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1. 4-dichlorobenzene
2. P-dichlorobenzene
3. Para-dichlorobenzene
4. Paradichlorobenzene
1. 106-46-7
2. P-dichlorobenzene
3. Paradichlorobenzene
4. Para-dichlorobenzene
5. Paracide
6. Paramoth
7. Benzene, 1,4-dichloro-
8. Dichlorobenzene
9. Paranuggets
10. Santochlor
11. Paradow
12. Evola
13. P-dichlorbenzol
14. Persia-perazol
15. P-dichlorobenzol
16. P-chlorophenyl Chloride
17. Globol
18. Para Crystals
19. Dichlorocide
20. Paradi
21. Di-chloricide
22. Paradichlorbenzol
23. Para
24. Pdcb
25. P-diclorobenzene
26. 1,4-dichloorbenzeen
27. P-dichloorbenzeen
28. Paradichlorobenzol
29. 1,4-dichlor-benzol
30. Dichloricide
31. 1,4-diclorobenzene
32. Benzene, P-dichloro-
33. 1,4-dichloro-benzene
34. Parazene
35. Rcra Waste Number U070
36. Rcra Waste Number U071
37. Rcra Waste Number U072
38. Para-zene
39. Dichlorobenzene, P-
40. Nci-c54955
41. Kaydox
42. P-dichlorbenzene
43. Pdb
44. Nsc 36935
45. Dichlorobenzene, Para
46. D149tyb5mk
47. Chembl190982
48. Chebi:28618
49. Nsc-36935
50. Ncgc00094540-01
51. 1,3-cyclohexadien-5-yne,1,4-dichloro-
52. Dsstox_cid_431
53. 106-46-725321-22-6(mixedisomers)
54. 4-dichlorobenzene
55. Dsstox_rid_75582
56. Dsstox_gsid_20431
57. 1,4 Dichlorobenzene
58. P-dcb
59. Caswell No. 632
60. P-dichlorbenzol [german]
61. P-dichloorbenzeen [dutch]
62. Paradichlorbenzol [german]
63. P-diclorobenzene [italian]
64. 1,4-chlorobenzene
65. Cas-106-46-7
66. Ccris 307
67. 1,4-dichloorbenzeen [dutch]
68. 1,4-dichlor-benzol [german]
69. 1,4-diclorobenzene [italian]
70. Hsdb 523
71. Einecs 203-400-5
72. Rcra Waste No. D027
73. Rcra Waste No. U072
74. Unii-d149tyb5mk
75. Epa Pesticide Chemical Code 061501
76. Diclorobenzene
77. Ai3-0050
78. P-dichlorobenzen
79. Ai3-00050
80. P-dichloro-benzene
81. Mfcd00000604
82. Benzene,4-dichloro-
83. Dichlorobenzene, Solid
84. 1, 4-dichlorobenzene
85. Spectrum_001891
86. Specplus_000512
87. Benzene, 1,4-dichloro-, Radical Ion(1-)
88. Spectrum2_001869
89. Spectrum3_000846
90. Spectrum4_000686
91. Spectrum5_002008
92. P-dichlorbenzol(german)
93. P-dichloorbenzeen(dutch)
94. Para-dichlorobenzene,(s)
95. Wln: Gr Dg
96. Ec 203-400-5
97. P-diclorobenzene(italian)
98. Dichlorobenzene, P-, Solid
99. Schembl5191
100. Bspbio_002431
101. Kbiogr_001151
102. Kbioss_002421
103. Spectrum330055
104. Bidd:er0278
105. Divk1c_006608
106. Spbio_001718
107. P-dichlorobenzene [mi]
108. 1, 4-dichloorbenzeen(dutch)
109. 1,4-dichlor-benzol(german)
110. 1,4-diclorobenzene(italian)
111. Dtxsid1020431
112. 1,4-dichlorobenzene, >=99%
113. Kbio1_001552
114. Kbio2_002415
115. Kbio2_004983
116. Kbio2_007551
117. Kbio3_001931
118. Paradichlorobenzene [vandf]
119. Zinc388507
120. Paradichlorobenzene [mart.]
121. Amy40774
122. Hy-y0496
123. Nsc36935
124. 1,4-dichlorobenzene [hsdb]
125. Paradichlorobenzene [who-dd]
126. Tox21_111293
127. Tox21_200399
128. Tox21_300018
129. 1,4-dichlorobenzene-ul-14c, Neat
130. Bdbm50159263
131. C0593
132. Ccg-39407
133. S6300
134. Stl445582
135. Akos000120016
136. Un 1592
137. 1,4-dichlorobenzene (acd/name 4.0)
138. Ncgc00094540-02
139. Ncgc00094540-03
140. Ncgc00094540-04
141. Ncgc00094540-05
142. Ncgc00253934-01
143. Ncgc00257953-01
144. 55232-43-4
145. Benzene,1-chloro-4-(chloro-38cl)-(9ci)
146. Cs-0015284
147. D0687
148. Ft-0606862
149. S0666
150. 1,4-dichlorobenzene 10 Microg/ml In Isooctane
151. C07092
152. 1,4-dichlorobenzene 100 Microg/ml In Methanol
153. 1,4-dichlorobenzene 1000 Microg/ml In Methanol
154. 1,4-dichlorobenzene, Saj First Grade, >=99.0%
155. Q161529
156. J-503986
157. 1,4-dichlorobenzene, Pestanal(r), Analytical Standard
158. F0001-0123
159. Hexanedioic Acid, Polymer With 1,3-butanediol, Diesters With C14-18 Fatty Acids
160. 68890-93-7
| Molecular Weight | 147.00 g/mol |
|---|---|
| Molecular Formula | C6H4Cl2 |
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 145.9690055 g/mol |
| Monoisotopic Mass | 145.9690055 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 54.9 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Insecticides
Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)
The material is apparently well absorbed by the gastrointestinal tract and from lung but not appreciably through skin.
