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Alysine
Also known as: 54-21-7, Sodium 2-hydroxybenzoate, Enterosalicyl, Kerasalicyl, Clin, Alysine
Molecular Formula
C7H5NaO3
Molecular Weight
160.10  g/mol
InChI Key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
FDA UNII
WIQ1H85SYP

A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
1 2D Structure

Alysine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;2-hydroxybenzoate
2.1.2 InChI
InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
2.1.3 InChI Key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
2.2 Other Identifiers
2.2.1 UNII
WIQ1H85SYP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Salicylate, Sodium

2.3.2 Depositor-Supplied Synonyms

1. 54-21-7

2. Sodium 2-hydroxybenzoate

3. Enterosalicyl

4. Kerasalicyl

5. Clin

6. Alysine

7. Salsonin

8. Benzoic Acid, 2-hydroxy-, Monosodium Salt

9. Enterosalil

10. Entrosalyl

11. Glutosalyl

12. Magsalyl

13. Aroall

14. Kerosal

15. Nadisal

16. Salisod

17. Idocyl Novum

18. Neo-salicyl

19. Natrum Salicylicum

20. Monosodium Salicylate

21. Salicylic Acid Sodium Salt

22. Diuretin

23. Parbocyl-rev

24. Sodium;2-hydroxybenzoate

25. Salicylate Sodium

26. Salicylic Acid, Sodium Salt

27. Sodium O-hydroxybenzoate

28. Salicylic Acid Sodium

29. Wiq1h85syp

30. O-hydroxybenzoic Acid, Sodium Salt

31. Chebi:9180

32. Nsc-202167

33. 90218-97-6

34. Benzoic Acid, 2-hydroxy-, Monosodium Salt, Coupled With 4-amino-1-naphthalenesulfonic Acid And Diazotized 2-(4-aminophenyl)-1h-benzimidazol-5-amine, Sodium Salt

35. Salicylic Acid Sodium Salt;2-hydroxybenzoic Acid Sodium Salt

36. Natrium Salicylat [german]

37. Ccris 6715

38. Einecs 200-198-0

39. Unii-wiq1h85syp

40. Nsc 202167

41. Sodium Salicylate [usp:jan]

42. Natrii Salicylas

43. Mfcd00002440

44. Sodium;2-carboxyphenolate

45. Sodium Salicylate, 99%

46. Spectrum2_001945

47. Spectrum3_000900

48. Spectrum4_000995

49. Spectrum5_001120

50. Dsstox_cid_1708

51. Ec 200-198-0

52. Schembl4603

53. Dsstox_rid_76287

54. Dsstox_gsid_21708

55. Kbiogr_001429

56. 90218-94-3

57. Spectrum1500533

58. Spbio_002009

59. Chembl447868

60. Sodium Salicylate [jan]

61. Dtxsid5021708

62. Sodium Salicylate (jp17/usp)

63. Sodium Salicylate [inci]

64. Hy-b0167a

65. Kbio3_001820

66. Natrum Salicylicum [hpus]

67. Sodium Salicylate [vandf]

68. Sodium Salicylate [mart.]

69. Hms1920p16

70. Hms2092g17

71. Salicylate Sodium [who-dd]

72. Sodium Salicylate [usp-rs]

73. Sodium Salicylate [who-ip]

74. Sodium Salicylate, P.a., 99.5%

75. Tox21_200411

76. 2-hydroxy Benzoic Acid, Sodium Salt

77. Ccg-39474

78. Akos003051698

79. Akos005766021

80. Cs-2008

81. Cas-54-21-7

82. Natrii Salicylas [who-ip Latin]

83. Salicylic Acid Sodium Salt [mi]

84. Sodium Salicylate [ep Monograph]

85. Ncgc00094780-01

86. Ncgc00094780-02

87. Ncgc00257965-01

88. Sodium Salicylate [usp Monograph]

89. Db-052516

90. Ft-0631235

91. C07587

92. D00566

93. D83111

94. Sodium Salicylate, Reagentplus(r), >=99.5%

95. Sodium Salicylate, Saj First Grade, >=99.5%

96. Sodium Salicylate, Tested According To Ph.eur.

97. Sodium Salicylate, Saj Special Grade, >=99.5%

98. 2,4-dimethoxyphenylboronicacid,pinacolester

99. Q414547

100. Sodium Salicylate, Vetec(tm) Reagent Grade, 99%

101. Sodium Salicylate, Meets Usp Testing Specifications

102. Sodium Salicylate, Puriss. P.a., >=99.5% (nt)

103. Sodium Salicylate, European Pharmacopoeia (ep) Reference Standard

104. Sodium Salicylate, United States Pharmacopeia (usp) Reference Standard

105. Benzoic Acid,2-hydroxy-,monosodium Salt,coupled With 4-amino-5-hydroxy-2,7-naphthalenedisulfonic Acid,diazotized 2-(4-aminophenyl)-1h-benzimidazol-5-amine And Diazotized 4-nitrobenzenamine,sodium

106. Sodium Salicylate, Puriss. P.a., Reag. Ph. Eur., 99.5-101.0% (calc. To The Dried Substance)

2.4 Create Date
2007-11-13
3 Chemical and Physical Properties
Molecular Weight 160.10 g/mol
Molecular Formula C7H5NaO3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass160.01363830 g/mol
Monoisotopic Mass160.01363830 g/mol
Topological Polar Surface Area60.4 Ų
Heavy Atom Count11
Formal Charge0
Complexity138
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)


4.2 ATC Code

N - Nervous system

N02 - Analgesics

N02B - Other analgesics and antipyretics

N02BA - Salicylic acid and derivatives

N02BA04 - Sodium salicylate


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