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Also known as: Fet f-18, 178433-03-9, L-tyrosine, o-(2-(fluoro-18f)ethyl)-, L-tyrosine, o-[2-(fluoro-18f)ethyl]-, Dtxsid601045942, O-(2-[18f]fluoroethyl)-l-tyrosine

Molecular Formula

C₁₁H₁₄FNO₃

Molecular Weight

226.23 g/mol

InChI Key

QZZYPHBVOQMBAT-LRAGLOQXSA-N

FDA UNII

1326R5J1IA

F-18 Fluoroethyltyrosine is an amino acid analog radiolabeled with fluorine F 18, a positron emitting isotope, used as a tracer in positron emission tomography (PET). Reflecting the increased amino acid transport capacity of tumor cells, F-18 fluroethyltyrosine (F-18 FET) is actively taken up in tumor cells via the amino acid transport system, but is neither incorporated into proteins nor readily degraded, resulting in high intracellular concentrations of this imaging agent. Radiolabeled amino acid-based agents are useful in PET brain tumor imaging because F-18 fluoro-deoxyglucose (F-18 FDG), commonly used in PET tumor imaging, is relatively insensitive for detecting tumors in the brain due to high levels of glycolytic metabolism in the normal cortex and to a lesser extent in white matter.

1 2D Structure

18-F Fluoroethyl-L-Tyrosine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-2-amino-3-[4-(2-(18F)fluoroethoxy)phenyl]propanoic acid

2.1.2 InChI

InChI=1S/C11H14FNO3/c12-5-6-16-9-3-1-8(2-4-9)7-10(13)11(14)15/h1-4,10H,5-7,13H2,(H,14,15)/t10-/m0/s1/i12-1

2.1.3 InChI Key

QZZYPHBVOQMBAT-LRAGLOQXSA-N

2.2 Other Identifiers

2.2.1 UNII

1326R5J1IA

2.3 Synonyms

2.3.1 MeSH Synonyms

1. L-(18f)fet

2. O-(2-((18)f)fluoroethyl)-l-tyrosine

2.3.2 Depositor-Supplied Synonyms

1. Fet F-18

2. 178433-03-9

3. L-tyrosine, O-(2-(fluoro-18f)ethyl)-

4. L-tyrosine, O-[2-(fluoro-18f)ethyl]-

5. Dtxsid601045942

6. O-(2-[18f]fluoroethyl)-l-tyrosine

7. Refchem:928016

8. L-(18f)fet

9. Dtxcid201527875

10. O-(2-((18)f)fluoroethyl)-l-tyrosine

11. (2s)-2-amino-3-(4-(2-(1?f)fluoroethoxy)phenyl)propanoic Acid

12. 18f-fet

13. (18f)fluoroethyltyrosine

14. 1326r5j1ia

15. 18f-fluoroethyltyrosine

16. Fluoroethyltyrosine F-18

17. 18f-fluoroethyl-l-tyrosine

18. 2-fluoroethyltyrosine F-18

19. Unii-1326r5j1ia

20. Fluoroethyl-l-tyrosine (18f)

21. O-(2-fluorethyl)-l-thyrosine

22. J1.857.391a

23. Floretyrosine F18 (usan)

24. Floretyrosine F18 [usan]

25. (s)-2-amino-3-(4-(2-(fluoro-18f)ethoxy)phenyl)propanoic Acid

26. Floretyrosine F18

27. Floretyrosine F-18

28. Floretyrosine (18f)

29. Tlx101-cdx

30. Floretyrosine (18f) [inn]

31. Chembl477278

32. Orb1697209

33. Schembl11939889

34. O-(2-fluoroethyl)-l-tyrosine F-18

35. Akos040751800

36. Db15405

37. O-[2-(fluoro-18f)ethyl]-l-tyrosine

38. D12767

39. Fluoroethyl-l-tyrosine (18f) [who-dd]

40. Q22908451

41. (2s)-2-amino-3-[4-(2-(18f)fluoranylethoxy)phenyl]propanoic Acid

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₄FNO₃
Molecular Weight	226.23 g/mol
XLogP3	-0.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	72.6
Heavy Atom Count	16
Formal Charge	0
Complexity	217
Isotope Atom Count	1
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 ATC Code

V - Various

V09 - Diagnostic radiopharmaceuticals

V09I - Tumour detection

V09IX - Other diagnostic radiopharmaceuticals for tumour detection

V09IX10 - Fluoroethyl-L-tyrosine (18F)

ATCvet Code

QV - Various

QV09 - Diagnostic radiopharmaceuticals

QV09I - Tumour detection

QV09IX - Other diagnostic radiopharmaceuticals for tumour detection

QV09IX10 - Fluoroethyl-l-tyrosine (18f)

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