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Chemistry

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Also known as: 357336-20-0, Briviact, Ucb-34714, Ucb 34714, Ucb34714, 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide
Molecular Formula
C11H20N2O2
Molecular Weight
212.29  g/mol
InChI Key
MSYKRHVOOPPJKU-BDAKNGLRSA-N
FDA UNII
U863JGG2IA

Brivaracetam
Brivaracetam is an orally bioavailable levetiracetam derivative, with anticonvulsant activity. Although the exact mechanism through which brivaracetam exerts its effects is not fully known, this agent targets and binds to synaptic vesicle protein 2A (SV2A) in the brain. This prevents synaptic vesicle exocytosis and the synaptic release of certain, as of yet not fully known, excitatory neurotransmitters. This may inhibit impulse conduction across synapses, decrease neuronal (hyper-)excitability, and may modulate epileptogenesis. SV2A, a membrane glycoprotein present in neuronal synaptic vesicles, plays a key role in action potential-induced neurotransmitter release in the brain.
The mechanism of action of brivaracetam is as an Epoxide Hydrolase Inhibitor.
1 2D Structure

Brivaracetam

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide
2.1.2 InChI
InChI=1S/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h8-9H,3-7H2,1-2H3,(H2,12,15)/t8-,9+/m1/s1
2.1.3 InChI Key
MSYKRHVOOPPJKU-BDAKNGLRSA-N
2.1.4 Canonical SMILES
CCCC1CC(=O)N(C1)C(CC)C(=O)N
2.1.5 Isomeric SMILES
CCC[C@@H]1CC(=O)N(C1)[C@@H](CC)C(=O)N
2.2 Other Identifiers
2.2.1 UNII
U863JGG2IA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2s)-2-((4r)-2-oxo-4-propylpyrrolidin-1-yl)butanamide

2. 1-pyrrolidineacetamide, Alpha-ethyl-2-oxo-4-propyl-, (alphas,4r)-

3. 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide

4. Briviact

5. Ucb 34714

6. Ucb-34714

7. Ucb34714

2.3.2 Depositor-Supplied Synonyms

1. 357336-20-0

2. Briviact

3. Ucb-34714

4. Ucb 34714

5. Ucb34714

6. 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide

7. (2s)-2-[(4r)-2-oxo-4-propylpyrrolidin-1-yl]butanamide

8. (2s)-2-((4r)-2-oxo-4-propylpyrrolidin-1-yl)butanamide

9. U863jgg2ia

10. Rikelta

11. Brivaracetam [usan:inn]

12. Unii-u863jgg2ia

13. Compound 83alpha

14. 1-pyrrolidineacetamide, Alpha-ethyl-2-oxo-4-propyl-, (alphas,4r)-

15. Brivaracetam 97%

16. Briviact (tn)

17. Brivaracetam [mi]

18. Brivaracetam [inn]

19. Brivaracetam [jan]

20. Brivaracetam [usan]

21. Brivaracetam [mart.]

22. Brivaracetam [who-dd]

23. Schembl122081

24. Brivaracetam (jan/usan/inn)

25. Chembl607400

26. Gtpl9041

27. Dtxsid00905081

28. Chebi:133013

29. Brivaracetam [orange Book]

30. Ex-a2748

31. Zinc3979899

32. Bdbm50422531

33. Mfcd25976668

34. Akos027324306

35. Ccg-266666

36. Cs-3418

37. Db05541

38. Ncgc00390779-02

39. Ac-29289

40. As-35277

41. Bb161996

42. Hy-14449

43. D08879

44. Q408099

45. (s)-2-((r)-2-oxo-4-propylpyrrolidin-1-yl)butanamide

46. (2s)-2-((4r)-2-oxo-4-n-propyl-1-pyrrolidinyl)butanamide

47. (2s)-2-((4r)-2-oxo-4-propyltetrahydro-1h-pyrrol-1-yl) Butanamide

48. 1-pyrrolidineacetamide, .alpha.-ethyl-2-oxo-4-propyl (.alpha.s,4r)-

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 212.29 g/mol
Molecular Formula C11H20N2O2
XLogP31
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass212.152477885 g/mol
Monoisotopic Mass212.152477885 g/mol
Topological Polar Surface Area63.4 Ų
Heavy Atom Count15
Formal Charge0
Complexity253
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used as adjunctive therapy for partial-onset seizures in patients 16 years of age or older.


