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04334_RIEDEL

04334_RIEDEL

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Also known as: 7758-29-4, Pentasodium triphosphate, Sodium triphosphate, Stpp, Pentasodium tripolyphosphate, Triphosphoric acid, pentasodium salt

Molecular Formula

Na₅O₁₀P₃

Molecular Weight

367.86 g/mol

InChI Key

HWGNBUXHKFFFIH-UHFFFAOYSA-I

FDA UNII

9SW4PFD2FZ

Sodium tripolyphosphate is an inorganic compound with formula Na5P3O10 and the sodium salt of the polyphosphate penta-anion. It is used as a component of a wide range domestic and industrial products, particularly detergents.

1 2D Structure

04334_RIEDEL

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate

2.1.2 InChI

InChI=1S/5Na.H5O10P3/c;;;;;1-11(2,3)9-13(7,8)10-12(4,5)6/h;;;;;(H,7,8)(H2,1,2,3)(H2,4,5,6)/q5*+1;/p-5

2.1.3 InChI Key

HWGNBUXHKFFFIH-UHFFFAOYSA-I

2.1.4 Canonical SMILES

[O-]P(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

9SW4PFD2FZ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Pentapotassium Triphosphate

2. Potassium Triphosphate

3. Sodium Triphosphate

4. Sodium Tripolyphosphate Anhydrous

5. Tetrasodium Tripolyphosphate

6. Triphosphate

7. Triphosphoric Acid

8. Triphosphoric Acid, 99tc-labeled Cpd

9. Triphosphoric Acid, Pentapotassium Salt

10. Triphosphoric Acid, Pentasodium Salt

11. Triphosphoric Acid, Sodium Salt

12. Triphosphoric Acid, Sodium, Potassium Salt

13. Tripolyphosphate

2.3.2 Depositor-Supplied Synonyms

1. 7758-29-4

2. Pentasodium Triphosphate

3. Sodium Triphosphate

4. Stpp

5. Pentasodium Tripolyphosphate

6. Triphosphoric Acid, Pentasodium Salt

7. Triphosphoric Acid, Sodium Salt

8. 9sw4pfd2fz

9. Sodium Tripolyphosphate Anhydrous

10. Thermphos

11. Mfcd00003514

12. Pentasodium;[oxido(phosphonatooxy)phosphoryl] Phosphate

13. Armofos

14. Polygon

15. Tripoly

16. Rhodiaphos Lv

17. Thermphos N

18. Empiphos Stp-d

19. Thermphos Spr

20. Thermphos L 50

21. Caswell No. 799

22. Natriumtripolyphosphat

23. Natriumtripolyphosphat [german]

24. Sodium Phosphate (na5p3o10)

25. Hsdb 1099

26. Sodium Tripolyphosphate, Anhydrous

27. Sodium Triphosphate (na5p3o10)

28. Einecs 231-838-7

29. Unii-9sw4pfd2fz

30. Sodium Tripolyphosphate (na5p3o10)

31. Epa Pesticide Chemical Code 076404

32. Na5p3o10

33. S 400

34. Ec 231-838-7

35. Dtxsid9036307

36. Sodium Tripolyphosphate [mi]

37. Sodium Triphosphate (na5(p3o10))

38. Akos015902309

39. Akos015951376

40. Db11493

41. Pentasodium Triphosphate [inci]

42. Triphosphoric Acid, Sodium Salt (1:5)

43. Pentasodium Tripolyphosphate [hsdb]

44. Sodium Tripolyphosphate [green Book]

45. Ft-0689070

46. Sodium Tripolyphosphate, Technical Grade, 85%

47. Q29145

48. Sodium Triphosphate Pentabasic, Purum P.a., >=98.0% (t)

49. Sodium Triphosphate Pentabasic, Vetec(tm) Reagent Grade, 98%

50. Sodium Tripolyphosphate, Saj First Grade, 56.0-61.0% P2o5 Basis

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	Na₅O₁₀P₃
Molecular Weight	367.86 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	2
Exact Mass	367.8192786 g/mol
Monoisotopic Mass	367.8192786 g/mol
Topological Polar Surface Area	185 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	241
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	6

4 Drug and Medication Information

4.1 Therapeutic Uses

MEDICATION (VET): USED IN WATER SOL DISPERSIBLE PREMIXES OR IN LIQ FEED SUPPLEMENTS AS PHOSPHORUS SOURCE FOR CATTLE. ... AS CALCIUM & MAGNESIUM CHELATOR, IT NOT ONLY FINDS WIDESPREAD USE IN WATER SOFTENING BUT AS ADJUNCTIVE ORAL PROPHYLAXIS AGAINST SUCH MINERAL BASED URINARY CALCULI IN CATS.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 548

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

If ingested in large amounts nausea, vomiting and diarrhea are probable. Thought to be hydrolyzed to (ortho)phosphates before absorption. If appreciable amounts of the intact polymer are absorbed from the alimentary tract, hypocalcemic tetany may be a danger due to the binding (chelation) of ionized calcium. Hypocalcemic tetany apparently occurred in one ingestion episode. /Tripolyphosphate/

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-121

5.2 Metabolism/Metabolites

THOUGHT TO BE HYDROLYZED TO (ORTHO)PHOSPHATES BEFORE ABSORPTION. /TRIPOLYPHOSPHATE/

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-121

In the body, phosphorus is converted to phosphates. /Phosphorus/

Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2122

5.3 Mechanism of Action

The effects of condensed phosphate ( ... sodium tripolyphosphate ... ) on the growth of Streptococcus mutans, sugar metabolism in vitro, and S mutans-induced caries of hamsters were studied. All condensed phosphates depressed the growth of S mutans. This growth inhibition was reversed by divalent metal ions. Thus, the chelating capacity of condensed phosphate is responsible for their antibacterial actions. Condensed phosphates depressed lactate production from glucose and sucrose by the S mutans.

PMID:7308964 Shibata H; Fukuoka Igaku Zasshi 72 (6): 379-91 (1981)