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  • CAPSULE;ORAL - 356.4MG;30MG;16MG
  • TABLET;ORAL - 325MG;50MG;40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
  • CAPSULE;ORAL - 325MG;50MG;40MG;30MG
  • TABLET, DELAYED RELEASE;ORAL - 325MG;40MG
  • TABLET, DELAYED RELEASE;ORAL - 81MG;40MG
  • TABLET;ORAL - 250MG;250MG;65MG
  • CAPSULE, EXTENDED RELEASE;ORAL - 25MG;200MG
  • TABLET;ORAL - 325MG;50MG;40MG

Details:

Xarelto (rivaroxaban) is an orally bioavailable factor Xa inhibitor and does not require a cofactor (such as Anti-thrombin III) for activity. Activation of factor X to factor Xa via the intrinsic and extrinsic pathways plays a central role in blood coagulation.


Lead Product(s): Rivaroxaban,Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Xarelto

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 09, 2023

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Details:

The polypill includes three drugs (aspirin, an ACE inhibitor, and a statin), is effective at preventing secondary adverse cardiovascular events in people who have previously had a heart attack.


Lead Product(s): Aspirin,Ramipril,Simvastatin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Polypill

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: CNIC

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 26, 2022

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Details:

Rivaroxaban is the most broadly indicated non-vitamin K antagonist oral anticoagulant (NOAC) worldwide and is marketed under the brand name Xarelto. Xarelto is approved for more venous and arterial thromboembolic (VAT) conditions.


Lead Product(s): Rivaroxaban,Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Xarelto

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 21, 2022

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Details:

VAZALORE is an FDA-approved liquid-filled aspirin capsule, available in 81 mg and 325 mg doses. VAZALORE delivers aspirin differently from plain and enteric coated aspirin products.


Lead Product(s): Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Vazalore

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 01, 2022

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Details:

COMPASS open label extension study results support the long-term use of XARELTO (rivaroxaban) plus aspirin for vascular protection in patients with chronic CAD and/or PAD.


Lead Product(s): Rivaroxaban,Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Xarelto

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 23, 2022

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Details:

Results from the extension part of the COMPASS study support the long-term use of Xarelto (rivaroxaban) plus aspirin for vascular protection in patients with chronic coronary artery disease (CAD) and/or peripheral artery disease (PAD).


Lead Product(s): Rivaroxaban,Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Xarelto

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 23, 2022

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Details:

Hyloris will use the net proceeds of the Offering primarily to fund the development of new products and accelerate in-house R&D activities including HY-073 (IV acetylsalicylic acid).


Lead Product(s): Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: HY-073

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Berenberg

Deal Size: $16.2 million Upfront Cash: Undisclosed

Deal Type: Private Placement April 01, 2022

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Details:

Data from the two analyses demonstrate the role that the Xarelto® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and without a history of statin therapy.


Lead Product(s): Rivaroxaban,Aspirin

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Xarelto

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 01, 2022

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