1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride

Synopsis, Chemistry

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9 API Suppliers, 5 USDMF, 2 KDMF, 3 NDC API, 6 Listed Suppliers

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DOSSIERs // Finished Dosage Formulations

19 Dossiers, 16 FDA Orange Book, 1 South Africa, 2 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, EXTENDED RELEASE;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, EXTENDED RELEASE;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers, 21 Kerry, 17 SPI Pharma, 15 Roquette, 14 BASF, 13 Microlex e.U, 10 Sigachi Industries, 9 Gangwal Healthcare, 7 Boai NKY Pharmaceuticals Ltd, 6 Gangwal Chemicals, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 5 Corel Pharma Chem, 5 Lubrizol Life Science Health, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 4 DFE Pharma, 3 Ingredion Pharma Solutions, 3 Pharmatrans-Sanaq, 3 Ulanqab Kema New Material, 2 DKSH, 2 Prachin Chemical, 2 The Dow Chemical Company, 2 Vasa Pharmachem, 1 Lonza Capsugel, 1 Actylis, 1 Pfanstiehl, 1 Aeon Procare, 1 Ideal Cures Pvt Ltd, 1 Alcedo Pharmachem, 1 Nanjing Well Pharmaceutical, 1 Rochem International Inc, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Seppic, 1 Shanghai Welltone Material Technology Co., Ltd

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73 Fillers, Diluents & Binders, 39 Direct Compression, 23 Disintegrants & Superdisintegrants, 22 Granulation, 20 Thickeners and Stabilizers, 17 Controlled & Modified Release, 16 Chewable & Orodispersible Aids, 15 Co-Processed Excipients, 15 Solubilizers, 14 Lubricants & Glidants, 13 Taste Masking, 7 Coating Systems & Additives, 6 Parenteral, 6 Topical, 3 Film Formers & Plasticizers, 2 API Stability Enhancers, 2 Rheology Modifiers, 1 Vegetarian Capsules, 1 Emulsifying Agents

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3 Finished Drug Prices

3 Finished Drug Prices

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3 APIs, 1 DOSSIERS // FDF

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1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride

Also known as: Amfepramone hydrochloride, 134-80-5, Moderatan, Dobesin, Tenuate, Diethylpropion hcl

Molecular Formula

C₁₃H₂₀ClNO

Molecular Weight

241.76 g/mol

InChI Key

ICFXZZFWRWNZMA-UHFFFAOYSA-N

FDA UNII

19V2PL39NG

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

1 2D Structure

1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(diethylamino)-1-phenylpropan-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H

2.1.3 InChI Key

ICFXZZFWRWNZMA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)C(C)C(=O)C1=CC=CC=C1.Cl

2.2 Other Identifiers

2.2.1 UNII

19V2PL39NG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-diethylaminopropiophenone

