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169D1260Km
Also known as: Nitroprusside [who-dd], Dtxsid2046963, 169d1260km
Molecular Formula
C5FeN6O-2
Molecular Weight
215.94  g/mol
InChI Key
YEESUBCSWGVPCE-UHFFFAOYSA-N
FDA UNII
169D1260KM

A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Nitroprusside is a Vasodilator. The physiologic effect of nitroprusside is by means of Vasodilation.
1 2D Structure

169D1260Km

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
azanylidyneoxidanium;iron(2+);pentacyanide
2.1.2 InChI
InChI=1S/5CN.Fe.NO/c5*1-2;;1-2/q5*-1;+2;+1
2.1.3 InChI Key
YEESUBCSWGVPCE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+].[Fe+2]
2.2 Other Identifiers
2.2.1 UNII
169D1260KM
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cyanonitrosylferrate

2. Disodium Salt Nitroprusside

3. Ketostix

4. Naniprus

5. Nipride

6. Nipruton

7. Nitriate

8. Nitroferricyanide

9. Nitropress

10. Nitroprussiat Fides

11. Nitroprusside

12. Nitroprusside, Disodium Salt

13. Nitroprusside, Disodium Salt, Dihydrate

14. Nitroprusside, Sodium

15. Sodium Nitroprusside

2.3.2 Depositor-Supplied Synonyms

1. Nitroprusside [who-dd]

2. Dtxsid2046963

3. 169d1260km

2.4 Create Date
2017-02-17
3 Chemical and Physical Properties
Molecular Weight 215.94 g/mol
Molecular Formula C5FeN6O-2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count11
Rotatable Bond Count0
Exact Mass215.948294 g/mol
Monoisotopic Mass215.948294 g/mol
Topological Polar Surface Area144 Ų
Heavy Atom Count13
Formal Charge-2
Complexity20
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count7
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Indicators and Reagents

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)


Nitric Oxide Donors

A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


4.2 FDA Pharmacological Classification
4.2.1 Active Moiety
NITROPRUSSIDE
4.2.2 FDA UNII
169D1260KM
4.2.3 Pharmacological Classes
Established Pharmacologic Class [EPC] - Vasodilator
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