FDA Label


Briviact is indicated as adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adult and adolescent patients from 16 years of age with epilepsy.


Treatment of epilepsy with partial-onset seizures, Treatment of neonatal seizures


Treatment of neonatal seizures, Treatment of paediatric epilepsy syndromes


Treatment of epilepsy with partial-onset seizures


5 Pharmacology and Biochemistry
5.1 Pharmacology

Brivaracetam binds SV2A with high affinity. SV2A is known to play a role in epileptogenesis through modulation of synaptic GABA release. It is thought that brivaracetam exerts its anti-epileptogenic effects through its binding to SV2A. Brivaracetam is also known to inhibit Na+ channels which may also contribute to its anti-epileptogenic action.


5.2 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
BRIVARACETAM
5.3.2 FDA UNII
U863JGG2IA
5.3.3 Pharmacological Classes
Epoxide Hydrolase Inhibitors [MoA]
5.4 ATC Code

N03AX23


N03AX23

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N03 - Antiepileptics

N03A - Antiepileptics

N03AX - Other antiepileptics

N03AX23 - Brivaracetam


5.5 Absorption, Distribution and Excretion

Absorption

Nearly 100% oral bioavailability.


Route of Elimination

\>95% excreted in urine with <10% of the parent compound unchanged. <1% excreted in feces.


Volume of Distribution

0.5L/kg.


Clearance

CL/F of 0.7-1.07 mL/min kg. Clearance is primarily metabolic with less than 10% of the parent drug excreted unchanged.


5.6 Metabolism/Metabolites

Primarily metabolized by hydrolysis of the acetamide moeity to form a carboxylic acid metabolite. Another metabolite is created via oxidation of the propyl side chain by CYP2C8 as well as CYP3A4, CYP2C19, and CYP2B6. Some conjugation with glucuronic acid and taurine account for a small amount of metabolism.


5.7 Biological Half-Life

7-8h.


5.8 Mechanism of Action

The precise mechanism of brivaracetam's anti-epileptogenic activity is unknown.


