Apricoxib

Synopsis, Chemistry

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Also known as: 197904-84-0, Tg01, Cs-706, Tg-01, R-109339, 5x5hb3vz3z

Molecular Formula

C₁₉H₂₀N₂O₃S

Molecular Weight

356.4 g/mol

InChI Key

JTMITOKKUMVWRT-UHFFFAOYSA-N

FDA UNII

5X5HB3VZ3Z

Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.

1 2D Structure

Apricoxib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[2-(4-ethoxyphenyl)-4-methylpyrrol-1-yl]benzenesulfonamide

2.1.2 InChI

InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23)

2.1.3 InChI Key

JTMITOKKUMVWRT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOC1=CC=C(C=C1)C2=CC(=CN2C3=CC=C(C=C3)S(=O)(=O)N)C

2.2 Other Identifiers

2.2.1 UNII

5X5HB3VZ3Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(4-ethoxyphenyl)-4-methyl 1-(4-sulfamoylphenyl)-1h-pyrrole

2. Cs 706

3. Cs-706

4. Cs706 Cpd

2.3.2 Depositor-Supplied Synonyms

1. 197904-84-0

2. Tg01

3. Cs-706

4. Tg-01

5. R-109339

6. 5x5hb3vz3z

7. 4-[2-(4-ethoxyphenyl)-4-methylpyrrol-1-yl]benzenesulfonamide

8. 4-(2-(4-ethoxyphenyl)-4-methyl-1h-pyrrol-1-yl)benzenesulfonamide

9. Cs 706; R 109339; Tg 01

10. Benzenesulfonamide, 4-(2-(4-ethoxyphenyl)-4-methyl-1h-pyrrol-1-yl)-

11. Apricoxib [usan]

12. Apricoxib [usan:inn]

13. Unii-5x5hb3vz3z

14. Capoxigem

15. Kymena

16. Tg 01

17. Cs 706

18. Apricoxib [inn]

19. Apricoxib (usan/inn)

20. Cs706 Cpd

21. Apricoxib [who-dd]

22. Schembl346028

23. R 109339

24. Chembl1835207

25. Dtxsid60173502

26. Cs701

27. Db12378

28. Tp-1001

29. Tp-2001

30. D08657

31. Q18209480

32. 2-(4-ethoxyphenyl)-4-methyl-1-(4-sulfamoylphenyl)pyrrole

33. 4-methyl-2-(4-ethoxyphenyl)-1-(4-sulfamoylphenyl)pyrrole

34. 2-(4-ethoxyphenyl)-4-methyl 1-(4-sulfamoylphenyl)-1h-pyrrole

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₀N₂O₃S
Molecular Weight	356.4 g/mol
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	356.11946368 g/mol
Monoisotopic Mass	356.11946368 g/mol
Topological Polar Surface Area	82.7 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	517
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1