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Chemistry

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Also known as: 86386-73-4, Diflucan, Triflucan, Biozolene, Elazor, Biocanol
Molecular Formula
C13H12F2N6O
Molecular Weight
306.27  g/mol
InChI Key
RFHAOTPXVQNOHP-UHFFFAOYSA-N
FDA UNII
8VZV102JFY

Fluconazole
Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
Fluconazole is an Azole Antifungal. The mechanism of action of fluconazole is as a Cytochrome P450 2C19 Inhibitor, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor.
1 2D Structure

Fluconazole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
2.1.2 InChI
InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
2.1.3 InChI Key
RFHAOTPXVQNOHP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
2.2 Other Identifiers
2.2.1 UNII
8VZV102JFY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apo Fluconazole

2. Apo-fluconazole

3. Bagyne

4. Diflucan

5. Fluc Hexal

6. Flucobeta

7. Flucolich

8. Fluconazol Abz

9. Fluconazol Al

10. Fluconazol Isis

11. Fluconazol Ratiopharm

12. Fluconazol Stada

13. Fluconazol Von Ct

14. Fluconazol-isis

15. Fluconazol-ratiopharm

16. Flunazul

17. Fungata

18. Lavisa

19. Loitin

20. Neofomiral

21. Oxifungol

22. Solacap

23. Triflucan

24. Uk 49858

25. Uk-49858

26. Uk49858

27. Zonal

2.3.2 Depositor-Supplied Synonyms

1. 86386-73-4

2. Diflucan

3. Triflucan

4. Biozolene

5. Elazor

6. Biocanol

7. Fluconazol

8. Fungata

9. Zoltec

10. Fluconazolum

11. Flucostat

12. Difluconazole

13. 2-(2,4-difluorophenyl)-1,3-di(1h-1,2,4-triazol-1-yl)propan-2-ol

14. 2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)propan-2-ol

15. Uk 49858

16. Uk-49858

17. 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol

18. Alkanazole

19. Flucazol

20. Fluconazole [usan]

21. 123631-92-5

22. Pritenzol

23. Flukezol

24. Flunizol

25. Zonal

26. Chembl106

27. Nsc-758661

28. 2-(2,4-difluorophenyl)-1,3-bis(1h-1,2,4-triazol-1-yl)-2-propanol

29. 8vzv102jfy

30. 2,4-difluoro-alpha,alpha-bis(1h-1,2,4-triazol-1-ylmethyl)benzyl Alcohol

31. 1h-1,2,4-triazole-1-ethanol, Alpha-(2,4-difluorophenyl)-alpha-(1h-1,2,4-triazol-1-ylmethyl)-

32. Uk-49,858

33. Alflucoz

34. Cryptal

35. Dimycon

36. Oxifugol

37. Canzol

38. Chebi:46081

39. Forcan

40. Syscan

41. Baten

42. Mutum

43. Zemyc

44. 2-(2,4-difluorophenyl)-1,3-di-1h-1,2,4-triazol-1-ylpropan-2-ol

45. Bayt006267

46. Bayt-006267

47. Alpha-(2,4-difluorophenyl)-alpha-(1h-1,2,4-triazol-1-ylmethyl)-1h-1,2,4-triazole-1-ethanol

48. Ncgc00095089-01

49. Flunazol

50. Fluconazol [spanish]

51. Fluconazolum [latin]

52. Loitin

53. Dsstox_cid_627

54. 2-(2,4-difluoro-phenyl)-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol

55. Dsstox_rid_75701

56. Dsstox_gsid_20627

57. Flc

58. Drg-0005

59. Diflazon

60. Fuconal

61. Triconal

62. Trican

63. 2-(2,4-difluorfenyl)-1,3-bis(1h-1,2,4-triazool-1-yl)propaan-2-ol

64. Diflucan (tn)

65. Smr000471882

66. Cas-86386-73-4

67. Flcz

68. Ccris 7211

69. Fluconazole & Hgcsf

70. Diflucan In Sodium Chloride 0.9%

71. Hsdb 7420

72. Sr-01000765440

73. Fluconazole In Sodium Chloride 0.9%

74. Unii-8vzv102jfy

75. Diflucan In Dextrose 5% In Plastic Container

76. Fluconazoli

77. Flucoral

78. Fluconazole & Mc-510,011

79. Fluconazole (f)

80. Fluconazole,(s)

81. 2,4-difluoro-,1-bis(1h-1,2,4-triazol-1-ylmethyl)benzyl Alcohol

82. Fluconazole In Dextrose 5% In Plastic Container

83. 2,4-difluoro-alpha,alpha-1-bis(1h-1,2,4-triazol-1-ylmethyl)benzyl Alcohol

84. Fluconazole- Bio-x

85. Fluzon [antifungal]

86. Mfcd00274549

87. Ks-1059

88. Fluconazole [usan:usp:inn:ban:jan]

89. Fluconazole In Sodium Chloride 0.9% In Plastic Container

90. Fluconazole In Combination With Mgcd290

91. Spectrum_001654

92. Diflucan In Sodium Chloride 0.9% In Plastic Container

93. Fluconazole [mi]

94. Spectrum2_001607

95. Spectrum3_001912

96. Spectrum4_000090

97. Spectrum5_001277

98. Fluconazole [inn]

99. Fluconazole [jan]

100. F0677

101. Fluconazole [hsdb]

102. Mgcd290 And Fluconazole

103. Fluconazole [vandf]

104. Cid_3365

105. Mg-3290 And Fluconazole

106. Schembl3151

107. Fluconazole [mart.]

108. Bspbio_003504

109. Fluconazole [usp-rs]

110. Fluconazole [who-dd]

111. Fluconazole [who-ip]

112. Kbiogr_000360

113. Kbioss_002134

114. Mls001066394

115. Mls001165780

116. Mls001195645

117. Mls001304713

118. Mls001306492

119. Mls006011884

120. Bidd:gt0799

121. Divk1c_001030

122. Spectrum1503975

123. Spbio_001613

124. Zinc4009

125. Fluconazole (jp17/usp/inn)

126. Dtxsid3020627

127. Bdbm25817

128. Hms503m21

129. Kbio1_001030

130. Kbio2_002134

131. Kbio2_004702

132. Kbio2_007270

133. Kbio3_003009

134. Fluconazole [orange Book]

135. Ninds_001030

136. Fluconazole [ep Monograph]

137. Hms1922o10

138. Hms2090i20

139. Hms2093m21

140. Hms2230o22

141. Hms3259h13

142. Hms3373i19

143. Hms3654p15

144. Hms3715f21

145. Hms3748g19

146. Pharmakon1600-01503975

147. Fluconazole [usp Monograph]

148. Fluconazoli [who-ip Latin]

149. Amy23415

150. Bcp28522

151. Fluconazole 2.0 Mg/ml In Methanol

152. Hy-b0101

153. 1,2,4-triazol-1-yl)propan-2-ol

154. Tox21_111419

155. Tox21_202240

156. Tox21_300581

157. Ac-428

158. Bbl005614

159. Ccg-39065

160. Dl-407

161. Fluconazole & Human Recombinant Granulocyte Colony Stimulating Factor

162. Nsc754343

163. Nsc758661

164. S1331

165. Stk619301

166. Akos000280854

167. Tox21_111419_1

168. Cs-1835

169. Db00196

170. Fluconazole 100 Microg/ml In Methanol

171. Fluconazole, >=98% (hplc), Powder

172. Nc00650

173. Nsc 758661

174. Nsc-754343

175. Idi1_001030

176. Ncgc00095089-02

177. Ncgc00095089-04

178. Ncgc00095089-05

179. Ncgc00095089-06

180. Ncgc00095089-07

181. Ncgc00095089-08

182. Ncgc00095089-09

183. Ncgc00095089-10

184. Ncgc00095089-11

185. Ncgc00254412-01

186. Ncgc00259789-01

187. 2-(2,4-difluorophenyl)-1,3-di(1h-

188. Bf164466

189. Fluconazole 100 Microg/ml In Acetonitrile

190. Sbi-0051880.p002

191. Uk-049858

192. Ft-0626437

193. Sw199616-2

194. En300-53634

195. C07002

196. D00322

197. Ab00052399-07

198. Ab00052399-08

199. Ab00052399_09

200. Ab00052399_10

201. 386f734

202. A841625

203. Q411478

204. Q-201120

205. Sr-01000765440-2

206. Sr-01000765440-4

207. Sr-01000765440-8

208. Uk-49858;uk 49858;uk49858

209. Brd-k05977355-001-02-6

210. Brd-k05977355-001-09-1

211. F2173-0496

212. Z235354561

213. Fluconazole, European Pharmacopoeia (ep) Reference Standard

214. 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)-2-propanol

215. Fluconazole, United States Pharmacopeia (usp) Reference Standard

216. 2-[2,4-bis(fluoranyl)phenyl]-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol

217. Fluconazole, Pharmaceutical Secondary Standard; Certified Reference Material

218. 2,4-difluoro-1',1'-bis(1h-1,2,4-triazol-1-ylmethyl)benzyl Alcohol

219. A-(2,4-difluorophenyl)-a-(1h-1,2,4-triazol-1- Ylmethyl)-1h-1,2,4-triazole-1-ethanol

220. Fluconazole For Peak Identification, European Pharmacopoeia (ep) Reference Standard

221. Fluconazole Solution, 2.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

222. .alpha.-(2,4-difluorophenyl)-.alpha.-(1h-1,2,4-triazol-1-ylmethyl)-1h-1,2,4-triazole-1-ethanol

223. 1h-1,2,4-triazole-1-ethanol, .alpha.-(2,4-difluorophenyl)-.alpha.-(1h-1,2,4-triazol-1-ylmethyl)-

224. 1h-1,2,4-triazole-1-ethanol, 1-(2,4-difluorophenyl)-1-(1h-1,2,4-triazol-1-ylmethyl)-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 306.27 g/mol
Molecular Formula C13H12F2N6O
XLogP30.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass306.10406535 g/mol
Monoisotopic Mass306.10406535 g/mol
Topological Polar Surface Area81.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity358
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameDiflucan
PubMed HealthFluconazole
Drug ClassesAntifungal
Drug LabelDIFLUCAN (fluconazole), the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration, as a powder for oral suspension, and as a sterile solution for intravenous use in glass and in Viaflex P...
Active IngredientFluconazole
Dosage FormTablet; For suspension
RouteOral
Strength200mg/5ml; 200mg; 100mg; 50mg; 150mg; 50mg/5ml
Market StatusPrescription
CompanyPfizer

2 of 4  
Drug NameFluconazole
PubMed HealthFluconazole
Drug ClassesAntifungal
Drug LabelFluconazole USP, the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration. Fluconazole USP is designated chemically as 2,4-difluoro-,1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol wit...
Active IngredientFluconazole
Dosage FormTablet; For suspension
RouteOral
Strength200mg/5ml; 200mg; 150mg; 50mg/5ml; 100mg; 50mg
Market StatusPrescription
CompanyRanbaxy; Teva; Apotex; Aurobindo Pharma; Taro; Unique Pharm Labs; Roxane; Glenmark Generics; Ivax Sub Teva Pharms; Aurobindo Pharm; Dr Reddys Labs; Mylan

3 of 4  
Drug NameDiflucan
PubMed HealthFluconazole
Drug ClassesAntifungal
Drug LabelDIFLUCAN (fluconazole), the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration, as a powder for oral suspension, and as a sterile solution for intravenous use in glass and in Viaflex P...
Active IngredientFluconazole
Dosage FormTablet; For suspension
RouteOral
Strength200mg/5ml; 200mg; 100mg; 50mg; 150mg; 50mg/5ml
Market StatusPrescription
CompanyPfizer

4 of 4  
Drug NameFluconazole
PubMed HealthFluconazole
Drug ClassesAntifungal
Drug LabelFluconazole USP, the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration. Fluconazole USP is designated chemically as 2,4-difluoro-,1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol wit...
Active IngredientFluconazole
Dosage FormTablet; For suspension
RouteOral
Strength200mg/5ml; 200mg; 150mg; 50mg/5ml; 100mg; 50mg
Market StatusPrescription
CompanyRanbaxy; Teva; Apotex; Aurobindo Pharma; Taro; Unique Pharm Labs; Roxane; Glenmark Generics; Ivax Sub Teva Pharms; Aurobindo Pharm; Dr Reddys Labs; Mylan

4.2 Therapeutic Uses

Mesh Heading: Antifungal agents

National Library of Medicine, SIS; ChemIDplus Record for Fluconazole (86386-73-4). Available from, as of April 17, 2006: https://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp


MEDICATION: Antifungal; Orally active bistriazole antifungal agent

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 728-9


MEDICATION (VET): Used to treat systemic mycoses, particularly CNS-related conditions in dogs.

