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1. Allyloestrenol
2. Gestanin
3. Gestanon
4. Turinal
1. 432-60-0
2. Gestanin
3. Gestanon
4. Allyloestrenol
5. Gestanol
6. Orageston
7. Turinal
8. Organon
9. Gestanyn
10. Estrenol, Allyl-
11. 17-allylestr-4-en-17-beta-ol
12. 17alpha-allyl-4-estren-17beta-ol
13. 17alpha-allylestr-4-en-17beta-ol
14. Perselin
15. I47vb5dz8o
16. 17.alpha.-allylestr-4-en-17.beta.-ol
17. (8r,9s,10r,13s,14s,17r)-13-methyl-17-prop-2-enyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ol
18. Chebi:31189
19. Estr-4-en-17-ol, 17-(2-propenyl)-, (17b)-
20. Nsc-37723
21. 19-norpregn-4-ene-20-yn-17beta-ol
22. Allyloestrenolum
23. 17-alpha-allylestr-4-en-17-beta-ol
24. 17alpha-allylestrenol
25. Allilestrenolo [dcit]
26. Gestanon-r
27. Alilestrenol [inn-spanish]
28. Allylestrenolum [inn-latin]
29. Perselin (tn)
30. 17.alpha.-allylestrenol
31. 17alpha-allyl-4-destrene-17beta-ol
32. 17alpha-allyl-4-oestrene-17beta-ol
33. Allylestrenol (jan/inn)
34. 17-hydroxy-17-alpha-allyl-4-estrene
35. 17-alpha-allyl-4-oestrene-17-beta-ol
36. 17alpha-allyl-17beta-hydroxy-4-estrene
37. Alilestrenol
38. Allilestrenolo
39. Allylestrenolum
40. 17alpha-allyl-3-deoxy-19-nortestosterone
41. Allyl Estrenol
42. 17-alpha-allyl-17-beta-hydroxy-4-estrene
43. Ccris 9068
44. 17-alpha-allyl-3-deoxy-19-nortestosterone
45. 17-alpha-allylhydroxy-19-nor-4-androstene
46. 3-deoxy-17-alpha-allyl-19-nortestosterone
47. Ncgc00159497-02
48. 21-methylene-19-nor-17-alpha-preg-4-en-17-ol
49. Einecs 207-082-9
50. Estr-4-en-17beta-ol, 17-allyl-
51. 17-alpha-allyl-17-beta-hydroxy-delta(sup 4)-estren
52. 17alpha-allyl-19-nor-delta-4-androstene-17beta-ol
53. Nsc 37723
54. Estr-4-en-17-ol, 17-(2-propenyl)-, (17beta)-
55. Brn 3148038
56. 17.alpha.-allyl-4-estren-17.beta.-ol
57. 17.alpha.-allyl-4-destrene-17.beta.-ol
58. 17.alpha.-allyl-4-oestrene-17.beta.-ol
59. Estr-4-en-17-beta-ol, 17-allyl-
60. 17.alpha.-allyl-3-deoxy-19-nortestosterone
61. Dsstox_cid_2574
62. 17.alpha.-allyl-17.beta.-hydroxy-4-estrene
63. Allylestrenol [mi]
64. Unii-i47vb5dz8o
65. Allylestrenol [inn]
66. Allylestrenol [jan]
67. Dsstox_rid_76637
68. (17beta)-17-prop-2-en-1-ylestr-4-en-17-ol
69. Dsstox_gsid_22574
70. Allylestrenol [mart.]
71. Schembl329623
72. 19-nor-17-alpha-preg-4-en-17-ol, 21-methylene-
73. Allylestrenol [who-dd]
74. Allylestrenol [inn:ban:jan]
75. Chembl3185133
76. Dtxsid9022574
77. 17.alpha.-allyl-17-.beta.-hydroxy-.delta.(sup 4)-estren
78. Bcp10809
79. Nsc37723
80. Zinc4214767
81. Tox21_111718
82. Lmst02030125
83. Mfcd00198957
84. S5219
85. Akos015964938
86. Db01431
87. Ds-8255
88. Estr-4-en-17-ol, (17.beta.)-
89. Estr-4-en-17.beta.-ol, 17-allyl-
90. Cas-432-60-0
91. Hy-17375
92. 3-deketo-17alpha-allyl-19-nortestosterone
93. Cs-0006769
94. Wln: L E5 B666 Mutj E1 Fq F2u1
95. D01374
96. 4-06-00-04143 (beilstein Handbook Reference)
97. 432a600
98. Q531965
99. Sr-01000883956
100. Sr-01000883956-1
| Molecular Weight | 300.5 g/mol |
|---|---|
| Molecular Formula | C21H32O |
| XLogP3 | 5.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 300.245315640 g/mol |
| Monoisotopic Mass | 300.245315640 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 492 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 6 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Allylestrenol was designed to be used for miscarriage prevention, prevention of premature labour and has been investigated for possible use in men for treatment for benign prostatic hyperplasia.
Allylestrenol is a progestogen structurally related to progesterone that has been given in threatened and recurrent miscarriage, and to prevent premature labour. However, with the exception of proven progesterone deficiency, such use is no longer recommended. In threatened miscarriage in progesterone-deficient women a suggested dose is 5 mg three times daily by mouth for 5 to 7 days.
Progestins
Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY. (See all compounds classified as Progestins.)
G - Genito urinary system and sex hormones
G03 - Sex hormones and modulators of the genital system
G03D - Progestogens
G03DC - Estren derivatives
G03DC01 - Allylestrenol
Route of Elimination
The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.
Allylestrenol is similar in structure and function to progesterone. Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.
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