API Reference Price

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AP","supplier":"OPTIMUS DRUGS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"BANK AL HABIB LIMITED","customerCountry":"PAKISTAN","quantity":"1.50","actualQuantity":"1.5","unit":"KGS","unitRateFc":"1000","totalValueFC":"1456.9","currency":"USD","unitRateINR":84462.94666666667,"date":"28-Feb-2025","totalValueINR":"126694.42","totalValueInUsd":"1456.9","indian_port":"Hyderabad Air","hs_no":"29331920","bill_no":"8575257","productDescription":"API","marketType":"","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.131,3RD FLOOR,NARMADA, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740940200,"product":"BRIVARACETAM","address":"8-3-166\/7\/1, HETERO HOUSE,","city":"HYDERABAD, AP.","supplier":"HONOUR LAB LIMITED","supplierCountry":"INDIA","foreign_port":"RIYADH","customer":"JPICENTRAL WAREHOUSE","customerCountry":"SAUDI ARABIA","quantity":"12.00","actualQuantity":"12","unit":"KGS","unitRateFc":"2350","totalValueFC":"27249","currency":"USD","unitRateINR":196686.83333333334,"date":"03-Mar-2025","totalValueINR":"2360242","totalValueInUsd":"27249","indian_port":"Vizag-HIPL SEZ","hs_no":"29242990","bill_no":"8676132","productDescription":"API","marketType":"","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Vizag-HIPL SEZ","supplierAddress":"8-3-166\/7\/1, HETERO HOUSE,, HYDERABAD, AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741804200,"product":"BRIVARACETAM (INJECTABLE GRADE)","address":"PLOT NO.131,3RD FLOOR,NARMADA","city":"HYDERABAD. AP","supplier":"OPTIMUS DRUGS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"APEX PHARMA","customerCountry":"EGYPT","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"850","totalValueFC":"25252.4","currency":"USD","unitRateINR":72910.066666666666,"date":"13-Mar-2025","totalValueINR":"2187302","totalValueInUsd":"25252.4","indian_port":"Hyderabad Air","hs_no":"29331920","bill_no":"8989744","productDescription":"API","marketType":"","country":"EGYPT","selfForZScoreResived":"Sterile","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO.131,3RD FLOOR,NARMADA, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1743100200,"product":"ACTIVE PHARMACEUTICALS INGREDIENTS (API)EXPORT INVOICE NUMBER : F32512201541DT. 27.03.2025 BRIVARACETAM","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"ALIVUS LIFE SCIENCES LIMITED","supplierCountry":"INDIA","foreign_port":"MALTA (VALETTA)","customer":"TO THE ORDER","customerCountry":"MALTA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"1575","totalValueFC":"46347","currency":"USD","unitRateINR":133815.62666666665,"date":"28-Mar-2025","totalValueINR":"4014468.8","totalValueInUsd":"46347","indian_port":"Dahez-SEZ","hs_no":"29332990","bill_no":"9440733","productDescription":"API","marketType":"REGULATED MARKET","country":"MALTA","selfForZScoreResived":"Pharma Grade","supplierPort":"Dahez-SEZ","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744223400,"product":"BRIVARACETAM","address":"PLOT NO. C-24, INDUSTRIAL ESTATE,","city":"HYDERABAD. AP","supplier":"MAITHRI LABORATORIES PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"AMMAN","customer":"THE UNITED PHARMACEUTICALS MFG CO","customerCountry":"JORDAN","quantity":"12.00","actualQuantity":"12","unit":"KGS","unitRateFc":"1925","totalValueFC":"22799","currency":"USD","unitRateINR":162636.58333333334,"date":"10-Apr-2025","totalValueINR":"1951639","totalValueInUsd":"22799","indian_port":"Hyderabad Air","hs_no":"29141990","bill_no":"9845328","productDescription":"API","marketType":"","country":"JORDAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"PLOT NO. C-24, INDUSTRIAL ESTATE,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1745865000,"product":"BRIVARACETAM IH (TAX INV NO.F22512900018DT.23.04.25) (GST NO.29AAWCS7320Q1Z8)","address":"SHED NO F-1, IDA, ROAD NO.6","city":"KUKATPALLY","supplier":"VIRUJ CHEMATRIX PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BAGDAD, METROPOLITAN","customer":"SAMA AL FAYHAA PHARMACEUTICAL INDUS","customerCountry":"IRAQ","quantity":"188.00","actualQuantity":"188","unit":"KGS","unitRateFc":"1900","totalValueFC":"353291","currency":"USD","unitRateINR":160863.51063829788,"date":"29-Apr-2025","totalValueINR":"30242340","totalValueInUsd":"353291","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"1370730","productDescription":"API","marketType":"","country":"IRAQ","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"SHED NO F-1, IDA, ROAD NO.6, KUKATPALLY","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1679769000,"product":"BRIVARACETAM (REIMPORT CARGO EXPORTED VIDE SHIPPING BILL NO.9859860 DT. 21.04.2022)","address":"NO.201, DEVAVRATA SECTOR 17, VASHI, NAVI MUMBAI - 400705. Contac","city":"NAVI MUMBAI","supplier":"PHARMAPATH","supplierCountry":"INDIA","foreign_port":"NA","customer":"SOLARA ACTIVE PHARMA SCIENCES LIMITED","customerCountry":"INDIA","quantity":"2.25","actualQuantity":"2.25","unit":"KGS","unitRateFc":"2500","totalValueFC":"6024.5","currency":"USD","unitRateINR":"220231.1","date":"26-Mar-2023","totalValueINR":"495519.86","totalValueInUsd":"6024.5","indian_port":"MADRAS AIR","hs_no":"29420090","bill_no":"5232956","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"NO.201, DEVAVRATA SECTOR 17, VASHI, NAVI MUMBAI - 400705. Contac"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703701800,"product":"BRIVARACETAM","address":"159, C.S.T. ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"ZHEJIANG HUAHAI PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1400","totalValueFC":"3523.4","currency":"USD","unitRateINR":"293300","date":"28-Dec-2023","totalValueINR":"293300","totalValueInUsd":"3523.4","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"9443792","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"XUNQIAO , LINHAI ZHEJIANG 317024 CHINA Zhenjiang, , ChinaSDNF China","customerAddress":"159, C.S.T. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717957800,"product":"BRIVARACETAM (NON STERILE BULK)","address":"3RD FLOOR, PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD, ANDHRA PRADESH","supplier":"YANGZHOU AURISCO PHARMACEUTICAL COLTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MS APL HEALTHCARE LIMITED","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"2900","totalValueFC":"87855.2","currency":"USD","unitRateINR":"244470","date":"10-Jun-2024","totalValueINR":"7334100","totalValueInUsd":"87855.2","indian_port":"APIIC MULTI PRODUCT SEZ NAIDUPET AP","hs_no":"29337990","bill_no":"1000830","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Non-sterile","supplierPort":"SHANGHAI","supplierAddress":"NO.28, JIAN'AN ROAD, HIG-TECH INDUSTRIAL DEVELOPMENT ZONE,YANGZHOU CITY, JIANGSU PROVINCE 225100,P.R. CHI China","customerAddress":"3RD FLOOR, PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737916200,"product":"BRIVARACETAM (RE-IMPORT MATERIAL VIDE SB NO-4000159 DT:19.02.2024, RID NO-252400672300)","address":"8-3-166\/7\/1, HETERO HOUSE,","city":"HYDERABAD, AP.","supplier":"XXMJIXXPHAXXACEXXICAXXCO XXD","supplierCountry":"KOREA, REPUBLIC OF","foreign_port":"INCHEON","customer":"HONOUR LAB LIMITED","customerCountry":"INDIA","quantity":"41.00","actualQuantity":"41","unit":"KGS","unitRateFc":"2807.7","totalValueFC":"116277.6","currency":"USD","unitRateINR":"244549.3","date":"27-Jan-2025","totalValueINR":"10026521","totalValueInUsd":"116277.6","indian_port":"Vizag-HIPL SEZ","hs_no":"29242990","bill_no":"1000048","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC O","selfForZScoreResived":"Pharma Grade","supplierPort":"INCHEON","supplierAddress":"N\/A","customerAddress":"8-3-166\/7\/1, HETERO HOUSE,"}]
31-Jan-2022
29-Apr-2025
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Drugs in Development

