Find Alrizomadlin manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Alrizomadlin, Aa-115, 1818393-16-6, 15qau0si9j, Apg-115, Apg115
Molecular Formula
C34H38Cl2FN3O4
Molecular Weight
642.6  g/mol
InChI Key
YJCZPJQGFSSFOL-MNZPCBJKSA-N
FDA UNII
15QAU0SI9J

Alrizomadlin
Alrizomadlin is an orally available inhibitor of human homolog of double minute 2 (HDM2; mouse double minute 2 homolog; MDM2), with potential antineoplastic activity. Upon oral administration,alrizomadlin binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This may result in the restoration of p53 signaling and lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and a negative regulator of the p53 pathway, is often overexpressed in cancer cells. It has been implicated in cancer cell proliferation and survival.
1 2D Structure

Alrizomadlin

2 Identification
2.1 Computed Descriptors
2.1.1 InChI
InChI=1S/C34H38Cl2FN3O4/c1-2-40-27(28(41)39-32-16-13-31(14-17-32,15-18-32)30(43)44)25(21-7-6-8-23(36)26(21)37)34(33(40)11-4-3-5-12-33)22-10-9-20(35)19-24(22)38-29(34)42/h6-10,19,25,27H,2-5,11-18H2,1H3,(H,38,42)(H,39,41)(H,43,44)/t25-,27+,31?,32?,34+/m0/s1
2.1.2 InChI Key
YJCZPJQGFSSFOL-MNZPCBJKSA-N
2.1.3 Canonical SMILES
CCN1C(C(C2(C13CCCCC3)C4=C(C=C(C=C4)Cl)NC2=O)C5=C(C(=CC=C5)Cl)F)C(=O)NC67CCC(CC6)(CC7)C(=O)O
2.1.4 Isomeric SMILES
CCN1[C@H]([C@@H]([C@]2(C13CCCCC3)C4=C(C=C(C=C4)Cl)NC2=O)C5=C(C(=CC=C5)Cl)F)C(=O)NC67CCC(CC6)(CC7)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
15QAU0SI9J
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Alrizomadlin

2. Aa-115

3. 1818393-16-6

4. 15qau0si9j

5. Apg-115

6. Apg115

7. Apg 115 [who-dd]

8. Chembl4091801

9. 4-((3'r,4's,5'r)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid

10. (3'r,4's,5'r)-4-((6-chloro-2-oxo-1,2-dihydro-spiro(indole-3,3'-pyrrolidin)e-4'-(3-chloro-2-fluoro -phenyl)-1'-ethyl-spiro(cyclohexane-1,2'-pyrrolidine)-5'-carbonyl)-amino)-bicyclo(2.2.2)octane-1-carboxylic Acid

11. Alrizomadlin [inn]

12. Unii-15qau0si9j

13. Schembl17189805

14. Bdbm50237739

15. Mfcd32197175

16. Nsc831270

17. Nsc-831270

18. Hy-101518

19. Cs-0021621

2.4 Create Date
2015-11-02
3 Chemical and Physical Properties
Molecular Weight 642.6 g/mol
Molecular Formula C34H38Cl2FN3O4
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass641.2223403 g/mol
Monoisotopic Mass641.2223403 g/mol
Topological Polar Surface Area98.7 Ų
Heavy Atom Count44
Formal Charge0
Complexity1160
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 1818393-16-6 / Alrizomadlin API manufacturers, exporters & distributors?

Alrizomadlin manufacturers, exporters & distributors 1

52

PharmaCompass offers a list of Alrizomadlin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Alrizomadlin manufacturer or Alrizomadlin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Alrizomadlin manufacturer or Alrizomadlin supplier.

PharmaCompass also assists you with knowing the Alrizomadlin API Price utilized in the formulation of products. Alrizomadlin API Price is not always fixed or binding as the Alrizomadlin Price is obtained through a variety of data sources. The Alrizomadlin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Alrizomadlin

Synonyms

Aa-115, 1818393-16-6, 15qau0si9j, Apg-115, Apg115, Apg 115 [who-dd]

Cas Number

1818393-16-6

Unique Ingredient Identifier (UNII)

15QAU0SI9J

About Alrizomadlin

Alrizomadlin is an orally available inhibitor of human homolog of double minute 2 (HDM2; mouse double minute 2 homolog; MDM2), with potential antineoplastic activity. Upon oral administration,alrizomadlin binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This may result in the restoration of p53 signaling and lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and a negative regulator of the p53 pathway, is often overexpressed in cancer cells. It has been implicated in cancer cell proliferation and survival.

Alrizomadlin Manufacturers

A Alrizomadlin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Alrizomadlin, including repackagers and relabelers. The FDA regulates Alrizomadlin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Alrizomadlin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Alrizomadlin Suppliers

A Alrizomadlin supplier is an individual or a company that provides Alrizomadlin active pharmaceutical ingredient (API) or Alrizomadlin finished formulations upon request. The Alrizomadlin suppliers may include Alrizomadlin API manufacturers, exporters, distributors and traders.

Alrizomadlin GMP

Alrizomadlin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Alrizomadlin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Alrizomadlin GMP manufacturer or Alrizomadlin GMP API supplier for your needs.

Alrizomadlin CoA

A Alrizomadlin CoA (Certificate of Analysis) is a formal document that attests to Alrizomadlin's compliance with Alrizomadlin specifications and serves as a tool for batch-level quality control.

Alrizomadlin CoA mostly includes findings from lab analyses of a specific batch. For each Alrizomadlin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Alrizomadlin may be tested according to a variety of international standards, such as European Pharmacopoeia (Alrizomadlin EP), Alrizomadlin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Alrizomadlin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty