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1. Thiamine Chloride Hydrochloride
1. 67-03-8
2. Thiamine Hcl
3. Aneurine Hydrochloride
4. Vitamin B1 Hydrochloride
5. Clotiamina
6. Thiamine Chloride Hydrochloride
7. Eskaphen
8. Betalin S
9. Vitamin B1
10. Thiamine Dichloride
11. Beatine
12. Begiolan
13. Benerva
14. Bethiazine
15. Bevitex
16. Bevitine
17. Bithiamin
18. Bivatin
19. Eskapen
20. Metabolin
21. Slowten
22. Thiaminal
23. Thiamol
24. Thiavit
25. Tiamidon
26. Tiaminal
27. Trophite
28. Vinothiam
29. Vitaneuron
30. Bedome
31. Beuion
32. Bivita
33. Berin
34. Bewon
35. Biuno
36. Hybee
37. Apate Drops
38. Lixa-beta
39. Thiamin Chloride
40. Thiaminum Hydrochloricum
41. Vetalin S
42. Thiaminium Chloride
43. Betaxin
44. Thiadoxine
45. Bequin
46. Thiamin Hydrochloride
47. Betabion Hydrochloride
48. Usaf Cb-20
49. Fema No. 3322
50. Vitamin B Hydrochloride
51. Thiaminium Chloride Hydrochloride
52. Thiamine(2+) Dichloride
53. Thiamine Monohydrochloride
54. Mfcd00012780
55. Betabion
56. Betamin
57. Biamine
58. Vitamin B(sub 1) Hydrochloride
59. Thiamine, Hydrochloride
60. Thiamine (hydrochloride)
61. Nsc-36226
62. 3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium Chloride Hydrochloride
63. Thiamine, Monohydrochloride
64. Thiamine Hcl (vitamin B1)
65. Vitamin B1 (thiamine Hcl)
66. 67-03-8 (hcl Salt)
67. Chebi:49105
68. Thiamine Hydrochloride (vitamin B1)
69. M572600e5p
70. Cas-67-03-8
71. Ncgc00017013-01
72. 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol Chloride Hydrochloride
73. 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride;hydrochloride
74. 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium Chloride Hydrochloride