Milne, G.W.A. Veterinary Drugs: Synonyms and Properties. Ashgate Publishing Limited, Aldershot, Hampshire, England 2002., p. 80


Fluconazole ... /is/ indicated for the prophylaxis of febrile neutropenia in patients with hematologic malignancies. /NOT included in US product labeling/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 335


For more Therapeutic Uses (Complete) data for FLUCONAZOLE (16 total), please visit the HSDB record page.


4.3 Drug Warning

Although serious adverse hepatic effects have been reported only rarely with fluconazole, the possibility that these effects may occur during fluconazole therapy should be considered. Fluconazole therapy should be discontinued if signs and symptoms consistent with liver disease develop. If abnormal liver function test results occur during fluconazole therapy, the patient should be monitored for the development of more severe hepatic injury.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 507


Serious hepatic reactions (eg, necrosis, clinical hepatitis, cholestasis, fulminant hepatic failure) have been reported rarely in patients receiving fluconazole therapy. The manufacturer states that a clear relationship between these hepatic effects and daily dosage, duration of therapy, gender, or age has not been demonstrated. While hepatotoxicity usually has been reversible, fatalities have been reported. Fatalities principally have occurred in patients with serious underlying disease (eg, AIDS, malignancy) who were receiving fluconazole concomitantly with other drugs; however, at least one fatality involved an immunocompetent geriatric individual with renal impairment who developed fulminant hepatic necrosis within 10 days after fluconazole therapy was initiated.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 507


Mild, transient increases (1.5-3 times the upper limit of normal) in serum concentrations of AST (SGOT), ALT (SGPT), alkaline phosphatase, gamma-glutamyltransferase (GGT, gamma-glutamyl transpeptidase, GGTP), and bilirubin have been reported in about 5-7% of patients receiving fluconazole. In most reported cases, concentrations returned to pretreatment levels either during or after fluconazole therapy and were not associated with hepatotoxicity. However, higher increases in serum transaminase concentrations (8 or more times the upper limit of normal), which required discontinuance of the drug, have been reported in about 1% of patients receiving fluconazole. Any patient who develops abnormal liver function test results while receiving fluconazole should be closely monitored for the development of more severe hepatic injury.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 507


Because potentially fatal exfoliative skin disorders have been reported rarely in patients with a serious underlying disease receiving fluconazole, the possibility that these effects can occur should be considered. Immunocompromised patients (e.g., patients with HIV infections) who develop rash during fluconazole therapy should be monitored closely and the drug discontinued if the lesions progress.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 507


For more Drug Warnings (Complete) data for FLUCONAZOLE (17 total), please visit the HSDB record page.


4.4 Drug Indication

Fluconazole can be administered in the treatment of the following fungal infections: 1) Vaginal yeast infections caused by Candida 2) Systemic Candida infections 3) Both esophageal and oropharyngeal candidiasis 4) Cryptococcal meningitis 5) UTI (urinary tract infection) by Candida 6) Peritonitis (inflammation of the peritoneum) caused by Candida **A note on fungal infection prophylaxis** Patients receiving bone marrow transplantation who are treated with cytotoxic chemotherapy and/or radiation therapy may be predisposed to candida infections, and may receive fluconazole as prophylactic therapy. **A note on laboratory testing** Obtaining specimens for fungal culture and other important laboratory studies such as serology or pathology is advised before starting fluconazole therapy in order to isolate the organisms to be eliminated through treatment. It is permissible to start therapy before the results are available, however, adjusting the therapy once laboratory results confirm the causative organism may be necessary.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Fluconazole has been demonstrated to show fungistatic activity against the majority of strains of the following microorganisms, curing fungal infections: _Candida albicans, Candida glabrata (Many strains are intermediately susceptible), Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans_ This is achieved through steroidal inhibition in fungal cells, interfering with cell wall synthesis and growth as well as cell adhesion, thereby treating fungal infections and their symptoms. The fungistatic activity of fluconazole has also been shown in normal and immunocompromised animal models with both systemic and intracranial fungal infections caused by _Cryptococcus neoformans_ and for systemic infections caused by Candida albicans. It is important to note that resistant organisms have been found against various strains of organisms treated with fluconazole. This further substantiates the need to perform susceptibility testing when fluconazole is considered as an antifungal therapy. **A note on steroidal effects of fluconazole** There has been some concern that fluconazole may interfere with and inactivate human steroids/hormones due to the inhibition of hepatic cytochrome enzymes. Fluconazole has demonstrated to be more selective for _fungal_ cytochrome P-450 enzymes than for a variety of mammalian cytochrome P-450 enzymes. Fluconazole 50 mg administered daily for up to 28 days in individuals of reproductive age has been show to have no effect on testosterone plasma concentrations of males and plasma concentrations of steroids in females. A 200-400 mg dose of fluconazole showed no clinically relevant effect on steroid levels or on ACTH-stimulated steroid response in healthy males, in one clinical study mentioned on the European Medicines Agency label. Other studies have shown no significant effects of fluconazole on steroid levels, further confirming these data.


5.2 MeSH Pharmacological Classification

Cytochrome P-450 CYP2C19 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19. (See all compounds classified as Cytochrome P-450 CYP2C19 Inhibitors.)


14-alpha Demethylase Inhibitors

Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism. (See all compounds classified as 14-alpha Demethylase Inhibitors.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


Cytochrome P-450 CYP2C9 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C9. (See all compounds classified as Cytochrome P-450 CYP2C9 Inhibitors.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
FLUCONAZOLE
5.3.2 FDA UNII
8VZV102JFY
5.3.3 Pharmacological Classes
Azoles [CS]; Cytochrome P450 2C19 Inhibitors [MoA]; Cytochrome P450 2C9 Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; Azole Antifungal [EPC]
5.4 ATC Code

J02AC01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


D - Dermatologicals

D01 - Antifungals for dermatological use

D01A - Antifungals for topical use

D01AC - Imidazole and triazole derivatives

D01AC15 - Fluconazole


J - Antiinfectives for systemic use

J02 - Antimycotics for systemic use

J02A - Antimycotics for systemic use

J02AC - Triazole and tetrazole derivatives

J02AC01 - Fluconazole


5.5 Absorption, Distribution and Excretion

Absorption

The pharmacokinetic properties of fluconazole are comparable after administration by the intravenous (IV) and oral (PO) routes. In healthy volunteers, the bioavailability of orally administered fluconazole is measured to be above 90%. It is extensively absorbed in the gastrointestinal tract when an oral dose is taken. Oral absorption is not affected by food intake with fluconazole but may increase the time until the maximum concentration is reached. Tmax (or the time taken to achieve the maximum concentration) in one clinical study of healthy patients receiving 50 mg/kg of fluconazole was 3 hours. Peak plasma concentrations (Cmax) in fasting and healthy volunteers occur between 1-2 hours post-dose. Steady-state concentrations are achieved within 5 to 10 days after oral doses of 50-400 mg administered once daily. Administration of a loading dose on the first day of fluconazole treatment, or twice the usual daily dose, leads to plasma concentrations close to steady-state by the second day. Mean AUC (area under the curve) was 20.3 in healthy volunteers receiving 25 mg of fluconazole. **A note on the capsule and powder form and malabsorption syndromes** The capsule forms of fluconazole often contain lactose and should not be administered with hereditary galactose intolerance, _Lapp lactase enzyme_ deficiency, or malabsorption of glucose/galactose. The powder form, used for the oral suspension, lists sucrose as an ingredient and should not be used in patients who have been diagnosed with fructose, glucose/galactose malabsorption, and _sucrase-isomaltase_ enzyme deficiency.


Route of Elimination

In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose measured in the urine as unchanged drug. About 11% of the dose is excreted in the urine as metabolites.. A study of a 50mg radiolabeled dose of fluconazole revealed that 93.3% of the dose was found excreted in the urine. **A note on renal failure** The pharmacokinetics of fluconazole are significantly affected by renal dysfunction. The dose of fluconazole may need to be reduced in patients with decreased renal function. A 3-hour hemodialysis treatment lowers plasma fluconazole concentrations by about 50%.


Volume of Distribution

The apparent volume of distribution is said to be similar to the volume of distribution of total body water. One clinical study of healthy volunteers administered 50 mg/kg of fluconazole was 39L, based on a body weight of 60kg. Fluconazole shows substantial penetration in many body fluids, which is a property that renders it an ideal treatment for systemic fungal infections, especially when administered over a longer time. Fluconazole is found in high concentrations in the stratum corneum and dermis-epidermis of skin, in addition to eccrine sweat. Fluconazole is found to accumulate especially well in the stratum corneum, which is beneficial in superficial fungal infections. Saliva and sputum concentrations of fluconazole are found to be similar to the plasma concentrations. In patients diagnosed with fungal meningitis, fluconazole CSF (cerebrospinal fluid) levels are measured to be about 80% of the corresponding plasma levels. Therefore, fluconazole crosses the blood-brain barrier. The meninges are increasingly permeable to fluconazole in states of inflammation, facilitating treatment in meningitis.


Clearance

This drug is mainly eliminated by the kidneys and the mean body clearance in adults is reported to be 0.23 mL/min/kg. One clinical study of healthy subjects showed total clearance of 19.5 4.7 mL/min and renal clearance of 14.7 3.7 mL/min (1.17 0.28 and 0.88 0.22 L/h). Clearance in the pediatric population varies according to age, as does clearance in patients with renal failure.


The pharmacokinetics of fluconazole are similar following IV or oral administration. The drug is rapidly and almost completely absorbed from the GI tract, and there is no evidence of first-pass metabolism. Oral bioavailability of fluconazole exceeds 90% in healthy, fasting adults; peak plasma concentrations of the drug generally are attained within 1-2 hours after oral administration. ... The rate and extent of GI absorption of fluconazole are not affected by food. The manufacturer states that the commercially available fluconazole suspensions are bioequivalent to the 100-mg fluconazole tablets.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 511


Peak plasma fluconazole concentrations and AUCs increase in proportion to the dose over the oral dosage range of 50-400 mg. Steady-state plasma concentrations of fluconazole are attained within 5-10 days following oral doses of 50-400 mg given once daily. ... When fluconazole therapy is initiated with a single loading dose equal to twice the usual daily dosage and followed by the usual dosage given once daily thereafter, plasma concentrations of the drug reportedly approach steady state by the second day of therapy.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 511


In healthy, fasting adults who received a single 1-mg/kg oral dose of fluconazole, peak plasma concentrations of the drug averaged 1.4 mcg/mL. Following oral administration of a single 400-mg dose of fluconazole in healthy, fasting adults, peak plasma concentrations average 6.72 mcg/mL (range: 4.12-8.1 mcg/mL).

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 511


In healthy adults receiving 50- or 100-mg doses of fluconazole given once daily by IV infusion over 30 minutes, serum concentrations of the drug 1 hour after dosing on the sixth or seventh day of therapy ranged from 2.14-2.81 or 3.86-4.96 mcg/mL, respectively.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 511


For more Absorption, Distribution and Excretion (Complete) data for FLUCONAZOLE (14 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Fluconazole is metabolized minimally in the liver. Fluconazole is an inhibitor of CYP2C9, CYP3A4 and CYP2C19. Two metabolites were detected in the urine of healthy volunteers taking a 50 mg radiolabeled dose of fluconazole; a glucuronidated metabolite on the hydroxyl moiety (6.5%) and a fluconazole N-oxide metabolite (2%). The same study indicated that no signs of metabolic cleavage of fluconazole were observed, suggesting a difference in metabolism when compared to other agents in the same drug class, which are heavily metabolized in the liver.


Hepatic accounts for <10% of elimination

Lelkin, J.B., Paloucek, F.P., Poisoning & Toxicology Compendium. LEXI-COMP Inc. & American Pharmaceutical Association, Hudson, OH 1998., p. 280


5.7 Biological Half-Life

The terminal elimination half-life in the plasma is approximately 30 hours (range: 20-50 hours) after oral administration. The long plasma elimination half-life supports a single dose therapy for vaginal candidiasis, once daily and once weekly dosing for other indications.. Patients with renal failure may require dosage adjustment, and half-life can be significantly increased in these patients.


