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1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt
Also known as: Tripotassium citrate, 866-84-2, Kaliksir, 7778-49-6, Potassium citrate anhydrous, Litocit
Molecular Formula
C6H5K3O7
Molecular Weight
306.39  g/mol
InChI Key
QEEAPRPFLLJWCF-UHFFFAOYSA-K
FDA UNII
86R1NVR0HW

A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.
1 2D Structure

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
tripotassium;2-hydroxypropane-1,2,3-tricarboxylate
2.1.2 InChI
InChI=1S/C6H8O7.3K/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
2.1.3 InChI Key
QEEAPRPFLLJWCF-UHFFFAOYSA-K
2.1.4 Canonical SMILES
C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+]
2.2 Other Identifiers
2.2.1 UNII
86R1NVR0HW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Anhydrous, Potassium Citrate

2. Citrate, Potassium

3. Potassium Citrate Anhydrous

2.3.2 Depositor-Supplied Synonyms

1. Tripotassium Citrate

2. 866-84-2

3. Kaliksir

4. 7778-49-6

5. Potassium Citrate Anhydrous

6. Litocit

7. Potassiumcitrate

8. Citric Acid, Tripotassium Salt

9. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Tripotassium Salt

10. Potassium Citrate Tribasic Solution

11. Tripotassium;2-hydroxypropane-1,2,3-tricarboxylate

12. 86r1nvr0hw

13. Chebi:64733

14. Tripotassium 2-hydroxypropane-1,2,3-tricarboxylate

15. Kalii Citras

16. Porekal

17. Kajos

18. Polycitra K

19. Urocit K

20. Seltz-k

21. K Citrate

22. Potassium Tribasic Citrate

23. Ins No.332(ii)

24. Ins-332(ii)

25. Tripotassium Citrate Anhydrous

26. Acalka

27. Ccris 6566

28. E-332(ii)

29. Hsdb 1248

30. Nsc-760107

31. Einecs 212-755-5

32. Unii-86r1nvr0hw

33. Potassium Citrate (anhydrous)

34. Einecs 231-905-0

35. Tri Potassium Citrate

36. Potassium Citrate (anh.)

37. Anhydrous Potassium Citrate

38. Ec 212-755-5

39. Tripotassium Citrate (anh.)

40. Anhydrous Tripotassium Citrate

41. Potassium Citrate [mi]

42. Chembl1200458

43. Dtxsid8027325

44. Tripotassium Citrate (anhydrous)

45. Potassium Citrate [who-dd]

46. Citric Acid Tripotassium Salt (anh.)

47. Akos015918285

48. Db09125

49. Citric Acid Tripotassium Salt (anhydrous)

50. E332

51. Potassium Citrate Anhydrous [hsdb]

52. Potassium Citrate Anhydrous [mart.]

53. Ft-0653076

54. Potassium 2-hydroxypropane-1,2,3-tricarboxylate

55. A841790

56. Q419921

57. Tripotassium 2-oxidanylpropane-1,2,3-tricarboxylate

58. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Potassium Salt (1:?)

59. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Potassium Salt (1:3)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 306.39 g/mol
Molecular Formula C6H5K3O7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass305.8946469 g/mol
Monoisotopic Mass305.8946469 g/mol
Topological Polar Surface Area141 Ų
Heavy Atom Count16
Formal Charge0
Complexity211
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NamePotassium citrate
PubMed HealthPotassium Citrate (By mouth)
Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
Drug LabelPotassium citrate USP is a citrate salt of potassium and has the chemical name 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate. Its molecular formula is K3C6H 5O7.H2O , and its structural formula is: M.W. 324.41Potassium c...
Active IngredientPotassium citrate
Dosage FormTablet, extended release
RouteOral
Strength5meq; 15meq; 10meq
Market StatusPrescription
CompanyCorepharma; Zydus Pharms Usa