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Details:

Positive topline results from a Phase 3 study investigating the efficacy and safety of adjunctive brivaracetam in participants across Asia (≥16 to 80 years of age) with partial seizures with or without secondary generalization.


Lead Product(s): Brivaracetam

Therapeutic Area: Neurology Brand Name: Brecita

Study Phase: Approved FDFProduct Type: Controlled Substance

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable October 10, 2022

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01

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

Details : Positive topline results from a Phase 3 study investigating the efficacy and safety of adjunctive brivaracetam in participants across Asia (≥16 to 80 years of age) with partial seizures with or without secondary generalization.

Product Name : Brecita

Product Type : Controlled Substance

Upfront Cash : Inapplicable

October 10, 2022

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Details:

With these positive CHMP opinions, BRIVIACT® (brivaracetam) and VIMPAT® (lacosamide) will provide young patients and their caregivers with additional treatment options for POS with or without secondary generalization.


Lead Product(s): Brivaracetam

Therapeutic Area: Neurology Brand Name: Brecita

Study Phase: Approved FDFProduct Type: Controlled Substance

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable February 02, 2022

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02

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

Details : With these positive CHMP opinions, BRIVIACT® (brivaracetam) and VIMPAT® (lacosamide) will provide young patients and their caregivers with additional treatment options for POS with or without secondary generalization.

Product Name : Brecita

Product Type : Controlled Substance

Upfront Cash : Inapplicable

February 02, 2022

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Details:

Brecita (brivaracetam) is indicated as adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 2 years of age with epilepsy.


Lead Product(s): Brivaracetam

Therapeutic Area: Neurology Brand Name: Brecita

Study Phase: Approved FDFProduct Type: Controlled Substance

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 12, 2022

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03

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

Details : Brecita (brivaracetam) is indicated as adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 2 years of age with epilepsy.

Product Name : Brecita

Product Type : Controlled Substance

Upfront Cash : Inapplicable

January 12, 2022

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Details:

BRIVIACT (brivaracetam) is indicated as adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 2 years of age with epilepsy.


Lead Product(s): Brivaracetam

Therapeutic Area: Neurology Brand Name: Brecita

Study Phase: Approved FDFProduct Type: Controlled Substance

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 04, 2022

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04

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

Details : BRIVIACT (brivaracetam) is indicated as adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 2 years of age with epilepsy.