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 3625
Moth repellent para-dichlorobenzene was detected in human adipose tissue and blood as pollutant together with polychlorinated biphenyls.
Kimura R et al; J Pharmacobio-dyn 2 (4): 237-44 (1980)
Absorption of 1,4-dichlorobenzene through the gastrointestinal tract is rapid. Oral doses of 200 or 800 mg/kg to male Wistar rats appeared in the blood and adipose, kidney, liver, lung, heart, and brain tissue within 30 minutes.
Kimura R et al; J Pharm Dyn 2 (4): 237-44 (1980) as cited in USEPA; Health Assessment Document: Chlorinated Benzenes p.8-2 (1985) EPA-600/8-84-015
The dichlorobenzenes may be absorbed through the lungs, gastrointestinal tract, and the intact skin. Relatively low water solubility and high lipid solubility favor their penetration of most membranes by diffusion, including pulmonary and GI epithelia, the brain, hepatic parenchyma, renal tubules, and the placenta. /Dichlorobenzenes/
Ware S, West WL; Investigation of Selected Potential Environmental Contaminants: Halogenated Benzenes (1977) EPA 560/2-77-004 as cited in USEPA; Ambient Water Quality Criteria Doc: Dichlorobenzenes p.C-11 (1980) EPA 400/5-80-039
For more Absorption, Distribution and Excretion (Complete) data for 1,4-Dichlorobenzene (14 total), please visit the HSDB record page.
A novel in vitro system was used to evaluate tissue specific toxicity. This system utilizes precision cut organ slices in dynamic organ culture and is viable for up to 24 hrs. The three isomers of dichlorobenzene were added to liver slices prepared from Sprague Dawley rats or human donors. The precursor dichlorobenzenes were radiolabelled and metabolites were separated by classes (i.e. glucuronides, sulfates and glutathione and cysteine conjugates). Covalent Binding of the dichlorobenzenes was also determined after extensive extraction of the tissue. The total amount of metabolism of the dichlorobenzenes varied depending on the isomer and the type of tissue. For example, the Sprague-Dawley rat liver slices metabolized 1,2-DCB and 1,3-DCB at approximately the same rate while 1,4-DCB was metabolized at a slower rate. This metabolism profile was also seen in the majority of the adult human liver slices. However, the fetal human slices showed that 1,4-DCB was metabolized to a greater extent than 1,3-DCB or 1,2-DCB while 1,3-DCB was metabolized at a faster rate than 1,2-DCB. Our results show that liver slices in organ culture are a suitable system for species comparisons and of structure/activity relationships in xenobiotic metabolism with an emphasis on the fate of reactive intermediates. In addition, this system is suitable for evaluation of hepatotoxic potency.
PMID:2069046 Fisher R et al; Adv Exp Med Biol 283: 717-23 (1991)
After ingestion of p-dichlorobenzene, 2,5-dichlorophenol (30%) free and as the glucuronide and sulfate and 2,5-dichloroquinol (6%) were excreted. In humans, 2,5-dichlorophenol was also found in the urine.
Menzie, C.M. Metabolism of Pesticides. U.S. Department of the Interior, Bureau of Sport Fisheries and Wildlife, Publication 127. Washington, DC: U.S. Government Printing Office, 1969., p. 155
After oral administration of para-dichlorobenzene to rats, 2 metabolites detected in blood. Metabolites M-1 and M-2 are 2,5-dichlorophenyl methyl sulfoxide and 2,5-dichlorophenyl methyl sulfone. Concentration of M-1 in blood was higher than M-2 for 12 hr after dosing, but blood level of M-2 was higher thereafter. After oral administration of p-DCB to rats 2,5-dichlorophenol was major metabolite.
Kimura R et al; J Pharmacobio-dyn 2 (4): 237-44 (1980)
Rabbits were fed an oral dose of 0.5 g/kg of p-dichlorobenzene /which was then/ oxidized to 2,5-dichlorophenol (35%); conjugated to form glucuronide (36%) and ethereal sulfate (27%); or excreted as 2,5-dichloroquinol (6%).
Azouz WM et al; Biochem Jour 59: 410-5 (1955)
For more Metabolism/Metabolites (Complete) data for 1,4-Dichlorobenzene (9 total), please visit the HSDB record page.
1,4-dichlorobenzene has known human metabolites that include 2,5-dichlorophenol.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
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