The plasma elimination half-life of fluconazole in adults with normal renal function is approximately 30 hours (range: 20-50 hours). In one study, plasma elimination half-life of the drug was 22 hours after the first day of therapy and 23.8 and 28.6 hours after 7 and 26 days of therapy, respectively.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 511


In a limited, single-dose study in HIV-infected adults, the plasma elimination half-life of fluconazole averaged 32 hours (range: 25-42 hours) in those with absolute helper/inducer (CD4+, T4+) T-cell counts greater than 200 cu m and 50 hours (range: 32-69 hours) in those with CD4+ T-cell counts less than 200 cu m. In other single-dose studies in a limited number of HIV-infected adults with CD4+ T-cell counts less than 200 cu m, the plasma elimination half-life of the drug averaged 35-40 hours (range 22-75 hours).

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 511


The mean plasma half-life of fluconazole in children 9 months to 15 years of age has ranged from about 15-25 hours. In a limited study in premature neonates who received IV fluconazole once every 72 hours, the plasma half-life decreased over time, averaging 88 hours after the first dose and 55 hours after the fifth dose (day 13).

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 511


5.8 Mechanism of Action

Fluconazole is a very selective inhibitor of fungal cytochrome P450 dependent enzyme _lanosterol 14--demethylase_. This enzyme normally works to convert _lanosterol_ to _ergosterol_, which is necessary for fungal cell wall synthesis. The free nitrogen atom located on the azole ring of fluconazole binds with a single iron atom located in the heme group of lanosterol 14--demethylase. This prevents oxygen activation and, as a result, inhibits the demethylation of lanosterol, halting the process of ergosterol biosynthesis. Methylated sterols are then found to accumulate in the fungal cellular membrane, leading to an arrest of fungal growth. These accumulated sterols negatively affect the structure and function of the fungal cell plasma membrane. Fluconazole resistance may arise from an alteration in the amount or function of the target enzyme (lanosterol 14--demethylase), altered access to this enzyme, or a combination of the above. Other mechanisms may also be implicated, and studies are ongoing.


Fluconazole usually is fungistatic in action. Fluconazole and other triazole-derivative antifungal agents (e.g., itraconazole, terconazole) appear to have a mechanism of action similar to that of the imidazole-derivative antifungal agents (e.g., butoconazole, clotrimazole, econazole, ketoconazole, miconazole, oxiconazole). Like imidazoles, fluconazole presumably exerts its antifungal activity by altering cellular membranes resulting in increased membrane permeability, leakage of essential elements (eg, amino acids, potassium), and impaired uptake of precursor molecules (eg, purine and pyrimidine precursors to DNA). Although the exact mechanism of action of fluconazole and other triazoles has not been fully determined, the drugs inhibit cytochrome P-450 14-a-desmethylase in susceptible fungi, which leads to accumulation of C-14 methylated sterols (e.g., lanosterol) and decreased concentrations of ergosterol. It appears that this may occur because a nitrogen atom (N-4) in the triazole molecule binds to the heme iron of cytochrome P-450 14-a-desmethylase in susceptible fungi. Unlike some imidazoles (eg, clotrimazole, econazole, miconazole, oxiconazole) that suppress ATP concentrations in intact cells and spheroplasts of C. albicans, fluconazole does not appear to have an appreciable effect on ATP concentrations in the organism. It is unclear whether this effect is related to the in vivo antifungal effects of the drugs. Fluconazole generally is fungistatic against Candida albicans when the organism is in either the stationary or early logarithmic phase of growth.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2006., p. 509


Fungistatic; may be fungicidal, depending on the concentration; azole antifungals interfere with cytochrome P450 enzyme activity, which is necessary for the demethylation of 14-alpha-methylsterols to ergosterol. Ergosterol, the principal sterol in the fungal cell membrane, becomes depleted. This damages the cell membrane, producing alterations in membrane functions and permeability. In Candida albicans, azole antifungals inhibit transformation of blastospores into invasive mycelial form.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006., p. 336


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03-Jan-2022
30-Apr-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 100MG

USFDA APPLICATION NUMBER - 19949

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DOSAGE - TABLET;ORAL - 150MG

USFDA APPLICATION NUMBER - 19949

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DOSAGE - TABLET;ORAL - 200MG

USFDA APPLICATION NUMBER - 19949

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DOSAGE - TABLET;ORAL - 50MG

USFDA APPLICATION NUMBER - 19949

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ABOUT THIS PAGE

Looking for 86386-73-4 / Fluconazole API manufacturers, exporters & distributors?