Product Name : Brecita

Product Type : Controlled Substance

Upfront Cash : Inapplicable

January 04, 2022

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Details:

Brivaracetam Tablets are indicated for the treatment of partial-onset seizures in patients four years of age and older.


Lead Product(s): Brivaracetam

Therapeutic Area: Neurology Brand Name: Brivaracetam-Generic

Study Phase: Approved FDFProduct Type: Controlled Substance

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 16, 2021

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05

Lupin Ltd

India
arrow
IMCAS Asia
Not Confirmed

Lupin Ltd

India
arrow
IMCAS Asia
Not Confirmed

Details : Brivaracetam Tablets are indicated for the treatment of partial-onset seizures in patients four years of age and older.

Product Name : Brivaracetam-Generic

Product Type : Controlled Substance

Upfront Cash : Inapplicable

August 16, 2021

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Details:

Natco Pharma has launched Brivaracetam tablets under brand BRECITA in India. Brivaracetam, indicated towards the treatment of epilepsy, is developed by UCB Pharma and currently marketed in India by Dr Reddy's under the brand name Briviact.


Lead Product(s): Brivaracetam

Therapeutic Area: Neurology Brand Name: Brecita

Study Phase: Approved FDFProduct Type: Controlled Substance

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable February 26, 2021

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06

Natco Pharma

India
arrow
IMCAS Asia
Not Confirmed

Natco Pharma

India
arrow
IMCAS Asia
Not Confirmed

Details : Natco Pharma has launched Brivaracetam tablets under brand BRECITA in India. Brivaracetam, indicated towards the treatment of epilepsy, is developed by UCB Pharma and currently marketed in India by Dr Reddy's under the brand name Briviact.

Product Name : Brecita

Product Type : Controlled Substance

Upfront Cash : Inapplicable

February 26, 2021

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Details:

15 scientific presentations highlight data on BRIVACT® (brivaracetam) CV, NAYZILAM® (midazolam) nasal spray CIV, VIMPAT® (lacosamide) CV, and others, illustrating UCB's commitment to developing new treatment options for patients in their treatment journey.


Lead Product(s): Brivaracetam

Therapeutic Area: Neurology Brand Name: Brecita

Study Phase: Approved FDFProduct Type: Controlled Substance

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable April 12, 2020

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07

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

UCB Pharma S.A

Belgium
arrow
IMCAS Asia
Not Confirmed

Details : 15 scientific presentations highlight data on BRIVACT® (brivaracetam) CV, NAYZILAM® (midazolam) nasal spray CIV, VIMPAT® (lacosamide) CV, and others, illustrating UCB's commitment to developing new treatment options for patients in their treatment jou...

Product Name : Brecita

Product Type : Controlled Substance

Upfront Cash : Inapplicable

April 12, 2020

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INTERMEDIATE SUPPLIERS

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothShanghai Minbiotech is the leading producer of biopharmaceuticals and a variety of high-end generic & innovative drugs.

CAS Number : 63095-51-2

End Use API : Brivaracetam

About The Company : ​Headquartered in Fengxian District, Shanghai Minbiotech Co., Ltd. is a company specializing in the R&D and production of advanced pharmaceutical intermediate...

Shanghai Minbiotech CB

02

IMCAS Asia
Not Confirmed
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IMCAS Asia
Not Confirmed
arrow

CAS Number : 63095-51-2

End Use API : Brivaracetam

About The Company : We are CDMO engaged in drug impurities research, customed synthesis for almost 10 years. In addition, we establish a long-term in-depth partnerships with many w...

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03

IMCAS Asia
Not Confirmed
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IMCAS Asia
Not Confirmed
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CAS Number : 63095-51-2

End Use API : Brivaracetam

About The Company : Aptra Synthesis Private Limited, is a reliable and vertically integrated manufacturer of APIs and intermediates, boasting state-of-the-art manufacturing facilit...

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04

IMCAS Asia
Not Confirmed
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IMCAS Asia
Not Confirmed
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CAS Number : 7682-20-4

End Use API : Brivaracetam

About The Company : Founded in 2003, Senary Chem is one of the Key High-Tech Enterprises of National Torch Plan. Senary located in National Cangzhou Lingang Economic and Technologi...

