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1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)-2-propanol Hydrochloride

1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)-2-propanol hydrochloride

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1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)-2-propanol hydrochloride

Also known as: 63659-19-8, Betaxolol hcl, Betoptic, Kerlone, Betoptima, Lokren

Molecular Formula

C₁₈H₃₀ClNO₃

Molecular Weight

343.9 g/mol

InChI Key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

FDA UNII

6X97D2XT0O

A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.

1 2D Structure

1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)-2-propanol hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

2.1.2 InChI

InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

2.1.3 InChI Key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O.Cl

2.2 Other Identifiers

2.2.1 UNII

6X97D2XT0O

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Alcon, Betaxolol

2. Alo 1401 02

3. Alo-1401-02

4. Alo140102

5. Betaxolol

6. Betaxolol Alcon

7. Betoptic

8. Betoptima

9. Hydrochloride, Betaxolol

10. Kerlon

11. Kerlone

12. Oxodal

13. Sl 75212

14. Sl-75212

15. Sl75212

2.3.2 Depositor-Supplied Synonyms

1. 63659-19-8

2. Betaxolol Hcl

3. Betoptic

4. Kerlone

5. Betoptima

6. Lokren

7. Betaxolol (hydrochloride)

8. Alo 1401-02

9. Sl75212

10. Betaxolol Hydrochloride (betoptic)

11. Nsc-760048

12. Alo-1401-02

13. Betoptic S

14. Mls000863279

15. 6x97d2xt0o

16. Dextrobetaxolol (hydrochloride)

17. Kerlon

18. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

19. Alo-140102

20. Smr000058420

21. Sl-7521210

22. Sl 75.212-10

23. Sl-75.212-10

24. 1-(isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hydrochloride

25. Betaxolo Hydrochloride

26. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol Hydrochloride

27. 2-propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, Hydrochloride, (+-)-

28. Chebi:643228

29. Chemical Name: 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol Hydrochloride

30. Betaxolol Hydrochloride [usan]

31. Sr-01000000108

32. Einecs 264-384-3

33. Mfcd00242959

34. Sl-75212-10

35. Unii-6x97d2xt0o

36. Kerlong

37. Sl-75212

38. Levobetaxololhcl

39. Sl 75 212-10

40. Betoptic (tn)

41. Prestwick_779

42. Kerlone (tn)

43. Betaxolol Hydrochloride [usan:usp:jan]

44. Cpd000058420

45. Opera_id_878

46. (+-)-1-(p-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride

47. 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylaminopropan-2-ol Hydrochloride

48. Chembl1691

49. Schembl42794

50. Mls000028464

51. Mls000758269

52. Mls001148209

53. Mls001424199

54. Mls002222261

55. Betaxolol Hydrochloride- Bio-x

56. Sl 75212 Hcl

57. Betaxolol For Peak Identification

58. Hy-b0381a

59. Dtxsid30979876

60. Mci-144

61. Hms1569m05

62. Pharmakon1600-01505512

63. (2s)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

64. Bcp02967

65. Betaxolol Hydrochloride [mi]

66. Tox21_500193

67. Betaxolol Hydrochloride (jp17/usp)

68. Betaxolol Hydrochloride [jan]

69. Nsc760048

70. Akos015843993

71. Ac-1412

72. Bcp9000394

73. Betaxolol Hydrochloride [mart.]

74. Betaxolol Hydrochloride [vandf]

75. Ccg-101057

76. Ccg-213473

77. Lp00193

78. Nc00307

79. Nsc 760048

80. Betaxolol Hydrochloride [usp-rs]

81. Betaxolol Hydrochloride [who-dd]

82. Betaxolol Hydrochloride, >98% (hplc)

83. Ncgc00093669-01

84. Ncgc00093669-02

85. Ncgc00260878-01

86. As-18082

87. Bb164245

88. Bcp0726000249

89. B4474

90. Betaxolol Hydrochloride [orange Book]

91. Eu-0100193

92. Ft-0645228

93. S1827

94. Sw196917-4

95. Betaxolol Hydrochloride [ep Monograph]

96. B 5683

97. Betaxolol Hydrochloride [usp Monograph]

98. D00598

99. T71164

100. Kerledex Component Betaxolol Hydrochloride

101. 659x198

102. A803574

103. Betaxolol Hydrochloride Component Of Kerledex

104. Q-200714

105. Sr-01000000108-2

106. Sr-01000000108-4

107. Sr-01000000108-9

108. Betoptic Pilo Component Betaxolol Hydrochloride

109. Q27105180

110. Betaxolol Hydrochloride Component Of Betoptic Pilo

111. Betaxolol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

112. Betaxolol Hydrochloride, United States Pharmacopeia (usp) Reference Standard

113. 1-(isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hcl

114. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydron;chloride

115. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanolhydrochloride

116. Betaxolol For Peak Identification, European Pharmacopoeia (ep) Reference Standard

117. (+/-)-1-(p-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride

118. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol Hydrochloride;levobetaxolol Hydrochloride

119. 2-propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, Hydrochloride, (+/-)-

120. 72424-72-7

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₃₀ClNO₃
Molecular Weight	343.9 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	11
Exact Mass	343.1914215 g/mol
Monoisotopic Mass	343.1914215 g/mol
Topological Polar Surface Area	50.7 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	286
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Betaxolol hydrochloride
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	Betaxolol Ophthalmic Solution USP, contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops; Tablet
Route	Ophthalmic; Oral
Strength	10mg; eq 0.5% base; 20mg
Market Status	Prescription
Company	Wockhardt; Epic Pharma; Kvk Tech; Bausch And Lomb; Akorn

2 of 6
Drug Name	Betoptic
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	BETOPTIC Sterile Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molec...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.5% base
Market Status	Prescription
Company	Alcon

3 of 6
Drug Name	Betoptic s
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Suspension/drops
Route	Ophthalmic
Strength	eq 0.25% base
Market Status	Prescription
Company	Alcon

4 of 6
Drug Name	Betaxolol hydrochloride
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	Betaxolol Ophthalmic Solution USP, contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops; Tablet
Route	Ophthalmic; Oral
Strength	10mg; eq 0.5% base; 20mg
Market Status	Prescription
Company	Wockhardt; Epic Pharma; Kvk Tech; Bausch And Lomb; Akorn

5 of 6
Drug Name	Betoptic
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	BETOPTIC Sterile Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molec...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.5% base
Market Status	Prescription
Company	Alcon

6 of 6
Drug Name	Betoptic s
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Suspension/drops
Route	Ophthalmic
Strength	eq 0.25% base
Market Status	Prescription
Company	Alcon

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]