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Chemistry

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Also known as: N-phenylacetamide, 103-84-4, Antifebrin, Acetamidobenzene, Acetanilid, Acetanil
Molecular Formula
C8H9NO
Molecular Weight
135.16  g/mol
InChI Key
FZERHIULMFGESH-UHFFFAOYSA-N
FDA UNII
SP86R356CC

Acetanilide
acetanilide is a natural product found in Dendrobium moniliforme, Dendrobium officinale, and other organisms with data available.
1 2D Structure

Acetanilide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-phenylacetamide
2.1.2 InChI
InChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
2.1.3 InChI Key
FZERHIULMFGESH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(=O)NC1=CC=CC=C1
2.2 Other Identifiers
2.2.1 UNII
SP86R356CC
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Acetanilid

2.3.2 Depositor-Supplied Synonyms

1. N-phenylacetamide

2. 103-84-4

3. Antifebrin

4. Acetamidobenzene

5. Acetanilid

6. Acetanil

7. Acetylaniline

8. Acetamide, N-phenyl-

9. N-acetylaniline

10. Phenalgene

11. Acetic Acid Anilide

12. Acetylaminobenzene

13. Acetoanilide

14. Phenalgin

15. Aniline, N-acetyl-

16. N-acetylarylamine

17. Benzenamine, N-acetyl-

18. Usaf Ek-3

19. Nsc 7636

20. An [analgesic]

21. N-acetylaminobenzene

22. Acetanilidum

23. Antifebrinum

24. Ethananilide

25. Mfcd00008674

26. N-phenyl-acetamide

27. Acetanilide (antifebrin)

28. Nsc-7636

29. Sp86r356cc

30. Chebi:28884

31. Nsc7636

32. Acetamide, N-phenyl-, Homopolymer

33. N-phenylacetamide;n-phenylacetamide

34. Nsc-203231

35. Ncgc00091326-01

36. Dsstox_cid_2543

37. Dsstox_rid_76620

38. Dsstox_gsid_22543

39. N-phenylacetamide (acetanilide)

40. Caswell No. 003e

41. Acetanilide (ring-13c6)

42. N-phenylethanamide

43. Acetanilide [nf]

44. 137020-73-6

45. Cas-103-84-4

46. Smr001306799

47. Acetic Acid Amide, N-phenyl-

48. Ccris 4452

49. Hsdb 2665

50. Einecs 203-150-7

51. Unii-sp86r356cc

52. Ai3-01045

53. Phnhac

54. N-phenyl Acetamide

55. Acetanilide, 99%

56. Spectrum_000178

57. Acetanilide [mi]

58. Spectrum2_001434

59. Spectrum3_000935

60. Spectrum4_001034

61. Spectrum5_000989

62. Acetanilid [inci]

63. Acetanilide [hsdb]

64. Wln: 1vmr

65. Acetanilide (acetylaniline)

66. Acetanilide [vandf]

67. Acetanilidum [hpus]

68. Acetanilide-[ring-13c6]

69. Acetanilide [mart.]

70. Schembl24681

71. Acetanilide [usp-rs]

72. Acetanilide [who-dd]

73. Kbiogr_001587

74. Kbioss_000658

75. 55576-55-1

76. Mls002207284

77. Mls002415707

78. Divk1c_000073

79. Spectrum1501173

80. Spbio_001568

81. Chembl269644

82. Acetaminophen Related Compound D

83. Dtxsid2022543

84. Schembl14255226

85. Acetanilide, Lr, >=98.5%

86. Hms500d15

87. Kbio1_000073

88. Kbio2_000658

89. Kbio2_003226

90. Kbio2_005794

91. Kbio3_001970

92. Ninds_000073

93. Acetic Acid,amide,n-phenyl

94. Bcpp000440

95. Hms1921n07

96. Hms2092j11

97. Hms2234e18

98. Hms3374l04

99. Hms3651d07

100. Pharmakon1600-01501173

101. Zinc142824

102. Bcp02363

103. Tox21_111113

104. Tox21_200925

105. Ccg-38984

106. Nsc757879

107. S2538

108. Stk046402

109. Akos000121114

110. Tox21_111113_1

111. Bcp9000226

112. Nsc-757879

113. Acetanilide, Nist(r) Srm(r) 141d

114. Idi1_000073

115. Acetanilide Melting Point Standard

116. Ncgc00091326-02

117. Ncgc00091326-03

118. Ncgc00091326-04

119. Ncgc00091326-06

120. Ncgc00258479-01

121. As-13389

122. Sbi-0051673.p002

123. B2071

124. Cs-0010112

125. Ft-0621730

126. Ft-0621731

127. Ft-0661046

128. Ft-0661047

129. Ft-0661154

130. Paracetamol Impurity D [ep Impurity]

131. Sw220057-1

132. C07565

133. D72485

134. Ab00052235_07

