1263-89-4

Synopsis, Chemistry

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Suppliers, 4 ACG Worldwide, 3 Lonza Capsugel, 2 Roquette, 1 Nanjing Well Pharmaceutical, 1 Gangwal Chemicals, 1 BASF, 1 Finar, 1 Qualicaps, 1 Seppic

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8 Empty Capsules, 4 Film Formers & Plasticizers, 4 Coating Systems & Additives, 2 Topical, 1 Solubilizers, 1 Fillers, Diluents & Binders, 1 Thickeners and Stabilizers, 1 Taste Masking, 1 Parenteral

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Also known as: 1263-89-4, Paromomycin sulfate salt, Aminosidine sulfate, Gabbroral, Humatin, Aminosidin sulfate

Molecular Formula

C₂₃H₄₇N₅O₁₈S

Molecular Weight

713.7 g/mol

InChI Key

LJRDOKAZOAKLDU-UDXJMMFXSA-N

FDA UNII

845NU6GJPS

An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.

1 2D Structure

1263-89-4

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid

2.1.2 InChI

InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

2.1.3 InChI Key

LJRDOKAZOAKLDU-UDXJMMFXSA-N

2.1.4 Canonical SMILES

C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

2.1.5 Isomeric SMILES

C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

845NU6GJPS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aminosidine

2. Beta-d-glucopyranosyl-isomer Paromomycin

3. Catenulin

4. Estomycin

5. Gabbromycin

6. Humatin

7. Hydroxymycin

8. Neomycin E

9. Paramomycin

10. Paromomycin

11. Paromomycin I

12. Paromomycin Phosphate

13. Paromomycin Sulfate (1:1)

14. Paromomycin Sulfate (2:5)

15. Paromomycin, Beta D Glucopyranosyl Isomer

16. Paromomycin, Beta-d-glucopyranosyl-isomer

2.3.2 Depositor-Supplied Synonyms

1. 1263-89-4

2. Paromomycin Sulfate Salt

3. Aminosidine Sulfate

4. Gabbroral

5. Humatin

6. Aminosidin Sulfate

7. Gabbromicina

8. Farmiglucin

9. Farminosidin

10. Aminoxidin

11. Humagel

12. Sinosid

13. Aminosidine Sulphate

14. Paromomycin (sulfate)

15. Paromomycin Sulphate

16. 845nu6gjps

17. Paromomycin, Sulfate (1:1)

18. 7205-49-4

19. Gabbromycin

20. Pargonyl

21. Fi 5853

22. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-(((2r,3s,4r,5s)-5-(((1r,2r,3s,5r,6s)-3,5-diamino-2-(((2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2h-pyran-3,4-diol Sulfate

23. Humycin Sulfate

24. Nsc-758421

25. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-(((2r,3s,4r,5s)-5-(((1r,2r,3s,5r,6s)-3,5-diamino-2-(((2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2h-pyran-3,4-diol Sulfate(1:x)

26. Paromomycin Sulphates

27. Mfcd00079278

28. Paromomycin Sulfate [jan]

29. Unii-845nu6gjps

30. Paramicina

31. Paricina

32. Paromomycin Sulfate [usp:jan]

33. 1600 Antibiotic

34. Einecs 215-031-7

35. Humatin (tn)

36. Paromomycine Sulphate

37. Aminosidine Sulfate;paromomycin Sulfate Salt

38. Estomycin Sulfate

39. Crestomycin Sulfate

40. Ncgc00166210-01

41. Cas-1263-89-4

42. Schembl3355

43. Dsstox_cid_27806

44. Dsstox_rid_82574

45. Dsstox_gsid_47829

46. Paromomycin Sulphate (1:1)

47. Mls000028384

48. Penicillamine [who-ip]

49. Chebi:7935

50. Paromomycin Sulfate (jan/usp)

51. Chembl2206196

52. Paromomycin Sulfate [mi]

53. Dtxsid601335979

54. Paromomycin Sulfate [vandf]

55. Hy-b0956

56. Paromomycin Sulfate [mart.]

57. Einecs 230-575-5

58. Tox21_112349

59. Paromomycin Sulfate [usp-rs]

60. Paromomycin Sulfate [who-dd]

61. Paromomycin Sulfate [who-ip]

62. S4183

63. Penicillaminum [who-ip Latin]

64. Akos015855755

65. Akos016009094

66. Ccg-270398

67. Cs-4433

68. Fi-5853

69. Ks-1378

70. Nsc 758421

71. Paromomycin Sulfate [orange Book]

72. Smr000058551

73. Paromomycin Sulfate [usp Monograph]

74. Paromomycini Sulfas [who-ip Latin]

75. D00868

76. 263p894

77. Q-201537

78. Q27269495

79. Z1551627167

80. Hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric Acid

81. Paromomycin Sulfate, Antibiotic For Culture Media Use Only

82. (1r,2r,3s,4r,6s)-4,6-diamino-2-{[3-o-(2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl)-beta-d-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-d-glucopyranoside Sulfate

83. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(

84. (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-{[(2r,3s,4r,5s)-5-{[(1r,2r,3s,5r,6s)-3,5-diamino-2-{[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; Sulfuric Acid

85. D-streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-o-.beta.-d-ribofuranosyl-(1->5)-o-(2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxy-, Sulfate (1:1)

86. D-streptamine, O-2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4)-o-(o-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-.beta.-d-ribofuranosyl-(1->5))-2-deoxy-, Sulfate (salt)

87. D-streptamine, O-2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4)-o-(o-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-.beta.-d-ribofuranosyl-(1->5))-2-deoxy-, Sulphate (salt)

88. D-streptamine, O-2-amino-2-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-beta-d-ribofuranosyl-(1-5))-2-deoxy-, Sulfate (salt)

89. D-streptamine, O-2-amino-2-deoxy-alpha-d-glucopyranosyl-(1.fwdarw.4)-o-(o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1.fwdarw.3)-beta-d-ribofuranosyl-(1.fwdarw.5))-2-deoxy-, Sulfate (salt)

90. D-streptamine, O-2-amino-2-deoxy-alpha-d-glucopyranosyl-1-(1-4)-o-(o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribofuranosyl-(1-5))-2-deoxy-, Sulfate (1:1) (salt)

91. O-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-o-.beta.-d-ribofuranosyl-(1->5)-o-(2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxystreptamine Sulfate (salt)

92. O-2,6-diamino-2,6-dideoxy-.beta.-l-idopyranosyl-(1->3)-o-.beta.-d-ribofuranosyl-(1->5)-o-(2-amino-2-deoxy-.alpha.-d-glucopyranosyl-(1->4))-2-deoxystreptamine Sulphate (salt)

93. O-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribofuranosyl-(1-5)-o-(2-amino-2-deoxy-alpha-d-glucopyranosyl-(1-4))-2-deoxystreptamine Sulfate (salt)

94. Paromomycin Sulfate Is The Sulfate Salt Of An Antibiotic Substance Or Substances Produced By The Growth Of Streptomyces Rimosus Var. Paromomycinus, Or A Mixture Of Two Or More Such Salts

95. Paromomycin Sulphate Is The Sulphate Salt Of An Antibiotic Substance Or Substances Produced By The Growth Of Streptomyces Rimosus Var. Paromomycinus, Or A Mixture Of Two Or More Such Salts

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₄₇N₅O₁₈S
Molecular Weight	713.7 g/mol
Hydrogen Bond Donor Count	15
Hydrogen Bond Acceptor Count	23
Rotatable Bond Count	9
Exact Mass	713.26368084 g/mol
Monoisotopic Mass	713.26368084 g/mol
Topological Polar Surface Area	430 Å²
Heavy Atom Count	47
Formal Charge	0
Complexity	952
Isotope Atom Count	0
Defined Atom Stereocenter Count	19
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Paromomycin sulfate
Drug Label	Paromomycin sulfate is a broad spectrum antibiotic produced by Streptomyces riomosus var. paromomycinus. It is a white, amorphous, stable, water-soluble product. Paromomycin sulfate is designated chemically as O-2,6-Diamino-2,6-dideoxy--L-idopyrano...
Active Ingredient	Paromomycin sulfate
Dosage Form	Capsule
Route	Oral
Strength	eq 250mg base
Market Status	Prescription
Company	Sun Pharm Inds; Heritage Pharms

2 of 2
Drug Name	Paromomycin sulfate
Drug Label	Paromomycin sulfate is a broad spectrum antibiotic produced by Streptomyces riomosus var. paromomycinus. It is a white, amorphous, stable, water-soluble product. Paromomycin sulfate is designated chemically as O-2,6-Diamino-2,6-dideoxy--L-idopyrano...
Active Ingredient	Paromomycin sulfate
Dosage Form	Capsule
Route	Oral
Strength	eq 250mg base
Market Status	Prescription
Company	Sun Pharm Inds; Heritage Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiprotozoal Agents

Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Antiprotozoal [EPC]

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1263-89-4

1263-89-4

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

2 API Suppliers

1 JDMF

6 NDC API

2 Listed Suppliers

DOSSIERs // Finished Dosage Formulations

6 Dossiers

5 FDA Orange Book

1 Canada

RELATED EXCIPIENT COMPANIES

Suppliers

4 ACG Worldwide

3 Lonza Capsugel

2 Roquette

1 Nanjing Well Pharmaceutical

1 Gangwal Chemicals

1 BASF

1 Finar

1 Qualicaps

1 Seppic

EXCIPIENTS BY APPLICATIONS

8 Empty Capsules

4 Film Formers & Plasticizers

4 Coating Systems & Additives

2 Topical

1 Solubilizers

1 Fillers, Diluents & Binders

1 Thickeners and Stabilizers

1 Taste Masking

1 Parenteral

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8 US Medicaid Prescriptions

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1 APIs

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1 USP Standards

1 Other Ref. Standards

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2 News

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