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1. (2e)-n-(4-(3-chloro-4-fluoroanilino)-7-(((3s)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide
2. Afatinib
3. Afatinib Maleate
4. Bibw 2992
5. Bibw 2992 Ma2
6. Bibw 2992ma2
7. Bibw-2992
8. Bibw-2992-ma2
9. Bibw-2992ma2
10. Bibw2992
11. Bibw2992 Ma2
12. Gilotrif
1. 850140-73-7
2. Afatinib (dimaleate)
3. Gilotrif
4. Afatinib Maleate
5. Bibw 2992ma2
6. Giotrif
7. Afatinib (bibw2992) Dimaleate
8. Afatinib Dimaleate [usan]
9. Bibw2992 Ma2
10. Afatinib Maleate (jan)
11. V1t5k7rz0b
12. Bibw-2992ma2
13. Bibw2992-ma2
14. Bibw-2992 Ma2
15. Bibw-2992-ma2
16. Chebi:76003
17. 850140-73-7 (dimaleate)
18. Bibw2992 Dimaleate
19. Afatinib Dimaleate (usan)
20. (s,e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide Dimaleate
21. Afatinib Maleate [jan]
22. Afatinib Impurity F
23. (2e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3s)-tetrahydrofuran-3-yl)oxy)quinazolin- 6-yl)-4-(dimethylamino)but-2-enamide Bis(hydrogen (2z)-but-2-enedioate)
24. (z)-but-2-enedioic Acid;(e)-n-[4-(3-chloro-4-fluoroanilino)-7-[(3s)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
25. Unii-v1t5k7rz0b
26. Mfcd25974239
27. Gilotrif (tn)
28. Giotrif (tn)
29. Bibw2993 Dimaleate
30. Amy499
31. Afatinib Dimaleate [mi]
32. Chembl2105712
33. Afatinib Dimaleate [vandf]
34. Dtxsid701027713
35. Afatinib Dimaleate [who-dd]
36. Hy-10261a
37. S7810
38. Akos025401819
39. Ccg-270401
40. Cs-1329
41. Afatinib Dimaleate [orange Book]
42. Ac-26080
43. As-56967
44. Ba162012
45. D09733
46. Q27145677
47. (2e)-n-(4-[(3-chloro-4-fluorophenyl)amino]-7-{[(3s)-tetrahydrofuran-3-yl]oxy}quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
48. (2e)-n-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3s)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Dimaleate
49. (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Di[(2z)-but-2-enedioate]
50. (e)-4-dimethylamino-but-2-enoic Acid-(4-(3-chloro-4-fluoro-phenylamino)-7-((s)-tetra-hydrofuran-3-yloxy)-quinazolin-6yl)-amide Dimaleate
51. 2-butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3s)-tetrahydro-3-furanyl)oxy)- 6-quinazolinyl)-4-(dimethylamino)-, (2e)-, (2z)-2-butenedioate (1:2)
52. 2-butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3s)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-, (2e)-, (2z)-2-butenedioate (1:2)
53. 936631-70-8
| Molecular Weight | 718.1 g/mol |
|---|---|
| Molecular Formula | C32H33ClFN5O11 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 16 |
| Rotatable Bond Count | 12 |
| Exact Mass | 717.1849127 g/mol |
| Monoisotopic Mass | 717.1849127 g/mol |
| Topological Polar Surface Area | 238 Ų |
| Heavy Atom Count | 50 |
| Formal Charge | 0 |
| Complexity | 821 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 3 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 3 |
Giotrif as monotherapy is indicated for the treatment of
- Epidermal Growth Factor Receptor (EGFR) TKI-nave adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating EGFR mutation(s);
- locally advanced or metastatic NSCLC of squamous histology progressing on or after platinum-based chemotherapy.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
Protein Kinase Inhibitors
Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)
L01XE13
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