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05

IMCAS Asia
Not Confirmed
arrow
IMCAS Asia
Not Confirmed
arrow

CAS Number : 63095-51-2

End Use API : Brivaracetam

About The Company : Dalian Richon Chem. Co., Ltd is a high-tech enterprise professionally involved in research and development, manufacturing process and sales service of pharmaceu...

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06

IMCAS Asia
Not Confirmed
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IMCAS Asia
Not Confirmed
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CAS Number : 63095-51-2

End Use API : Brivaracetam

About The Company : Based on the excellent enzymatic technology platform, Enzymaster Chemical applies innovative technology to realize its commercial production of chiral compounds...

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07

Epoch Labs

India
IMCAS Asia
Not Confirmed
arrow

Epoch Labs

India
IMCAS Asia
Not Confirmed
arrow

CAS Number : 63095-51-2

End Use API : Brivaracetam

About The Company : Epoch-Labs is a Hyderabad, India based Research Organization that gives science administrations to expansive pharmaceutical organization, agrochemical organizat...

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08

IMCAS Asia
Not Confirmed
arrow
IMCAS Asia
Not Confirmed
arrow

CAS Number : 63095-51-2

End Use API : Brivaracetam

About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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09

IMCAS Asia
Not Confirmed
arrow
IMCAS Asia
Not Confirmed
arrow

CAS Number : 103765-03-3

End Use API : Brivaracetam

About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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10

IMCAS Asia
Not Confirmed
arrow
IMCAS Asia
Not Confirmed
arrow

CAS Number : 357338-13-7

End Use API : Brivaracetam

About The Company : Established in 2011 and situated in Hangzhou, Zhejiang, China, Hangzhou Longshine Bio-Tech CO., Ltd is dedicated to providing services for pharmaceutical and ch...

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FDF Dossiers

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01

Apotex Inc

Canada
IMCAS Asia
Not Confirmed
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Apotex Inc

Canada
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IMCAS Asia
Not Confirmed

BRIVARACETAM

Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

Dosage Strength : 75MG

Packaging :

Approval Date :

Application Number : 214875

Regulatory Info :

Registration Country : USA

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02

Apotex Inc

Canada
IMCAS Asia
Not Confirmed
arrow

Apotex Inc

Canada
arrow
IMCAS Asia
Not Confirmed

BRIVARACETAM

Brand Name : APO-BRIVARACETAM

Dosage Form : TABLET

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number : 2538717

Regulatory Info : Prescription

Registration Country : Canada

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03

IMCAS Asia
Not Confirmed
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IMCAS Asia
Not Confirmed

brivaracetam

Brand Name :

Dosage Form : Tablet

Dosage Strength : 100MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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04

IMCAS Asia
Not Confirmed
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IMCAS Asia
Not Confirmed

BRIVARACETAM

Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

Dosage Strength : 50MG

Packaging :

Approval Date : 2023-01-06

Application Number : 214848

Regulatory Info : DISCN

Registration Country : USA

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05

IMCAS Asia
Not Confirmed
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IMCAS Asia
Not Confirmed

BRIVARACETAM

Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

Dosage Strength : 25MG

Packaging :

Approval Date :

Application Number : 214921

Regulatory Info :

Registration Country : USA

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BRIVARACETAM

Brand Name : BRIVARACETAM

Dosage Form : SOLUTION;INTRAVENOUS

Dosage Strength : 50MG/5ML (10MG/ML)

Packaging :

Approval Date :

Application Number : 214924

Regulatory Info :

Registration Country : USA

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brivaracetam

Brand Name : Briviact

Dosage Form : Antic-calc Tablet, Film Coated

Dosage Strength : 75 mg

Packaging : Blister

Approval Date :

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Regulatory Info :

Registration Country : Norway

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BRIVARACETAM

Brand Name : BRIVLERA

Dosage Form : TABLET

Dosage Strength : 25MG

Packaging : 1/14/60

Approval Date :

Application Number : 2452944

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : BRIVARACETAM

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Dosage Strength : 50MG

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Application Number : 214875

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Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

Dosage Strength : 50MG

Approval Date : 2023-01-06

Application Number : 214848

RX/OTC/DISCN : DISCN

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Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

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Approval Date : 2022-12-20

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Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

Dosage Strength : 25MG

Approval Date : 2022-06-09

Application Number : 214748

RX/OTC/DISCN : DISCN

RLD : No

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Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

