, intermedia...

IOL Chemicals

03

IOPC
Not Confirmed
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IOPC
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CAS Number : CAS-156-83-2

End Use API : Minoxidil

About The Company : Hebi Xinhe Pharmaceutical Co., Ltd. is a subsidiary of Tianjin Zhennuo Pharmaceutical Group Co., Ltd., with a registered capital of CNY 100 million. Located in ...

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04

IOPC
Not Confirmed
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IOPC
Not Confirmed
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CAS Number : 156-83-2

End Use API : Minoxidil

About The Company : Hiray Pharma Solutions is an international end-to-end CDMO, facilitating the development and manufacturing of important drug products and key intermediates arou...

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05

IOPC
Not Confirmed
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IOPC
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CAS Number : 56-06-4

End Use API : Minoxidil

About The Company : Saflik Pharma is a registered company that was started with the aim of providing top notch quality of pharmaceutical API’s and Intermediates to our buyers. We...

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06

IOPC
Not Confirmed
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IOPC
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CAS Number : 56-06-4

End Use API : Minoxidil

About The Company : Sudarshan Pharma operates in the pharmaceutical and specialty chemicals industries. Their specialty chemicals and intermediates are used in pharma, paint, food,...

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07

IOPC
Not Confirmed
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IOPC
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CAS Number : 156-83-2

End Use API : Minoxidil

About The Company : Sudarshan Pharma operates in the pharmaceutical and specialty chemicals industries. Their specialty chemicals and intermediates are used in pharma, paint, food,...

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08

IOPC
Not Confirmed
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IOPC
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CAS Number : 156-83-2

End Use API : Minoxidil

About The Company : Symphony Pharma Life Sciences Private Limited was established in 2008 by pharma industry experts with an excellent track record in the pharmaceutical industry. ...

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09

IOPC
Not Confirmed
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IOPC
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CAS Number : 56-06-4

End Use API : Minoxidil

About The Company : Telangana Pharmatech is a specialty pharmaceutical company engaged in the drug development, manufacture and commercialization of pharmaceutical products. The co...

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FDF Dossiers

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01

Apotex Inc

Canada
IOPC
Not Confirmed
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Apotex Inc

Canada
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR MEN)

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 2%

Packaging :

Approval Date : 1998-04-29

Application Number : 74924

Regulatory Info : DISCN

Registration Country : USA

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02

IOPC
Not Confirmed
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Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL

Dosage Form : TABLET;ORAL

Dosage Strength : 10MG

Packaging :

Approval Date : 1988-11-14

Application Number : 71839

Regulatory Info : RX

Registration Country : USA

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03

IOPC
Not Confirmed
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MINOXIDIL

Brand Name : MEN'S ROGAINE FOAM 5%

Dosage Form : AEROSOL, FOAM

Dosage Strength : 5%/W/W

Packaging : 60G

Approval Date :

Application Number : 2368684

Regulatory Info : OTC

Registration Country : Canada

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04

IOPC
Not Confirmed
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minoxidil

Brand Name : Minoxidil Orifarm

Dosage Form : KUTAN LÖSNING

Dosage Strength : 20 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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05

IOPC
Not Confirmed
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Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL EXTRA STRENGTH (FOR MEN)

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 5%

Packaging :

Approval Date : 2001-06-13

Application Number : 75598

Regulatory Info : OTC

Registration Country : USA

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06

Pfizer Inc

U.S.A
IOPC
Not Confirmed
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Pfizer Inc

U.S.A
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IOPC
Not Confirmed

Minoxidil

Brand Name : Loniten 10mg

Dosage Form : TAB

Dosage Strength : 10mg

Packaging : 100X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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07

IOPC
Not Confirmed
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Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR WOMEN)

Dosage Form : AEROSOL, FOAM;TOPICAL

Dosage Strength : 5%

Packaging :

Approval Date : 2017-07-27

Application Number : 208092

Regulatory Info : OTC

Registration Country : USA

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08

IOPC
Not Confirmed
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Minoxidil; alcohol

Brand Name :

Dosage Form : Topical Solution

Dosage Strength : 20MG; 40%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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09

IOPC
Not Confirmed
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Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR MEN)