75. Thiamine Hydrochloride 10 Microg/ml In Acetonitrile
76. Thiamine Chloride Hydrochloride;vitamin B1 Hydrochloride
77. Thd
78. Thiamin Dichloride
79. Smr000875246
80. Nsc36226
81. Ccris 1906
82. Vitamin Bl
83. Unii-m572600e5p
84. Vitamin B1 Hydrochloride (van)
85. Thiamine Hydrochloride [usp:jan]
86. Vitamin B(sup1)
87. Aneurinehydrochloride
88. Prestwick_441
89. Einecs 200-641-8
90. Nsc 36226
91. Thiamini Hydrochloridum
92. Thiamine Hcl (tn)
93. Vitamin B1hydrochloride
94. Ai3-18993
95. Thiazolium, Hydrochloride
96. Vitamin B1 [fhfi]
97. Dsstox_cid_20622
98. Dsstox_rid_79516
99. Thiamine Hcl [inci]
100. Thiazolium, Monohydrochloride
101. Dsstox_gsid_40622
102. Schembl41101
103. Mls001332447
104. Mls001332448
105. Thiamine Hydrochloride (usp)
106. Aneurine Hydrochloride Hydrate
107. Thiamine For System Suitability
108. Thiamine Chloride, Hydrochloride
109. Chembl1200941
110. Dtxsid0040622
111. Vitamin B1 Hydrochloride Hydrate
112. Thiamine, Chloride, Hydrochloride
113. Hms1569p04
114. Thiamine Hydrochloride [mi]
115. Bcp27971
116. Hy-n0680
117. Thiamine Hydrochloride [fcc]
118. Tox21_110736
119. S3211
120. Thiamine Hcl (vitamin B1) Solution
121. Thiamine Hydrochloride, P.a., 98%
122. Thiamine Hydrochloride [vandf]
123. Akos015905506
124. Thiamine Hydrochloride [mart.]
125. Thymine Hydrochloride [who-dd]
126. Ccg-220677
127. Chloride-hydrochloride Salt Of Thiamine
128. Cs-8164
129. Sb57886
130. Thiamine Hydrochloride [usp-rs]
131. Thiamine Hydrochloride [who-dd]
132. Thiamine Hydrochloride [who-ip]
133. Thiaminum Hydrochloricum [hpus]
134. Thiamine Chloride Hydrochloride (jp17)
135. Ncgc00017013-02
136. 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl}ethan- 1-ol, Chloride, Chloride
137. 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium Chloride Monohydrochloride
138. As-14151
139. Sy010871
140. Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- Chloride, Monohydrochloride
141. Db-054984
142. Thiamine Hydrochloride [ep Impurity]
143. Thiamine Hydrochloride [orange Book]
144. Thiamine Hydrochloride, >=98%, Fcc, Fg
145. Ft-0631293
146. Ft-0777960
147. T0181
148. Thiamine Chloride Hydrochloride [jan]
149. Thiamine Hydrochloride [ep Monograph]
150. Thiamine Hydrochloride [usp Monograph]
151. Thiamini Hydrochloridum [who-ip Latin]
152. D02094
153. Thiamine Hydrochloride 100 Microg/ml In Water
154. Thiamine Hydrochloride (b1), Analytical Standard
155. Thiamine Chloride, Hydrochloride [who-ip]
156. Q-201928
157. Thiamine Hydrochloride, Tested According To Ph.eur.
158. Q27121486
159. Thiamine Hydrochloride, Reagent Grade, >=99% (hplc)
160. Thiamine Hydrochloride, Saj Special Grade, >=98.5%
161. F0001-2415
162. F2173-0852
163. Thiamine Hydrochloride, Meets Usp Testing Specifications
164. Wln: T6n Cnj B1 Dz E1- At5k Csj D2q E1 &q &g &gh
165. Thiamine Hydrochloride, 99% (dry Wt.), May Cont. Up To 5% Water
166. Thiamine Hydrochloride (vitamin B1) 1.0 Mg/ml In Methanol (as Free Base)
167. Thiamine Hydrochloride, European Pharmacopoeia (ep) Reference Standard
168. Thiamine Hydrochloride, United States Pharmacopeia (usp) Reference Standard
169. Thiamine For System Suitability, European Pharmacopoeia (ep) Reference Standard
170. Thiamine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
171. Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-
172. 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- Ethylthiazolium Chloride, Monohydrochloride
173. 3-[(4-azaniumyl-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium Dichloride
174. Thiamine Hcl (vitamin B1) Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material
175. Thiamine Hydrochloride, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture, Suitable For Plant Cell Culture
176. Thiamine Hydrochloride, Pharmagrade, Ep, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production
177. Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m- Ethyl, Chloride, Monohydrochloride
178. Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, Chloride, Hydrochloride (1:1:1)
179. Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, Chloride, Monohydrochloride
| Molecular Weight | 337.3 g/mol |
|---|---|
| Molecular Formula | C12H18Cl2N4OS |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 336.0578378 g/mol |
| Monoisotopic Mass | 336.0578378 g/mol |
| Topological Polar Surface Area | 104 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 269 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 3 |
| 1 of 2 | |
|---|---|
| Drug Name | Thiamine hydrochloride |
| Drug Label | Thiamine Hydrochloride Injection, USP is a sterile solution of thiamine hydrochloride in Water for Injection for intramuscular (IM) or slow intravenous (IV) administration.Each mL contains: Thiamine hydrochloride 100 mg; chlorobutanol anhydrous (chlo... |
| Active Ingredient | Thiamine hydrochloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 100mg/ml |
| Market Status | Prescription |
| Company | Fresenius Kabi Usa; Mylan Institutional |
| 2 of 2 | |
|---|---|
| Drug Name | Thiamine hydrochloride |
| Drug Label | Thiamine Hydrochloride Injection, USP is a sterile solution of thiamine hydrochloride in Water for Injection for intramuscular (IM) or slow intravenous (IV) administration.Each mL contains: Thiamine hydrochloride 100 mg; chlorobutanol anhydrous (chlo... |
| Active Ingredient | Thiamine hydrochloride |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 100mg/ml |
| Market Status | Prescription |
| Company | Fresenius Kabi Usa; Mylan Institutional |
Thiamine is used to prevent and to treat thiamine deficiency syndromes including beriberi, Wernicke's encephalopathy syndrome, delirium, and peripheral neuritis associated with pellagra or neuritis of pregnancy (if associated with severe vomiting).
American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)
Although thiamine has not been shown by well-controlled trials to have any therapeutic value, the drug has been used for the management of poor appetite, ulcerative colitis, chronic diarrhea, other GI disorders, and the cerebellar syndrome. Thiamine has also been used orally as an insect repellent, but there is a lack of adequate evidence to establish the efficacy of thiamine for this use.
American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)
Low plasma thiamine concentrations have been found in patients with type 1 and type 2 diabetes mellitus. In a small placebo-controlled study, benfotiamine /a related vitamin B1 substance/ 100 mg given four times daily by mouth significantly improved neuropathic pain in patients with diabetic polyneuropathy. /Benfotiamine/
Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1976-7.
/This study assessed/ the effect of thiamine repletion on thiamine status, functional capacity, and left ventricular ejection fraction (LVEF) in patients with moderate to severe congestive heart failure (CHF) who had received furosemide in doses of 80 mg/d or more for at least 3 months. PATIENTS AND METHODS: Thirty patients were randomized to 1 week of double-blind inpatient therapy with either iv thiamine 200 mg/d or placebo (n = 15 each). All previous drugs were continued. Following discharge, all 30 patients received oral thiamine 200 mg/d as outpatients for 6 weeks. Thiamine status was determined by the erythrocyte thiamine-pyrophosphate effect (TPPE). LVEF was determined by echocardiography. RESULTS: TPPE, diuresis, and LVEF were unchanged with iv placebo. After iv thiamine, TPPE decreased (11.7% +/- 6.5% to 5.4% +/- 3.2%; P < 0.01). LVEF increased (0.28 +/- 0.11 to 0.32 +/- 0.09; P < 0.05), as did diuresis (1,731 +/- 800 mL/d to 2,389 +/- 752 mL/d; P < 0.02), and sodium excretion (84 +/- 52 mEq/d to 116 +/- 83 mEq/d, P < 0.05). In the 27 patients completing the full 7-week intervention, LVEF rose by 22% (0.27 +/- 0.10 to 0.33 +/- 0.11, P < 0.01). CONCLUSIONS: Thiamine repletion can improve left ventricular function and biochemical evidence of thiamine deficiency in some patients with moderate-to-severe CHF who are receiving longterm furosemide therapy.
PMID:7733128 Shimon I et al; Am J Med 98 (5): 485-90 (1995).
For more Therapeutic Uses (Complete) data for Vitamin B1 (11 total), please visit the HSDB record page.
Serious hypersensitivity/anaphylactic reactions can occur, especially after repeated administration. Deaths have resulted from IV or IM administration of thiamine.
Novak, K.M. (ed.). Drug Facts and Comparisons2008 Edition. Wolters Kluwer Health. St. Louis, Missouri 2008., p. 18
Anaphylaxis as an adverse systemic reaction to thiamine (vitamin B1) has been described in the literature since 1938. Although its precise mechanism is still uncertain, the reaction appears to involve immediate type hypersensitivity and to be exclusively related to parenteral administration...
PMID:9846348 Morinville V et al; Schweiz Med Wochenschr 128 (44): 1743-4 (1998).
Anaphylaxis. There have been occasional reports of serious and even fatal responses to the parenteral administration of thiamin. The clinical characteristics have strongly suggested an anaphylactic reaction. Symptoms associated with thiamin-induced anaphylaxis include anxiety, pruritus, respiratory distress, nausea, abdominal pain, and shock, sometimes progressing to death.
NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 81, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html
Adverse reactions with thiamine are rare, but hypersensitivity reactions have occurred, mainly after parenteral doses. These reactions have ranged in severity from very mild to, very rarely, fatal anaphylactic shock ... The UK Committee on Safety of Medicines had received, between 1970 and July, 1988, 90 reports of adverse reactions associated with the use of an injection containing high doses of vitamins B and C. The most frequent reactions were anaphylaxis (41 cases, including 2 fatalities), dyspnea or bronchospasm (13 cases), and rash or flushing (22 cases); 78 of the reactions occurred during, or shortly after, intravenous injection and the other 12 after intramuscular injectdion. They recommended that parenteral treatment be used only when essential, and that, when given, facilities for treating anaphylaxis should be available. They also recommended that, when the intravenous route was used, the injection be given slowly (over 10 minutes). Various authors have noted that parenteral treatment is essential for the prophylaxis and treatment of Wernicke's encephalopathy. However, further reports of anaphylaxis to parenteral thiamine have since been described, including one with a fatal outcome.
Sweetman SC (ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press (2009), p.1976.
For more Drug Warnings (Complete) data for Vitamin B1 (15 total), please visit the HSDB record page.
Absorption of thiamin occurs mainly in the jejunum. At low concentrations of thiamin, absorption occurs by an active transport system that involves phosphyrylation; at higher concentrations, absorption occurs by passive diffusion. Only a small percentage of a high dose of thiamin is absorbed, and elevated serum values result in active urinary excretion of the vitamin.
Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p. 281
Thiamin is transported in blood in both erythrocytes and plasma and is excreted in the urine.
Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p.281
Thiamine is absorbed from the small intestine and is phosphorylated in the intestinal mucosa.
Furia, T.E. (ed.). CRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 89
The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Thiamine is absorbed mainly in the duodenum.
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 2647
For more Absorption, Distribution and Excretion (Complete) data for Vitamin B1 (8 total), please visit the HSDB record page.
Converted in vivo to thiamine diphosphate, a coenzyme in the decarboxylation of alpha-keto acids.
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1598
Compound 3-(2'-methyl-4'-amino-5'-pyrimidylmethyl)-4-methylthiazole-5-acetic acid, ie thiamine acetic acid, 2-methyl-4-amino-5-formylaminomethylpyrimidine, and 5-(2-hydroxyethyl)-4-methylthiazole have been identified as important metabolites of thiamine, vitamin B1.
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 248
Biotransformation of thiamine in mammals is generally supposed to /yield/ thiochrome, thiamine disulfide, 5-(2-hydroxyethyl)-4-methyl-thiazole, and some form corresponding to pyrimidine residue of thiamine.
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 1: A Review of the Literature Published Between 1960 and 1969. London: The Chemical Society, 1970., p. 229
Thiamine is metabolized in the liver of animals. Several urinary metabolites of thiamine have been identified in humans. Little or no unchanged thiamine is excreted in urine following administration of physiologic doses; however, following administration of larger doses, both unchanged thiamine and metabolites are excreted after tissue stores become saturated.
American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)
The biological half-life of the vitamin is in the range of 9-18 days.
Otten JJ, Hellwig JP, Meyers LD, eds; Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, Washington, DC: The National Academies Press, 2006, p.281
With higher pharmacological levels, namely repetitive 250-mg amounts taken orally and 500 mg given intramuscularly, nearly 1 week was required for steady state plasma concentrations to be reached; a mean elimination half-life of 1.8 days was estimated.
NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 59, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html
Total thiamin content of the adult human has been estimated to be approximately 30 mg, and the biological half-life of the vitamin is probably in the range of 9 to 18 days.
NAS, Food and Nutrition Board, Institute of Medicine; Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press, Washington, D.C., pg. 59, 1998. Available from, as of March 2, 2010: https://www.nap.edu/catalog/6015.html
Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-1) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that transketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of patients with cancer.
PMID:10890024 Cascante M et al; Nutr Cancer 36 (2): 150-4 (2000).
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