Dosage Strength : 50MG

Approval Date : 2022-06-09

Application Number : 214748

RX/OTC/DISCN : DISCN

RLD : No

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Brand Name : BRIVARACETAM

Dosage Form : TABLET;ORAL

Dosage Strength : 75MG

Approval Date : 2022-06-09

Application Number : 214748

RX/OTC/DISCN : DISCN

RLD : No

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Brand Name : BRIVIACT

Dosage Form : SOLUTION;ORAL

Dosage Strength : 10MG/ML

Approval Date : 2016-05-12

Application Number : 205838

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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Brivaracetam

Brand Name : Briviact

Dosage Form : Tablet, film-coated

Dosage Strength : 50 mg

Packaging : Blisterpakning 56item

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Brand Name : Briviact

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Brand Name : Briviact

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Dosage Strength : 100 MG

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Brand Name : Briviact

Dosage Form : Injection/infusion fluid, resolution

Dosage Strength : 10 mg/ml

Packaging : Hood glass

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Brand Name : Briviact

Dosage Form : Antic-calc Tablet, Film Coated

Dosage Strength : 100 mg

Packaging : Blister

Approval Date :

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Regulatory Info :

Registration Country : Norway

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Brand Name : Briviact

Dosage Form : Tablet, film-coated

Dosage Strength : 100 mg

Packaging : Blisterpakning 56item

Approval Date :

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Brand Name : Briviact

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Dosage Strength : 10 mg/ml

Packaging : Vials 10 5ml

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Registration Country : Norway

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Brand Name : Briviact

Dosage Form : Tablet, film-coated

Dosage Strength : 50 mg

Packaging : Blisterpakning 56item

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Registration Country : Norway

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Brand Name : Briviact

Dosage Form : Film-Coated Tablets

Dosage Strength : 100mg

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Approval Date :

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Registration Country : Switzerland

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BRIVARACETAM

Brand Name : APO-BRIVARACETAM

Dosage Form : TABLET

Dosage Strength : 10MG

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Approval Date :

Application Number : 2538679

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : APO-BRIVARACETAM

Dosage Form : TABLET

Dosage Strength : 50MG

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Application Number : 2538695

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : APO-BRIVARACETAM

Dosage Form : TABLET

Dosage Strength : 75MG

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Application Number : 2538709

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : APO-BRIVARACETAM

Dosage Form : TABLET

Dosage Strength : 100MG

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Application Number : 2538717

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : AURO-BRIVARACETAM

Dosage Form : TABLET

Dosage Strength : 50MG

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Application Number : 2539292

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : AURO-BRIVARACETAM

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Application Number : 2539306

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : BRIVLERA

Dosage Form : TABLET

Dosage Strength : 10MG

Packaging : 1/14/60

Approval Date :

Application Number : 2452936

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : BRIVLERA

Dosage Form : TABLET

Dosage Strength : 50MG

Packaging : 1/14/60

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Application Number : 2452952

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : BRIVLERA

Dosage Form : TABLET

Dosage Strength : 75MG

Packaging : 1/14/60

Approval Date :

Application Number : 2452960

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : BRIVLERA

Dosage Form : SOLUTION

Dosage Strength : 10MG/ML

Packaging : 300ML

Approval Date :

Application Number : 2452987

Regulatory Info : Prescription

Registration Country : Canada

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Brand Name : Briviact

Dosage Form :

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Packaging : 56

Approval Date :

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Registration Country : Australia

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ABOUT THIS PAGE

Looking for 357336-20-0 / Brivaracetam API manufacturers, exporters & distributors?

Brivaracetam manufacturers, exporters & distributors 1

23

PharmaCompass offers a list of Brivaracetam API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Brivaracetam manufacturer or Brivaracetam supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Brivaracetam manufacturer or Brivaracetam supplier.

