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1. Acid Blue 9
2. Blue 4
3. Blue No. 1
4. Brilliant Blue
5. Brilliant Blue Al (3:1) Salt
6. Brilliant Blue Diammonium Salt
7. Brilliant Blue Dipotassium Salt
8. Brilliant Blue Fcf, Diammonium Salt
9. Brilliant Blue Potassium, Sodium Salt
10. Brilliant Blue, Aluminium Salt
11. Brilliant Blue, Disodium Salt
12. C.i. 42090
13. Caries Check Blue
14. Ci 42090
15. D And C Blue No.4
16. Dc Blue No. 4
17. Erioglaucine
18. F D And C Blue #1
19. Fd And C Blue No.1
20. Food Blue 2
1. 3844-45-9
2. Acid Blue 9
3. Brilliant Blue
4. Erioglaucine Disodium Salt
5. Fd&c Blue No. 1
6. Erioglaucine
7. Alphazurine Fg
8. Blue 1206
9. Food Blue No. 1
10. Fd & C Blue No. 1
11. Dolkwal Brilliant Blue
12. Acid Sky Blue A
13. Hexacol Brilliant Blue A
14. Brilliant Blue Fcf Supra
15. Fd And C Blue No. 1
16. C.i. Food Blue 2
17. Food Blue 1
18. C.i. Acid Blue 9, Disodium Salt
19. Usacert Blue No. 1
20. Chebi:82411
21. 1206 Blue
22. Canacert Brilliant Blue Fcf
23. Ppq093m8hr
24. Fd&c Blue 1
25. Benzenemethanaminium, N-ethyl-n-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(2-sulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-3-sulfo-, Hydroxide, Inner Salt, Disodium Salt
26. Chembl3184128
27. Acid Blue 9;fd&c Blue No. 1;e133
28. Fenazo Blue Xi
29. Merantine Blue Eg
30. Benzenemethanaminium, N-ethyl-n-[4-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl](2-sulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-3-sulfo-, Inner Salt, Disodium Salt
31. Cosmetic Blue Lake
32. Blue No. 1
33. Japan Blue No. 1
34. Intracid Pure Blue L
35. Fdc Blue No. 1
36. Erioglaucin A
37. Food Blue Dye No. 1
38. Modr Kysela 9 [czech]
39. Aizen Food Blue No. 2
40. Ccris 97
41. Modr Kysela 9
42. Benzenemethanaminium, N-ethyl-n-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(2-sulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-3-sulfo-, Inner Salt, Disodium Salt
43. Benzenemethanaminium, N-ethyl-n-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(2-sulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-3-sulfo-, Inner Salt, Sodium Salt (1:2)
44. Disodium 2-{(z)-(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)[(4z)-4-{ethyl[(3-sulfonatophenyl)methyl]iminio}cyclohexa-2,5-dien-1-ylidene]methyl}benzenesulfonate
45. Disodium;2-[[4-[ethyl-[(3-sulfonatophenyl)methyl]amino]phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]benzenesulfonate
46. Modr Brilantni Fcf [czech]
47. Food Blue No.1
48. Modr Brilantni Fcf
49. Modr Potravinarska 2 [czech]
50. Modr Potravinarska 2
51. Usacert Fd And C Blue No. 1
52. Brilliant Blue Fcf, Disodium Salt
53. Brilliant Blue E 133
54. D&c Blue No. 1
55. E133
56. Einecs 223-339-8
57. Mfcd00012141
58. Unii-h3r47k3tbd
59. Unii-ppq093m8hr
60. Hsdb 7972
61. 8-(phenylamino)-5-[(e)-{4-[(e)-(3-sulfophenyl)diazenyl]naphthalen-1-yl}diazenyl]naphthalene-1-sulfonic Acid
62. Fd&c Blue #1
63. Dsstox_cid_189
64. Dsstox_rid_75422
65. H3r47k3tbd
66. Dsstox_gsid_20189
67. Schembl124486
68. Dtxsid2020189
69. Amy22374
70. Tox21_300516
71. Bdbm50574568
72. Akos037643360
73. Ncgc00254363-01
74. Ammonium, Ethyl(4-(p-(ethyl(m-sulfobenzyl)amino)-alpha-(o-sulfophenyl)benzylidene)-2,5-cyclohexadien-1-ylidene)(m-sulfobenzyl)-, Hydroxide, Inner Salt, Disodium Salt
75. As-15303
76. Dihydrogen (ethyl)(4-(4-(ethyl(3-sulphonatobenzyl)amino)-2'-sulphonatobenzhydrylidene)cyclohexa-2,5-dien-1-ylidene)(3-sulphonatobenzyl)ammonium, Disodium Salt
77. Cas-3844-45-9
78. B0790
79. F0147
80. Ft-0625694
81. C19352
82. D88693
83. Q420093
84. Disodium N-ethyl-n-4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(2-sulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-3-sulfobenzenemethanaminium
85. Disodium Salt Of Ethyl(4-(p-(ethyl(m-sulfobenzyl)amino)-(alpha)-(o-sulfophenyl) Benzylidene)-2,5-cyclohexadien-1-ylidene)(m-sulfobenzyl) Ammonium Hydroxide Inner Salt
86. N-ethyl-n-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(2-sulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-3-sulfobenzeneme- Thanaminium Hydroxide, Inner Salt, Disodium Salt
87. N-ethyl-n-4-4-ethyl(3-sulfophenyl)methylaminophenyl(2-sulfophenyl)methylene-2,5-cyclohexadien-1-ylidene-3-sulfo-benzenemethanaminium Inner Salt, Disodium Salt
88. Sodium 2-((4-(ethyl(3-sulfonatobenzyl)amino)phenyl)(4-(ethyl(3-sulfonatobenzyl)iminio)cyclohexa-2,5-dien-1-ylidene)methyl)benzenesulfonate
