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Looking for 955365-80-7 / Adavosertib API manufacturers, exporters & distributors?

Adavosertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Adavosertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Adavosertib manufacturer or Adavosertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Adavosertib manufacturer or Adavosertib supplier.

PharmaCompass also assists you with knowing the Adavosertib API Price utilized in the formulation of products. Adavosertib API Price is not always fixed or binding as the Adavosertib Price is obtained through a variety of data sources. The Adavosertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Adavosertib

Synonyms

Mk-1775, 955365-80-7, Mk1775, Mk 1775, Azd1775, Azd-1775

Cas Number

955365-80-7

Unique Ingredient Identifier (UNII)

K2T6HJX3I3

About Adavosertib

Adavosertib is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. Adavosertib selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53 deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect.

Adavosertib Manufacturers

A Adavosertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Adavosertib, including repackagers and relabelers. The FDA regulates Adavosertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Adavosertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Adavosertib Suppliers

A Adavosertib supplier is an individual or a company that provides Adavosertib active pharmaceutical ingredient (API) or Adavosertib finished formulations upon request. The Adavosertib suppliers may include Adavosertib API manufacturers, exporters, distributors and traders.

Adavosertib GMP

Adavosertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Adavosertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Adavosertib GMP manufacturer or Adavosertib GMP API supplier for your needs.

Adavosertib CoA

A Adavosertib CoA (Certificate of Analysis) is a formal document that attests to Adavosertib's compliance with Adavosertib specifications and serves as a tool for batch-level quality control.

Adavosertib CoA mostly includes findings from lab analyses of a specific batch. For each Adavosertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Adavosertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Adavosertib EP), Adavosertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Adavosertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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