135. Ab00052235_08

136. Acetanilide, Purified By Sublimation, >=99.9%

137. Acetanilide, Puriss. P.a., >=99.5% (chn)

138. Acetaminophen Related Compound D [usp-rs]

139. Ah-034/32461060

140. Q421761

141. Sr-05000001777

142. Q-200578

143. Sr-05000001777-1

144. Acetaminophen Related Compound D [usp Impurity]

145. Brd-k11094367-001-04-4

146. F0808-0907

147. Acetanilide, Zone-refined, Purified By Sublimation, >=99.95%

148. Acetaminophen Related Compound D, United States Pharmacopeia (usp) Reference Standard

149. Acetanilide Melting Point Standard, United States Pharmacopeia (usp) Reference Standard

150. Acetanilide (acetaminophen Related Compound D), Pharmaceutical Secondary Standard; Certified Reference Material

151. Acetanilide Melting Point Standard, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 135.16 g/mol
Molecular Formula C8H9NO
XLogP31.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass135.068413911 g/mol
Monoisotopic Mass135.068413911 g/mol
Topological Polar Surface Area29.1 Ų
Heavy Atom Count10
Formal Charge0
Complexity116
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

IT IS PARTICULARLY EFFECTIVE AS AN ANALGESIC IN PAIN OF THE NEURALGIC TYPE...

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1053


MEDICATION (VET): ANALGESIC, ANTIPYRETIC AGENT

Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 10


4.2 Drug Warning

.../ACETANILID IS/ ESPECIALLY DANGEROUS IN ANEMIA, AFTER HEMORRHAGE AND DURING MENSTRUATION.

Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 81


...ITS USE AS AN ANALGESIC /IS CONDEMNED/ BECAUSE SAFER & EQUALLY EFFECTIVE DRUGS ARE AVAILABLE.

American Medical Association, Council on Drugs. AMA Drug Evaluations. 2nd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1973., p. 262


...NECROSIS OF RENAL PAPILLAE & TERMINAL TUBULES HAS BEEN ASSOCIATED WITH EXCESSIVE DOSES OF DRUG MIXTURES CONTAINING ACETOPHENETIDIN WITH...ACETANILID...

Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 81


...ACETANILID.../PRODUCES/ HEMOLYTIC ANEMIA IN INDIVIDUALS WITH GENETIC DEFICIENCY OF ERYTHROCYTIC GLUCOSE-6-PHOSPHATE DEHYDROGENASE. DARK SKINNED RACES HAVE HIGHER INCIDENCE THAN LIGHT SKINNED BUT DISEASE HAS NOT BEEN NOTED IN NORTH AMERICAN INDIANS OR ESKIMOS.

Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 232


For more Drug Warnings (Complete) data for ACETANILIDE (6 total), please visit the HSDB record page.


4.3 Minimum/Potential Fatal Human Dose

/BETWEEN 4 & 5/: 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOONFUL & 1 OZ FOR A 70 KG PERSON (150 LB). 5= EXTREMELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-50 MG/KG, BETWEEN 7 DROPS & 1 TEASPOONFUL FOR 70 KG PERSON (150 LB).

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-139


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

IT IS READILY EXCRETED IN THE URINE AS SULFATE OR GLUCURONATE CONJUGATE OF THE PHENOL /N-ACETYL-P-AMINOPHENOL/.

Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1835


36% OF ACETANILIDE DISSOLVED IN 0.1 N HCL (PKA 0.3) WAS ABSORBED FROM RAT STOMACH IN ONE HOUR. /FROM TABLE/

LaDu, B.N., H.G. Mandel, and E.L. Way. Fundamentals of Drug Metabolism and Disposition. Baltimore: Williams and Wilkins, 1971., p. 27


...GREATER THAN 99.9% OF ACETANILIDE REMAINS UN-IONIZED @ BODY PH, FACILITATING ABSORPTION FROM BLOOD TO CEREBROSPINAL FLUID. THE BLOOD-CEREBROSPINAL FLUID PERMEABILITY COEFFICIENT IS 0.039/MIN. /FROM TABLE/

LaDu, B.N., H.G. Mandel, and E.L. Way. Fundamentals of Drug Metabolism and Disposition. Baltimore: Williams and Wilkins, 1971., p. 82


.../ACETANILID IS/ READILY ABSORBED FROM GASTROINTESTINAL TRACT.

Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 80


For more Absorption, Distribution and Excretion (Complete) data for ACETANILIDE (14 total), please visit the HSDB record page.


5.2 Metabolism/Metabolites

.../RESEARCHERS/ FOUND THAT STARVATION DECREASED RATE OF METABOLISM OF...ACETANILIDE. ...STARVATION REDUCED OXIDATIVE PATHWAYS OF MALE RATS...

LaDu, B.N., H.G. Mandel, and E.L. Way. Fundamentals of Drug Metabolism and Disposition. Baltimore: Williams and Wilkins, 1971., p. 529


STRAIN DIFFERENCES /WITHIN THE SAME SPECIES/ WERE...NOTED IN ACETANILIDE...METABOLISM.

LaDu, B.N., H.G. Mandel, and E.L. Way. Fundamentals of Drug Metabolism and Disposition. Baltimore: Williams and Wilkins, 1971., p. 530


HEPATIC MICROSOMES FROM RABBITS WITH OBSTRUCTIVE JAUNDICE SHOW IMPAIRED METABOLISM OF ACETANILIDE...

LaDu, B.N., H.G. Mandel, and E.L. Way. Fundamentals of Drug Metabolism and Disposition. Baltimore: Williams and Wilkins, 1971., p. 530


2 NEW URINARY METABOLITES OF ACETANILIDE IN RATS THAT HAVE BEEN IDENTIFIED AS N-ACETYL-S-(5-ACETAMIDO-2-HYDROXYPHENYL)CYSTEINE & N-ACETYL-S-(3-ACETAMIDOPHENYL)CYSTEINE MAY HAVE BEEN FORMED VIA AN INTERMEDIATE EPOXIDE.

The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 4: A Review of the Literature Published during 1974 and 1975. London: The Chemical Society, 1977., p. 182


For more Metabolism/Metabolites (Complete) data for ACETANILIDE (20 total), please visit the HSDB record page.


Acetanilide has known human metabolites that include N-Hydroxy-N-phenylacetamide and acetaminophen.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.3 Biological Half-Life

T/2 OF ACETANILID MEASURED IN POPULATIONS OF YOUNG (AGED 20-35 YR) & ELDERLY (AGED OVER 65 YR) PEOPLE (TOTAL= 93). T/2 WERE SIGNIFICANTLY LONGER IN THE ELDERLY.

FARAH F ET AL; HEPATIC DRUG ACETYLATION AND OXIDATION: EFFECTS OF AGING IN MAN; BR MED J 2(JUL 16) 155 (1977)


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ABOUT THIS PAGE

Looking for 103-84-4 / Acetanilide API manufacturers, exporters & distributors?

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API | Excipient name

Acetanilide

Synonyms

N-phenylacetamide, 103-84-4, Antifebrin, Acetamidobenzene, Acetanilid, Acetanil

Cas Number

103-84-4

Unique Ingredient Identifier (UNII)

SP86R356CC

About Acetanilide

acetanilide is a natural product found in Dendrobium moniliforme, Dendrobium officinale, and other organisms with data available.

Acetanilide Manufacturers

A Acetanilide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acetanilide, including repackagers and relabelers. The FDA regulates Acetanilide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acetanilide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Acetanilide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PhamaCompass.

Acetanilide Suppliers

A Acetanilide supplier is an individual or a company that provides Acetanilide active pharmaceutical ingredient (API) or Acetanilide finished formulations upon request. The Acetanilide suppliers may include Acetanilide API manufacturers, exporters, distributors and traders.

click here to find a list of Acetanilide suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

Acetanilide GMP

Acetanilide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Acetanilide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Acetanilide GMP manufacturer or Acetanilide GMP API supplier for your needs.

Acetanilide CoA

A Acetanilide CoA (Certificate of Analysis) is a formal document that attests to Acetanilide's compliance with Acetanilide specifications and serves as a tool for batch-level quality control.

Acetanilide CoA mostly includes findings from lab analyses of a specific batch. For each Acetanilide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Acetanilide may be tested according to a variety of international standards, such as European Pharmacopoeia (Acetanilide EP), Acetanilide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acetanilide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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