89. Sodium 2-((e)-(4-(ethyl(3-sulfonatobenzyl)amino)phenyl)((e)-4-(ethyl(3-sulfonatobenzyl)iminio)cyclohexa-2,5-dienylidene)methyl)benzenesulfonate
| Molecular Weight | 792.9 g/mol |
|---|---|
| Molecular Formula | C37H34N2Na2O9S3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 9 |
| Exact Mass | 792.12218275 g/mol |
| Monoisotopic Mass | 792.12218275 g/mol |
| Topological Polar Surface Area | 203 Ų |
| Heavy Atom Count | 53 |
| Formal Charge | 0 |
| Complexity | 1510 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 3 |
Coloring Agents
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)
The absorption, metabolism and excretion of (14)C-labelled Green S and Brilliant Blue FCF have been studied in the rat, mouse and guinea-pig. Following administration of a single oral dose of Green S at either 100 ug/kg or 10 mg/kg of Brilliant Blue FCF at either 30 ug/kg or 3 mg/kg to male or female rats, substantially all of the dose was excreted unchanged in the feces within 72 hr. Pretreating male rats with unlabelled Green S or Brilliant Blue FCF in the diet (100 or 30 mg/kg day, respectively) for 21 days prior to dosing with (14)C-labelled coloring had no effect on the route of excretion or the time taken to eliminate all of the label. Similarly male mice and guinea-pigs excreted in the feces all of a single oral dose of Green S or Brilliant Blue FCF. The lack of absorption and metabolism of the labelled dye in the gastro-intestinal tract of all three species investigated was confirmed by studies using isolated loops of small intestine. It was shown that no radioactivity was taken up by the fetuses of pregnant rats given (14)C-labelled Green S or Brilliant Blue FCF.
Phillips JC et al; Food and Cosmetics Toxicology 18 (1): 7-13 (1980)
Female Sprague-Dawley rats were given a single dose (0.27 mg; 1.74 uCi) of the (14)C-labelled coloring by gavage. In bile-duct ligated rats, intestinal absorption of FD & C Blue No.1 (estimated from urinary (14)C excretion, expired (14)CO2 and residual radioactivity in internal organs and tissues 96 hr after oral administration) averaged 2.05% of the dose. Mean fecal excretion was 97.28% and the total recovery of administered radioactivity was 99.38%. Intestinal absorption (14)C-FD & C Blue No. 1 in intact rats averaged only 0.27% (91% recovery), while biliary excretion in bile-duct cannulated animals averaged 1.32% of the dose. Thin-layer chromatography of urine and bile samples revealed that about 95% of excreted radioactivity was unaltered FD & C Blue No. 1 and that about 5% was an unidentified metabolite or degradation product of FD & C Blue No. 1. The results show that FD & C Blue No.1 is poorly absorbed from the gastro-intestinal tract, and undergoes subsequent rapid and complete biliary excretion /of the absorbed compound/.
Brown JP et al; Food and Cosmetics Toxicology 18 (1): 1-5(1980)
... Less than 0.05% of a labeled dose of 3 mg/kg bw was excreted in the bile of rats over a 5-hour period. Very little radioactivity (0.004 - 0.006% of dose) was detected on day 11 in the fetuses of pregnant rats given (14)C-labelled Brilliant Blue FCF orally on day 8 of gestation. ... Brilliant Blue FCF was labeled with (14)C in the central methane ring and had a radioactive purity of greater than 95%. ...
European Food Safety Authority (EFSA); Scientific Opinion of the ANS Panel on the re-evaluation of Brilliant Blue FCF (E 133) Published: 22 November 2010 Available from, as of July 1, 2011: https://www.efsa.europa.eu/en/publications.htm
Following administration of either 30 ug/kg bw or 3 mg/kg bw of (14)C-Brilliant Blue FCF by gavage to male or female rats, substantially all of the dose was excreted unchanged in the feces within 72 hours (99.9% at low dose, 95.4% at high dose). No radioactivity was detected in the expired air and less than 0.5% was detected in the urine. ...
European Food Safety Authority (EFSA); Scientific Opinion of the ANS Panel on the re-evaluation of Brilliant Blue FCF (E 133) Published: 22 November 2010 Available from, as of July 1, 2011: https://www.efsa.europa.eu/en/publications.htm
For more Absorption, Distribution and Excretion (Complete) data for Brilliant Blue (6 total), please visit the HSDB record page.
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