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 2%

Packaging :

Approval Date : 1996-04-05

Application Number : 74589

Regulatory Info : DISCN

Registration Country : USA

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10

Country
IOPC
Not Confirmed
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Country
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : WOMENS ROGAINE

Dosage Form : AEROSOL, FOAM;TOPICAL

Dosage Strength : 5%

Packaging :

Approval Date : 2014-02-28

Application Number : 21812

Regulatory Info : OTC

Registration Country : USA

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FDA Orange Book

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01

APOTEX INC

Canada
IOPC
Not Confirmed
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APOTEX INC

Canada
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR MEN)

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 2%

Approval Date : 1998-04-29

Application Number : 74924

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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02

APOTEX INC

Canada
IOPC
Not Confirmed
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APOTEX INC

Canada
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR WOMEN)

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 2%

Approval Date : 1998-04-29

Application Number : 74924

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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03

L PERRIGO CO

Ireland
IOPC
Not Confirmed
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L PERRIGO CO

Ireland
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR MEN)

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 2%

Approval Date : 1999-07-30

Application Number : 75357

RX/OTC/DISCN : OTC

RLD : No

TE Code :

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04

IOPC
Not Confirmed
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL

Dosage Form : AEROSOL, FOAM;TOPICAL

Dosage Strength : 5%

Approval Date : 2011-04-28

Application Number : 91344

RX/OTC/DISCN : OTC

RLD : No

TE Code :

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05

PURE SOURCE

U.S.A
IOPC
Not Confirmed
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PURE SOURCE

U.S.A
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : THEROXIDIL

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 2%

Approval Date : 2007-11-09

Application Number : 78176

RX/OTC/DISCN : OTC

RLD : No

TE Code :

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06

IOPC
Not Confirmed
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL

Dosage Form : TABLET;ORAL

Dosage Strength : 10MG

Approval Date : 1995-12-14

Application Number : 72709

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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07

IOPC
Not Confirmed
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL

Dosage Form : TABLET;ORAL

Dosage Strength : 2.5MG

Approval Date : 1995-12-14

Application Number : 72709

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

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08

TARO

U.S.A
IOPC
Not Confirmed
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TARO

U.S.A
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR WOMEN)

Dosage Form : AEROSOL, FOAM;TOPICAL

Dosage Strength : 5%

Approval Date : 2019-04-22

Application Number : 209074

RX/OTC/DISCN : OTC

RLD : No

TE Code :

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09

TARO

U.S.A
IOPC
Not Confirmed
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TARO

U.S.A
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IOPC
Not Confirmed

MINOXIDIL

Brand Name : MINOXIDIL (FOR WOMEN)

Dosage Form : SOLUTION;TOPICAL

Dosage Strength : 2%

Approval Date : 2024-11-26

Application Number : 218175

RX/OTC/DISCN : OTC

RLD : No

TE Code :

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10

KENVUE BRANDS

Country
IOPC
Not Confirmed
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KENVUE BRANDS

Country
arrow
IOPC
Not Confirmed

MINOXIDIL

Brand Name : MENS ROGAINE

Dosage Form : AEROSOL, FOAM;TOPICAL

Dosage Strength : 5%

Approval Date : 2006-01-20

Application Number : 21812

RX/OTC/DISCN : OTC

RLD : Yes

TE Code :

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION;TOPICAL - 2%

USFDA APPLICATION NUMBER - 19501

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DOSAGE - SOLUTION;TOPICAL - 5%

USFDA APPLICATION NUMBER - 20834

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DOSAGE - AEROSOL, FOAM;TOPICAL - 5%

USFDA APPLICATION NUMBER - 21812

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ABOUT THIS PAGE

Looking for 38304-91-5 / Minoxidil API manufacturers, exporters & distributors?

Minoxidil manufacturers, exporters & distributors 1

35

PharmaCompass offers a list of Minoxidil API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Minoxidil manufacturer or Minoxidil supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Minoxidil manufacturer or Minoxidil supplier.

