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Aprindine Hydrochloride

Aprindine Hydrochloride

Synopsis, Chemistry

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Also known as: Aprindine hcl, 33237-74-0, Aspenon, Fibocil, Compound 83846, Aprinidine chloride

Molecular Formula

C₂₂H₃₁ClN₂

Molecular Weight

358.9 g/mol

InChI Key

KIPFVRHNAAZJOD-UHFFFAOYSA-N

FDA UNII

PB5EKT7Q2V

A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.

1 2D Structure

Aprindine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine;hydrochloride

2.1.2 InChI

InChI=1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H

2.1.3 InChI Key

KIPFVRHNAAZJOD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C3=CC=CC=C3.Cl

2.2 Other Identifiers

2.2.1 UNII

PB5EKT7Q2V

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Amidonal

2. Aprindine

3. Fiboran

2.3.2 Depositor-Supplied Synonyms

1. Aprindine Hcl

2. 33237-74-0

3. Aspenon

4. Fibocil

5. Compound 83846

6. Aprinidine Chloride

7. Amidonal

8. Aprindinehcl

9. Aprindine (hydrochloride)

10. Pb5ekt7q2v

11. N-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-1,3-propanediamine Hydrochloride

12. Nsc-284614

13. Fiboran

14. Ritmusin

15. 33237-74-0 (hcl)

16. Dsstox_cid_26726

17. Dsstox_rid_81856

18. Dsstox_gsid_46726

19. Lilly 83846

20. N'-(2,3-dihydro-1h-inden-2-yl)-n,n-diethyl-n'-phenylpropane-1,3-diamine;hydrochloride

21. Cas-33237-74-0

22. Ccris 5480

23. Ncgc00167576-01

24. Aprindine Hydrochloride [usan:jan]

25. Einecs 251-418-7

26. Unii-pb5ekt7q2v

27. Nsc 284614

28. Ms 5075

29. Ms-5075

30. Aspenon (tn)

31. N-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenylpropane-1,3-diamine Monohydrochloride

32. 2-indanamine, N-(3-(diethylamino)propyl)-n-phenyl-, Hydrochloride

33. N,n-diethyl-n'-2-indanyl-n'-phenyl-1,3-propanediamine Hydrochloride

34. N,n-diethyl-n'-2-indanyl-n'-phenyl-1,3-propanediamine Monohydrochloride

35. 1,3-propanediamine, N-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-, Monohydrochloride

36. Compound-83846

37. Mls004712062

38. Schembl122403

39. Chembl2104501

40. Dtxsid5046726

41. Chebi:31229

42. Hy-a0236a

43. Aprindine Hydrochloride [mi]

44. Tox21_112569

45. Tox21_501190

46. Aprindine Hydrochloride [jan]

47. Aprindine Hydrochloride [usan]

48. 1,3-propanediamine, N,n-diethyl-n'-2-indanyl-n'-phenyl-, Monohydrochloride

49. Akos015994694

50. Aprindine Hydrochloride (jp17/usan)

51. Tox21_112569_1

52. Aprindine Hydrochloride [mart.]

53. Ccg-222494

54. Ks-1222

55. Lp01190

56. Aprindine Hydrochloride [who-dd]

57. Ncgc00167576-02

58. Ncgc00261875-01

59. Smr001456520

60. Cs-0133610

61. D01326

62. Aprindine Hydrochloride, >=98% (hplc), Solid

63. J-019105

64. Q27286446

65. N1-(2,3-dihydro-1h-inden-2-yl)-n3,n3-diethyl-n1-phenylpropane-1,3-diamine Hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₃₁ClN₂
Molecular Weight	358.9 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Exact Mass	358.2175767 g/mol
Monoisotopic Mass	358.2175767 g/mol
Topological Polar Surface Area	6.5 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	332
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)