Fluconazole manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Fluconazole API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Fluconazole manufacturer or Fluconazole supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Fluconazole manufacturer or Fluconazole supplier.

PharmaCompass also assists you with knowing the Fluconazole API Price utilized in the formulation of products. Fluconazole API Price is not always fixed or binding as the Fluconazole Price is obtained through a variety of data sources. The Fluconazole Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Fluconazole

Synonyms

86386-73-4, Diflucan, Triflucan, Biozolene, Elazor, Biocanol

Cas Number

86386-73-4

Unique Ingredient Identifier (UNII)

8VZV102JFY

About Fluconazole

Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.

Afungil Manufacturers

A Afungil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Afungil, including repackagers and relabelers. The FDA regulates Afungil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Afungil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Afungil manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Afungil Suppliers

A Afungil supplier is an individual or a company that provides Afungil active pharmaceutical ingredient (API) or Afungil finished formulations upon request. The Afungil suppliers may include Afungil API manufacturers, exporters, distributors and traders.

click here to find a list of Afungil suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Afungil USDMF

A Afungil DMF (Drug Master File) is a document detailing the whole manufacturing process of Afungil active pharmaceutical ingredient (API) in detail. Different forms of Afungil DMFs exist exist since differing nations have different regulations, such as Afungil USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Afungil DMF submitted to regulatory agencies in the US is known as a USDMF. Afungil USDMF includes data on Afungil's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Afungil USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Afungil suppliers with USDMF on PharmaCompass.

Afungil JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Afungil Drug Master File in Japan (Afungil JDMF) empowers Afungil API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Afungil JDMF during the approval evaluation for pharmaceutical products. At the time of Afungil JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Afungil suppliers with JDMF on PharmaCompass.

Afungil KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Afungil Drug Master File in Korea (Afungil KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Afungil. The MFDS reviews the Afungil KDMF as part of the drug registration process and uses the information provided in the Afungil KDMF to evaluate the safety and efficacy of the drug.

After submitting a Afungil KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Afungil API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Afungil suppliers with KDMF on PharmaCompass.

Afungil CEP

A Afungil CEP of the European Pharmacopoeia monograph is often referred to as a Afungil Certificate of Suitability (COS). The purpose of a Afungil CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Afungil EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Afungil to their clients by showing that a Afungil CEP has been issued for it. The manufacturer submits a Afungil CEP (COS) as part of the market authorization procedure, and it takes on the role of a Afungil CEP holder for the record. Additionally, the data presented in the Afungil CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Afungil DMF.

A Afungil CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Afungil CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Afungil suppliers with CEP (COS) on PharmaCompass.

Afungil WC

A Afungil written confirmation (Afungil WC) is an official document issued by a regulatory agency to a Afungil manufacturer, verifying that the manufacturing facility of a Afungil active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Afungil APIs or Afungil finished pharmaceutical products to another nation, regulatory agencies frequently require a Afungil WC (written confirmation) as part of the regulatory process.

click here to find a list of Afungil suppliers with Written Confirmation (WC) on PharmaCompass.

Afungil NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Afungil as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Afungil API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Afungil as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Afungil and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Afungil NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Afungil suppliers with NDC on PharmaCompass.

Afungil GMP

Afungil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Afungil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Afungil GMP manufacturer or Afungil GMP API supplier for your needs.

Afungil CoA

A Afungil CoA (Certificate of Analysis) is a formal document that attests to Afungil's compliance with Afungil specifications and serves as a tool for batch-level quality control.

Afungil CoA mostly includes findings from lab analyses of a specific batch. For each Afungil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Afungil may be tested according to a variety of international standards, such as European Pharmacopoeia (Afungil EP), Afungil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Afungil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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