PharmaCompass also assists you with knowing the Minoxidil API Price utilized in the formulation of products. Minoxidil API Price is not always fixed or binding as the Minoxidil Price is obtained through a variety of data sources. The Minoxidil Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Minoxidil

Synonyms

38304-91-5, Rogaine, Loniten, Minoximen, Regaine, Theroxidil

Cas Number

38304-91-5

Unique Ingredient Identifier (UNII)

5965120SH1

About Minoxidil

A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)

Avacor and Mintop Manufacturers

A Avacor and Mintop manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Avacor and Mintop, including repackagers and relabelers. The FDA regulates Avacor and Mintop manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Avacor and Mintop API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Avacor and Mintop manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Avacor and Mintop Suppliers

A Avacor and Mintop supplier is an individual or a company that provides Avacor and Mintop active pharmaceutical ingredient (API) or Avacor and Mintop finished formulations upon request. The Avacor and Mintop suppliers may include Avacor and Mintop API manufacturers, exporters, distributors and traders.

click here to find a list of Avacor and Mintop suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Avacor and Mintop USDMF

A Avacor and Mintop DMF (Drug Master File) is a document detailing the whole manufacturing process of Avacor and Mintop active pharmaceutical ingredient (API) in detail. Different forms of Avacor and Mintop DMFs exist exist since differing nations have different regulations, such as Avacor and Mintop USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Avacor and Mintop DMF submitted to regulatory agencies in the US is known as a USDMF. Avacor and Mintop USDMF includes data on Avacor and Mintop's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Avacor and Mintop USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Avacor and Mintop suppliers with USDMF on PharmaCompass.

Avacor and Mintop KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Avacor and Mintop Drug Master File in Korea (Avacor and Mintop KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Avacor and Mintop. The MFDS reviews the Avacor and Mintop KDMF as part of the drug registration process and uses the information provided in the Avacor and Mintop KDMF to evaluate the safety and efficacy of the drug.

After submitting a Avacor and Mintop KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Avacor and Mintop API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Avacor and Mintop suppliers with KDMF on PharmaCompass.

Avacor and Mintop CEP

A Avacor and Mintop CEP of the European Pharmacopoeia monograph is often referred to as a Avacor and Mintop Certificate of Suitability (COS). The purpose of a Avacor and Mintop CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Avacor and Mintop EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Avacor and Mintop to their clients by showing that a Avacor and Mintop CEP has been issued for it. The manufacturer submits a Avacor and Mintop CEP (COS) as part of the market authorization procedure, and it takes on the role of a Avacor and Mintop CEP holder for the record. Additionally, the data presented in the Avacor and Mintop CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Avacor and Mintop DMF.

A Avacor and Mintop CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Avacor and Mintop CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Avacor and Mintop suppliers with CEP (COS) on PharmaCompass.

Avacor and Mintop WC

A Avacor and Mintop written confirmation (Avacor and Mintop WC) is an official document issued by a regulatory agency to a Avacor and Mintop manufacturer, verifying that the manufacturing facility of a Avacor and Mintop active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Avacor and Mintop APIs or Avacor and Mintop finished pharmaceutical products to another nation, regulatory agencies frequently require a Avacor and Mintop WC (written confirmation) as part of the regulatory process.

click here to find a list of Avacor and Mintop suppliers with Written Confirmation (WC) on PharmaCompass.

Avacor and Mintop NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Avacor and Mintop as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Avacor and Mintop API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Avacor and Mintop as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Avacor and Mintop and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Avacor and Mintop NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Avacor and Mintop suppliers with NDC on PharmaCompass.

Avacor and Mintop GMP

Avacor and Mintop Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Avacor and Mintop GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Avacor and Mintop GMP manufacturer or Avacor and Mintop GMP API supplier for your needs.

Avacor and Mintop CoA

A Avacor and Mintop CoA (Certificate of Analysis) is a formal document that attests to Avacor and Mintop's compliance with Avacor and Mintop specifications and serves as a tool for batch-level quality control.

Avacor and Mintop CoA mostly includes findings from lab analyses of a specific batch. For each Avacor and Mintop CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Avacor and Mintop may be tested according to a variety of international standards, such as European Pharmacopoeia (Avacor and Mintop EP), Avacor and Mintop JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Avacor and Mintop USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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