Find Ulipristal Acetate manufacturers, exporters & distributors on PharmaCompass

(11beta)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

(11beta)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

19 API Suppliers, 7 USDMF, 1 JDMF, 2 KDMF, 1 NDC API, 14 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Imports

INTERMEDIATES

7 Suppliers

7 Suppliers

DOSSIERs // Finished Dosage Formulations

11 Dossiers, 2 FDA Orange Book, 6 Europe, 1 Canada, 1 South Africa, 1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 14 Kerry, 7 Microlex e.U, 6 Gangwal Healthcare, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 3 DFE Pharma, 3 Sigachi Industries, 2 Vasa Pharmachem, 2 Boai NKY Pharmaceuticals Ltd, 2 Prachin Chemical, 1 Roquette, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Jai Radhe Sales, 1 Nanjing Well Pharmaceutical, 1 Ulanqab Kema New Material, 1 Ingredion Pharma Solutions

EXCIPIENTS BY APPLICATIONS

29 Fillers, Diluents & Binders, 10 Disintegrants & Superdisintegrants, 9 Lubricants & Glidants, 8 Direct Compression, 6 Granulation, 6 Co-Processed Excipients, 1 Emulsifying Agents, 1 API Stability Enhancers, 1 Thickeners and Stabilizers, 1 Solubilizers, 1 Parenteral, 1 Controlled & Modified Release, 1 Rheology Modifiers

GLOBAL SALES INFORMATION

8 US Medicaid Prescriptions, 5 Finished Drug Prices

MARKET PLACE

7 APIs, 1 DOSSIERS // FDF

PATENTS

8 US Patents, 1 US Exclusivities, 3 Health Canada Patents

ANALYTICAL SOLUTION(s)

2 BioAnalytical Methods, 3 Other Ref. Standards

DIGITAL CONTENT

42 News

42 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

14,561

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

(11beta)-17-(Acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione

Also known as: 126784-99-4, Cdb-2914, Ella, Ellaone, Cdb 2914, Hrp 2000

Molecular Formula

C₃₀H₃₇NO₄

Molecular Weight

475.6 g/mol

InChI Key

OOLLAFOLCSJHRE-ZHAKMVSLSA-N

FDA UNII

YF7V70N02B

Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception

1 2D Structure

(11beta)-17-(Acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate

2.1.2 InChI

InChI=1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1

2.1.3 InChI Key

OOLLAFOLCSJHRE-ZHAKMVSLSA-N

2.1.4 Canonical SMILES

CC(=O)C1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)OC(=O)C

2.1.5 Isomeric SMILES

CC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)OC(=O)C

2.2 Other Identifiers

2.2.1 UNII

YF7V70N02B

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (11beta)-17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione

2. Ella Norpregnadiene

3. Esmya

2.3.2 Depositor-Supplied Synonyms

1. 126784-99-4

2. Cdb-2914

3. Ella

4. Ellaone

5. Cdb 2914

6. Hrp 2000

7. Ulipristal Acetate [usan]

8. Va2914

9. (8s,11r,13s,14s,17r)-17-acetyl-11-(4-(dimethylamino)phenyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl Acetate

10. (11beta)-17-(acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

11. Yf7v70n02b

12. Chebi:71025

13. 17-acetoxy-11-(4-n,n-dimethylaminophenyl)pregna-4,9-diene-3,20-dione

14. Pgl-4001

15. Va-2914

16. Rti-3021-012

17. Ulipristal (acetate)

18. (11b)-17-(acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

19. (11beta)-17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione

20. (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-yl Acetate

21. 17beta-acetyl-11beta-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17alpha-yl Acetate

22. Unii-yf7v70n02b

23. Hrp-2000

24. Ulipristal Acet

25. Mfcd00899035

26. 4oar

27. Ulipristal-acetate

28. Ella Norpregnadiene

29. [(8s,11r,13s,14s,17r)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] Acetate

30. Cbd 2914

31. Ella (tn)

32. Rti 3021-012

33. C17 Epi Ulipristal Acetate

34. Schembl544957

35. Chembl260538

36. Gtpl7460

37. Ulipristal Acetate [mi]

38. Ulipristal Acetate (jan/usan)

39. Ulipristal Acetate [jan]

40. Dtxsid30155294

41. Ta[a]phenanthren-17-yl] Acetate

42. Ulipristal Acetate [vandf]

43. Ulipristal Acetate [mart.]

44. Ulipristal Acetate [who-dd]

45. Zinc3920657

46. Bdbm50375424

47. Ulipristal Acetate, >=98% (hplc)

48. Akos026750526

49. Ccg-269500

50. Cs-1157

51. Ulipristal Acetate [orange Book]

52. Ncgc00378913-02

53. [(8s,11r,13s,14s,17r)-17-acetyl-11-(4-dimethylaminophenyl)-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] Acetate

54. As-73950

55. Bu161520

56. Hy-16508

57. U0102

58. C72119

59. D09687

60. Ab01566874_01

61. 784a994

62. Q975059

63. J-005436

64. Brd-k64381438-001-03-8

65. Z2216208644

66. 5-(hydroxymethyl)-alpha,alpha,alpha,alpha-tetramethyl-1,3-benzenediacetonitrile

67. (10s,11s,14r,15s,17r)-14-acetyl-17-[4-(dimethylamino)phenyl]-15-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-14-yl Acetate

68. (11.beta.)-17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione

69. (11alpha,13alpha,17beta)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-yl Acetate

70. (1r,3as,3bs,10r,11as)-1-acetyl-10-[4-(dimethylamino)phenyl]-11a-methyl-7-oxo-1h,2h,3h,3ah,3bh,4h,5h,7h,8h,9h,10h,11h,11ah-cyclopenta[a]phenanthren-1-yl Acetate

71. (8s,11r,13s,14s,17r)-17-acetyl-11-(4-(dimethylamino)phenyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-ylacetate

72. [(8s,11r,13s,14s,17r)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopen

73. 17.alpha.-acetoxy-11.beta.-(4-dimethylaminophenyl)-19-norpregna-4,9-dien-3,20-dione

74. 19-norpregna-4,9-diene-3,20-dione, 17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-, (11beta)-

75. C17 Isomer Ulipristal Acetate; (10s,11s,14s,15s,17r)-14-acetyl-17-[p-(dimethylamino)phenyl]-15-methyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadeca-1,6-dien-14-yl Acetate

76. Cbd 2914; Va 2914; (11b)-17-(acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₃₀H₃₇NO₄
Molecular Weight	475.6 g/mol
XLogP3	3.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	475.27225866 g/mol
Monoisotopic Mass	475.27225866 g/mol
Topological Polar Surface Area	63.7 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	984
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Ulipristal acetate is indicated for one treatment course of pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age.

Ulipristal acetate is indicated for intermittent treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age who are not eligible for surgery.

Emergency contraception within 120 hours (five days) of unprotected sexual intercourse or contraceptive failure.

Contraception

Leiomyoma of uterus

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Contraceptive Agents, Female

Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading. (See all compounds classified as Contraceptive Agents, Female.)

Contraceptive Agents, Hormonal

Contraceptive agents that act on the ENDOCRINE SYSTEM. (See all compounds classified as Contraceptive Agents, Hormonal.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Selective Progesterone Receptor Modulators [MoA]; Progesterone Agonist/Antagonist [EPC]

5.3 ATC Code

G03XB02

G03AD02