PharmaCompass also assists you with knowing the Brivaracetam API Price utilized in the formulation of products. Brivaracetam API Price is not always fixed or binding as the Brivaracetam Price is obtained through a variety of data sources. The Brivaracetam Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Brivaracetam

Synonyms

357336-20-0, Briviact, Ucb-34714, Ucb 34714, Ucb34714, 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide

Cas Number

357336-20-0

Unique Ingredient Identifier (UNII)

U863JGG2IA

About Brivaracetam

Brivaracetam is an orally bioavailable levetiracetam derivative, with anticonvulsant activity. Although the exact mechanism through which brivaracetam exerts its effects is not fully known, this agent targets and binds to synaptic vesicle protein 2A (SV2A) in the brain. This prevents synaptic vesicle exocytosis and the synaptic release of certain, as of yet not fully known, excitatory neurotransmitters. This may inhibit impulse conduction across synapses, decrease neuronal (hyper-)excitability, and may modulate epileptogenesis. SV2A, a membrane glycoprotein present in neuronal synaptic vesicles, plays a key role in action potential-induced neurotransmitter release in the brain.

357336-20-0 Manufacturers

A 357336-20-0 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 357336-20-0, including repackagers and relabelers. The FDA regulates 357336-20-0 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 357336-20-0 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of 357336-20-0 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

357336-20-0 Suppliers

A 357336-20-0 supplier is an individual or a company that provides 357336-20-0 active pharmaceutical ingredient (API) or 357336-20-0 finished formulations upon request. The 357336-20-0 suppliers may include 357336-20-0 API manufacturers, exporters, distributors and traders.

click here to find a list of 357336-20-0 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

357336-20-0 USDMF

A 357336-20-0 DMF (Drug Master File) is a document detailing the whole manufacturing process of 357336-20-0 active pharmaceutical ingredient (API) in detail. Different forms of 357336-20-0 DMFs exist exist since differing nations have different regulations, such as 357336-20-0 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A 357336-20-0 DMF submitted to regulatory agencies in the US is known as a USDMF. 357336-20-0 USDMF includes data on 357336-20-0's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 357336-20-0 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of 357336-20-0 suppliers with USDMF on PharmaCompass.

357336-20-0 KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a 357336-20-0 Drug Master File in Korea (357336-20-0 KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of 357336-20-0. The MFDS reviews the 357336-20-0 KDMF as part of the drug registration process and uses the information provided in the 357336-20-0 KDMF to evaluate the safety and efficacy of the drug.

After submitting a 357336-20-0 KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their 357336-20-0 API can apply through the Korea Drug Master File (KDMF).

click here to find a list of 357336-20-0 suppliers with KDMF on PharmaCompass.

357336-20-0 CEP

A 357336-20-0 CEP of the European Pharmacopoeia monograph is often referred to as a 357336-20-0 Certificate of Suitability (COS). The purpose of a 357336-20-0 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of 357336-20-0 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of 357336-20-0 to their clients by showing that a 357336-20-0 CEP has been issued for it. The manufacturer submits a 357336-20-0 CEP (COS) as part of the market authorization procedure, and it takes on the role of a 357336-20-0 CEP holder for the record. Additionally, the data presented in the 357336-20-0 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the 357336-20-0 DMF.

A 357336-20-0 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. 357336-20-0 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of 357336-20-0 suppliers with CEP (COS) on PharmaCompass.

357336-20-0 WC

A 357336-20-0 written confirmation (357336-20-0 WC) is an official document issued by a regulatory agency to a 357336-20-0 manufacturer, verifying that the manufacturing facility of a 357336-20-0 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting 357336-20-0 APIs or 357336-20-0 finished pharmaceutical products to another nation, regulatory agencies frequently require a 357336-20-0 WC (written confirmation) as part of the regulatory process.

click here to find a list of 357336-20-0 suppliers with Written Confirmation (WC) on PharmaCompass.

357336-20-0 NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing 357336-20-0 as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for 357336-20-0 API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture 357336-20-0 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain 357336-20-0 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a 357336-20-0 NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of 357336-20-0 suppliers with NDC on PharmaCompass.

357336-20-0 GMP

357336-20-0 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 357336-20-0 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 357336-20-0 GMP manufacturer or 357336-20-0 GMP API supplier for your needs.

357336-20-0 CoA

A 357336-20-0 CoA (Certificate of Analysis) is a formal document that attests to 357336-20-0's compliance with 357336-20-0 specifications and serves as a tool for batch-level quality control.

357336-20-0 CoA mostly includes findings from lab analyses of a specific batch. For each 357336-20-0 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

357336-20-0 may be tested according to a variety of international standards, such as European Pharmacopoeia (357336-20-0 EP), 357336-20-0 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (357336-20-0 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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