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1. Db11573
2. Q27280046
| Molecular Weight | 192.47 g/mol |
|---|---|
| Molecular Formula | Al2ClH7O6 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 0 |
| Exact Mass | 191.956192 g/mol |
| Monoisotopic Mass | 191.956192 g/mol |
| Topological Polar Surface Area | 6 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 0 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 9 |
Indicated for use as an antiperspirant.
Aluminum chlorohydrate serves to reduce excessive sweating by directly blocking the sweat ducts.
Absorption
Penetration of aluminum chlorohydrate following dermal application is minimal, with the rate being around 0.01% and up to 0.06% in pre-damaged skin. In a preliminary study, dermally applied aluminium chlorohydrate displayed 0.012% of the applied aluminium being absorbed through the skin, which accounts for 4 mcg of aluminum following a single dermal application. This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period.
Route of Elimination
No pharmacokinetic information available.
Volume of Distribution
No pharmacokinetic information available.
Clearance
No pharmacokinetic information available.
No pharmacokinetic information available.
No pharmacokinetic information available.
Aluminum salts plug eccrine sweat pores and forms aggregates with swear proteins that bind to the wall of the sweat duct and form a tenuous membrane.
Market Place