2. Amfepramon

3. Amfepramone

4. Anorex

5. Delgamer

6. Diethylpropion

7. Dietil Retard

8. Dietil-retard

9. Dietilretard

10. Hydrochloride, Diethylpropion

11. Ifa Norex

12. Lipomin

13. Maruate

14. Modratan

15. Neobes

16. Nobesine

17. Norex, Ifa

18. Phepranon

19. Prfamone

20. Propion

21. Regenon

22. Regibon

23. Tenuate

24. Tepanil

2.3.2 Depositor-Supplied Synonyms

1. Amfepramone Hydrochloride

2. 134-80-5

3. Moderatan

4. Dobesin

5. Tenuate

6. Diethylpropion Hcl

7. Tepanil

8. Anorex

9. Tenuate Dospan

10. Regenon Hydrochloride

11. 2-(diethylamino)propiophenone Hydrochloride

12. Amfepramone (hydrochloride)

13. Prefamone

14. Regenon

15. Amphepramonum Hydrochloride

16. 1-propanone, 2-(diethylamino)-1-phenyl-, Hydrochloride

17. 19v2pl39ng

18. Diethylpropion Hydrochloride Civ

19. Alpha-benzoyltriethylammonium Chloride

20. Alpha-benzoyltriethylamine Hydrochloride

21. D03801

22. Diethylpropion Hydrochloride [usp]

23. Menutil

24. 1-phenyl-2-diethylaminopropanone-1 Hydrochloride

25. Magrex Retard

26. Tenuate-dospan

27. Amfepramon Hydrochloride

28. Lineal-rivo

29. Tepanil Ten-tab

30. Nu-dispoz

31. Dsstox_cid_27816

32. Dsstox_rid_82580

33. Dsstox_gsid_47838

34. Propiophenone, 2-(diethylamino)-, Hydrochloride

35. Diethylpropion Hydrochloride (usp)

36. 2-(diethylamino)-1-phenylpropan-1-one Hydrochloride

37. Cas-134-80-5

38. Chebi:643703

39. 2-diethylaminopropiophenone Hydrochloride

40. Sr-01000220674

41. Ncgc00167475-01

42. Einecs 205-156-5

43. Unii-19v2pl39ng

44. Tenuate (tn)

45. Rac Diethylpropion-d10 Hydrochloride

46. Diethylproion Hydrochloride

47. Cambridge Id 5809497

48. Chembl1693

49. Schembl15483

50. 2-(diethylamino)-1-phenyl-1-propanone Hydrochloride

51. 2-(diethylamino)-1-phenylpropan-1-one;hydrochloride

52. Dtxsid4047838

53. Hy-b0981

54. Tox21_112479

55. Akos015962206

56. Tox21_112479_1

57. Ccg-220122

58. Cs-4472

59. Diethylpropion Hydrochloride [mi]

60. Ncgc00167475-02

61. Ac-16025

62. Amfepramone Hydrochloride [who-dd]

63. As-16865

64. Diethylpropion Hydrochloride [mart.]

65. Diethylpropion Hydrochloride [vandf]

66. Diethylpropion Hydrochloride [usp-rs]

67. .alpha.-benzoyltriethylamine Hydrochloride

68. 090d846

69. Diethylpropion Hydrochloride [orange Book]

70. Diethylpropion Hydrochloride [usp Monograph]

71. Sr-01000220674-1

72. Sr-01000220674-2

73. Q27105182

74. Diethylpropion Hydrochloride Solution, 1.0 Mg/ml In Methanol (with 1% 1 M Hcl; As Free Base), Certified Reference Material

2.4 Create Date

2005-07-29

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₂₀ClNO
Molecular Weight	241.76 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	241.1233420 g/mol
Monoisotopic Mass	241.1233420 g/mol
Topological Polar Surface Area	20.3 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	193
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Diethylpropion hydrochloride
Active Ingredient	Diethylpropion hydrochloride
Dosage Form	Tablet, extended release; Tablet
Route	Oral
Strength	75mg; 25mg
Market Status	Prescription
Company	Lannett Holdings; Corepharma; Avanthi

2 of 6
Drug Name	Tenuate
Active Ingredient	Diethylpropion hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg
Market Status	Prescription
Company	Watson Pharms

3 of 6
Drug Name	Tenuate dospan
PubMed Health	Diethylpropion (By mouth)
Drug Classes	Appetite Suppressant, Centrally Acting
Drug Label	Diethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
Active Ingredient	Diethylpropion hydrochloride
Dosage Form	Tablet, extended release
Route	Oral
Strength	75mg
Market Status	Prescription
Company	Watson Pharms

4 of 6
Drug Name	Diethylpropion hydrochloride
Active Ingredient	Diethylpropion hydrochloride
Dosage Form	Tablet, extended release; Tablet
Route	Oral
Strength	75mg; 25mg
Market Status	Prescription
Company	Lannett Holdings; Corepharma; Avanthi

5 of 6
Drug Name	Tenuate
Active Ingredient	Diethylpropion hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg
Market Status	Prescription
Company	Watson Pharms

6 of 6
Drug Name	Tenuate dospan
PubMed Health	Diethylpropion (By mouth)
Drug Classes	Appetite Suppressant, Centrally Acting
Drug Label	Diethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
Active Ingredient	Diethylpropion hydrochloride
Dosage Form	Tablet, extended release
Route	Oral
Strength	75mg
Market Status	Prescription
Company	Watson Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Increased Sympathetic Activity [PE]; Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]

Find Diethylpropion Hydrochloride manufacturers, exporters & distributors on PharmaCompass

1-Propanone, 2-(diethylamino)-1-phenyl-, Hydrochloride

1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

9 API Suppliers

5 USDMF

2 KDMF

3 NDC API

6 Listed Suppliers

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Exports

FDF Imports

DOSSIERs // Finished Dosage Formulations

19 Dossiers

16 FDA Orange Book

1 South Africa

2 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, EXTENDED RELEASE;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers

21 Kerry

17 SPI Pharma

15 Roquette

14 BASF

13 Microlex e.U

10 Sigachi Industries

9 Gangwal Healthcare

7 Boai NKY Pharmaceuticals Ltd

6 Gangwal Chemicals

5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

5 Corel Pharma Chem

5 Lubrizol Life Science Health

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

4 DFE Pharma

3 Ingredion Pharma Solutions

3 Pharmatrans-Sanaq

3 Ulanqab Kema New Material

2 DKSH

2 Prachin Chemical

2 The Dow Chemical Company

2 Vasa Pharmachem

1 Lonza Capsugel

1 Actylis

1 Pfanstiehl

1 Aeon Procare

1 Ideal Cures Pvt Ltd

1 Alcedo Pharmachem

1 Nanjing Well Pharmaceutical

1 Rochem International Inc

1 Shijiazhuang Huaxu Pharmaceutical

1 Seppic

1 Shanghai Welltone Material Technology Co., Ltd

EXCIPIENTS BY APPLICATIONS

73 Fillers, Diluents & Binders

39 Direct Compression

23 Disintegrants & Superdisintegrants

22 Granulation

20 Thickeners and Stabilizers

17 Controlled & Modified Release

16 Chewable & Orodispersible Aids

15 Co-Processed Excipients

15 Solubilizers

14 Lubricants & Glidants

13 Taste Masking

7 Coating Systems & Additives

6 Parenteral

6 Topical

3 Film Formers & Plasticizers

2 API Stability Enhancers

2 Rheology Modifiers

1 Vegetarian Capsules

1 Emulsifying Agents

GLOBAL SALES INFORMATION

TABLET;ORAL - 25MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, EXTENDED RELEASE;ORAL - 75MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons