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1. Tetralin
1. Tetralin
2. 119-64-2
3. Benzocyclohexane
4. Tetrahydronaphthalene
5. Bacticin
6. Tetraline
7. Tetranap
8. Naphthalene, 1,2,3,4-tetrahydro-
9. Tetralina
10. Naphthalene, Tetrahydro-
11. Naphthalene 1,2,3,4-tetrahydride
12. Tetralene
13. Nsc 77451
14. (c4-c5) Alkyltetrahydronaphthalenes
15. Ft6xmi58yq
16. Naphthalene, 1,2,3,4-tetrahydro-, C1-4-alkyl Derivs.
17. Chebi:35008
18. 1,2,3,4-tetrahydro-naphthalene
19. Nsc-77451
20. Dsstox_cid_6118
21. Dsstox_rid_78023
22. Dsstox_gsid_26118
23. 68412-24-8
24. Tetralina [polish]
25. Caswell No. 842a
26. Cas-119-64-2
27. Ccris 3564
28. Hsdb 127
29. Delta(sup 5,7,9)-naphthantriene
30. Einecs 204-340-2
31. Unii-ft6xmi58yq
32. 1,2,3,4-tetrahydronaphthalene, Reagent Grade, >=97%
33. Epa Pesticide Chemical Code 055901
34. Ai3-01257
35. Tetralin Solvent
36. Einecs 270-178-4
37. Mfcd00001733
38. Tetralin [hsdb]
39. Tetralin [mi]
40. Bmse000530
41. Tetralin [usp-rs]
42. Tetralin [who-dd]
43. Ec 204-340-2
44. Nciopen2_000650
45. 1,3,4-tetrahydronaphthalene
46. 1,2,3,4-tetrahydronapthalene
47. 5,6,7,8-tetrahydronaphthalene
48. Chembl1575635
49. Dtxsid1026118
50. Naphthalene 1,3,4-tetrahydride
51. Wln: L66 & Tj
52. 1,2,3,4 Tetrahyclronaphthalene
53. .delta.(5,7,9)-naphthantriene
54. .delta.(sup 5,9)-naphthantriene
55. Naphthalene-1,2,3,4-tetrahydride
56. Nsc77451
57. Zinc8437660
58. Tox21_201793
59. Tox21_303325
60. Stl264224
61. .delta.(sup 5,7,9)-naphthantriene
62. Akos000121383
63. Ncgc00091744-01
64. Ncgc00091744-02
65. Ncgc00256948-01
66. Ncgc00259342-01
67. Ft-0654145
68. T0107
69. T0713
70. 1,2,3,4-tetrahydronaphthalene, Tetralin, Thn
71. 1,2,3,4-tetrahydronaphthalene, Anhydrous, 99%
72. Q420416
73. 1,2,3,4-tetrahydronaphthalene, Analytical Standard
74. W-108503
75. 1,2,3,4-tetrahydronaphthalene, Reagentplus(r), 99%
76. F1908-0164
77. 1,2,3,4-tetrahydronaphthalene, Vetec(tm) Reagent Grade, 98%
| Molecular Weight | 132.20 g/mol |
|---|---|
| Molecular Formula | C10H12 |
| XLogP3 | 3.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 132.093900383 g/mol |
| Monoisotopic Mass | 132.093900383 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 92.6 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
ABSORBED VAPOR IS EXCRETED BY KIDNEYS AS ALPHA- AND BETA-TETRAHYDRONAPHTHOLS ANDTHEIR GLUCURONIDES ... .
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-153
RADIOACTIVE TETRALIN, WHEN ADMIN TO RABBIT, WAS EXCRETED IN URINE AS GLUCURONIDEAT 87-99% AND IN FECES AT 0.6-1.8% OF ORIGINAL DOSE. ... WAS ABSORBED BY MUSSEL BUT NOT METABOLIZED; ... UP TO 80% WAS RELEASED IN UNCHANGED FORM WHEN THE ORGANISM WAS TRANSFERRED TO FRESH SEAWATER.
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 3242
When radioactive tetralin was fed to rabbits, 87-90% of the activity was excreted in the urine in 2 days and 0.5-3.7% on the third day. The feces contained only 0.6-1.8%. No radioactivity was found in the breath, and negligible amounts were retained in the tissues. About 90-99% of the dose was accounted for.
Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide Toxicology. Volume 2. Classes of Pesticides. New York, NY: Academic Press, Inc., 1991., p. 643
(1-(14)C)-TETRALIN IS METABOLIZED IN RABBITS BY HYDROXYLATION OF ALICYCLIC RING TO YIELD CONJUGATES OF AC-ALPHA-TETRALOL (60% OF DOSE), AC-BETA-TETRALOL (20%) & TETRALIN-1,2-DIOL (2.5%), & HYDROXYLATION OF AROMATIC RING ... YIELDING AR-BETA-TETRALOL (5,6,7,8-TETRAHYDRO-2-NAPHTHOL, 0.1%).
Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 220
YIELDS 2-HYDROXYTETRALYLMERCAPTURIC ACID, 1,2,3,4-TETRAHYDRO-1-NAPHTHOL, 1,2,3,4-TETRAHYDRO-2-NAPHTHOL IN RABBIT. YIELDS 1,2,3,4-TETRAHYDRO-1,2-DIHYDROXYNAPHTHALENE, 5,6,7,8-TETRAHYDRO-2-NAPHTHOL IN RABBIT. /FROM TABLE/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. T-10
In rabbits, the main urinary metabolite was the glucuronide of alpha-tetralol (52.4%). Other conjugated metabolites were beta-tetralol (25.3%), 4-hydroxy-alpha-tetralone (6.1%), and cis-tetralin-1,2-diol (0.4%). Using rat liver homogenates, it was shown that conversion of tetralin to tetralol requires reduced nicotinamide adenine dinucleotide phosphate and that tetralin hydroperoxide is a probable intermediate. Further study confirmed this possibility and indicated that tetralin hydroxylation proceeds via a radical mechanism similar to that of lipid peroxidation.
Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide Toxicology. Volume 2. Classes of Pesticides. New York, NY: Academic Press, Inc., 1991., p. 643
Tetralin, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1-tetralol, 2-tetralol, 2-hydroxyl-1-tetralone, 4-hydroxyl-1-tetralone, 1,2-tetralindiol, and 1,4-tetralindiol.
PMID:2926829 Serve MP et al; J Toxicol Environ Health 26 (3): 267-75 (1989)
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