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AM20050421

AM20050421

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

6 API Suppliers, 4 USDMF, 3 NDC API, 4 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Formulations

4 Dossiers, 4 FDA Orange Book

DRUG PRODUCT COMPOSITION

CREAM;TOPICAL - EQ 85MG BASE/GM, FOR SOLUTION;TOPICAL - 5%

CREAM;TOPICAL - EQ 85MG BASE/GM
FOR SOLUTION;TOPICAL - 5%

RELATED EXCIPIENT COMPANIES

Suppliers, 2 Actylis, 2 BASF, 1 Nanjing Well Pharmaceutical, 1 Gangwal Chemicals, 1 Kerry, 1 Seppic

EXCIPIENTS BY APPLICATIONS

3 Parenteral, 3 Topical, 1 Controlled & Modified Release, 1 Lubricants & Glidants, 1 Granulation, 1 Direct Compression, 1 Coating Systems & Additives, 1 Surfactant & Foaming Agents, 1 Solubilizers, 1 Emulsifying Agents, 1 Thickeners and Stabilizers

GLOBAL SALES INFORMATION

14 US Medicaid Prescriptions

14 US Medicaid Prescriptions

MARKET PLACE

2 APIs, 1 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

2 USP Standards, 2 Other Ref. Standards

DIGITAL CONTENT

2 News

2 News

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JDMFs Filed

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API REF. PRICE (USD / KG)

373

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

1.00

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

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SERVICES

Also known as: 13009-99-9, 4-(aminomethyl)benzenesulfonamide acetate, Mafenamide acetate, Mafenide (acetate), Benzenesulfonamide, 4-(aminomethyl)-, monoacetate, Acetic acid;4-(aminomethyl)benzenesulfonamide

Molecular Formula

C₉H₁₄N₂O₄S

Molecular Weight

246.29 g/mol

InChI Key

UILOTUUZKGTYFQ-UHFFFAOYSA-N

FDA UNII

RQ6LP6Z0WY

A sulfonamide that inhibits the enzyme CARBONIC ANHYDRASE and is used as a topical anti-bacterial agent, especially in burn therapy.

1 2D Structure

AM20050421

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;4-(aminomethyl)benzenesulfonamide

2.1.2 InChI

InChI=1S/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)

2.1.3 InChI Key

UILOTUUZKGTYFQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(=O)O.C1=CC(=CC=C1CN)S(=O)(=O)N

2.2 Other Identifiers

2.2.1 UNII

RQ6LP6Z0WY

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4 Homosulfanilamide

2. 4-homosulfanilamide

3. Bensulfamide

4. Mafenide

5. Mafylon

6. Maphenid

7. Marfanil

8. Napaltan

9. Sulfabenzamine

10. Sulfamylon

2.3.2 Depositor-Supplied Synonyms

1. 13009-99-9

2. 4-(aminomethyl)benzenesulfonamide Acetate

3. Mafenamide Acetate

4. Mafenide (acetate)

5. Benzenesulfonamide, 4-(aminomethyl)-, Monoacetate

6. Acetic Acid;4-(aminomethyl)benzenesulfonamide

7. Mafatate

8. Rq6lp6z0wy

9. Maphenide Acetate

10. Winthrocine

11. Sulfamilon

12. Alpha-amino-p-toluenesulfonamide

13. Alpha-amino-p-toluenesulfonamide Monoacetate

14. 4-(aminomethyl)benzenesulfonamide Monoacetate

15. Alpha-aminotoluene-4-sulphonamide Monoacetate

16. Einecs 235-855-0

17. Unii-rq6lp6z0wy

18. Mafenide Acetate [usp:jan]

19. Sulfamylon (tn)

20. Mfcd00072089

21. Mafenide Acetate Salt

22. P-toluenesulfonamide, Alpha-amino-, Monoacetate

23. Schembl41627

24. Mafenide Acetate (jan/usp)

25. Mls000069581

26. Mafenide Acetate [mi]

27. Mafenide Acetate [jan]

28. Benzenesulfonamide, 4-(aminomethyl)-, Acetate (1:1)

29. Chembl1201161

30. Mafenide Acetate [vandf]

31. Chebi:31792

32. Hy-b0614a

33. Dtxsid00156334

34. Mafenide Acetate [mart.]

35. Mafenide Acetate [usp-rs]

36. Mafenide Acetate [who-dd]

37. Hms2231m06

38. Hms3259n08

39. Hms3370m14

40. Bcp28537

41. S3647

42. Mafenide Acetate [green Book]

43. Akos000121908

44. Mafenide Acetate [orange Book]

45. Ccg-266920

46. Ds-2178

47. Nc00709

48. 4-(aminomethyl)benzenesulfonimideacetate

49. Mafenide Acetate [usp Monograph]

50. Ac-22835

51. Smr000058778

52. 4-(aminomethyl)benzenesulfonamide (acetate)

53. Db-041939

54. Am20050421

55. Ft-0630395

56. D01166

57. 4-(aminomethyl)benzene-1-sulfonamide; Acetic Acid

58. A806018

59. W-108356

60. .alpha.-amino-p-toluenesulfonamide Monoacetate

61. Q27288250

62. Mafenide Acetate; 4-(aminomethyl)-benzenesulfoamide Monoacetate

63. Mafenide Acetate, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₉H₁₄N₂O₄S
Molecular Weight	246.29 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	246.06742811 g/mol
Monoisotopic Mass	246.06742811 g/mol
Topological Polar Surface Area	132 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	255
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Mafenide acetate
Drug Label	Mafenide acetate, USP is a synthetic antimicrobial agent designated chemically as -amino-p-toluenesulfonamide monoacetate. It has the following structural formula:C7H10N2O2SC2H4O2 M.W. 246.29 C7H10N2O2SC2H4O2 M.W. 246.29 Mafenide acetate, USP...
Active Ingredient	Mafenide acetate
Dosage Form	For solution
Route	Topical
Strength	5%
Market Status	Prescription
Company	Par Form

2 of 2
Drug Name	Mafenide acetate
Drug Label	Mafenide acetate, USP is a synthetic antimicrobial agent designated chemically as -amino-p-toluenesulfonamide monoacetate. It has the following structural formula:C7H10N2O2SC2H4O2 M.W. 246.29 C7H10N2O2SC2H4O2 M.W. 246.29 Mafenide acetate, USP...
Active Ingredient	Mafenide acetate
Dosage Form	For solution
Route	Topical
Strength	5%
Market Status	Prescription
Company	Par Form

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Carbonic Anhydrase Inhibitors

A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES. (See all compounds classified as Carbonic Anhydrase Inhibitors.)

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Methylated Sulfonamides [EXT]; Methylated Sulfonamide Antibacterial [EPC]