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Chemistry

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Also known as: 179474-85-2, Resolor, Prucalopride succinat, Prucalopride (succinate), R-108512, Butanedioic acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
Molecular Formula
C22H32ClN3O7
Molecular Weight
486.0  g/mol
InChI Key
QZRSNVSQLGRAID-UHFFFAOYSA-N
FDA UNII
4V2G75E1CK

Prucalopride Succinate
1 2D Structure

Prucalopride Succinate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acid
2.1.2 InChI
InChI=1S/C18H26ClN3O3.C4H6O4/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;5-3(6)1-2-4(7)8/h11-12H,2-10,20H2,1H3,(H,21,23);1-2H2,(H,5,6)(H,7,8)
2.1.3 InChI Key
QZRSNVSQLGRAID-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
4V2G75E1CK
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-amino-5-chloro-n-(1-(3-methoxypropyl)-4-piperidinyl)-2,3-dihydro-1-benzofuran-7-carboxamide

2. Motegrity

3. Prucalopride

4. R 093877

5. R093877

6. Resolor

7. Resotran

8. Resotrans

2.3.2 Depositor-Supplied Synonyms

1. 179474-85-2

2. Resolor

3. Prucalopride Succinat

4. Prucalopride (succinate)

5. R-108512

6. Butanedioic Acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide

7. Prucalopride Succinate [usan]

8. Prucalopride (as Succinate)

9. 4v2g75e1ck

10. 179474-85-2 (succinate)

11. 4-amino-5-chloro-n-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide Succinate

12. Butanedioic Acid, Compd. With 4-amino-5-chloro-2,3-dihydro-n-(1-(3-methoxypropyl)-4-piperidinyl)-7-benzofurancarboxamide (1:1)

13. Butanedioic Acid, Compd. With 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)

14. Prucalopride Succinate (usan)

15. Resotran

16. 4-amino-5-chloro-n-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic Acid

17. Resolor (tn)

18. Unii-4v2g75e1ck

19. R-93877

20. Resolor Succinate

21. Motegrity (tn)

22. Prucalopridesuccinate

23. R 108512

24. Mls006011219

25. Schembl1230437

26. Chembl2105748

27. Dtxsid701027749

28. Hms3652b21

29. Hms3885j13

30. Bcp09320

31. Mfcd00948731

32. S4247

33. Akos015994741

34. Prucalopride Succinate [mart.]

35. Ccg-269590

36. Cs-3907

37. Ks-1283

38. Prucalopride Succinate [who-dd]

39. 4-amino-5-chloro-n-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic Acid

40. Ac-29960

41. Butanedioic Acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarb

42. Hy-12694

43. Smr004702981

44. Db-065276

45. Prucalopride Succinate [orange Book]

46. Ft-0745512

47. Sw219198-1

48. D10152

49. A812449

50. J-519956

51. Q27260539

52. B0084-470898

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 486.0 g/mol
Molecular Formula C22H32ClN3O7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass485.1928781 g/mol
Monoisotopic Mass485.1928781 g/mol
Topological Polar Surface Area151 Ų
Heavy Atom Count33
Formal Charge0
Complexity538
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Resolor is indicated for symptomatic treatment of chronic constipation in adults in whom laxatives fail to provide adequate relief.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Laxatives

Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION. (See all compounds classified as Laxatives.)


Serotonin 5-HT4 Receptor Agonists

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS. (See all compounds classified as Serotonin 5-HT4 Receptor Agonists.)


5.2 ATC Code

A06AX05


API Reference Price

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11-Jan-2022
22-Apr-2025
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ABOUT THIS PAGE

Looking for 179474-85-2 / Prucalopride Succinate API manufacturers, exporters & distributors?

Prucalopride Succinate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Prucalopride Succinate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Prucalopride Succinate manufacturer or Prucalopride Succinate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Prucalopride Succinate manufacturer or Prucalopride Succinate supplier.

PharmaCompass also assists you with knowing the Prucalopride Succinate API Price utilized in the formulation of products. Prucalopride Succinate API Price is not always fixed or binding as the Prucalopride Succinate Price is obtained through a variety of data sources. The Prucalopride Succinate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Prucalopride Succinate

Synonyms

179474-85-2, Resolor, Prucalopride succinat, Prucalopride (succinate), R-108512, Butanedioic acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide

Cas Number

179474-85-2

Unique Ingredient Identifier (UNII)

4V2G75E1CK

179474-85-2 Manufacturers

A 179474-85-2 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 179474-85-2, including repackagers and relabelers. The FDA regulates 179474-85-2 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 179474-85-2 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of 179474-85-2 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

179474-85-2 Suppliers

A 179474-85-2 supplier is an individual or a company that provides 179474-85-2 active pharmaceutical ingredient (API) or 179474-85-2 finished formulations upon request. The 179474-85-2 suppliers may include 179474-85-2 API manufacturers, exporters, distributors and traders.

click here to find a list of 179474-85-2 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

179474-85-2 USDMF

A 179474-85-2 DMF (Drug Master File) is a document detailing the whole manufacturing process of 179474-85-2 active pharmaceutical ingredient (API) in detail. Different forms of 179474-85-2 DMFs exist exist since differing nations have different regulations, such as 179474-85-2 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A 179474-85-2 DMF submitted to regulatory agencies in the US is known as a USDMF. 179474-85-2 USDMF includes data on 179474-85-2's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 179474-85-2 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of 179474-85-2 suppliers with USDMF on PharmaCompass.

179474-85-2 KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a 179474-85-2 Drug Master File in Korea (179474-85-2 KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of 179474-85-2. The MFDS reviews the 179474-85-2 KDMF as part of the drug registration process and uses the information provided in the 179474-85-2 KDMF to evaluate the safety and efficacy of the drug.

After submitting a 179474-85-2 KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their 179474-85-2 API can apply through the Korea Drug Master File (KDMF).

click here to find a list of 179474-85-2 suppliers with KDMF on PharmaCompass.

179474-85-2 WC

A 179474-85-2 written confirmation (179474-85-2 WC) is an official document issued by a regulatory agency to a 179474-85-2 manufacturer, verifying that the manufacturing facility of a 179474-85-2 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting 179474-85-2 APIs or 179474-85-2 finished pharmaceutical products to another nation, regulatory agencies frequently require a 179474-85-2 WC (written confirmation) as part of the regulatory process.

click here to find a list of 179474-85-2 suppliers with Written Confirmation (WC) on PharmaCompass.

179474-85-2 NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing 179474-85-2 as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for 179474-85-2 API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture 179474-85-2 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain 179474-85-2 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a 179474-85-2 NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of 179474-85-2 suppliers with NDC on PharmaCompass.

179474-85-2 GMP

179474-85-2 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 179474-85-2 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 179474-85-2 GMP manufacturer or 179474-85-2 GMP API supplier for your needs.

179474-85-2 CoA

A 179474-85-2 CoA (Certificate of Analysis) is a formal document that attests to 179474-85-2's compliance with 179474-85-2 specifications and serves as a tool for batch-level quality control.

179474-85-2 CoA mostly includes findings from lab analyses of a specific batch. For each 179474-85-2 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

179474-85-2 may be tested according to a variety of international standards, such as European Pharmacopoeia (179474-85-2 EP), 179474-85-2 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (179474-85-2 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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