2 of 4  
Drug NameUrocit-k
PubMed HealthPotassium Citrate (By mouth)
Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
Drug LabelUrocit-K is a citrate salt of potassium. Its empirical formula is K3C6H5O7 H2O, and it has the following chemical structure:Urocit-K yellowish to tan, oral wax-matrix tablets, contain 5 mEq (540 mg) potassium citrate, 10 mEq (1080 mg) potassi...
Active IngredientPotassium citrate
Dosage FormTablet, extended release
RouteOral
Strength5meq; 15meq; 10meq
Market StatusPrescription
CompanyMission Pharma

3 of 4  
Drug NamePotassium citrate
PubMed HealthPotassium Citrate (By mouth)
Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
Drug LabelPotassium citrate USP is a citrate salt of potassium and has the chemical name 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate. Its molecular formula is K3C6H 5O7.H2O , and its structural formula is: M.W. 324.41Potassium c...
Active IngredientPotassium citrate
Dosage FormTablet, extended release
RouteOral
Strength5meq; 15meq; 10meq
Market StatusPrescription
CompanyCorepharma; Zydus Pharms Usa

4 of 4  
Drug NameUrocit-k
PubMed HealthPotassium Citrate (By mouth)
Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
Drug LabelUrocit-K is a citrate salt of potassium. Its empirical formula is K3C6H5O7 H2O, and it has the following chemical structure:Urocit-K yellowish to tan, oral wax-matrix tablets, contain 5 mEq (540 mg) potassium citrate, 10 mEq (1080 mg) potassi...
Active IngredientPotassium citrate
Dosage FormTablet, extended release
RouteOral
Strength5meq; 15meq; 10meq
Market StatusPrescription
CompanyMission Pharma

4.2 Therapeutic Uses

Diuretics; Expectorants

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


THE...CITRATE...OF POTASSIUM.../IS/ ADMIN ORALLY. ... 40 MEQ OF POTASSIUM IS PROVIDED BY APPROX...4.3 G OF POTASSIUM CITRATE.

American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 40:12


A SYSTEMIC & URINARY ALKALIZER & FOR THE EFFECTS OF THE POTASSIUM ION. IT HAS ALSO BEEN USED AS AN EXPECTORANT & A DIURETIC. DOSE- USUAL, 1 G. ...USED IN DOSE OF 1-2 G EVERY FEW HR, DILUTED WITH AT LEAST 1/2 GLASSFUL OF WATER OR FRUIT JUICE.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 801


COMPOSITION CONTAINS POTASSIUM CITRATE.

GAGIU F; PREPN FOR TREATMENT OF URIC LITHIASIS; ROMANIAN PATENT NUMBER 57645 09/12/74


MEDICATION (VET): DIURETIC AGENT

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 990


4.3 Drug Indication

For the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Potassium citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.g. calcium oxalate, calcium phosphate and uric acid. Increased citrate levels in the urine will make complexation with calcium which decrease the calcium ion activity and decrease the chance for the formation of calcium phosphate crystals. Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate.


5.2 MeSH Pharmacological Classification

Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)


Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
POTASSIUM CITRATE ANHYDROUS
5.3.2 FDA UNII
86R1NVR0HW
5.3.3 Pharmacological Classes
Anti-coagulant [EPC]; Calcium Chelating Activity [MoA]; Calculi Dissolution Agent [EPC]; Decreased Coagulation Factor Activity [PE]; Acidifying Activity [MoA]
5.4 ATC Code

A - Alimentary tract and metabolism

A12 - Mineral supplements

A12B - Potassium

A12BA - Potassium

A12BA02 - Potassium citrate


5.5 Absorption, Distribution and Excretion

Route of Elimination

Urinary; less than 5% unchanged.


5.6 Metabolism/Metabolites

Potassium Citrate is absorbed and the citrate is metabolised to bicarbonate.


5.7 Mechanism of Action

After oral administration of potassium citrate, its metabolism yields alkaline load. Potassium Citrate therapy appears to increase urinary citrate mainly by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. In addition to raising urinary pH and citrate, Potassium Citrate increases urinary potassium by approximately the amount contained in the medication. In some patients, Potassium Citrate causes a transient reduction in urinary calcium.


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  • TABLET, EXTENDED RELEASE;ORAL - 10MEQ
  • TABLET, EXTENDED RELEASE;ORAL - 15MEQ
  • TABLET, EXTENDED RELEASE;ORAL - 5MEQ
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